letter Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
Kristijan Ramadan et al. Nature450, 1258–1262
(20 December 2007); doi:10.1038/nature06388
| Summary | Full Text (HTML / PDF) |
letter MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling
Rehan Ahmad et al. Nature Cell Biology9, 1419–1427
(December 2007); doi:10.1038/ncb1661
| Summary | Full Text (HTML / PDF) |
article CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
Pushpa Pandiyan, Lixin Zheng, Satoru Ishihara, Jennifer Reed & Michael J Lenardo Nature Immunology8, 1353–1362
(December 2007); doi:10.1038/ni1536
| Summary | Full Text (HTML / PDF) |
news and views Competition for cytokines: Treg cells take all
Alexander Scheffold, Kenneth M Murphy & Thomas Höfer Nature Immunology8, 1285–1287
(December 2007); doi:10.1038/ni1207-1285
| Full Text (HTML / PDF) |
article p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation
Shravanti Rampalli et al. Nature Structural & Molecular Biology14, 1150–1156
(December 2007); doi:10.1038/nsmb1316
| Summary | Full Text (HTML / PDF) |
news and views A monkey wrench in the kinase machine
Daniel J Leahy Nature Structural & Molecular Biology14, 1120–1121
(December 2007); doi:10.1038/nsmb1207-1120
| Full Text (HTML / PDF) |
article Pim-1 regulates cardiomyocyte survival downstream of Akt
John A Muraski et al. Nature Medicine13, 1467–1475
(December 2007); doi:10.1038/nm1671
| Summary | Full Text (HTML / PDF) |
scientific report Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors
Emma Sandilands, Shiva Akbarzadeh, Anna Vecchione, David G McEwan, Margaret C Frame & John K Heath EMBO Reports8, 1162–1169
(December 2007); doi:10.1038/sj.embor.7401097
| Summary | Full Text (HTML / PDF) |
November
letter Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
Coenraad Kuijl et al. Nature450, 725–730
(29 November 2007); doi:10.1038/nature06345
| Summary | Full Text (HTML / PDF) |
letter Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole & John Kuriyan Nature450, 741–744
(29 November 2007); doi:10.1038/nature05998
| Summary | Full Text (HTML / PDF) |
letter AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10
Ho-June Lee et al. Nature Cell Biology9, 1303–1310
(November 2007); doi:10.1038/ncb1650
| Summary | Full Text (HTML / PDF) |
letter Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling
Celine I. Maeder, Mark A. Hink, Ali Kinkhabwala, Reinhard Mayr, Philippe I. H. Bastiaens & Michael Knop Nature Cell Biology9, 1319–1326
(November 2007); doi:10.1038/ncb1652
| Summary | Full Text (HTML / PDF) |
article Autonomous synchronization of the circadian KaiC phosphorylation rhythm
Hiroshi Ito, Hakuto Kageyama, Michinori Mutsuda, Masato Nakajima, Tokitaka Oyama & Takao Kondo Nature Structural & Molecular Biology14, 1084–1088
(November 2007); doi:10.1038/nsmb1312
| Summary | Full Text (HTML / PDF) |
article Human CtIP promotes DNA end resection
Alessandro A. Sartori et al. Nature450, 509–514
(22 November 2007); doi:10.1038/nature06337
| Summary | Full Text (HTML / PDF) |
article TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases
Janni Petersen & Paul Nurse Nature Cell Biology9, 1263–1272
(November 2007); doi:10.1038/ncb1646
| Summary | Full Text (HTML / PDF) |
news and views Holding back TOR advances mitosis
Thomas W. Sturgill & Michael N. Hall Nature Cell Biology9, 1221–1222
(November 2007); doi:10.1038/ncb1107-1221
| Summary | Full Text (HTML / PDF) |
article STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
Qian Zhang, Hong Y Wang, Xiaobin Liu & Mariusz A Wasik Nature Medicine13, 1341–1348
(November 2007); doi:10.1038/nm1659
| Summary | Full Text (HTML / PDF) |
article A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
Ichiro Takada et al. Nature Cell Biology9, 1273–1285
(November 2007); doi:10.1038/ncb1647
| Summary | Full Text (HTML / PDF) |
news and views Fat or bone? A non-canonical decision
Thomas Günther & Roland Schüle Nature Cell Biology9, 1229–1231
(November 2007); doi:10.1038/ncb1107-1229
| Summary | Full Text (HTML / PDF) |
article The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
Rossana Zaru, Natalia Ronkina, Matthias Gaestel, J Simon C Arthur & Colin Watts Nature Immunology8, 1227–1235
(November 2007); doi:10.1038/ni1517
| Summary | Full Text (HTML / PDF) |
perspective Proteins, drug targets and the mechanisms they control: the simple truth about complex networks
Robyn P. Araujo, Lance A. Liotta & Emanuel F. Petricoin Nature Reviews Drug Discovery6, 871–880
(November 2007); doi:10.1038/nrd2381
| Summary | Full Text (HTML / PDF) |
scientific report AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum
Birgitte Lygren et al. EMBO Reports8, 1061–1067
(November 2007); doi:10.1038/sj.embor.7401081
| Summary | Full Text (HTML / PDF) |
article The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Hélène Plun-Favreau et al. Nature Cell Biology9, 1243–1252
(November 2007); doi:10.1038/ncb1644
| Summary | Full Text (HTML / PDF) |
news and views HtrA2 and Parkinson's disease: think PINK?
