Research library: Kinases
2008:
| July
| June
| May
| April
| March
| February
| January
Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2007
July
article
Positive feedback of G1 cyclins ensures coherent cell cycle entry
Jan M. Skotheim, Stefano Di Talia, Eric D. Siggia & Frederick R. Cross
Nature 454, 291–296
(17 July 2008); doi:10.1038/nature07118
| Summary | Full Text (HTML / PDF) |
letter
Positive feedback sharpens the anaphase switch
Liam J. Holt, Andrew N. Krutchinsky & David O. Morgan
Nature 454, 353–357
(17 July 2008); doi:10.1038/nature07050
| Summary | Full Text (HTML / PDF) |
news and views
Systems biology: On the cell cycle and its switches
Silvia D. M. Santos & James E. Ferrell
Nature 454, 288–289
(17 July 2008); doi:10.1038/454288a
| Full Text (HTML / PDF) |
article
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
Melanie Winter et al.
Nature Cell Biology 10, 812–824
(July 2008); doi:10.1038/ncb1743
| Summary | Full Text (HTML / PDF) |
review
Colony-stimulating factors in inflammation and autoimmunity
John A. Hamilton
Nature Reviews Immunology 8, 533–544
(July 2008); doi:10.1038/nri2356
| Summary | Full Text (HTML / PDF) |
scientific report
Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles
Christian Ghiglione, Olivier Devergne, Delphine Cerezo & Stéphane Noselli
EMBO reports 9, 676–682
doi:10.1038/embor.2008.79
| Summary | Full Text (HTML / PDF) |
June
letter
Analysis of a spatial orientation memory in Drosophila
Kirsa Neuser, Tilman Triphan, Markus Mronz, Burkhard Poeck & Roland Strauss
Nature 453, 1244–1247
(26 June 2008); doi:10.1038/nature07003
| Summary | Full Text (HTML / PDF) |
news and views
Behavioural neuroscience: Out of sight, but not out of mind
Seth M. Tomchik & Ronald L. Davis
Nature 453, 1192–1194
(26 June 2008); doi:10.1038/4531192a
| Full Text (HTML / PDF) |
article
Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle
Karen Crasta, Hong Hwa Lim, Thomas H. Giddings, Jr, Mark Winey & Uttam Surana
Nature Cell Biology 10, 665–675
doi:10.1038/ncb1729
| Summary | Full Text (HTML / PDF) |
letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
| Summary | Full Text (HTML / PDF) |
letter
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
Brian G. Fuller et al.
Nature 453, 1132–1136
(19 June 2008); doi:10.1038/nature06923
| Summary | Full Text (HTML / PDF) |
letter
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation
Maria Emanuela Cuomo et al.
Nature Cell Biology 10, 723–730
(June 2008); doi:10.1038/ncb1735
| Summary | Full Text (HTML / PDF) |
article
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
Claudia Waskow et al.
Nature Immunology 9, 676–683
(June 2008); doi:10.1038/ni.1615
| Summary | Full Text (HTML / PDF) |
news and views
Homeostasis of dendritic cell pool in lymphoid organs
Cedric Auffray, Yalin Emre & Frederic Geissmann
Nature Immunology 9, 584–586
(June 2008); doi:10.1038/ni0608-584
| Full Text (HTML / PDF) |
article
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
Nobutaka Kato et al.
Nature Chemical Biology 4, 347–356
(June 2008); doi:10.1038/nchembio.87
| Summary | Full Text (HTML / PDF) |
news and views
Stopping malaria parasites dead in their tracks
Christian D Doerig
Nature Chemical Biology 4, 334–335
(June 2008); doi:10.1038/nchembio0608-3340
| Full Text (HTML / PDF) |
letter
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
Jennifer S. Ziegenfuss et al.
Nature 453, 935–939
(12 June 2008); doi:10.1038/nature06901
| Summary | Full Text (HTML / PDF) |
letter
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
Scott W. Rowlinson et al.
Nature Cell Biology 10, 740–747
(June 2008); doi:10.1038/ncb1737
| Summary | Full Text (HTML / PDF) |
article
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
Rupesh H Amin & Mark S Schlissel
Nature Immunology 9, 613–622
(June 2008); doi:10.1038/ni.1612
| Summary | Full Text (HTML / PDF) |
article
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K–PKB–Foxo pathway
Sebastian Herzog et al.
