letter Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin
Toru Hirota, Jesse J. Lipp, Ban-Hock Toh and Jan-Michael Peters Nature438, 1176–1180
(22 December 2005); doi:10.1038/nature04254
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article Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2
Xiaogang Li, Ying Luo, Patrick G. Starremans, Coleen A. McNamara, York Pei and Jing Zhou Nature Cell Biology7, 1202–1212
(December 2005); doi:10.1038/ncb1326
| Abstract | Full Text (HTML/PDF) |
Review article Oncogenic PI3K deregulates transcription and translation
Andreas G. Bader, Sohye Kang, Li Zhao and Peter K. Vogt Nature Reviews Cancer5, 921–929
(December 2005); doi:10.1038/nrc1753
| Summary | Full Text (HTML / PDF) |
article A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control
Vadim Budagian, Elena Bulanova, Zane Orinska, Lutz Thon, Uwe Mamat1, Paola Bellosta, Claudio Basilico, Dieter Adam, Ralf Paus and Silvia Bulfone-Paus The EMBO Journal24, 4260–4270
(December 2005); doi:10.1038/sj.emboj.7600874
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article Regulation of G0 entry by the Pho80—Pho85 cyclin—CDK complex
Valeria Wanke, Ivo Pedruzzi, Elisabetta Cameroni, Frédérique Dubouloz and Claudio De Virgilio The EMBO Journal24, 4271–4278
(December 2005); doi:10.1038/sj.emboj.7600889
| First Paragraph | Full Text (HTML/PDF) |
letter Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction
Gary Davidson, Wei Wu, Jinlong Shen, Josipa Bilic, Ursula Fenger, Peter Stannek, Andrei Glinka and Christof Niehrs Nature438, 867–872
(08 December 2005); doi:10.1038/nature04170
| First Paragraph | Full Text (HTML / PDF) |
letter A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
Xin Zeng, Keiko Tamai, Brad Doble, Shitao Li, He Huang, Raymond Habas, Heidi Okamura, Jim Woodgett and Xi He Nature438, 873–877
(08 December 2005); doi:10.1038/nature04185
| First Paragraph | Full Text (HTML / PDF) |
news and views Cell biology: Relays at the membrane
Roel Nusse Nature438, 747–749
(08 December 2005); doi:10.1038/438747a
| Full Text (HTML / PDF) |
article Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
Koichi Yoshimura, Hiroki Aoki, Yasuhiro Ikeda, Kozo Fujii, Norio Akiyama, Akira Furutani, Yoshinobu Hoshii, Nobuyuki Tanaka, Romeo Ricci, Tokuhiro Ishihara, Kensuke Esato, Kimikazu Hamano and Masunori Matsuzaki Nature Medicine11, 1330–1338
(December 2005); doi:10.1038/nm1335
| Abstract | Full Text (HTML/PDF) |
news and views Aneurysm treatments expand
Robert W Thompson Nature Medicine11, 1279–1281
(December 2005); doi:10.1038/nm1205-1279
| Full Text (HTML/PDF) |
letter Global analysis of protein phosphorylation in yeast
Jason Ptacek, Geeta Devgan, Gregory Michaud, Heng Zhu, Xiaowei Zhu, Joseph Fasolo, Hong Guo, Ghil Jona, Ashton Breitkreutz, Richelle Sopko, Rhonda R. McCartney, Martin C. Schmidt, Najma Rachidi, Soo-Jung Lee, Angie S. Mah, Lihao Meng, Michael J. R. Stark, David F. Stern, Claudio De Virgilio, Mike Tyers, Brenda Andrews, Mark Gerstein, Barry Schweitzer, Paul F. Predki and Michael Snyder Nature438, 679–684
(01 December 2005); doi:10.1038/nature04187
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article Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76
Tadashi Yokosuka, Kumiko Sakata-Sogawa, Wakana Kobayashi, Michio Hiroshima, Akiko Hashimoto-Tane, Makio Tokunaga, Michael L Dustin and Takashi Saito Nature Immunology6, 1253–1262
(December 2005); doi:10.1038/ni1272
| Abstract | Full Text (HTML/PDF) |
brief communication Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR
Daphne W Bell, Ira Gore, Ross A Okimoto, Nadia Godin-Heymann, Raffaella Sordella, Roseann Mulloy, Sreenath V Sharma, Brian W Brannigan, Gayatry Mohapatra, Jeff Settleman and Daniel A Haber Nature Genetics37, 1315–1316
(December 2005); doi:10.1038/ng1671
| First Paragraph | Full Text (HTML/PDF) |
November
letter The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation
Uttiya Basu, Jayanta Chaudhuri , Craig Alpert, Shilpee Dutt, Sheila Ranganath, Gang Li, Jason Patrick Schrum, John P. Manis and Frederick W. Alt Nature438, 508–511
(24 November 2005); doi:10.1038/nature04255
| First Paragraph | Full Text (HTML / PDF) |
letter Spatial regulation of β-actin translation by Src-dependent phosphorylation of ZBP1
Stefan Hüttelmaier, Daniel Zenklusen, Marcell Lederer, Jason Dictenberg, Mike Lorenz, XiuHua Meng, Gary J. Bassell, John Condeelis and Robert H. Singer Nature438, 512–515
(24 November 2005); doi:10.1038/nature04115