Emad S. Alnemri Nature Cell Biology9, 1227–1229
(November 2007); doi:10.1038/ncb1107-1227
| Summary | Full Text (HTML / PDF) |
review The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
Kun Ping Lu & Xiao Zhen Zhou Nature Reviews Molecular Cell Biology8, 904–916
(November 2007); doi:10.1038/nrm2261
| Summary | Full Text (HTML / PDF) |
October
review IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-κB activation
Paolo Puccetti & Ursula Grohmann Nature Reviews Immunology7, 817–823
(October 2007); doi:10.1038/nri2163
| Summary | Full Text (HTML / PDF) |
review Flying under the radar: the new wave of BCR-ABL inhibitors
Alfonso Quintás-Cardama, Hagop Kantarjian & Jorge Cortes Nature Reviews Drug Discovery6, 834–848
(October 2007); doi:10.1038/nrd2324
| Summary | Full Text (HTML / PDF) |
review Genetic analysis of resistance to viral infection
Bruce Beutler et al. Nature Reviews Immunology7, 753–766
(October 2007); doi:10.1038/nri2174
| Summary | Full Text (HTML / PDF) |
letter Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation
Xiaoling Tang, Sung-Wuk Jang, Xuerong Wang, Zhixue Liu, Scott M. Bahr, Shi-Yong Sun, Daniel Brat, David H. Gutmann & Keqiang Ye Nature Cell Biology9, 1199–1207
(October 2007); doi:10.1038/ncb1641
| Summary | Full Text (HTML / PDF) |
review AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie Nature Reviews Molecular Cell Biology8, 774–785
(October 2007); doi:10.1038/nrm2249
| Summary | Full Text (HTML / PDF) |
article Nucleolar release of Hand1 acts as a molecular switch to determine cell fate
David M. J. Martindill, Catherine A. Risebro, Nicola Smart, Maria Del Mar Franco-Viseras, Carla O. Rosario, Carol J. Swallow, James W. Dennis & Paul R. Riley Nature Cell Biology9, 1131–1141
(October 2007); doi:10.1038/ncb1633
| Summary | Full Text (HTML / PDF) |
news and views Cell fate in the Hand of Plk4
Marvin E. Tanenbaum & René H. Medemao Nature Cell Biology9, 1127–1129
(October 2007); doi:10.1038/ncb1007-1127
| Summary | Full Text (HTML / PDF) |
news and views Two in one: dual function of an invertebrate antigen receptor
Thomas Boehm Nature Immunology8, 1031–1033
(October 2007); doi:10.1038/ni1007-1031
| Full Text (HTML / PDF) |
September
article Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex
Bryan Serrels, Alan Serrels, Valerie G. Brunton, Mark Holt, Gordon W. McLean, Christopher H. Gray, Gareth E. Jones & Margaret C. Frame Nature Cell Biology9, 1046–1056
(September 2007); doi:10.1038/ncb1626
| Summary | Full Text (HTML / PDF) |
article A stream of cells migrating from the caudal telencephalon reveals a link between the amygdala and neocortex
Ryan Remedios, Dhananjay Huilgol, Bhaskar Saha, Padmanabhan Hari, Lahar Bhatnagar, Thomas Kowalczyk, Robert F Hevner, Yoko Suda, Shinichi Aizawa, Toshio Ohshima, Anastassia Stoykova & Shubha Tole Nature Neuroscience10, 1141–1150
(September 2007); doi:10.1038/nn1955
| Summary | Full Text (HTML / PDF) |
news and views Amygdala and neocortex: common origins and shared mechanisms
Jan M Deussing & Wolfgang Wurst Nature Neuroscience10, 1081–1082
(September 2007); doi:10.1038/nn0907-1081
| Summary | Full Text (HTML / PDF) |
news and views On the iTRAQ of kinase inhibitors
Forest M White Nature Biotechnology25, 994–996
(September 2007); doi:10.1038/nbt0907-994
| Summary | Full Text (HTML / PDF) |
letter Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
Renaud Dentin, Yi Liu, Seung-Hoi Koo, Susan Hedrick, Thomas Vargas, Jose Heredia, John Yates, III & Marc Montminy Nature449, 366–369