Nature Immunology 9, 623–631
(June 2008); doi:10.1038/ni.1616
| Summary | Full Text (HTML / PDF) |
news and views
Foxos around make B cells tolerable
Marta A W Rowh & Craig H Bassing
Nature Immunology 9, 586–588
(June 2008); doi:10.1038/ni0608-586
| Full Text (HTML / PDF) |
article
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
Tatsukata Kawagoe et al.
Nature Immunology 9, 684–691
(June 2008); doi:10.1038/ni.1606
| Summary | Full Text (HTML / PDF) |
news and views
IRAK2 takes its place in TLR signaling
Etienne Meylan & Jürg Tschopp
Nature Immunology 9, 581–582
(June 2008); doi:10.1038/ni0608-581
| Full Text (HTML / PDF) |
May
letter
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera et al.
Nature 453, 662–666
(29 May 2008); doi:10.1038/nature06892
| Summary | Full Text (HTML / PDF) |
letter
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
Derek J. Richard et al.
Nature 453, 677–681
(29 May 2008); doi:10.1038/nature06883
| Summary | Full Text (HTML / PDF) |
letter
HP1-β mobilization promotes chromatin changes that initiate the DNA damage response
Nabieh Ayoub, Anand D. Jeyasekharan, Juan A. Bernal & Ashok R. Venkitaraman
Nature 453, 682–686
(29 May 2008); doi:10.1038/nature06875
| Summary | Full Text (HTML / PDF) |
article
Identification of RIP1 kinase as a specific cellular target of necrostatins
Alexei Degterev et al.
Nature Chemical Biology 5, 313–321
(May 2008); doi:10.1038/nchembio.83
| Summary | Full Text (HTML / PDF) |
letter
The ground state of embryonic stem cell self-renewal
Qi-Long Ying et al.
Nature 453, 519–523
(22 May 2008); doi:10.1038/nature06968
| Summary | Full Text (HTML / PDF) |
article
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
Huazhang An et al.
Nature Immunology 9, 542–550
(May 2008); doi:10.1038/ni.1604
| Summary | Full Text (HTML / PDF) |
news and views
'Fine tuning' TLR signaling
Luke A J O'Neill
Nature Immunology 9, 459–461
(May 2008); doi:10.1038/ni0508-459
| Full Text (HTML / PDF) |
review
Immunobiology of the TAM receptors
Greg Lemke & Carla V. Rothline
Nature Reviews Immunology 8, 327–336
(May 2008); doi:10.1038/nri2303
| Summary | Full Text (HTML / PDF) |
article
Functional identification of sensory mechanisms required for developmental song learning
Sarah E London & David F Clayton
Nature Neuroscience 11, 579–586
(May 2008); doi:10.1038/nn.2103
| Summary | Full Text (HTML / PDF) |
news and views
Learning outside the song system
Noah Gray
Nature Neuroscience 11, 533
(May 2008); doi:10.1038/nn0508-533
| Full Text (HTML / PDF) |
review
Up on the tightrope: natural killer cell activation and inhibition
Lewis L Lanier
Nature Immunology 9, 495–502
(May 2008); doi:10.1038/ni1581
| Summary | Full Text (HTML / PDF) |
perpective
High-throughput kinase profiling as a platform for drug discovery
David M. Goldstein, Nathanael S. Gray & Patrick P. Zarrinkar
Nature Reviews Drug Discovery 7, 391–397
(May 2008); doi:10.1038/nrd2541
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome
Rebecca Mathew, Klaus Hartmuth, Sina Möhlmann, Henning Urlaub, Ralf Ficner & Reinhard Lührmann
Nature Structural & Molecular Biology 14, 435–443
(May 2008); doi:10.1038/nsmb.1415
| Summary | Full Text (HTML / PDF) |
article
Kemp elimination catalysts by computational enzyme design
Daniela Röthlisberger et al.
