article Tyrosine phosphorylation controls PCNA function through protein stability
Shao-Chun Wang, Yusuke Nakajima, Yung-Luen Yu, Weiya Xia, Chun-Te Chen, Cheng-Chieh Yang, Eric W. McIntush, Long-Yuan Li, David H. Hawke, Ryuji Kobayashi & Mien-Chie Hung Nature Cell Biology8, 1359–1368
(December 2006); doi:10.1038/ncb1501
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article CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression
Quiping Cao, Jong Heon Kim & Joel D Richter Nature Structural & Molecular Biology 13, 1128–1134
(December 2006); doi:10.1038/nsmb1169
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article A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
David Biron, Mayumi Shibuya, Christopher Gabel, Sara M Wasserman, Damon A Clark, Adam Brown, Piali Sengupta & Aravinthan D T Samuel Nature Neuroscience9, 1499–1505
(December 2006); doi:10.1038/nn1796
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article Dynorphin A activates bradykinin receptors to maintain neuropathic pain
Josephine Lai, Miaw-Chyi Luo, Qingmin Chen, Shouwu Ma, Luis R Gardell, Michael H Ossipov & Frank Porreca Nature Neuroscience9, 1534–1540
(December 2006); doi:10.1038/nn1804
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article Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
Mark A. Daniels, Emma Teixeiro, Jason Gill, Barbara Hausmann, Dominique Roubaty, Kaisa Holmberg, Guy Werlen, Georg A. Holländer, Nicholas R. J. Gascoigne and Ed Palmer Nature444, 724–729
(7 December 2006); doi:10.1038/nature05269
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article Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
Attila Mócsai, Clare L Abram, Zoltán Jakus, Yongmei Hu, Lewis L Lanier & Clifford A Lowell Nature Immunology7, 1326–1333
(December 2006); doi:10.1038/ni1407
| Summary | Full Text (HTML / PDF) |
news and views Integrins and ITAMs: more than just good neighbors
Mark L Kahn & Gary A Koretzky Nature Immunology7, 1286–1288
(December 2006); doi:10.1038/ni1206-1286
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November
letter A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Adam Friedman and Norbert Perrimon Nature444, 230–234
(09 November 2006); doi:10.1038/nature05280
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article T cell anergy is reversed by active Ras and is regulated by diacylglycerol kinase-α
Yuanyuan Zha, Reinhard Marks, Allen W Ho, Amy C Peterson, Sujit Janardhan, Ian Brown, Kesavannair Praveen, Stacey Stang, James C Stone & Thomas F Gajewski Nature Immunology7, 1166–1173
(November 2006); doi:10.1038/ni1394
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article Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
Benjamin A Olenchock, Rishu Guo, Jeffery H Carpenter, Martha Jordan, Matthew K Topham, Gary A Koretzky & Xiao-Ping Zhong Nature Immunology7, 1174–1181
(November 2006); doi:10.1038/ni1400
| Summary | Full Text (HTML / PDF) |
news and views Linking diacylglycerol kinase to T cell anergy
Daniel L Mueller Nature Immunology7, 1132–1134
(November 2006); doi:10.1038/ni1106-1132
| Summary | Full Text (HTML / PDF) |
review PI3K γ inhibition: towards an 'aspirin of the 21st century'?