| First Paragraph | Full Text (HTML / PDF) |
article Essential function for the kinase TAK1 in innate and adaptive immune responses
Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Kunihiro Matsumoto, Osamu Takeuchi and Shizuo Akira Nature Immunology6, 1087–1095
(November 2005); doi:10.1038/ni1255
| Abstract | Full Text (HTML/PDF) |
article The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer
Pavel Tolar, Hae Won Sohn and Susan K Pierce Nature Immunology6, 1168–1176
(November 2005); doi:10.1038/ni1262
| Abstract | Full Text (HTML/PDF) |
article Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo
Juhua Chen, Payaningal R Somanath, Olga Razorenova, William S Chen, Nissim Hay, Paul Bornstein and Tatiana V Byzova Nature Medicine11, 1188–1196
(November 2005); doi:10.1038/nm1307
| Abstract | Full Text (HTML/PDF) |
article Distinct enzyme combinations in AKAP signalling complexes permit functional diversity
Naoto Hoshi, Lorene K. Langeberg and John D. Scott Nature Cell Biology7, 1066–1073
(November 2005); doi:10.1038/ncb1315
| Abstract | Full Text (HTML/PDF) |
news and views A-kinase anchoring proteins: different partners, different dance
Lei Chen and Robert S. Kass Nature Cell Biology7, 1050–1051
(November 2005); doi:10.1038/ncb1105-1050
| Full Text (HTML/PDF) |
news and views Autophagy: to die or not to die
Myrto Raftopoulou Nature Cell Biology7, 1056
(November 2005); doi:10.1038/ncb1105-1056
| Full Text (HTML/PDF) |
article Essential function for the kinase TAK1 in innate and adaptive immune responses
Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, Jun Ninomiya-Tsuji, Masahiro Yamamoto, Taro Kawai, Kunihiro Matsumoto, Osamu Takeuchi and Shizuo Akira Nature Immunology6, 1087–1095
(November 2005); doi:10.1038/ni1255
| Abstract | Full Text (HTML/PDF) |
letter Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs
Nara Lee, Cédric Maurange, Leonie Ringrose and Renato Paro Nature438, 234–237
(10 November 2005); doi:10.1038/nature04120
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article MPS-1 is a K+ channel β-subunit and a serine/threonine kinase
Shi-Qing Cai, Leonardo Hernandez, Yi Wang, Ki Ho Park and Federico Sesti Nature Neuroscience8, 1503–1509
(November 2005); doi:10.1038/nn1557
| Abstract | Full Text (HTML/PDF) |
review article Coordinating ERK/MAPK signaling through scaffolds and inhibitors
Walter Kolch Nature Reviews Molecular Cell Biology6, 827–837
(November 2005); doi:10.1038/nrm1743
| Abstract
| Full Text (HTML / PDF) |
news and views Hitching RIG to action
Ganes C Sen and Saumendra N Sarkar Nature Immunology6, 1074–1076
(November 2005); doi:10.1038/ni1105-1074
| Full Text (HTML / PDF) |
article Phosphorylation of ephrin-B1 via the interaction with claudin following cell–cell contact formation
Masamitsu Tanaka, Reiko Kamata and Ryuichi Sakai The EMBO Journal24, 3700–3711
(2 November 2005); doi:10.1038/sj.emboj.7600831
| Abstract
| Full Text (HTML / PDF) |
October
article The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Seung-Hoi Koo, Lawrence Flechner, Ling Qi, Xinmin Zhang, Robert A. Screaton, Shawn Jeffries, Susan Hedrick, Wu Xu, Fayçal Boussouar, Paul Brindle, Hiroshi Takemori and Marc Montminy Nature437, 1109–11
(20 October 2005); doi:10.1038/nature03967
| Abstract | Full Text (HTML / PDF) |
letter Photosystem II core phosphorylation and photosynthetic acclimation require two different protein kinases
Vera Bonardi, Paolo Pesaresi, Thomas Becker, Enrico Schleiff, Raik Wagner, Thomas Pfannschmidt, Peter Jahns and Dario Leister Nature437, 1179–1182
(20 October 2005); doi:10.1038/nature04016
| First Paragraph | Full Text (HTML / PDF) |
article The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome
Elena N. Pugacheva and Erica A. Golemis Nature Cell Biology7, 937–946
(October 2005); doi:10.1038/ncb1309
| Abstract | Full Text (HTML/PDF) |
letter Cdk5-dependent regulation of glucose-stimulated insulin secretion
Fan-Yan Wei, Kazuaki Nagashima, Toshio Ohshima, Yasunori Saheki, Yun-Fei Lu, Masayuki Matsushita, Yuichiro Yamada, Katsuhiko Mikoshiba, Yutaka Seino, Hideki Matsui and Kazuhito Tomizawa Nature Medicine11, 1104–1108
(October 2005); doi:10.1038/nm1299
| First Paragraph | Full Text (HTML/PDF) |
September
letter Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
Jin Zhang , Christopher J. Hupfeld, Susan S. Taylor, Jerrold M. Olefsky and Roger Y. Tsien Nature437, 569–573
(22 September 2005); doi:10.1038/nature04140
| First Paragraph | Full Text (HTML / PDF) |