(20 September 2007); doi:10.1038/nature06128
| Summary | Full Text (HTML / PDF) |
article Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
Marcus Bantscheff, Dirk Eberhard, Yann Abraham, Sonja Bastuck, Markus Boesche, Scott Hobson, Toby Mathieson, Jessica Perrin, Manfred Raida, Christina Rau, Valérie Reader, Gavain Sweetman, Andreas Bauer, Tewis Bouwmeester, Carsten Hopf, Ulrich Kruse, Gitte Neubauer, Nigel Ramsden, Jens Rick, Bernhard Kuster & Gerard Drewes Nature Biotechnology25, 1035–1044
(September 2007); doi:10.1038/nbt1328
| Summary | Full Text (HTML / PDF) |
review Molecular basis for sunitinib efficacy and future clinical development
Sandrine Faivre, George Demetri, William Sargent & Eric Raymond Nature Reviews Drug Discovery6, 734–745
(September 2007); doi:10.1038/nrd2380
| Summary | Full Text (HTML / PDF) |
news and views Muscle growth learns new tricks from an old dog
Gustavo A Nader Nature Medicine13, 1016–1018
(2007); doi:10.1038/nm0907-1016
| Full Text (HTML / PDF) |
technical report Molecular imaging of Akt kinase activity
Limin Zhang, Kuei C Lee, Mahaveer S Bhojani, Amjad P Khan, Alla Shilman, Eric C Holland, Brian D Ross & Alnawaz Rehemtulla Nature Medicine13, 1114–1119
(September 2007); doi:10.1038/nm1608
| Summary | Full Text (HTML / PDF) |
review Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
Ross L. Levine, Animesh Pardanani, Ayalew Tefferi & D. Gary Gilliland Nature Reviews Cancer7, 673–683
(September 2007); doi:10.1038/nrc2210
| Summary | Full Text (HTML / PDF) |
letter Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype
Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean-Pierre Fryns, Jan Cools, Peter Marynen, Gilles Thomas, Akihiko Yoshimura & Eric Legius Nature Genetics39, 1120–1126
(2007); doi:10.1038/ng2113
| Summary | Full Text (HTML / PDF) |
article Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
Krisztina Foltenyi, Ralph J Greenspan & John W Newport Nature Neuroscience10, 1160–1167
(2007); doi:10.1038/nn1957
| Summary | Full Text (HTML / PDF) |
news and views Soporific signaling: how flies sleep through the night
Christopher S Colwell Nature Neuroscience10, 1079–1080
(2007); doi:10.1038/nn0907-1079
| Full Text (HTML / PDF) |
article MRE11—RAD50—NBS1 and ATM function as co-mediators of TRF1 in telomere length control
Yili Wu, Shujie Xiao & Xu-Dong Zhu Nature Structural & Molecular Biology14, 832–840
(2007); doi:10.1038/nsmb1286
| Summary | Full Text (HTML / PDF) |
letter RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Vivek Shukla, Xavier Coumoul, Rui-Hong Wang, Hyun-Seok Kim & Chu-Xia Deng Nature Genetics39, 1145–1150
(September 2007); doi:10.1038/ng2096
| Summary | Full Text (HTML / PDF) |
news and views Cancer drugs to treat birth defects
Andrew O M Wilkie Nature Genetics39, 1057–1059
(September 2007); doi:10.1038/ng0907-1057
| Full Text (HTML / PDF) |
brief communication Kinase activity is not required for αCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses
Mohammad Reza Hojjati, Geeske M van Woerden, William J Tyler, Karl Peter Giese, Alcino J Silva, Lucas Pozzo-Miller & Ype Elgersma Nature Neuroscience10, 1125–1127
(September 2007); doi:10.1038/nn1946
| Summary | Full Text (HTML / PDF) |
scientific report The Arabidopsis TOR kinase links plant growth, yield, stress resistance and mRNA translation
Dorothée Deprost, Lei Yao, Rodnay Sormani, Manon Moreau, Guillaume Leterreux, Maryse Nicolaï, Magali Bedu, Christophe Robaglia & Christian Meyer EMBO Reports8, 864–870
