Research library: Kinases
2009:
| December
| November
| October
| September
| August
| July
| June
| May
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Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008
December
review
TrkB signalling pathways in LTP and learning
Liliana Minichiello
Nature Reviews Neuroscience 10, 850–860
(December 2009); doi:10.1038/nrn2738
| Summary | Full Text (HTML / PDF) |
letter
Cell fate decisions are specified by the dynamic ERK interactome
Alex von Kriegsheim et al.
Nature Cell Biology 11, 1458–1464
(December 2009); doi:10.1038/ncb1994
| Summary | Full Text (HTML / PDF) |
article
Dynamic refolding of IFN-γ mRNA enables it to function as PKR activator and translation template
Smadar Cohen-Chalamish et al.
Nature Chemical Biology 5, 896–903
(December 2009); doi:10.1038/nchembio.234
| Summary | Full Text (HTML / PDF) |
November
article
GSK-3 is a master regulator of neural progenitor homeostasis
Woo-Yang Kim et al.
Nature Neuroscience 12, 1390–1397
(November 2009); doi:10.1038/nn.2408
| Summary | Full Text (HTML / PDF) |
article
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
Teresa L M Thurston, Grigory Ryzhakov, Stuart Bloor, Natalia von Muhlinen & Felix Randow
Nature Immunology 10, 1215–1221
(November 2009); doi:10.1038/ni.1800
| Summary | Full Text (HTML / PDF) |
news and views
NDP52: the missing link between ubiquitinated bacteria and autophagy
Stanimir Ivanov & Craig R Roy
Nature Immunology 10, 1137–1139
(November 2009); doi:10.1038/ni1109-1137
| Full Text (HTML / PDF) |
review
Targeting protein kinases in central nervous system disorders
Laura K. Chico, Linda J. Van Eldik & D. Martin Watterson
Nature Reviews Drug Discovery 8, 892–909
(November 2009); doi:10.1038/nrd2999
| Summary | Full Text (HTML / PDF) |
article
Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways
Barbara Lorber, Mariko L Howe, Larry I Benowitz & Nina Irwin
Nature Neuroscience 12, 1407–1414
(November 2009); doi:10.1038/nn.2414
| Summary | Full Text (HTML / PDF) |
article
The kinase TNIK is an essential activator of Wnt target genes
Tokameh Mahmoudi et al.
The EMBO Journal 28, 3329–3340
(November 2009); doi:10.1038/emboj.2009.285
| Summary | Full Text (HTML / PDF) |
brief communication
DNA damage signalling prevents deleterious telomere addition at DNA breaks
Svetlana Makovets & Elizabeth H. Blackburn
Nature Cell Biology 11, 1383–1386
(November 2009); doi:10.1038/ncb1985
| Summary | Full Text (HTML / PDF) |
October
letter
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
Marina Melixetian, Ditte Kjærsgaard Klein, Claus Storgaard Sørensen & Kristian Helin
Nature Cell Biology 11, 1247–1253
(October 2009); doi:10.1038/ncb1969
| Summary | Full Text (HTML / PDF) |
article
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification
Kazuishi Kubota et al.
Nature Biotechnology 27, 933–940
(October 2009); doi:10.1038/nbt.1566
| Summary | Full Text (HTML / PDF) |
news and views
Snapshots of kinase activities
Javier Muñoz & Albert J R Heck
Nature Biotechnology 27, 912–913
(October 2009); doi:10.1038/nbt1009-912
| Full Text (HTML / PDF) |
article
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
Hidetaka Kosako et al.
Nature Structural & Molecular Biology 16, 1026–1035
(October 2009); doi:10.1038/nsmb.1656
| Summary | Full Text (HTML / PDF) |
news and views
PORE-ing over ERK substrates
Natalie G Ahn
Nature Structural & Molecular Biology 16, 1004–1005
(October 2009); doi:10.1038/nsmb1009-1004
| Full Text (HTML / PDF) |
article
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
Valerie Hindie et al.