letter The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
Kimberly L. Dodge-Kafka, Joseph Soughayer, Genevieve C. Pare, Jennifer J. Carlisle Michel, Lorene K. Langeberg, Michael S. Kapiloff and John D. Scott Nature437, 574–578
(22 September 2005); doi:10.1038/nature03966
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brief communication PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Domingo F Barber, Almira Bartolomé, Carmen Hernandez, Juana M Flores, Clara Redondo, Cristina Fernandez-Arias, Montserrat Camps, Thomas Rückle, Matthias K Schwarz, Santiago Rodríguez, Carlos Martinez-A, Dimitrios Balomenos, Christian Rommel and Ana C Carrera Nature Medicine11, 933–935
(September 2005); doi:10.1038/nm1291
| First Paragraph | Full Text (HTML/PDF) |
article Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Montserrat Camps, Thomas Rückle, Hong Ji, Vittoria Ardissone, Felix Rintelen, Jeffrey Shaw, Chiara Ferrandi, Christian Chabert, Corine Gillieron, Bernard Françon, Thierry Martin, Denise Gretener, Dominique Perrin, Didier Leroy, Pierre-Alain Vitte, Emilio Hirsch, Matthias P Wymann, Rocco Cirillo, Matthias K Schwarz and Christian Rommel Nature Medicine11, 936–943
(September 2005); doi:10.1038/nm1284
| Abstract | Full Text (HTML/PDF) |
news and views Modulating autoimmunity: pick your PI3 kinase
Pamela S Ohashi and James R Woodgett Nature Medicine11, 924–925
(September 2005); doi:10.1038/nm0905-924
| Full Text (HTML/PDF) |
review article Urothelial tumorigenesis: a tale of divergent pathways
Xue-Ru Wu Nature Reviews Cancer5, 713–725
(September 2005); doi:10.1038/nrc1697
| Abstract | Full Text (HTML / PDF) |
article Activation of GPCRs modulates quantal size in chromaffin cells through Gβγ and PKC
Xiao-Ke Chen, Lie-Cheng Wang, Yang Zhou, Qian Cai, Murali Prakriya, Kai-Lai Duan, Zu-Hang Sheng, Christopher Lingle and Zhuan Zhou Nature Neuroscience8, 1160–1168
(September 2005); doi:10.1038/nn1529
| Abstract | Full Text (HTML/PDF) |
August
letter Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration
Krishnaraj Rajalingam, Christian Wunder, Volker Brinkmann, Yuri Churin, Mirko Hekman, Claudia Sievers, Ulf R. Rapp and Thomas Rudel Nature Cell Biology7, 837–843
(August 2005); doi:10.1038/ncb1283
| First Paragraph | Full Text (HTML/PDF) |
letter Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2
Mauro Costa-Mattioli, Delphine Gobert, Heather Harding, Barbara Herdy, Mounia Azzi, Martin Bruno, Michael Bidinosti, Cyrinne Ben Mamou, Edwige Marcinkiewicz, Madoka Yoshida, Hiroaki Imataka, A. Claudio Cuello, Nabil Seidah, Wayne Sossin, Jean-Claude Lacaille, David Ron, Karim Nader and Nahum Sonenberg Nature436, 1166–1173
(25 August 2005); doi:10.1038/nature03897
| First Paragraph | Full Text (HTML / PDF) |
letter Cdc2-cyclin E complexes regulate the G1/S phase transition
Eiman Aleem, Hiroaki Kiyokawa and Philipp Kaldis Nature Cell Biology7, 831–836
(August 2005); doi:10.1038/ncb1284
| First Paragraph | Full Text (HTML/PDF) |
news and views Cdk1: the dominant sibling of Cdk2
Tarig Bashir and Michele Pagano Nature Cell Biology7, 779–781
(August 2005); doi:10.1038/ncb0805-779
| Full Text (HTML/PDF) |
letter The ERECTA gene regulates plant transpiration efficiency in Arabidopsis
Josette Masle, Scott R. Gilmore and Graham D. Farquhar Nature436, 866–870
(11 August 2005); doi:10.1038/nature03835
| First Paragraph | Full Text (HTML / PDF) |
brief communication Colorectal cancer: Mutations in a signalling pathway
D. Williams Parsons, Tian-Li Wang, Yardena Samuels, Alberto Bardelli, Jordan M. Cummins, Laura DeLong, Natalie Silliman, Janine Ptak, Steve Szabo, James K. V. Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer and Victor E. Velculescu Nature436, 792
(11 August 2005); doi:10.1038/436792a
| First Paragraph | Full Text (HTML / PDF) |
article Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosis
Sathyamangla V. Naga Prasad, Arundathi Jayatilleke, Aasakiran Madamanchi and Howard A. Rockman Nature Cell Biology7, 785–796
(August 2005); doi:10.1038/ncb1278
| Abstract | Full Text (HTML/PDF) |
news and views Substrate specificity: PI(3)Kγ has it both ways
Jonathan M. Backer Nature Cell Biology7, 773–774
(August 2005); doi:10.1038/ncb0805-773
| Full Text (HTML/PDF) |
article Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
Michael Martin, Kunal Rehani, Richard S Jope and Suzanne M Michalek Nature Immunology6, 777–784
(August 2005); doi:10.1038/ni1221
| Abstract | Full Text (HTML/PDF) |
news and views GSK3: an in-Toll-erant protein kinase?