(September 2007); doi:10.1038/nchembio.2007.19
| Summary | Full Text (HTML / PDF) |
August
letter Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi & Titia de Lange Nature448, 1068–1071
(30 August 2007); doi:10.1038/nature06065
| Summary | Full Text (HTML / PDF) |
article Cables links Robo-bound Abl kinase to N-cadherin-bound β-catenin to mediate Slit-induced modulation of adhesion and transcription
Jinseol Rhee, Tim Buchan, Lawrence Zukerberg, Jack Lilien & Janne Balsamo Nature Cell Biology9, 883–892
(August 2007); doi:10.1038/ncb1614
| Summary | Full Text (HTML / PDF) |
letter Germline gain-of-function mutations in RAF1 cause Noonan syndrome
M Abdur Razzaque, Tsutomu Nishizawa, Yuta Komoike, Hisato Yagi, Michiko Furutani, Ryunosuke Amo, Mitsuhiro Kamisago, Kazuo Momma, Hiroshi Katayama, Masao Nakagawa, Yuko Fujiwara, Masaki Matsushima, Katsumi Mizuno, Mika Tokuyama, Hamao Hirota, Jun Muneuchi, Toru Higashinakagawa & Rumiko Matsuoka Nature Genetics39, 1013–1017
(August 2007); doi:10.1038/ng2078
| Summary | Full Text (HTML / PDF) |
article A hippocampal Cdk5 pathway regulates extinction of contextual fear
Farahnaz Sananbenesi, Andre Fischer, Xinyu Wang, Christina Schrick, Rachael Neve, Jelena Radulovic & Li-Huei Tsai Nature Neuroscience10, 1012–1019
(August 2007); doi:10.1038/nn1943
| Summary | Full Text (HTML / PDF) |
letter Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Bhaswati Pandit, Anna Sarkozy, Len A Pennacchio, Claudio Carta, Kimihiko Oishi, Simone Martinelli, Edgar A Pogna, Wendy Schackwitz, Anna Ustaszewska, Andrew Landstrom, J Martijn Bos, Steve R Ommen, Giorgia Esposito, Francesca Lepri, Christian Faul, Peter Mundel, Juan P López Siguero, Romano Tenconi, Angelo Selicorni, Cesare Rossi, Laura Mazzanti, Isabella Torrente, Bruno Marino, Maria C Digilio, Giuseppe Zampino, Michael J Ackerman, Bruno Dallapiccola, Marco Tartaglia & Bruce D Gelb Nature Genetics39, 1007–1012
(August 2007); doi:10.1038/ng2073
| Summary | Full Text (HTML / PDF) |
article PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
Alessio Zippo, Alessandra De Robertis, Riccardo Serafini & Salvatore Oliviero Nature Cell Biology9, 932–944
(August 2007); doi:10.1038/ncb1618
| Summary | Full Text (HTML / PDF) |
news and views PIM1 and MYC: a changing relationship?
Jean-Francois Naud & Martin Eilers Nature Cell Biology9, 873–875
(August 2007); doi:10.1038/ncb0807-873
| Summary | Full Text (HTML / PDF) |
July
article A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik, Aimin Lin, Jian Du, Yue-Wei Qian, Douglas J. Zeckner, Greg Tucker-Kellogg, Jeffrey Touchman, Ketan Patel, Spyro Mousses, Michael Bittner, Richard Schevitz, Mei-Huei T. Lai, Kerry L. Blanchard & James E. Thomas Nature448, 439–444
(26 July 2007); doi:10.1038/nature05933
| Summary | Full Text (HTML / PDF) |
letter A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence
Delphine Chinchilla, Cyril Zipfel, Silke Robatzek, Birgit Kemmerling, Thorsten Nürnberger, Jonathan D. G. Jones, Georg Felix & Thomas Boller Nature448, 497–500
(26 July 2007); doi:10.1038/nature05999
| Summary | Full Text (HTML / PDF) |
letter Maximal chromosome compaction occurs by axial shortening in anaphase and depends on Aurora kinase
Felipe Mora-Bermúdez, Daniel Gerlich & Jan Ellenberg Nature Cell Biology9, 822–831
(July 2007); doi:10.1038/ncb1606
| Summary | Full Text (HTML / PDF) |
perspective Targeting the protein kinase C family: are we there yet?