Nature 453, 190–195
(8 May 2008); doi:10.1038/nature06879
| Summary | Full Text (HTML / PDF) |
news and views
Computational biochemistry: Old enzymes, new tricks
Giovanna Ghirlanda
Nature 453, 164–166
(8 May 2008); doi:10.1038/453164a
| Full Text (HTML / PDF) |
perspective
A new penumbra: transitioning from injury into repair after stroke
Eng H Lo
Nature Medicine 14, 497–500
(May 2008); doi:10.1038/nm1735
| Summary | Full Text (HTML / PDF) |
article
A role for ubiquitin in the spliceosome assembly pathway
Priya Bellare, Eliza C Small, Xinhua Huang, James A Wohlschlegel, Jonathan P Staley & Erik J Sontheimer
Nature Structural & Molecular Biology 14, 444–451
(May 2008); doi:10.1038/nsmb.1401
| Summary | Full Text (HTML / PDF) |
news and views
Modifications target spliceosome dynamics
Corina Maeder & Christine Guthrie
Nature Structural & Molecular Biology 14, 426–428
(May 2008); doi:10.1038/nsmb0508-426
| Full Text (HTML / PDF) |
April
letter
Functional interaction between FOXO3a and ATM regulates DNA damage response
Wen-Bin Tsai, Young Min Chung, Yoko Takahashi, Zhaohui Xu & Mickey C.-T. Hu
Nature Cell Biology 10, 460–467
(April 2008); doi:10.1038/ncb1709
| Summary | Full Text (HTML / PDF) |
letter
A bistable Rb–E2F switch underlies the restriction point
Guang Yao, Tae Jun Lee, Seiichi Mori, Joseph R. Nevins & Lingchong You
Nature Cell Biology 10, 476–482
(April 2008); doi:10.1038/ncb1711
| Summary | Full Text (HTML / PDF) |
article
TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation
Megumi Kaneko, Jessica L Hanover, Pamela M England & Michael P Stryker
Nature Neuroscience 11, 497–504
(April 2008); doi:10.1038/nn2068
| Summary | Full Text (HTML / PDF) |
letter
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
Song Shi et al.
Nature Cell Biology 10, 489–496
(April 2008); doi:10.1038/ncb1713
| Summary | Full Text (HTML / PDF) |
review
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Isabel M. Chu, Ludger Hengst & Joyce M. Slingerland
Nature Reviews Cancer 8, 253–267
(April 2008); doi:10.1038/nrc2347
| Summary | Full Text (HTML / PDF) |
letter
Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation
Daniel R. Gestaut et al.
Nature Cell Biology 10, 407–414
(April 2008); doi:10.1038/ncb1702
| Summary | Full Text (HTML / PDF) |
news and views
Dam1 complexes go it alone on disassembling microtubules
Melissa K. Gardner & David J. Odde
Nature Cell Biology 10, 379–381
(April 2008); doi:10.1038/ncb0408-379
| Full Text (HTML / PDF) |
review
Regulation of DNA repair throughout the cell cycle
Dana Branzei & Marco Foiani
Nature Reviews Molecular Cell Biology 9, 297–308
(April 2008); doi:10.1038/nrm2351
| Summary | Full Text (HTML / PDF) |
review
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway
Nicholas J. Buchkovich, Yongjun Yu, Carisa A. Zampieri & James C. Alwine
Nature Reviews Microbiology 6, 266–275
(April 2008); doi:10.1038/nrmicro1855
| Summary | Full Text (HTML / PDF) |
letter
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
Nature 452, 646–649
(3 April 2008); doi:10.1038/nature06778
| Summary | Full Text (HTML / PDF) |
letter
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
Kyu-Sun Lee et al.
Nature Cell Biology 10, 468–475
(April 2008); doi:10.1038/ncb1710
| Summary | Full Text (HTML / PDF) |
March
letter
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
Tomoya Kitamura et al.
Nature Cell Biology 10, 329–337
(March 2008); doi:10.1038/ncb1695
| Summary | Full Text (HTML / PDF) |
article
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara & Lewis C. Cantley
Nature 452, 181–186
(13 March 2008); doi:10.1038/nature06667
| Summary | Full Text (HTML / PDF) |
letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230–233
(13 March 2008); doi:10.1038/nature06734
| Summary | Full Text (HTML / PDF) |
article
Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart
Ludger Hauck et al.
Nature Medicine 14, 315–324
(March 2008); doi:10.1038/nm1729
| Summary | Full Text (HTML / PDF) |
news and views
The weakness of a big heart
Thomas Force
Nature Medicine 14, 244–245
(March 2008); doi:10.1038/nm0308-244
| Summary | Full Text (HTML / PDF) |
February
article
NGF-promoted axon growth and target innervation requires GITRL–GITR signaling
Gerard W O'Keeffe, Humberto Gutierrez, Pier Paolo Pandolfi, Carlo Riccardi & Alun M Davies
Nature Neuroscience 11, 135–142
(February 2008); doi:10.1038/nn2034
| Summary | Full Text (HTML / PDF) |
article
Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
Sang-Dong Yoo, Young-Hee Cho, Guillaume Tena, Yan Xiong & Jen Sheen
Nature 451, 789–795
(14 February 2008); doi:10.1038/nature06543
| Summary | Full Text (HTML / PDF) |
article
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
Nature Cell Biology 10, 138–148
(February 2008); doi:10.1038/ncb1676
| Summary | Full Text (HTML / PDF) |
news and views
ERK and MDM2 prey on FOXO3a
Wensheng Yang, Nathan G. Dolloff & Wafik S. El-Deiry
Nature Cell Biology 10, 125–126
(February 2008); doi:10.1038/ncb0208-125
| Summary | Full Text (HTML / PDF) |
letter
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ken J. Ishii et al.