Thomas Rückle, Matthias K. Schwarz and Christian Rommel Nature Reviews Drug Discovery6, 903–918
(November 2006); doi:10.1038/nrd2145
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October
article Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway
Christophe Denoyelle, George Abou-Rjaily, Vladimir Bezrookove, Monique Verhaegen, Timothy M. Johnson, Douglas R. Fullen, Jenny N. Pointer, Stephen B. Gruber, Lyndon D. Su, Mikhail A. Nikiforov, Randal J. Kaufman, Boris C. Bastian & Maria S. Soengas Nature Cell Biology8, 1053–1063
(2006); doi:10.1038/ncb1471
| Summary | Full Text (HTML / PDF) |
September
letter JAK signaling globally counteracts heterochromatic gene silencing
Song Shi, Healani C Calhoun, Fan Xia, Jinghong Li, Long Le & Willis X Li Nature Genetics38, 1071–1076
(2006); doi:10.1038/ng1860
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news and views A Hopscotch-chromatin connection
Aurel Betz & James E Darnell Jr Nature Genetics38, 977–979
(2006); doi:10.1038/ng0906-977
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letter The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance
Kazuo Emoto, Jay Z. Parrish, Lily Yeh Jan and Yuh-Nung Jan Nature443, 210–213
(14 September 2006); doi:10.1038/nature05090
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letter Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
Manuela Pellegrini, Arkady Celeste, Simone Difilippantonio, Rong Guo, Weidong Wang, Lionel Feigenbaum and André Nussenzweig Nature443, 222–225
(14 September 2006); doi:10.1038/nature05112
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article Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth
Qiyu Feng, Dan Baird, Xu Peng, Jianbin Wang, Thi Ly, Jun-Lin Guan & Richard A. Cerione Nature Cell Biology8, 945–956
(September 2006); doi:10.1038/ncb1453
| Summary | Full Text (HTML / PDF) |
news and views Src transforms in a Cool way
Jeffrey R. Peterson & Jonathan Chernoff Nature Cell Biology8, 905–907
(September 2006); doi:10.1038/ncb0906-905
| Summary | Full Text (HTML / PDF) |
letter Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5
Alex von Kriegsheim, Andrew Pitt, G. Joan Grindlay, Walter Kolch & Amardeep S. Dhillon Nature Cell Biology8, 1011–1016
(September 2006); doi:10.1038/ncb1465
| Summary | Full Text (HTML / PDF) |
August
article The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
Yisong Y Wan, Hongbo Chi, Min Xie, Michael D Schneider & Richard A Flavell Nature Immunology7, 851–858
(August 2006); doi:10.1038/ni1355
| Summary | Full Text (HTML / PDF) |
review The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman, Ji Luo and Lewis C. Cantley Nature Review Genetics7, 606–619
(10 August 2006); doi:10.1038/nrg1879
| Summary | Full Text (HTML / PDF) |
letter Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase
Tae-Hong Kang & Kyong-Tai Kim Nature Cell Biology8, 863–869
(27 July 2006); doi:10.1038/ncb1447
| First Paragraph | Full Text (HTML / PDF) |
July
letter Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
Min Zhao, Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V. Forrester, Henry R. Bourne, Peter N. Devreotes, Colin D. McCaig and Josef M. Penninger Nature442, 457–460
(27 July 2006); doi:10.1038/nature04925
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letter ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
Andrea L. Bredemeyer, Girdhar G. Sharma, Ching-Yu Huang, Beth A. Helmink, Laura M. Walker, Katrina C. Khor, Beth Nuskey, Kathleen E. Sullivan, Tej K. Pandita, Craig H. Bassing and Barry P. Sleckman Nature442, 466–470
(27 July 2006); doi:10.1038/nature04866
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article Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases
Anouk Caraux, Qingxian Lu, Nadine Fernandez, Sylvain Riou, James P Di Santo, David H Raulet, Greg Lemke & Claude Roth Nature Immunology7, 747–754
(June 2006); doi:10.1038/ni1353
| Summary | Full Text (HTML / PDF) |
news and views NK cell development: Gas matters
Thierry Walzer & Eric Vivier Nature Immunology7, 702–704
(July 2006); doi:10.1038/ni0706-702
| Summary | Full Text (HTML / PDF) |
article JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport
Gerardo Morfini, Gustavo Pigino, Györgyi Szebenyi, Yimei You, Sarah Pollema & Scott T Brady Nature Neuroscience9, 907–916
(June 2006); doi:10.1038/nn1717
| Summary | Full Text (HTML / PDF) |
review The many paths to p38 mitogen-activated protein kinase activation in the immune system
Jonathan D. Ashwell Nature Reviews Immunology6, 532–540
(July 2006); doi:10.1038/nri1865
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article Regulation of naive T cell function by the NF-κB2 pathway