Nature Chemical Biology 5, 758–764
(October 2009); doi:10.1038/nchembio.208
| Summary | Full Text (HTML / PDF) |
letter
Integrin-linked kinase is an adaptor with essential functions during mouse development
Anika Lange et al.
Nature 461, 1002–1006
(15 October 2009); doi:10.1038/nature08468
| Full Text (HTML / PDF) |
letter
Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors
Tae-Wuk Kim et al.
Nature Cell Biology 11, 1254–1260
(October 2009); doi:10.1038/ncb1970
| Summary | Full Text (HTML / PDF) |
letter
JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin
Mark A. Dawson et al.
Nature 461, 819–822
(08 October 2009); doi:10.1038/nature08448
| Full Text (HTML / PDF) |
article
Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori
Sonja I Gringhuis, Jeroen den Dunnen, Manja Litjens, Michiel van der Vlist & Teunis B H Geijtenbeek
Nature Immunology 10, 1081–1088
(October 2009); doi:10.1038/ni.1778
| Summary | Full Text (HTML / PDF) |
letter
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Todd D Prickett et al.
Nature Genetics 41, 1127–1132
(October 2009); doi:10.1038/ng.438
| Summary | Full Text (HTML / PDF) |
letter
A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
Anne-Kathrin Classen, Brandon D Bunker, Kieran F Harvey, Thomas Vaccari & David Bilder
Nature Genetics 41, 1150–1155
(October 2009); doi:10.1038/ng.445
| Summary | Full Text (HTML / PDF) |
September
letter
A dimerization-dependent mechanism drives RAF catalytic activation
Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois, Frank Sicheri & Marc Therrien
Nature 461, 542–545
(24 September 2009); doi:10.1038/nature08314
| Full Text (HTML / PDF) |
article
SADB phosphorylation of γ-tubulin regulates centrosome duplication
María Alvarado-Kristensson, María Josefa Rodríguez, Virginia Silió, José M. Valpuesta & Ana C. Carrera
Nature Cell Biology 11, 1081–1092
(September 2009); doi:10.1038/ncb1921
| Summary | Full Text (HTML / PDF) |
news and views
SAD kinase keeps centrosomes lonely
Daici Chen & Jackie Vogel
Nature Cell Biology 11, 1047–1048
(September 2009); doi:10.1038/ncb0909-1047
| Full Text (HTML / PDF) |
review
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Pasi A. Jänne, Nathanael Gray & Jeff Settleman
Nature Reviews Drug Discovery 8, 709–723
(September 2009); doi:10.1038/nrd2871
| Summary | Full Text (HTML / PDF) |
letter
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Jennifer O. Lauchle et al.
Nature 461, 411–414
(17 September 2009); doi:10.1038/nature08279
| Full Text (HTML / PDF) |
article
An essential role of the aPKC–Aurora A–NDEL1 pathway in neurite elongation by modulation of microtubule dynamics
Daisuke Mori et al.
Nature Cell Biology 11, 1057–1068
(September 2009); doi:10.1038/ncb1919
| Summary | Full Text (HTML / PDF) |
news and views
Aurora A moonlights in neurite extension
Gloria Kuo Lefkowitz & Joseph G. Gleeson
Nature Cell Biology 11, 1053–1054
(September 2009); doi:10.1038/ncb0909-1053
| Full Text (HTML / PDF) |
article
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
Tatsukata Kawagoe et al.
Nature Immunology 10, 965–972
(September 2009); doi:10.1038/ni.1771
| Summary | Full Text (HTML / PDF) |
article
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling
Emma Puighermanal et al.
Nature Neuroscience 12, 1152–1158
(September 2009); doi:10.1038/nn.2369
| Summary | Full Text (HTML / PDF) |
news and views
Get stoned in GABAergic synapses
Ken Mackie & István Katona
Nature Neuroscience 12, 1081–1083
(September 2009); doi:10.1038/nn0909-1081
| Full Text (HTML / PDF) |
letter
Direct activation of protein kinases by unanchored polyubiquitin chains
Zong-Ping Xia et al.
