Research library: Membrane receptors
2002: December | November
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December
letters to nature
Helper T cells regulate type-2 innate immunity in vivo
Kanade Shinkai, Markus Mohrs and Richard M. Locksley
Nature 420, 825–829
(19 December 2002); doi:10.1038/nature01202
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article
c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation
Mayumi Naramura, Ihn-Kyung Jang, Hemanta Kole, Fang Huang, Diana Haines and Hua Gu
Nature Immunology 3, 1192–1199
(December 2002); doi:10.1038/ni855
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article
Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease
Yonglian Sun, Helen M. Chen, Sumit K. Subudhi, Jonathan Chen, Rima Koka, Lieping Chen and Yang-Xin Fu
Nature Medicine 8, 1405–1413
(December 2002); doi:10.1038/nm796
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news and views
Immunotherapy tackles lupus
Gary M. Kammer
Nature Medicine 8, 1356–1358
(December 2002); doi:10.1038/nm1202-1356
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article
The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs
Alon Chen, Yonatan Ganor, Shai Rahimipour, Nurit Ben-Aroya, Yitzhak Koch and Mia Levite
Nature Medicine 8, 1421–1426
(December 2002); doi:10.1038/nm801
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news and views
Skin antibiotics get in the loop
Elizabeth Kopp and Ruslan Medzhitov
Nature Medicine 8, 1359–1360
(December 2002); doi:10.1038/nm1202-1359
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article
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
Jay Groppe, Jason Greenwald, Ezra Wiater, Joaquin Rodriguez-Leon, Aris N. Economides, Witek Kwiatkowski, Markus Affolter, Wylie W. Vale, Juan Carlos Izpisua Belmonte and Senyon Choe
Nature 420, 636–642
(12 December 2002); doi:10.1038/nature01245
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news and views
On the wings of inhibition
Jeffrey L. Wrana
Growth factors regulate cell behaviour, and are kept in check by inhibitors. The structure of a complex of two such proteins shows that they form back-to-back butterflies, with the inhibitor's wings stretching to embrace its partner.
Nature 420, 613–614
(12 December 2002); doi:10.1038/420613a
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news and views
PLC-γ: an old player has a new role
James W. Putney Jr
Nature Cell Biology 4, E280
(December 2002); doi:10.1038/ncb1202-e280
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review article
Immunoglobulin transport across polarized epithelial cells
Raul Rojas and Gerard Apodaca
Nature Reviews Molecular Cell Biology 3, 944–956
(December 2002); doi:10.1038/nrm972
| Summary | Full Text (HTML / PDF) |
review article
uPAR: a versatile signalling orchestrator
Francesco Blasi and Peter Carmeliet
Nature Reviews Molecular Cell Biology 3, 932–943
(December 2002); doi:10.1038/nrm977
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article
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
Andreas Diefenbach, Elena Tomasello, Mathias Lucas, Amanda M. Jamieson, Jennifer K. Hsia, Eric Vivier and David H. Raulet
Nature Immunology 3, 1142–1149
(December 2002); doi:10.1038/ni858
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article
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
Susan Gilfillan, Emily L. Ho, Marina Cella, Wayne M. Yokoyama and Marco Colonna
Nature Immunology 3, 1150–1155
(December 2002); doi:10.1038/ni857
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news and views
Versatile signaling through NKG2D
Eric O. Long
Nature Immunology 3, 1119–1120
(December 2002); doi:10.1038/ni1202-1119
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review article
Regulation of B-cell fate by antigen-receptor signals
Hiroaki Niiro and Edward A. Clark
Nature Reviews Immunology 2, 945–956
(December 2002); doi:10.1038/nri955
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article
A p75NTR and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein
Scott T. Wong, John R. Henley, Kevin C. Kanning, Kuo-hua Huang, Mark Bothwell and Mu-ming Poo
Nature Neuroscience 5, 1302–1308
(December 2002); doi:10.1038/nn975
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review article
Receptor Downregulation and Multivesicular-Body Sorting
David J. Katzmann, Greg Odorizzi and Scott D. Emr
Nature Reviews Molecular Cell Biology 3, 893–905
(December 2002); doi:10.1038/nrm973
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news and views
Do T cell receptors do it alone?