Helen J. Mackay & Christopher J. Twelves Nature Reviews Cancer7, 554–562
(July 2007); doi:10.1038/nrc2168
| Summary | Full Text (HTML / PDF) |
review Mechanisms of specificity in protein phosphorylation
Jeffrey A. Ubersax & James E. Ferrell Jr Nature Reviews Molecular Cell Biology8, 530–541
(July 2007); doi:10.1038/nrm2203
| Summary | Full Text (HTML / PDF) |
article Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
Ammar H Hawasli, David R Benavides, Chan Nguyen, Janice W Kansy, Kanehiro Hayashi, Pierre Chambon, Paul Greengard, Craig M Powell, Donald C Cooper & James A Bibb Nature Neuroscience10, 880–886
(July 2007); doi:10.1038/nn1914
| Summary | Full Text (HTML / PDF) |
news and views Bypassing interneurons: inhibition in neocortex
Barry W Connors & Scott J Cruikshank Nature Neuroscience10, 808–810
(July 2007); doi:10.1038/nn0707-808
| Summary | Full Text (HTML / PDF) |
article Dishevelled promotes axon differentiation by regulating atypical protein kinase C
Xian Zhang, Ji Zhu, Guo-Ying Yang, Qing-Jie Wang, Lei Qian, Yan-Min Chen, Fei Chen, Yu Tao, Han-Song Hu, Tong Wang & Zhen-Ge Luo Nature Cell Biology9, 743–754
(July 2007); doi:10.1038/ncb1603
| Summary | Full Text (HTML / PDF) |
news and views Extrinsic Wnt signalling controls the polarity component aPKC
Shigeo Ohno Nature Cell Biology9, 738–740
(July 2007); doi:10.1038/ncb0707-738
| Summary | Full Text (HTML / PDF) |
news and views Threonine phosphorylation times bacterial secretion
Hemantha D. Kulasekara & Samuel I. Miller Nature Cell Biology9, 734–736
(July 2007); doi:10.1038/ncb0707-734
| Summary | Full Text (HTML / PDF) |
June
letter A microRNA component of the p53 tumour suppressor network
Lin He, Xingyue He, Lee P. Lim, Elisa de Stanchina, Zhenyu Xuan, Yu Liang, Wen Xue, Lars Zender, Jill Magnus, Dana Ridzon, Aimee L. Jackson, Peter S. Linsley, Caifu Chen, Scott W. Lowe, Michele A. Cleary & Gregory J. Hannon Nature447, 1130–1134
(28 June 2007); doi:10.1038/nature05939
| Summary | Full Text (HTML / PDF) |
letter Rad3-dependent phosphorylation of the checkpoint clamp regulates repair-pathway choice
Mihoko Kai, Kanji Furuya, Francesca Paderi, Antony M. Carr & Teresa S.F. Wang Nature Cell Biology9, 691–697
(June 2007); doi:10.1038/ncb1600
| Summary | Full Text (HTML / PDF) |
article Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
Salomé LeibundGut-Landmann, Olaf Grosß, Matthew J Robinson, Fabiola Osorio, Emma C Slack, S Vicky Tsoni, Edina Schweighoffer, Victor Tybulewicz, Gordon D Brown, Jürgen Ruland & Caetano Reis e Sousa Nature Immunology8, 630–638
(June 2007); doi:10.1038/ni1460
| Summary | Full Text (HTML / PDF) |
perspective Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg Nature Reviews Immunology7, 479–453
(June 2007); doi:10.1038/nri2091
| Summary | Full Text (HTML / PDF) |
article A semisynthetic epitope for kinase substrates
Jasmina J Allen, Manqing Li, Craig S Brinkworth, Jennifer L Paulson, Dan Wang, Anette Hübner, Wen-Hai Chou, Roger J Davis, Alma L Burlingame, Robert O Messing, Carol D Katayama, Stephen M Hedrick & Kevan M Shokat Nature Methods4, 511–516
(June 2007); doi:10.1038/nmeth1048
| Summary | Full Text (HTML / PDF) |
letter Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
Elijahu Berkovich, Raymond J. Monnat Jr. & Michael B. Kastan Nature Cell Biology9, 683–690
(June 2007); doi:10.1038/ncb1599
| Summary | Full Text (HTML / PDF) |
review The cofilin pathway in breast cancer invasion and metastasis
Weigang Wang, Robert Eddy & John Condeelis Nature Reviews Cancer7, 429–440
(June 2007); doi:10.1038/nrc2148
| Summary | Full Text (HTML / PDF) |
article The NEMO adaptor bridges the nuclear factor-κB and interferon regulatory factor signaling pathways
Tiejun Zhao, Long Yang, Qiang Sun, Meztli Arguello, Dean W Ballard, John Hiscott & Rongtuan Lin Nature Immunology8, 592–600
(June 2007); doi:10.1038/ni1465
| Summary | Full Text (HTML / PDF) |
perspective Signalling through TEC kinases regulates conventional versus innate CD8+ T-cell development