Nature 461, 114–119
(03 September 2009); doi:10.1038/nature08247
| Full Text (HTML / PDF) |
review
Target profiling of small molecules by chemical proteomics
Uwe Rix & Giulio Superti-Furga
Nature Chemical Biology 5, 616–624
(September 2009); doi:10.1038/nchembio.216
| Summary | Full Text (HTML / PDF) |
August
letter
Riboflavin kinase couples TNF receptor 1 to NADPH oxidase
Benjamin Yazdanpanah et al.
Nature 460, 1159–1163
(27 August 2009); doi:10.1038/nature08206
| Full Text (HTML / PDF) |
review
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Jeffrey A. Engelman
Nature Reviews Cancer 9, 550–562
(August 2009); doi:10.1038/nrc2664
| Summary | Full Text (HTML / PDF) |
article
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Sang-Moon Yun et al.
Nature Structural & Molecular Biology 16,
doi:10.1038/nsmb.1628
| Summary | Full Text (HTML / PDF) |
review
Signal integration by JNK and p38 MAPK pathways in cancer development
Erwin F. Wagner & Ángel R. Nebreda
Nature Reviews Cancer 9, 537–549
(August 2009); doi:10.1038/nrc2694
| Summary | Full Text (HTML / PDF) |
review
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
David B. Shackelford & Reuben J. Shaw
Nature Reviews Cancer 9, 563–575
(August 2009); doi:10.1038/nrc2676
| Summary | Full Text (HTML / PDF) |
review
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu, Hailing Cheng, Thomas M. Roberts & Jean J. Zhao
Nature Reviews Drug Discovery 8, 627–644
(August 2009); doi:10.1038/nrd2926
| Summary | Full Text (HTML / PDF) |
July
article
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
Gerardo A Morfini et al.
Nature Neuroscience 12, 864–871
(July 2009); doi:10.1038/nn.2346
| Summary | Full Text (HTML / PDF) |
brief communication
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Yanping Li et al.
Nature Neuroscience 12, 826–828
(July 2009); doi:10.1038/nn.2349
| Summary | Full Text (HTML / PDF) |
review
Cell cycle kinases as therapeutic targets for cancer
Silvia Lapenna & Antonio Giordano
Nature Reviews Drug Discovery 8, 547–566
(July 2009); doi:10.1038/nrd2907
| Summary | Full Text (HTML / PDF) |
letter
The tyrosine kinase Stitcher activates Grainy head and epidermal wound healing in Drosophila
Shenqiu Wang et al.
Nature Cell Biology 11, 890–895
(July 2009); doi:10.1038/ncb1898
| Summary | Full Text (HTML / PDF) |
article
Inhibitor hijacking of Akt activation
Tatsuya Okuzumi et al.
Nature Chemical Biology 5, 484–493
(July 2009); doi:10.1038/nchembio.183
| Summary | Full Text (HTML / PDF) |
news and views
Inhibitors paradoxically prime kinases
Stephen V Frye & Gary L Johnson
Nature Chemical Biology 5, 448–449
(July 2009); doi:10.1038/nchembio.f.11
| Full Text (HTML / PDF) |
review
Proximal events in Wnt signal transduction
Stephane Angers & Randall T. Moon
Nature Reviews Molecular Cell Biology 10, 468–477
(July 2009); doi:10.1038/nrm2717
| Summary | Full Text (HTML / PDF) |
brief communication
βCaMKII controls the direction of plasticity at parallel fiber–Purkinje cell synapses
Geeske M van Woerden et al.
Nature Neuroscience 12, 823–825
(July 2009); doi:10.1038/nn.2329
| Summary | Full Text (HTML / PDF) |
letter
Unlimited multistability in multisite phosphorylation systems
Matthew Thomson & Jeremy Gunawardena
Nature 460, 274–277
(09 July 2009); doi:10.1038/nature08102
| Full Text (HTML / PDF) |
article
The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR
Guangwei Liu et al.