James R Woodgett and Pamela S Ohashi Nature Immunology6, 751–752
(August 2005); doi:10.1038/ni0805-751
| Full Text (HTML/PDF) |
July
article PI3 kinase signaling is required for retrieval and extinction of contextual memory
Xi Chen, Michael G Garelick, Hongbing Wang, Vicky Li, Jaime Athos and Daniel R Storm Nature Neuroscience8, 925–931
(July 2005); doi:10.1038/nn1482
| Abstract | Full Text (HTML/PDF) |
letter DNA processing is not
required for ATM-mediated telomere damage response after TRF2
deletion Giulia B. Celli and Titia de Lange Nature Cell Biology7, 712–718 (July 2005); doi:10.1038/ncb1275 | First Paragraph | Full Text (HTML/PDF)
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article Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases
Patrick M Reeves, Bettina Bommarius, Sarah Lebeis, Shannon McNulty, Jens Christensen, Alyson Swimm, Ann Chahroudi, Rahul Chavan, Mark B Feinberg, Darren Veach, William Bornmann, Melanie Sherman and Daniel Kalman Nature Medicine11, 731–739
(July 2005); doi:10.1038/nm1265
| Abstract | Full Text (HTML/PDF) |
news and views Gleevec casts a pox on poxviruses
Grant McFadden Nature Medicine11, 711–712
(July 2005); doi:10.1038/nm0705-711
| Full Text (HTML/PDF) |
article Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis
Lucas Pelkmans, Eugenio Fava, Hannes Grabner, Michael Hannus, Bianca Habermann, Eberhard Krausz and Marino Zerial Nature436, 78–86
(07 July 2005); doi:10.1038/nature03571
| Summary | Full Text (HTML / PDF) |
letter Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae
Lucas Pelkmans and Marino Zerial Nature436, 128–133
(07 July 2005); doi:10.1038/nature03866
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article Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig, and André Nussenzweig Nature Cell Biology7 675–685
(July 2005); doi:10.1038/ncb1270
| Abstract | Full Text (HTML/PDF) |
news and views Nbs1 moving up in the world
Elena S. Stavridi and Thanos D. Halazonetis Nature Cell Biology7, 648–650
(July 2005); doi:10.1038/ncb0705-648
| Full Text (HTML/PDF) |
news and views Huntingtin and the vicious circle
Jack Horne Nature Cell Biology7, 650
(July 2005); doi:10.1038/ncb0705-650
| Full Text (HTML/PDF) |
June
article Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation
Fan Pan, Anthony R Means and Jun O Liu The EMBO Journal24, 2104–2113
(June 2005); doi:10.1038/sj.emboj.7600685
| Abstract | Full Text (HTML/PDF) |
article ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
Atsushi Matsuzawa, Kaoru Saegusa, Takuya Noguchi, Chiharu Sadamitsu, Hideki Nishitoh, Shigenori Nagai, Shigeo Koyasu, Kunihiro Matsumoto, Kohsuke Takeda and Hidenori Ichijo Nature Immunology6, 587–592
(June 2005); doi:10.1038/ni1200
| Abstract | Full Text (HTML/PDF) |
news and views Linking stress to immunity?
Bing Su Nature Immunology6, 541–542
(June 2005); doi:10.1038/ni0605-541
| Full Text (HTML/PDF) |
article Dynamic recruitment of PAK1 to the immunological synapse is mediated by PIX independently of SLP-76 and Vav1
Hyewon Phee, Robert T Abraham and Arthur Weiss Nature Immunology6, 608–617
(June 2005); doi:10.1038/ni1199
| Abstract | Full Text (HTML/PDF) |
article Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase
Ellen J. Ezratty, Michael A. Partridge and Gregg G. Gundersen Nature Cell Biology7, 581–590
(June 2005); doi:10.1038/ncb1262
| Abstract | Full Text (HTML/PDF) |
news and views Foot in mouth: do focal adhesions disassemble by endocytosis?
Keith Burridge Nature Cell Biology7, 545–547
(June 2005); doi:10.1038/ncb0605-545
| Full Text (HTML/PDF) |
brief communication A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens, Sarah O'Meara, Adrian Parker, Patrick Tarpey, Tim Avis, Andy Barthorpe, Lisa Brackenbury, Gemma Buck, Adam Butler, Jody Clements, Jennifer Cole, Ed Dicks, Ken Edwards, Simon Forbes, Matthew Gorton, Kristian Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jonathon Hinton, David Jones, Vivienne Kosmidou, Ross Laman, Richard Lugg, Andrew Menzies, Janet Perry, Robert Petty, Keiran Raine, Rebecca Shepherd, Alexandra Small, Helen Solomon, Yvonne Stephens, Calli Tofts, Jennifer Varian, Anthony Webb, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S Cooper, Adrienne M Flanagan, Anthony Green, Maggie Knowles, Suet Y Leung, Leendert H J Looijenga, Bruce Malkowicz, Marco A Pierotti, Bin Teh, Siu T Yuen, Andrew G Nicholson, Sunil Lakhani, Douglas F Easton, Barbara L Weber, Michael R Stratton, P Andrew Futreal and Richard Wooster Nature Genetics37, 590–592
(June 2005); doi:10.1038/ng1571
| First Paragraph | Full Text (HTML/PDF) |
May
letter to nature Polo kinase links the stress pathway to cell cycle control and tip growth in fission yeast
Janni Petersen and Iain M. Hagan Nature435, 507–512
(26 May 2005); doi:10.1038/nature03590
| First Paragraph | Full Text (HTML / PDF) |
letter Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
Emilie A Bard-Chapeau, Andrea L Hevener, Shinong Long, Eric E Zhang, Jerrold M Olefsky and Gen-Sheng Feng Nature Medicine11, 567–571
(May 2005); doi:10.1038/nm1227
| First Paragraph | Full Text (HTML/PDF) |
article Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Kei Sakamoto, Afshan McCarthy, Darrin Smith, Kevin A Green, D Grahame Hardie, Alan Ashworth and Dario R Alessi The EMBO Journal24, 1810–1820
(May 2005); doi:10.1038/sj.emboj.7600667
| Abstract | Full Text (HTML/PDF) |
letter Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Min Hee Choi, In Kyung Lee, Gyung Whan Kim, Bang Ul Kim, Ying-Hao Han, Dae-Yeul Yu, Hye Sun Park, Kyung Yong Kim, Jong Seo Lee, Chulhee Choi, Yun Soo Bae, Byung In Lee, Sue Goo Rhee and Sang Won Kang Nature435, 347–353
(19 May 2005); doi:10.1038/nature03587
| First Paragraph | Full Text (HTML / PDF) |
article α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
Li Chen and Mel B Feany Nature Neuroscience8, 657–663
(May 2005); doi:10.1038/nn1443
| Abstract | Full Text (HTML/PDF) |
letter EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1
Fumitoshi Irie, Misako Okuno, Elena B. Pasquale and Yu Yamaguchi Nature Cell Biology7, 501–509
(May 2005); doi:10.1038/ncb1252
| First Paragraph | Full Text (HTML/PDF) |
news and views Ephrin tempers two-faced synaptojanin 1
Neil A. Hopper and Vincent O'Connor Nature Cell Biology7, 454–456
(May 2005); doi:10.1038/ncb0505-454
| Full Text (HTML/PDF) |
review article Mechanisms of type-I- and type-II-interferon-mediated signalling
Leonidas C. Platanias Nature Reviews Immunology5, 375–386
(May 2005); doi:10.1038/nri1604
| Summary | Full Text (HTML / PDF) |
article Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase
Alan Lau, Karra M. Swinbank, Parvin S. Ahmed, Debra L. Taylor, Stephen P. Jackson, Graeme C. M. Smith and Mark J. O'Connor Nature Cell Biology7, 493–500
(May 2005); doi:10.1038/ncb1250
| Abstract | Full Text (HTML/PDF) |
news and views ATM: HIV-1's Achilles heel?
René Daniel and Roger J. Pomerantz Nature Cell Biology7, 452–453
(May 2005); doi:10.1038/ncb0505-452
| Full Text (HTML/PDF) |
article The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids
Jean-Michel Revest, Francesco Di Blasi, Pierre Kitchener, Françoise Rougé-Pont, Aline Desmedt, Marc Turiault, François Tronche and Pier Vincenzo Piazza Nature Neuroscience8, 664–672
(May 2005); doi:10.1038/nn1441
| Abstract | Full Text (HTML/PDF) |
article PI 3-kinase p110β: a new target for antithrombotic therapy
Shaun P Jackson, Simone M Schoenwaelder, Isaac Goncalves, Warwick S Nesbitt, Cindy L Yap, Christine E Wright, Vijaya Kenche, Karen E Anderson, Sacha M Dopheide, Yuping Yuan, Sharelle A Sturgeon, Hishani Prabaharan, Philip E Thompson, Gregg D Smith, Peter R Shepherd, Nathalie Daniele, Suhasini Kulkarni, Belinda Abbott, Dilek Saylik, Catherine Jones, Lucy Lu, Simon Giuliano, Sascha C Hughan, James A Angus, Alan D Robertson and Hatem H Salem Nature Medicine11, 507–514
(May 2005); doi:10.1038/nm1232
| Abstract | Full Text (HTML/PDF) |
April
letters to nature IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
Toby Lawrence , Magali Bebien, George Y. Liu, Victor Nizet and Michael Karin Nature434, 1138–1143
(28 April 2005); doi:10.1038/nature03491
| First Paragraph | Full Text (HTML / PDF) |
letters to nature A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
Chloé James, Valérie Ugo, Jean-Pierre Le Couédic, Judith Staerk, François Delhommeau, Catherine Lacout, Loïc Garçon, Hana Raslova, Roland Berger, Annelise Bennaceur-Griscelli, Jean Luc Villeval, Stefan N.Constantinescu, Nicole Casadevall and William Vainchenker Nature434, 1144–1148
(28 April 2005); doi:10.1038/nature03546
| First Paragraph | Full Text (HTML / PDF) |
review article TEC-family kinases: regulators of T-helper-cell differentiation
Pamela L. Schwartzberg, Lisa D. Finkelstein and Julie A. Readinger Nature Reviews Immunology5, 284–295
(April 2005); doi:10.1038/nri1591
| Summary | Full Text (HTML / PDF) |
article The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis
Teiji Wada, Tomoki Nakashima, Antonio J Oliveira-dos-Santos, Juerg Gasser, Hiromitsu Hara, Georg Schett and Josef M Penninger Nature Medicine11, 394–399
(April 2005); doi:10.1038/nm1203
| Abstract | Full Text (HTML/PDF) |
review article Nuclear factor-κB inhibitors as sensitizers to anticancer drugs
Chikashi Nakanishi and Masakazu Toi Nature Reviews Cancer5, 297–309
(April 2005); doi:10.1038/nrc1588
| Summary | Full Text (HTML / PDF) |
letters to nature Visualizing the mechanical activation of Src
Yingxiao Wang, Elliot L. Botvinick, Yihua Zhao, Michael W. Berns , Shunichi Usami, Roger Y. Tsien and Shu Chien Nature434, 1040–1045
(21 April 2005); doi:10.1038/nature03469
| First Paragraph | Full Text (HTML / PDF) |
article Prediction and validation of the distinct dynamics of transient and sustained ERK activation
Satoru Sasagawa, Yu-ichi Ozaki, Kazuhiro Fujita and Shinya Kuroda Nature Cell Biology7, 365–373
(April 2005); doi:10.1038/ncb1233
| Abstract | Full Text (HTML/PDF) |
news and views Directing NGF's actions: it's a Rap
Philip J. S. Stork Nature Cell Biology7, 338–339
(April 2005); doi:10.1038/ncb0405-338
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article Calmodulin kinase II inhibition protects against structural heart disease