Leslie J. Berg Nature Reviews Immunology7, 479–485
(June 2007); doi:10.1038/nri2091
| Summary | Full Text (HTML / PDF) |
technical report The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
Eva Hernando, Elizabeth Charytonowicz, Maria E Dudas, Silvia Menendez, Igor Matushansky, Joslyn Mills, Nicholas D Socci, Nille Behrendt, Li Ma, Robert G Maki, Pier Paolo Pandolfi & Carlos Cordon-Cardo Nature Medicine13, 748–753
(June 2007); doi:10.1038/nm1560
| Summary | Full Text (HTML / PDF) |
letter The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
Michael Kruhlak, Elizabeth E. Crouch, Marika Orlov, Carolina Montaño, Stanislaw A. Gorski, André Nussenzweig, Tom Misteli, Robert D. Phair & Rafael Casellas Nature447, 730–734
(7 June 2007); doi:10.1038/nature05842
| Summary | Full Text (HTML / PDF) |
article p38α suppresses normal and cancer cell proliferation by antagonizing the JNK–c-Jun pathway
Lijian Hui, Latifa Bakiri, Andreas Mairhorfer, Norbert Schweifer, Christian Haslinger, Lukas Kenner, Vukoslav Komnenovic, Harald Scheuch, Hartmut Beug & Erwin F Wagner Nature Genetics39, 741–749
(June 2007); doi:10.1038/ng2033
| Summary | Full Text (HTML / PDF) |
article p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
Juan José Ventura, Stephan Tenbaum, Eusebio Perdiguero, Marion Huth, Carmen Guerra, Mariano Barbacid, Manolis Pasparakis & Angel R Nebreda Nature Genetics39, 750–758
(June 2007); doi:10.1038/ng2037
| Summary | Full Text (HTML / PDF) |
May
article Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
Suntaek Hong, Seunghwan Lim, Allen G Li, Chan Lee, Youn Sook Lee, Eun-Kyung Lee, Seok Hee Park, Xiao-Jing Wang & Seong-Jin Kim Nature Immunology8, 504–513
(May 2007); doi:10.1038/ni1451
| Summary | Full Text (HTML / PDF) |
news and views Smads keep TABs on inflammation
Rashu B Seth & Zhijian J Chen Nature Immunology8, 477–478
(May 2007); doi:10.1038/ni0507-477
| Summary | Full Text (HTML / PDF) |
brief communication Quantitative proteomic assessment of very early cellular signaling events
Joern Dengjel, Vyacheslav Akimov, Jesper V Olsen, Jakob Bunkenborg, Matthias Mann, Blagoy Blagoev & Jens S Andersen Nature Biotechnology25, 566–568
(May 2007); doi:10.1038/nbt1301
| Summary | Full Text (HTML / PDF) |
letter Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Klaus Dieterich, Ricardo Soto Rifo, Anne Karen Faure, Sylviane Hennebicq, Baha Ben Amar, Mohamed Zahi, Julia Perrin, Delphine Martinez, Bernard Sèle, Pierre-Simon Jouk, Théophile Ohlmann, Sophie Rousseaux, Joel Lunardi & Pierre F Ray Nature Genetics39, 661–665
(May 2007); doi:10.1038/ng2027
| Summary | Full Text (HTML / PDF) |
scientific report Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating the physical association of Tak1–IKK
Xuefeng Wu & Shao-Cong Sun EMBO Reports8, 510–515
(May 2007); doi:10.1038/sj.embor.7400931
| Summary | Full Text (HTML / PDF) |
letter The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs
Stefan Weitzer & Javier Martinez Nature447, 222–226
(10 May 2007); doi:10.1038/nature05777
| Summary | Full Text (HTML / PDF) |
letter pVHL and GSK3β are components of a primary cilium-maintenance signalling network
Claudio R. Thoma, Ian J. Frew, Christian R. Hoerner, Matteo Montani, Holger Moch & Wilhelm Krek Nature Cell Biology9, 588–595
(May 2007); doi:10.1038/ncb1579
| Summary | Full Text (HTML / PDF) |
news and views A new way to regulate the NMJ
Kay E Davies & Tejvir S Khurana Nature Medicine13, 538–539
(May 2007); doi:10.1038/nm0507-538
| Summary | Full Text (HTML / PDF) |
review Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
Kate L. Jeffrey, Montserrat Camps, Christian Rommel & Charles R. Mackay Nature Reviews Drug Discovery6, 391–403
(May 2007); doi:10.1038/nrd2289
| Summary | Full Text (HTML / PDF) |
article TRPC channels promote cerebellar granule neuron survival
Yichang Jia, Jian Zhou, Yilin Tai & Yizheng Wang Nature Neuroscience10, 559–567
(May 2007); doi:10.1038/nn1870
| Summary | Full Text (HTML / PDF) |