Nature Immunology 10, 769–777
(July 2009); doi:10.1038/ni.1743
| Summary | Full Text (HTML / PDF) |
news and views
A novel modifier of regulatory T cells
Naganari Ohkura & Shimon Sakaguchi
Nature Immunology 10, 685–686
(July 2009); doi:10.1038/ni0709-685
| Full Text (HTML / PDF) |
letter
TGF-β activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN
Mitsuo Kato et al.
Nature Cell Biology 11, 881–889
(July 2009); doi:10.1038/ncb1897
| Summary | Full Text (HTML / PDF) |
June
letter
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
Lei Chen et al.
Nature 459, 1146–1149
(25 June 2009); doi:10.1038/nature08075
| Full Text (HTML / PDF) |
review
Targeting innate immunity protein kinase signalling in inflammation
Matthias Gaestel, Alexey Kotlyarov & Michael Kracht
Nature Reviews Drug Discovery 8, 480–499
(June 2009); doi:10.1038/nrd2829
| Summary | Full Text (HTML / PDF) |
article
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity
Angus J M Cameron, Cristina Escribano, Adrian T Saurin, Brenda Kostelecky & Peter J Parker
Nature Structural & Molecular Biology 16, 624–630
(June 2009); doi:10.1038/nsmb.1606
| Summary | Full Text (HTML / PDF) |
letter
Polar gradients of the DYRK-family kinase Pom1 couple cell length with the cell cycle
Sophie G. Martin & Martine Berthelot-Grosjean
Nature 459, 852–856
(11 June 2009); doi:10.1038/nature08054
| Full Text (HTML / PDF) |
letter
A spatial gradient coordinates cell size and mitotic entry in fission yeast
James B. Moseley, Adeline Mayeux, Anne Paoletti & Paul Nurse
Nature 459, 857–860
(11 June 2009); doi:10.1038/nature08074
| Full Text (HTML / PDF) |
news and views
Cell cycle: Cell division brought down to size
Kenneth E. Sawin
Nature 459, 782–783
(11 June 2009); doi:10.1038/459782a
| Full Text (HTML / PDF) |
brief communication
A new screening assay for allosteric inhibitors of cSrc
Jeffrey R Simard et al.
Nature Chemical Biology 5, 394–396
(June 2009); doi:10.1038/nchembio.162
| Summary | Full Text (HTML / PDF) |
May
letter
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment
Minsoo Kim et al.
Nature 459, 578–582
(28 May 2009); doi:10.1038/nature07952
| Full Text (HTML / PDF) |
review
Assessing the potential of glucokinase activators in diabetes therapy
Franz M. Matschinsky
Nature Reviews Drug Discovery 8, 399–416
(May 2009); doi:10.1038/nrd2850
| Summary | Full Text (HTML / PDF) |
letter
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
Olaf Gross et al.
Nature 459, 433–436
(21 May 2009); doi:10.1038/nature07965
| Full Text (HTML / PDF) |
article
T cell antigen receptor signaling and immunological synapse stability require myosin IIA
Tal Ilani, Gaia Vasiliver-Shamis, Santosh Vardhana, Anthony Bretscher & Michael L Dustin
Nature Immunology 10, 531–539
(May 2009); doi:10.1038/ni.1723
| Summary | Full Text (HTML / PDF) |
article
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot
Tim Eiseler et al.
Nature Cell Biology 11, 545–556
(May 2009); doi:10.1038/ncb1861
| Summary | Full Text (HTML / PDF) |
letter
Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration
Cai Huang et al.
Nature Cell Biology 11, 624–630
(May 2009); doi:10.1038/ncb1868
| Summary | Full Text (HTML / PDF) |
news and views
Smurf1 zaps the talin head
David R. Critchley
Nature Cell Biology 11, 538–540
(May 2009); doi:10.1038/ncb0509-538
| Full Text (HTML / PDF) |
progress
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
Mark S. Cragg, Claire Harris, Andreas Strasser & Clare L. Scott
Nature Reviews Cancer 9, 321–326
(May 2009); doi:10.1038/nrc2615
| Summary | Full Text (HTML / PDF) |
review
Immunoregulatory functions of mTOR inhibition
Angus W. Thomson, Hēth R. Turnquist & Giorgio Raimondi
Nature Reviews Immunology 9, 324–337
(May 2009); doi:10.1038/nri2546
| Summary | Full Text (HTML / PDF) |
article
The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death
Takahiro Miyawaki et al.