Nature 451, 725–729
(7 February 2008); doi:10.1038/nature06537
| Summary | Full Text (HTML / PDF) |
letter
Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells
Kazuko Hanyu-Nakamura, Hiroko Sonobe-Nojima, Akie Tanigawa, Paul Lasko & Akira Nakamura
Nature 451, 730–733
(7 February 2008); doi:10.1038/nature06498
| Summary | Full Text (HTML / PDF) |
letter
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation
Tetsuya Hosooka et al.
Nature Medicine 14, 188–193
(February 2008); doi:10.1038/nm1706
| Summary | Full Text (HTML / PDF) |
article
High-content single-cell drug screening with phosphospecific flow cytometry
Peter O Krutzik, Janelle M Crane, Matthew R Clutter & Garry P Nolan
Nature Chemical Biology 4, 132–142
(February 2008); doi:10.1038/nchembio.2007.59
| Summary | Full Text (HTML / PDF) |
scientific report
A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding
Harold B J Jefferies et al.
EMBO Reports 9, 164–170
(February 2008); doi:10.1038/sj.embor.7401155
| Summary | Full Text (HTML / PDF) |
article
'Tuning' of type I interferon-induced Jak–STAT1 signaling by calcium-dependent kinases in macrophages
Lu Wang et al.
Nature Immunology 9, 186–193
(February 2008); doi:10.1038/ni1548
| Summary | Full Text (HTML / PDF) |
January
review
The anaplastic lymphoma kinase in the pathogenesis of cancer
Roberto Chiarle, Claudia Voena, Chiara Ambrogio, Roberto Piva & Giorgio Inghirami
Nature Reviews Cancer 8, 11–23
(January 2008); doi:10.1038/nrc2291
| Summary | Full Text (HTML / PDF) |
letter
A quantitative analysis of kinase inhibitor selectivity
Mazen W Karaman et al.
Nature Biotechnology 26, 127–132
(January 2008); doi:10.1038/nbt1358
| Summary | Full Text (HTML / PDF) |
perspective
Protein therapeutics: a summary and pharmacological classification
Benjamin Leader, Quentin J. Baca & David E. Golan
Nature Reviews Drug Discovery 7, 21–39
(January 2008); doi:10.1038/nrd2399
| Summary | Full Text (HTML / PDF) |
article
Disruption of KIF17–Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin–cargo release
Laurent Guillaud, Richard Wong & Nobutaka Hirokawa
Nature Cell Biology 10, 19–29
(January 2008); doi:10.1038/ncb1665
| Summary | Full Text (HTML / PDF) |
news and views
Motor-cargo release: CaMKII as a traffic cop
Shabeen Ally, Amber L. Jolly & Vladimir I. Gelfand
Nature Cell Biology 10, 3–5
(January 2008); doi:10.1038/ncb0108-3
| Summary | Full Text (HTML / PDF) |
news and views
IP7 guards the CDK gate
John D York & Daniel J Lew
Nature Chemical Biology 4, 16–17
(January 2008); doi:10.1038/nchembio0108-16
| Full Text (HTML / PDF) |
letter
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu et al.
Nature 451, 202–206
(10 January 2008); doi:10.1038/nature06468
| Summary | Full Text (HTML / PDF) |
brief communication
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
Margarita Malakhova et al.
Nature Structural & Molecular Biology 15, 112–113
(January 2008); doi:10.1038/nsmb1347
| Summary | Full Text (HTML / PDF) |
article
Molecular basis of cyclin–CDK–CKI regulation by reversible binding of an inositol pyrophosphate
Young-Sam Lee, Kexin Huang, Florante A Quiocho & Erin K O'Shea
Nature Chemical Biology 4, 25–32
(January 2008); doi:10.1038/nchembio.2007.52
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
Eric Metzger et al.
Nature Cell Biology 10, 53–60
(January 2008); doi:10.1038/ncb1668
| Summary | Full Text (HTML / PDF) |
news and views
Thrilling transcription through threonine phosphorylation
Luciano Di Croce & Ramin Shiekhattar
Nature Cell Biology 10, 5–6
(January 2008); doi:10.1038/ncb0108-5
| Summary | Full Text (HTML / PDF) |
|