news and views Something old, something new: BDNF-induced neuron survival requires TRPC channel function
Wayne S Sossin & Philip A Barker Nature Neuroscience10, 537–538
(May 2007); doi:10.1038/nn0507-537
| Summary | Full Text (HTML / PDF) |
April
letter Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs
Tomoko Nishiyama, Keita Ohsumi & Takeo Kishimoto Nature446, 1096–1099
(26 April 2007); doi:10.1038/nature05696
| Summary | Full Text (HTML / PDF) |
letter A direct link of the Mos–MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs
Daigo Inoue, Munemichi Ohe, Yoshinori Kanemori, Toshiya Nobui & Noriyuki Sagata Nature446, 1100–1104
(26 April 2007); doi:10.1038/nature05688
| Summary | Full Text (HTML / PDF) |
article The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan
Daisuke Yamazaki, Junjiro Horiuchi, Yasuko Nakagami, Shintaro Nagano, Takuya Tamura & Minoru Saitoe Nature Neuroscience10, 478–484
(April 2007); doi:10.1038/nn1863
| Summary | Full Text (HTML / PDF) |
review Protein kinase C and other diacylglycerol effectors in cancer
Erin M. Griner & Marcelo G. Kazanietz Nature Reviews Cancer7, 281–294
(April 2007); doi:10.1038/nrc2110
| Summary | Full Text (HTML / PDF) |
March
article Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3β activity
Chinmay M Trivedi, Yang Luo, Zhan Yin, Maozhen Zhang, Wenting Zhu, Tao Wang, Thomas Floss, Martin Goettlicher, Patricia Ruiz Noppinger, Wolfgang Wurst, Victor A Ferrari, Charles S Abrams, Peter J Gruber & Jonathan A Epstein Nature Medicine13, 324–331
(March 2007); doi:10.1038/nm1552
| Summary | Full Text (HTML / PDF) |
letter A clickable inhibitor reveals context-dependent autoactivation of p90 RSK
Michael S Cohen, Haralambos Hadjivassiliou and Jack Taunton Nature Chemical Biology3, 156–160
(March 2007); doi:10.1038/nchembio859
| Summary | Full Text (HTML / PDF) |
news and views A RSK kinase inhibitor reporting its selectivity in vivo
Morten Frödin Nature Chemical Biology3, 138–139
(March 2007); doi:10.1038/nchembio0307-138
| Summary | Full Text (HTML / PDF) |
letter Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar, Seong-il Lee, Sricharan Bandhakavi, Timothy J. Griffin & Do-Hyung Kim Nature Cell Biology9, 316–323
(March 2007); doi:10.1038/ncb1547
| Summary | Full Text (HTML / PDF) |
scientific report Interferons induce tyrosine phosphorylation of the eIF2alpha kinase PKR through activation of Jak1 and Tyk2
Qiaozhu Su, Shuo Wang, Dionissios Baltzis, Li-Ke Qu, Jennifer F Raven, Suiyang Li, Andrew Hoi-Tao Wong & Antonis E Koromilas EMBO reports8, 265 – 270
(March 2007); doi:10.1038/sj.embor.7400891
| Summary | Full Text (HTML / PDF) |
article Patterns of somatic mutation in human cancer genomes
Christopher Greenman et al. Nature446, 153–158
(8 March 2007); doi:10.1038/nature05610
| Summary | Full Text (HTML / PDF) |
news and views Cancer: Drivers and passengers
Daniel A. Haber and Jeff Settleman Nature446, 145–146
(8 March 2007); doi:10.1038/446145a
| Summary | Full Text (HTML / PDF) |
letter Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
Silvia D. M. Santos, Peter J. Verveer & Philippe I. H. Bastiaens Nature Cell Biology9, 324–330
(March 2007); doi:10.1038/ncb1543
| Summary | Full Text (HTML / PDF) |
news and views Untangling the signalling wires
Boris N. Kholodenko Nature Cell Biology9, 247–249
(March 2007); doi:10.1038/ncb0307-247
| Summary | Full Text (HTML / PDF) |
review MAPK phosphatases — regulating the immune response
Yusen Liu, Edward G. Shepherd and Leif D. Nelin Nature Reviews Immunology7, 202–212
(March 2007); doi:10.1038/nri2035
| Summary | Full Text (HTML / PDF) |
letter Cross-talk and decision making in MAP kinase pathways
Megan N McClean, Areez Mody, James R Broach & Sharad Ramanathan Nature Genetics 39, 409–414
(March 2007); doi:10.1038/ng1957
| Summary | Full Text (HTML / PDF) |
news and views Shaping specificity in signaling networks
Réka Albert & Zoltán N Oltvai Nature Genetics 39, 286–287
(March 2007); doi:10.1038/ng0307-286
| Summary | Full Text (HTML / PDF) |
February