Nature Neuroscience 12, 618–626
(May 2009); doi:10.1038/nn.2299
| Summary | Full Text (HTML / PDF) |
letter
Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation
Myriam Aouadi et al.
Nature 458, 1180–1184
(30 April 2009); doi:10.1038/nature07774
| Summary | Full Text (HTML / PDF) |
article
Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt
Anna C.-C. Jang, Yu-Chiuan Chang, Jianwu Bai & Denise Montell
Nature Cell Biology 11, 569–579
(May 2009); doi:10.1038/ncb1863
| Summary | Full Text (HTML / PDF) |
review
Molecular mechanisms of mTOR-mediated translational control
Xiaoju Max Ma & John Blenis
Nature Reviews Molecular Cell Biology 10, 307–318
(May 2009); doi:10.1038/nrm2672
| Summary | Full Text (HTML / PDF) |
article
A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
Eiichiro Noguchi, Yoichiro Homma, Xiaoyan Kang, Mihai G Netea & Xiaojing Ma
Nature Immunology 10, 471–479
(May 2009); doi:10.1038/ni.1722
| Summary | Full Text (HTML / PDF) |
news and views
Crohn's disease-associated Nod2 mutants reduce IL10 transcription
Dana J Philpott & Stephen E Girardin
Nature Immunology 10, 455–457
(May 2009); doi:10.1038/ni0509-455
| Full Text (HTML / PDF) |
April
letter
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
Carles Cantó et al.
Nature 458, 1056–1060
(23 April 2009); doi:10.1038/nature07813
| Summary | Full Text (HTML / PDF) |
letter
Modularity of MAP kinases allows deformation of their signalling pathways
Areez Mody, Joan Weiner & Sharad Ramanathan
Nature Cell Biology 11, 484–491
(April 2009); doi:10.1038/ncb1856
| Summary | Full Text (HTML / PDF) |
review
Polo-like kinases: conservation and divergence in their functions and regulation
Vincent Archambault & David M. Glover
Nature Reviews Molecular Cell Biology 10, 265–275
(April 2009); doi:10.1038/nrm2653
| Summary | Full Text (HTML / PDF) |
article
Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination
Bao Q Vuong et al.
Nature Immunology 10, 420–426
(April 2009); doi:10.1038/ni.1708
| Summary | Full Text (HTML / PDF) |
news and views
AID and RPA: PKA makes the connection local
Cristina Rada
Nature Immunology 10, 367–369
(April 2009); doi:10.1038/ni0409-367
| Full Text (HTML / PDF) |
brief communication
CK2α phosphorylates BMAL1 to regulate the mammalian clock
Teruya Tamaru et al.
Nature Structural & Molecular Biology 16, 446–448
(April 2009); doi:10.1038/nsmb.1578
| Summary | Full Text (HTML / PDF) |
scientific report
Regulation of human myoblast differentiation by PEBP4
Reynaldo Garcia et al.
EMBO Reports 10, 278–284
(April 2009); doi:10.1038/embor20094
| Summary | Full Text (HTML / PDF) |
scientific report
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway
Young Joo Jeon et al.
EMBO Reports 10, 374–380
(April 2009); doi:10.1038/embor200923
| Summary | Full Text (HTML / PDF) |
scientific report
Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination
Hui Geng et al.
EMBO Reports 10, 381–386
(April 2009); doi:10.1038/embor200910
| Summary | Full Text (HTML / PDF) |
letter
IFNα activates dormant haematopoietic stem cells in vivo
Marieke A. G. Essers et al.
Nature 458, 904–908
(16 April 2009); doi:10.1038/nature07815
| Summary | Full Text (HTML / PDF) |
article
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Kohichi Matsunaga et al.
Nature Cell Biology 11, 385–396
(April 2009); doi:10.1038/ncb1846
| Summary | Full Text (HTML / PDF) |
letter
Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex
Yun Zhong et al.