Naozumi Ishimaru, Hidehiro Kishimoto, Yoshio Hayashi & Jonathan Sprent Nature Immunology7, 763–772
(July 2006); doi:10.1038/ni1351
| Summary | Full Text (HTML / PDF) |
June
letter Nodulation independent of rhizobia induced by a calcium-activated kinase lacking autoinhibition
Cynthia Gleason, Shubho Chaudhuri, Tianbao Yang, Alfonso Muñoz, B. W. Poovaiah and Giles E. D. Oldroyd Nature441, 1149–1152
(29 June 2006); doi:10.1038/nature04812
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letter Deregulation of a Ca2+/calmodulin-dependent kinase leads to spontaneous nodule development
Leïla Tirichine, Haruko Imaizumi-Anraku, Satoko Yoshida, Yasuhiro Murakami, Lene H. Madsen, Hiroki Miwa, Tomomi Nakagawa, Niels Sandal, Anita S. Albrektsen, Masayoshi Kawaguchi, Allan Downie, Shusei Sato, Satoshi Tabata, Hiroshi Kouchi, Martin Parniske, Shinji Kawasaki and Jens Stougaard Nature441, 1153–1156
(29 June 2006); doi:10.1038/nature04862
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article ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
Stamatia Papoutsopoulou, Antony Symons, Tharsana Tharmalingham, Monica P Belich, Frank Kaiser, Dimitris Kioussis, Anne O'Garra, Victor Tybulewicz & Steven C Ley Nature Immunology7, 606 - 615
(June 2006); doi:10.1038/ni1334
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letter Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
Patricia M. White, Angelika Doetzlhofer, Yun Shain Lee, Andrew K. Groves and Neil Segil Nature441, 984–987
(22 June 2006); doi:10.1038/nature04849
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review article p21-activated kinases in cancer
Rakesh Kumar, Anupama E. Gururaj and Christopher J. Barnes Nature Reviews Cancer6, 459–471
(June 2006); doi:10.1038/nrc1892
| Summary | Full Text (HTML / PDF) |
article
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21
Joseph R. Arron, Monte M. Winslow, Alberto Polleri, Ching-Pin Chang, Hai Wu, Xin Gao, Joel R. Neilson, Lei Chen, Jeremy J. Heit, Seung K. Kim, Nobuyuki Yamasaki, Tsuyoshi Miyakawa, Uta Francke, Isabella A. Graef and Gerald R. Crabtree Nature441, 595–600
(01 June 2006); doi:10.1038/nature04678
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letter A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT
Yousang Gwack, Sonia Sharma, Julie Nardone, Bogdan Tanasa, Alina Iuga, Sonal Srikanth, Heidi Okamura, Diana Bolton, Stefan Feske, Patrick G. Hogan and Anjana Rao Nature441, 646–650
(01 June 2006); doi:10.1038/nature04631
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news and views Down's syndrome: Critical genes in a critical region
Charles J. Epstein Nature441, 582–583
(01 June 2006); doi:10.1038/441582a
| Full Text (HTML / PDF) |
letter Hrr25-dependent phosphorylation state regulates organization of the pre-40S subunit
Thorsten Schäfer, Bohumil Maco, Elisabeth Petfalski, David Tollervey, Bettina Böttcher, Ueli Aebi and Ed Hurt Nature441, 651–655
(01 June 2006); doi:10.1038/nature04840
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May
letter Identification of a tumour suppressor network opposing nuclear Akt function
Lloyd C. Trotman, Andrea Alimonti, Pier Paolo Scaglioni, Jason A. Koutcher, Carlos Cordon-Cardo and Pier Paolo Pandolfi Nature441, 523–527
(25 May 2006) ; doi:10.1038/nature04809
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letter Critical role for the p110α phosphoinositide–3–OH kinase in growth and metabolic regulation
Lazaros C. Foukas, Marc Claret, Wayne Pearce, Klaus Okkenhaug, Stephen Meek, Emma Peskett, Sara Sancho, Andrew J. H. Smith, Dominic J. Withers and Bart Vanhaesebroeck Nature441, 366–370
(18 May 2006); doi:10.1038/nature04694
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letter Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass
Naoko Hashimoto, Yoshiaki Kido, Tohru Uchida, Shun-ichiro Asahara, Yutaka Shigeyama, Tomokazu Matsuda, Akihiko Takeda, Daisuke Tsuchihashi, Akihiko Nishizawa, Wataru Ogawa, Yoshito Fujimoto, Hitoshi Okamura, Karen C Arden, Pedro L Herrera, Tetsuo Noda & Masato Kasuga Nature Genetics38, 589–593
(May 2006); doi:10.1038/ng1774
| Summary | Full Text (HTML / PDF) |
article CNTF reverses obesity–induced insulin resistance by activating skeletal muscle AMPK
Matthew J Watt, Nicolas Dzamko, Walter G Thomas, Stefan Rose–John, Matthias Ernst, David Carling, Bruce E Kemp, Mark A Febbraio & Gregory R Steinberg Nature Medicine12, 541–548
(May 2006); doi:10.1038/nm1383
| Summary | Full Text (HTML / PDF) |
April
article Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Keisuke Ito, Atsushi Hirao, Fumio Arai, Keiyo Takubo, Sahoko Matsuoka, Kana Miyamoto, Masako Ohmura, Kazuhito Naka, Kentaro Hosokawa, Yasuo Ikeda & Toshio Suda Nature Medicine12, 446–451
(April 2006); doi:10.1038/nm1388
| First Paragraph
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article Protein kinase A regulates calcium permeability of NMDA receptors
V Arvydas Skeberdis, Vivien Chevaleyre, C Geoffrey Lau, Jesse H Goldberg, Diana L Pettit, Sylvia O Suadicani, Ying Lin, Michael V L Bennett, Rafael Yuste, Pablo E Castillo & R Suzanne Zukin Nature Neuroscience9, 501–510
(April 2006); doi:10.1038/nn1664
| First Paragraph
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review article Analyzing phosphoinositides and their interacting proteins
Tor Erik Rusten & Harald Stenmark Nature Methods3, 251–258
(April 2006); doi:10.1038/nmeth867
| Summary | Full Text (HTML / PDF) |
March
review article Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis
Megan Cully , Han You, Arnold J. Levine and Tak W. Mak Nature Reviews Cancer6, 184–192
(March 2006); doi:10.1038/nrc1819
| Summary | Full Text (HTML / PDF) |
February
review article MAPKAP kinases — MKs — two's company, three's a crowd
Matthias Gaestel Nature Reviews Molecular Cell Biology AOP published online 18 January 2006; doi:10.1038/nrm1834
| Summary | Full Text (HTML / PDF) |
letter Complex formation of Plk1 and INCENP required for metaphase-anaphase transition
Hidemasa Goto, Tohru Kiyono, Yasuko Tomono, Aie Kawajiri, Takeshi Urano, Koichi Furukawa, Erich A. Nigg and Masaki Inagaki Nature Cell Biology8, 180–187
(February 2006); doi:10.1038/ncb1350
| First Paragraph | Full Text (HTML/PDF) |
news and views INCENP at the kinase crossroads
Mar Carmena and William C. Earnshaw Nature Cell Biology8, 110–111
(February 2006); doi:10.1038/ncb0206-110
| Full Text (HTML/PDF) |
article Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease
Lixia Zhao, Qiu-Lan Ma, Frédéric Calon, Marni E Harris-White, Fusheng Yang, Giselle P Lim, Takashi Morihara, Oliver J Ubeda, Surendra Ambegaokar, James E Hansen, Richard H Weisbart, Bruce Teter, Sally A Frautschy and Greg M Cole Nature Neuroscience9, 234–242
(February 2006); doi:10.1038/nn1630
| Abstract | Full Text (HTML/PDF) |
letter Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
Cheng-Yu Lee, Kristin J. Robinson and Chris Q. Doe Nature439, 594–598
(02 February 2006); doi:10.1038/nature04299
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article MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration
Miho Kobayashi, Michiru Nishita, Toshiaki Mishima, Kazumasa Ohashi and Kensaku Mizuno The EMBO Journal advance online publication
(2 February 2006); doi:10.1038/sj.emboj.7600973
| Abstract | Full Text (HTML/PDF) |
January
news and views Kinase cogs go forward and reverse in the Wnt signaling machine
Trevor Dale Nature Structural and Molecular Biology13, 9–11
(January 2006); doi:10.1038/nsmb0106-9
| Full Text (HTML/PDF) |
letter Oscillations of cyclic AMP in hormone-stimulated insulin-secreting β-cells
Oleg Dyachok, Yegor Isakov, Jenny Sågetorp and Anders Tengholm Nature439, 349–352
(19 January 2006); doi:10.1038/nature04410
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letter BRAF mutation predicts sensitivity to MEK inhibition
David B. Solit, Levi A. Garraway, Christine A. Pratilas, Ayana Sawai, Gad Getz, Andrea Basso, Qing Ye, Jose M. Lobo, Yuhong She, Iman Osman, Todd R. Golub, Judith Sebolt-Leopold, William R. Sellers and Neal Rosen Nature439, 358–362
(February 2006); doi:10.1038/nature04304
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article A role for the scaffolding adapter GAB2 in breast cancer
Mohamed Bentires-Alj, Susana G Gil, Richard Chan, Zhigang C Wang, Yongping Wang, Naoko Imanaka, Lyndsay N Harris, Andrea Richardson, Benjamin G Neel and Haihua Gu Nature Medicine12, 114–121
(January 2006); doi:10.1038/nm1341
| Abstract | Full Text (HTML/PDF) |
letter The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores
Benjamin A. Pinsky, Charles Kung, Kevan M. Shokat and Sue Biggins Nature Cell Biology8, 78–83
(January 2006); doi:10.1038/ncb1341
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article CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels
Jianxi Liu, Maria Asuncion-Chin, Pengchong Liu and Alejandro M Dopico Nature Neuroscience9, 41–49
(January 2006); doi:10.1038/nn1602
| Abstract | Full Text (HTML/PDF) |
article Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation
Jennifer J Trowbridge, Anargyros Xenocostas, Randall T Moon and Mickie Bhatia Nature Medicine12, 89–98
(January 2006); doi:10.1038/nm1339
| Abstract | Full Text (HTML/PDF) |