Rong Zhang, Michelle S C Khoo, Yuejin Wu, Yingbo Yang, Chad E Grueter, Gemin Ni, Edward E Price, Jr. William Thiel, Silvia Guatimosim, Long-Sheng Song, Ernest C Madu, Anisha N Shah, Tatiana A Vishnivetskaya, James B Atkinson, Vsevolod V Gurevich, Guy Salama, W J Lederer, Roger J Colbran and Mark E Anderson Nature Medicine11, 409–417
(April 2005); doi:10.1038/nm1215
| Abstract | Full Text (HTML/PDF) |
news and views Beyond beta blockers
Donald M Bers Nature Medicine11, 379–380
(April 2005); doi:10.1038/nm0405-379
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review article Cellular processing of platinum anticancer drugs
Dong Wang and Stephen J. Lippard Nature Reviews Drug Discovery4, 307–320
(April 2005); doi:10.1038/nrd1691
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article Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
Edward J McManus, Kei Sakamoto, Laura J Armit, Leah Ronaldson, Natalia Shpiro, Rodolfo Marquez and Dario R Alessi The EMBO Journal24, 1571–1583
(April 2005); doi:10.1038/7600633a
| Abstract | Full Text (HTML/PDF) |
article DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Jirina Bartkova, Zuzana Hoejí, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas and Jiri Bartek Nature434, 864–870
(14 April 2005); doi:10.1038/nature03482
| Summary | Full Text (HTML / PDF) |
news and views Medicine: Aborting the birth of cancer
Ashok R. Venkitaraman Nature434, 829–830
(14 April 2005); doi:10.1038/434829a
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letter Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition
Kathrine Abell, Antonio Bilancio, Richard W. E. Clarkson, Paul G. Tiffen, Anton I. Altaparmakov, Thomas G. Burdon, Tomoichiro Asano, Bart Vanhaesebroeck and Christine J. Watson Nature Cell Biology7, 392–398
(April 2005); doi:10.1038/ncb1242
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article Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
Jesus M Salvador, Paul R Mittelstadt, Tad Guszczynski, Terry D Copeland, Hiroshi Yamaguchi, Ettore Appella, Albert J Fornace and Jr Jonathan D Ashwell Nature Immunology6, 390–395
(April 2005); doi:10.1038/ni1177
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article The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
Jesus M Salvador, Paul R Mittelstadt, Galina I Belova, Albert J Fornace and Jr Jonathan D Ashwell Nature Immunology6, 396–402
(April 2005); doi:10.1038/ni1176
| Abstract | Full Text (HTML/PDF) |
news and views MAPK p38: alternative and nonstressful in T cells
Christopher E Rudd Nature Immunology6, 368–370
(April 2005); doi:10.1038/ni0405-368
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news and views The shear stress of keeping arteries clear
David G Harrison Nature Medicine11, 375–376
(April 2005); doi:10.1038/nm0405-375
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article Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
Beth A Firulli, Dayana Krawchuk, Victoria E Centonze, Neil Vargesson, David M Virshup, Simon J Conway, Peter Cserjesi, Ed Laufer and Anthony B Firulli Nature Genetics37, 373–381
(April 2005); doi:10.1038/ng1525
| Abstract | Full Text (HTML/PDF) |
article A multiplexed homogeneous fluorescence-based assay for protein kinase activity in cell lysates
Melissa D Shults, Kevin A Janes, Douglas A Lauffenburger and Barbara Imperiali Nature Methods2, 277–284
(April 2005); doi:10.1038/nmeth747
| Abstract | Full Text (HTML/PDF) |
news and views Measuring kinase activity: finding needles in a haystack
Benjamin E Turk Nature Methods2, 251–252
(April 2005); doi:10.1038/nmeth0405-251
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letter SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions
Jordi Torres-Rosell, Félix Machín, Sarah Farmer, Adam Jarmuz, Trevor Eydmann, Jacob Z. Dalgaard and Luis Aragón Nature Cell Biology7, 412–419
(April 2005); doi:10.1038/ncb1239
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news and views The importance of being Smc5/6
Yoshinori Watanabe Nature Cell Biology7, 329–331
(April 2005); doi:10.1038/ncb0405-329
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article CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
Fumiko Esashi, Nicole Christ, Julian Gannon, Yilun Liu, Tim Hunt, Maria Jasin and Stephen C. West Nature434, 598–604
(31 March 2005); doi:10.1038/nature03404
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letter Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis
Jiro Toshima, Junko Y. Toshima, Adam C. Martin and David G. Drubin Nature Cell Biology7, 246–254
(March 2005); doi:10.1038/ncb1229
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news and views An endocytic Prk-ing brake
Mara C. Duncan and Gregory S. Payne Nature Cell Biology7, 210–212
(March 2005); doi:10.1038/ncb0305-210
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research article A small molecule-kinase interaction map for clinical kinase inhibitors
Miles A Fabian, William H Biggs, III Daniel K Treiber, Corey E Atteridge, Mihai D Azimioara, Michael G Benedetti, Todd A Carter, Pietro Ciceri, Philip T Edeen, Mark Floyd, Julia M Ford, Margaret Galvin, Jay L Gerlach, Robert M Grotzfeld, Sanna Herrgard, Darren E Insko, Michael A Insko, Andiliy G Lai, Jean-Michel Lélias, Shamal A Mehta, Zdravko V Milanov, Anne Marie Velasco, Lisa M Wodicka, Hitesh K Patel, Patrick P Zarrinkar and David J Lockhart Nature Biotechnology23, 329–336