Nature Cell Biology 11, 468–476
(April 2009); doi:10.1038/ncb1854
| Summary | Full Text (HTML / PDF) |
letter
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
Amy V Jones et al.
Nature Genetics 41, 446–449
(April 2009); doi:10.1038/ng.334
| Summary | Full Text (HTML / PDF) |
letter
A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms
Damla Olcaydu et al.
Nature Genetics 41, 450–454
(April 2009); doi:10.1038/ng.341
| Summary | Full Text (HTML / PDF) |
letter
A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms
Outi Kilpivaara et al.
Nature Genetics 41, 455–459
(April 2009); doi:10.1038/ng.342
| Summary | Full Text (HTML / PDF) |
news and views
Somatic and germline genetics at the JAK2 locus
Peter J Campbell
Nature Methods 41, 385–386
(April 2009); doi:10.1038/ng0409-385
| Full Text (HTML / PDF) |
brief communication
A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration
Bradley R Miller et al.
Nature Neuroscience 12, 387–389
(April 2009); doi:10.1038/nn.2290
| Summary | Full Text (HTML / PDF) |
article
Acetylation by GCN5 regulates CDC6 phosphorylation in the S phase of the cell cycle
Roberta Paolinelli, Ramiro Mendoza-Maldonado, Anna Cereseto & Mauro Giacca
Nature Structural & Molecular Biology 16, 412–420
(April 2009); doi:10.1038/nsmb.1583
| Summary | Full Text (HTML / PDF) |
article
Tumours with PI3K activation are resistant to dietary restriction
Nada Y. Kalaany & David M. Sabatini
Nature 458, 725–731
(09 April 2009); doi:10.1038/nature07782
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: When restriction is good
Anne Brunet
Nature 458, 713–714
(09 April 2009); doi:10.1038/458713a
| Full Text (HTML / PDF) |
article
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
Subbareddy Maddika & Junjie Chen
Nature Cell Biology 11, 409–419
(April 2009); doi:10.1038/ncb1848
| Summary | Full Text (HTML / PDF) |
news and views
Targeting protein ubiquitylation: DDB1 takes its RING off
Sarah Jackson & Yue Xiong
Nature Cell Biology 11, 379–381
(April 2009); doi:10.1038/ncb0409-379
| Full Text (HTML / PDF) |
perspective
Selectivity and therapeutic inhibition of kinases: to be or not to be?
Kamran Ghoreschi, Arian Laurence & John J O'Shea
Nature Immunology 10, 356–360
(April 2009); doi:10.1038/ni.1701
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
Daming Gao et al.
Nature Cell Biology 11, 397–408
(April 2009); doi:10.1038/ncb1847
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
Hui-Kuan Lin et al.
Nature Cell Biology 11, 420–432
(April 2009); doi:10.1038/ncb1849
| Summary | Full Text (HTML / PDF) |
news and views
Skp2: caught in the Akt
Karin Ecker & Ludger Hengst
Nature Cell Biology 11, 377–379
(April 2009); doi:10.1038/ncb1859
| Full Text (HTML / PDF) |
March
article
A Mek1–Mek2 heterodimer determines the strength and duration of the Erk signal
Federica Catalanotti et al.
Nature Structural & Molecular Biology 16, 294–303
(March 2009); doi:10.1038/nsmb.1564
| Summary | Full Text (HTML / PDF) |
article
TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells
Griselda Herrero-Martín et al.