letter A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction
Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, Koichi Matsuda, Koji Yonemoto, Toshiaki Nakano, Tomonaga Matsushita, Keiko Yamazaki, Yozo Ohnishi, Susumu Saito, Takanari Kitazono, Setsuro Ibayashi, Katsuo Sueishi, Mitsuo Iida, Yusuke Nakamura & Yutaka Kiyohara Nature Genetics39, 212–217
(February 2007); doi:10.1038/ng1945
| Summary | Full Text (HTML / PDF) |
article The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a
Michael L Reese, Srikanth Dakoji, David S Bredt & Volker Dötsch Nature Structural & Molecular Biology14, 155–163
(February 2007); doi:10.1038/nsmb1195
| Summary | Full Text (HTML / PDF) |
article The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
Jiyong Liang, Shan H. Shao, Zhi-Xiang Xu, Bryan Hennessy, Zhiyong Ding, Michelle Larrea, Seiji Kondo, Dan J. Dumont, Jordan U. Gutterman, Cheryl L. Walker, Joyce M. Slingerland & Gordon B. Mills Nature Cell Biology9, 218–224
(February 2007); doi:10.1038/ncb1537
| Summary | Full Text (HTML / PDF) |
article Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-κB transcription factors
June L Round, Lisa A Humphries, Tamar Tomassian, Paul Mittelstadt, Min Zhang & M Carrie Miceli Nature Immunology8, 154–161
(February 2007); doi:10.1038/ni1422
| Summary | Full Text (HTML / PDF) |
news and views Choreography of MAGUKs during T cell activation
Mercedes Rincón & Roger J Davis Nature Immunology8, 126–127
(February 2007); doi:10.1038/ni0207-126
| Summary | Full Text (HTML / PDF) |
January
letter Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
Natalia V. Sergina, Megan Rausch, Donghui Wang, Jimmy Blair, Byron Hann, Kevan M. Shokat and Mark M. Moasser Nature445, 437–441
(25 January 2007); doi:10.1038/nature05474
| First Paragraph | Full Text (HTML / PDF) |
review The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes
Jianxun Song, Shahram Salek-Ardakani, Takanori So & Michael Croft Nature Immunology8, 64–73
(January 2007); doi:10.1038/ni1413
| Summary | Full Text (HTML / PDF) |
article Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
Wing-Yu Fu, Yu Chen, Mustafa Sahin, Xiao-Su Zhao, Lei Shi, Jay B Bikoff, Kwok-On Lai, Wing-Ho Yung, Amy K Y Fu, Michael E Greenberg & Nancy Y Ip Nature Neuroscience10, 67–76
(January 2007); doi:10.1038/nn1811
| Summary | Full Text (HTML / PDF) |
letter PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis
G. John Ferguson, Laura Milne, Suhasini Kulkarni, Takehiko Sasaki, Simon Walker, Simon Andrews, Tom Crabbe, Peter Finan, Gareth Jones, Shaun Jackson, Montserrat Camps, Christian Rommel, Matthias Wymann, Emilio Hirsch, Phillip Hawkins & Len Stephens Nature Cell Biology9, 86–91
(January 2007); doi:10.1038/ncb1517
| First Paragraph | Full Text (HTML / PDF) |
article PKC-1 regulates secretion of neuropeptides
Derek Sieburth, Jon M Madison & Joshua M Kaplan Nature Neuroscience10, 49–57
(January 2007); doi:10.1038/nn1810
| Summary | Full Text (HTML / PDF) |
article Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses
Jr-Wen Shui, Jonathan S Boomer, Jin Han, Jun Xu, Gregory A Dement, Guisheng Zhou & Tse-Hua Tan Nature Immunology8, 84–91
(January 2007); doi:10.1038/ni1416
| Summary | Full Text (HTML / PDF) |
article Essential function of HIPK2 in TGFβ-dependent survival of midbrain dopamine neurons
Jiasheng Zhang, Vanee Pho, Stephen J Bonasera, Jed Holzmann, Amy T Tang, Joanna Hellmuth, Siuwah Tang, Patricia H Janak, Laurence H Tecott & Eric J Huang Nature Neuroscience10, 77–86
(January 2007); doi:10.1038/nn1816
| Summary | Full Text (HTML / PDF) |
news and views How dopamine neurons survive
Annette Markus Nature Neuroscience10, 12
(January 2007); doi:10.1038/nn0107-12
| Summary | Full Text (HTML / PDF) |
article CDK1 and calcineurin regulate Maskin association with eIF4E and translational control of cell cycle progression
Quiping Cao, Jong Heon Kim & Joel D Richter Nature Structural & Molecular Biology13, 1128–1134
(January 2007); doi:10.1038/nsmb1169
| Summary | Full Text (HTML / PDF) |