(March 2005); doi:10.1038/nbt1068
| Abstract | Full Text (HTML/PDF) |
news and views Interaction maps for kinase inhibitors
James D Griffin Nature Biotechnology23, 308–309
(March 2005); doi:10.1038/nbt0305-308
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March
letter Atrophy of S6K1−/− skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
Mickaël Ohanna, Andrew K. Sobering, Thomas Lapointe, Lazaro Lorenzo, Christophe Praud, Emmanuel Petroulakis, Nahum Sonenberg, Paul A. Kelly, Athanassia Sotiropoulos and Mario Pende Nature Cell Biology7, 286–294
(March 2005); doi:10.1038/ncb1231
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review article Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia
Ruibao Ren Nature Reviews Cancer5, 172–183
(March 2005); doi:10.1038/nrc1567
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article Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase
Catherine van Vliet, Patricia E Bukczynska, Michelle A Puryer, Christine M Sadek, Benjamin J Shields, Michel L Tremblay and Tony Tiganis Nature Immunology6, 253–260
(March 2005); doi:10.1038/ni1169
| Abstract | Full Text (HTML/PDF) |
letters to nature Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates
Mart Loog and David O. Morgan Nature434, 104–108
(03 March 2005); doi:10.1038/nature03329
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news and views Cell cycle: Cyclin guides the way
Curt Wittenberg Nature434, 34–35
(03 March 2005); doi:10.1038/434034a
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letter Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
Simon Wilkinson, Hugh F. Paterson and Christopher J. Marshall Nature Cell Biology7, 255–261
(March 2005); doi:10.1038/ncb1230
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February
letters to nature State transitions and light adaptation require chloroplast thylakoid protein kinase STN7
Stéphane Bellafiore, Frédy Barneche, Gilles Peltier and Jean-David Rochaix Nature433, 892–895
(24 February 2005); doi:10.1038/nature03286
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article Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Dongsheng Cai, Minsheng Yuan, Daniel F Frantz, Peter A Melendez, Lone Hansen, Jongsoon Lee and Steven E Shoelson Nature Medicine11, 183–190
(February 2005); doi:10.1038/nm1166
| Abstract | Full Text (HTML/PDF) |
article IKK-β links inflammation to obesity-induced insulin resistance
Melek C Arkan, Andrea L Hevener, Florian R Greten, Shin Maeda, Zhi-Wei Li, Jeffrey M Long, Anthony Wynshaw-Boris, Giuseppe Poli, Jerrold Olefsky and Michael Karin Nature Medicine11, 191–198
(February 2005); doi:10.1038/nm1185
| Abstract | Full Text (HTML/PDF) |
article Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase
Kenta Terai and Michiyuki Matsuda EMBO ReportsAOP
(11 February 2005); doi:10.1038/sj.embor.7400349
| Abstract | Full Text (HTML/PDF) |
letter The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski, Randi G. Syljuåsen, Cecilia Lundin, Jiri Bartek and Thomas Helleday Nature Cell Biology7, 195–201
(February 2005); doi:10.1038/ncb1212
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article Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Eiki Takimoto, Hunter C Champion, Manxiang Li, Diego Belardi, Shuxun Ren, E Rene Rodriguez, Djahida Bedja, Kathleen L Gabrielson, Yibin Wang and David A Kass Nature Medicine11, 214–222
(February 2005); doi:10.1038/nm1175
| Abstract | Full Text (HTML/PDF) |
news and views Viagra: now mending hearts
Michael E Mendelsohn Nature Medicine11, 115–116
(February 2005); doi:10.1038/nm0205-115
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letter Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage
Paul S Bradshaw, Dimitrios J Stavropoulos and M Stephen Meyn Nature Genetics37, 193–197
(February 2005); doi:10.1038/ng1506
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news and views Telomere-binding factors and general DNA repair
Woodring E Wright and Jerry W Shay Nature Genetics37, 116–118
(February 2005); doi:10.1038/ng0205-116
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article Downregulation of lipopolysaccharide response in drosophila by negative crosstalk between the AP1 and NF-κB signaling modules
Taeil Kim, Joonsun Yoon, Hwansung Cho, Wook-bin Lee, Joon Kim, Young-Hwa Song, Se Nyun Kim, Jeong Ho Yoon, Jeongsil Kim-Ha and Young-Joon Kim Nature Immunology6, 211–218
(February 2005); doi:10.1038/ni1159
| Abstract | Full Text (HTML/PDF) |
article Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex
Wanping Xu, Xitong Yuan, Zhexin Xiang, Edward Mimnaugh, Monica Marcu and Len Neckers Nature Structural and Molecular Biology12, 120–126
(February 2005); doi:10.1038/nsmb885
| Abstract | Full Text (HTML/PDF) |
January
review article Integrin-linked kinase: a cancer therapeutic target unique among its ILK
Gregory Hannigan, Armelle A. Troussard and Shoukat Dedhar Nature Reviews Cancer5, 51–63
(January 2005); doi:10.1038/nrc1524
| Summary | Full Text (HTML / PDF) |
letters to nature Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins
Alice E. Chen, David D. Ginty and Chen-Ming Fan Nature433, 317–322
(20 January 2005); doi:10.1038/nature03126
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news and views Signal transduction: A new canon
Olivier Pourquié Nature433, 208–209
(20 January 2005); doi:10.1038/433208a
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letter The human mitotic checkpoint protein BubR1 regulates chromosome-spindle attachments
Michael A. Lampson and Tarun M. Kapoor Nature Cell Biology7, 93–98
(January 2005); doi:10.1038/ncb1208
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article Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton
Mira Barda-Saad, Alex Braiman, Rachel Titerence, Stephen C Bunnell, Valarie A Barr and Lawrence E Samelson Nature Immunology6, 80–89
(January 2005); doi:10.1038/ni1143
| Abstract | Full Text (HTML/PDF) |
review article Aurora-A — A guardian of poles
Tomotoshi Marumoto, Dongwei Zhang and Hideyuki Saya Nature Reviews Cancer5, 42–50
(January 2005); doi:10.1038/nrc1526
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research article Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
John Rush, Albrecht Moritz, Kimberly A Lee, Ailan Guo, Valerie L Goss, Erik J Spek, Hui Zhang, Xiang-Ming Zha, Roberto D Polakiewicz and Michael J Comb Nature Biotechnology23, 94–101
(January 2005); doi:10.1038/nbt1046
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news and views An enriched look at tyrosine phosphorylation
Thomas P Conrads and Timothy D Veenstra Nature Biotechnology23, 36–37
(January 2005); doi:10.1038/nbt0105-36
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article Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
Clemens Steegborn, Tatiana N Litvin, Lonny R Levin, Jochen Buck and Hao Wu Nature Structural and Molecular Biology12, 32–37
(January 2005); doi:10.1038/nsmb880
| Abstract | Full Text (HTML/PDF) |
news and views A seminal study of soluble adenylyl cyclase
John J G Tesmer Nature Structural and Molecular Biology12, 7–8
(January 2005); doi:10.1038/nsmb0105-7
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letters to nature Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1
Toshinori Kinoshita , Ana Caño-Delgado, Hideharu Seto, Sayoko Hiranuma, Shozo Fujioka, Shigeo Yoshida and Joanne Chory Nature433, 167–171
(13 January 2005); doi:10.1038/nature03227
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article Akt and 14-3-3η regulate Miz1 to control cell-cycle arrest after DNA damage
Michael Wanzel, Daniela Kleine-Kohlbrecher, Steffi Herold, Andreas Hock, Katrien Berns, Jongsun Park, Brian Hemmings and Martin Eilers Nature Cell Biology7, 30–41
(January 2005); doi:10.1038/ncb1202
| Abstract | Full Text (HTML/PDF) |
review article Focal adhesion kinase: in command and control of cell motility
Satyajit K. Mitra, Daniel A. Hanson and David D. Schlaepfer Nature Reviews Molecular Cell Biology6, 56–68
(January 2005); doi:10.1038/nrm1549
| Summary | Full Text (HTML / PDF) |
article Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Silvana B Rosso, Daniel Sussman, Anthony Wynshaw-Boris and Patricia C Salinas Nature Neuroscience8, 34–42
(January 2005); doi:10.1038/nn1374
| Abstract | Full Text (HTML/PDF) |
review article Kinomics: methods for deciphering the kinome
Sam A Johnson and Tony Hunter
Nature Methods2, 17–25
(January 2005); doi:10.1038/nmeth731
| Summary | Full Text (HTML / PDF) |
article The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots
Ikram Blilou, Jian Xu, Marjolein Wildwater, Viola Willemsen, Ivan Paponov, Jiří Friml, Renze Heidstra, Mitsuhiro Aida, Klaus Palme and Ben Scheres Nature433, 39–44
(06 January 2005); doi:10.1038/nature03184
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letter Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
Sergey Apionishev, Natalya M. Katanayeva, Steven A. Marks, Daniel Kalderon and Andrew Tomlinson Nature Cell Biology7, 86–92
(January 2005); doi:10.1038/ncb1210
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article Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes
Nami McCarty, Silke Paust, Koichi Ikizawa, Ippeita Dan, Xiaoyan Li and Harvey Cantor Nature Immunology6, 65–72
(January 2005); doi:10.1038/ni1145
| Abstract | Full Text (HTML/PDF) |
news and views Signaling negative selection: is MINK the missing link?
Ed Palmer Nature Immunology6, 9–10
(January 2005); doi:10.1038/ni0105-9
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letter EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output
Peleg Hasson, Nirit Egoz, Clint Winkler, Gloria Volohonsky, Songtao Jia, Tama Dinur, Talila Volk, Albert J Courey and Ze'ev Paroush Nature Genetics37, 101–105
(January 2005); doi:10.1038/ng1486
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review article Dysregulation of the TSC-mTOR pathway in human disease
Ken Inoki, Michael N Corradetti and Kun-Liang Guan Nature Genetics37, 19–24
(January 2005); doi:10.1038/ng1494
| Abstract | Full Text (HTML/PDF) |
ej
í, Karen Koed, Alwin Krämer, Frederic Tort, Karsten Zieger, Per Guldberg, Maxwell Sehested, Jahn M. Nesland, Claudia Lukas, Torben Ørntoft, Jiri Lukas and Jiri Bartek