The EMBO Journal 28, 677–685
(March 2009); doi:10.1038/emboj.2009.8
| Summary | Full Text (HTML / PDF) |
article
Activation of CaMKII in single dendritic spines during long-term potentiation
Seok-Jin R. Lee, Yasmin Escobedo-Lozoya, Erzsebet M. Szatmari & Ryohei Yasuda
Nature 458, 299–304
(19 March 2009); doi:10.1038/nature07842
| Summary | Full Text (HTML / PDF) |
news and views
Neuroscience: Secret of synapse specificity
Scott M. Thompson & Hayley A. Mattison
Nature 458, 296–197
(19 March 2009); doi:10.1038/458296a
| Full Text (HTML / PDF) |
review
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres & Mariano Barbacid
Nature Reviews Cancer 9, 153–166
(March 2009); doi:10.1038/nrc2602
| Summary | Full Text (HTML / PDF) |
article
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes
Shigeyki Nada, Akihiro Hondo, Atsuko Kasai, Masato Koike, Kazunobu Saito, Yasuo Uchiyama & Masato Okada
The EMBO Journal 28, 477–489
(March 2009); doi:10.1038/emboj.2008.308
| Summary | Full Text (HTML / PDF) |
article
Neuroimmune regulation of antimicrobial peptide expression by a noncanonical TGF-β signaling pathway in Caenorhabditis elegans epidermis
Olivier Zugasti & Jonathan J Ewbank
Nature Immunology 10, 249–256
(March 2009); doi:10.1038/ni.1700
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding
Irene Díaz-Moreno et al.
Nature Structural & Molecular Biology 16, 238–246
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Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival
Nicolas Bidère et al.
Nature 458, 92–96
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An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63
Eloise Smith et al.
Nature Cell Biology 11, 278–285
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The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation
Zhong-Jian Shen, Stephane Esnault, Anna Schinzel, Christoph Borner & James S Malter
Nature Immunology 10, 257–265
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February
letter
Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance
Bing Luan et al.
Nature 457, 1146–1149
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Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
Bo Tian, Qian Yang & Zixu Mao
Nature Cell Biology 11, 211–218
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Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7
Surabhi Dangi-Garimella et al.
The EMBO Journal 28, 347–358
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Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes
Glòria Mas et al.
The EMBO Journal 28, 326–336
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Interaction between TAK1–TAB1–TAB2 and RCAN1–calcineurin defines a signalling nodal control point
Qinghang Liu, Jennifer Caldwell Busby & Jeffery D. Molkentin
Nature Cell Biology 11, 154–161
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The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-κB and activate T cells
Sung-Gyoo Park et al.
Nature Immunology 10, 158–166
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Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk
Sonja I Gringhuis et al.
Nature Immunology 10, 203–213
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The unfolded protein response signals through high-order assembly of Ire1
Alexei V. Korennykh et al.
Nature 457, 687–693
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news and views
Cell biology: How to combat stress
Christopher V. Nicchitta
Nature 457, 668–669
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January
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An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
Marco A. Calzado, Laureano de la Vega, Andreas Möller, David D. L. Bowtell & M. Lienhard Schmitz
Nature Cell Biology 11, 85–91
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TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch
Irwin M Liu et al.
The EMBO Journal 28, 88–98
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Protein kinase R reveals an evolutionary model for defeating viral mimicry
Nels C. Elde, Stephanie J. Child, Adam P. Geballe & Harmit S. Malik
Nature 457, 485–489
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Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance
Tae Ho Lee et al.
Nature Cell Biology 11, 97–105
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Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors
Stefan Rothenburg, Eun Joo Seo, James S Gibbs, Thomas E Dever & Katharina Dittmar
Nature Structural & Molecular Biology 16, 63–70
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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage
Yong-Chul Kim et al.
Nature Cell Biology 11, 92–96
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A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy
Kristina Lorenz, Joachim P Schmitt, Eva M Schmitteckert & Martin J Lohse
Nature Medicine 15, 75–83
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Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
Nisha Limaye et al.
Nature Genetics 41, 118–124
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PTEN regulation by Akt–EGR1–ARF–PTEN axis
Jianxiu Yu et al.
The EMBO Journal 28, 21–33
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Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival
Patrick Narbonne & Richard Roy
Nature 457, 210–214
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brief communication
Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning
Hiroshi Hanafusa, Kunihiro Matsumoto & Eisuke Nishida
Nature Cell Biology 11, 106–109
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article
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor
Griet Van Zeebroeck, Beatriz Monge Bonini, Matthias Versele & Johan M Thevelein
Nature Chemical Biology 5, 45–52
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