P.Anton van der Merwe
Nature Immunology 3, 1122–1123
(December 2002); doi:10.1038/ni1202-1122
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November
review article
Viral interference with antigen presentation
Jonathan W. Yewdell and Ann B. Hill
Nature Immunology 3, 1019–1025
(November 2002); doi:10.1038/ni1102-1019
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review article
Bacterial strategies for overcoming host innate and adaptive immune responses
Mathias W. Hornef, Mary Jo Wick, Mikael Rhen and Staffan Normark
Nature Immunology 3, 1033–1040
(November 2002); doi:10.1038/ni1102-1033
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review article
Platelets in atherothrombosis
Zaverio M. Ruggeri
Nature Medicine 8, 1227–1234
(November 2002); doi:10.1038/nm1102-1227
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letters to nature
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
Masahiro Yamamoto, Shintaro Sato, Hiroaki Hemmi, Hideki Sanjo, Satoshi Uematsu, Tsuneyasu Kaisho , Katsuaki Hoshino, Osamu Takeuchi, Masaya Kobayashi, Takashi Fujita, Kiyoshi Takeda and Shizuo Akira
Nature 420, 324–329
(21 November 2002); doi:10.1038/nature01182
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letters to nature
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors
Tiffany Horng, Gregory M. Barton, Richard A. Flavell and Ruslan Medzhitov
Nature 420, 329–333
(21 November 2002); doi:10.1038/nature01180
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article
Thymocyte expression of cathepsin L is essential for NKT cell development
Karen Honey, Kamel Benlagha, Courtney Beers, Katherine Forbush, Luc Teyton, Monique J. Kleijmeer, Alexander Y. Rudensky and Albert Bendelac
Nature Immunology 3, 1069–1074
(November 2002); doi:10.1038/ni844
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article
Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor
Mauro Perretti, Nan Chiang, Mylinh La, Iolanda M. Fierro, Stefano Marullo, Stephen J Getting, Egle Solito and Charles N. Serhan
Nature Medicine 8, 1296–1302
(November 2002); doi:10.1038/nm786
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review article
Innate and acquired immunity in atherogenesis
Christoph J. Binder, Mi-Kyung Chang, Peter X. Shaw, Yury I. Miller, Karsten Hartvigsen, Asheesh Dewan and Joseph L. Witztum
Nature Medicine 8, 1218–1226
(November 2002); doi:10.1038/nm1102-1218
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brief communication
Hippocampal CRE-mediated gene expression is required for contextual memory formation
Jaime Athos, Soren Impey, Victor V. Pineda, Xi Chen and Daniel R. Storm
Nature Neuroscience 5, 1119–1120
(November 2002); doi:10.1038/nn951
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review
Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches
Hans Thoenen and Michael Sendtner
Nature Neuroscience 5, 1046–1050
(November 2002); doi:10.1038/nn938
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review article
Designing peptide receptor agonists and antagonists
Victor J. Hruby
Nature Reviews Drug Discovery 1, 847–858
(November 2002); doi:10.1038/nrd939
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letters to nature
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response
Cecilia Garlanda, Emilio Hirsch, Silvia Bozza, Antonietta Salustri, Marika De Acetis, Rachele Nota, Alessia Maccagno, Federica Riva, Barbara Bottazzi, Giuseppe Peri, Andrea Doni, Luca Vago, Marina Botto, Rita De Santis, Paolo Carminati, Gregorio Siracusa, Fiorella Altruda, Annunciata Vecchi, Luigina Romani and Alberto Mantovani
Nature 420, 182–186
(14 November 2002); doi:10.1038/nature01195
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article
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
Hiroshi Hanafusa, Satoru Torii, Takayuki Yasunaga and Eisuke Nishida
Nature Cell Biology 4, 850–858
(November 2002); doi:10.1038/ncb867
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review article
Viral evasion of natural killer cells
Jordan S. Orange, Marlys S. Fassett, Louise A. Koopman, Jonathan E. Boyson and Jack L. Strominger
Nature Immunology 3, 1006–1012
(November 2002); doi:10.1038/ni1102-1006
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article
Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function
Timothy W. Yu, Joe C. Hao, Wendell Lim, Marc Tessier-Lavigne and Cornelia I. Bargmann
Nature Neuroscience 5, 1147–1154
(November 2002); doi:10.1038/nn956
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review
NMDA receptor pathways as drug targets
John A. Kemp & Ruth M. McKernan
Nature Neuroscience 5, 1039–1042
(November 2002); doi:10.1038/nn936
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review article
The molecular organization of cerebellar long-term depression
Masao Ito
Nature Reviews Neuroscience 3, 896–902
(November 2002); doi:10.1038/nrn962
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letters to nature
p75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
Kevin C. Wang, Jieun A. Kim, Rajeev Sivasankaran, Rosalind Segal and Zhigang He
Nature 420, 74–78
(07 November 2002); doi:10.1038/nature01176
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article
Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism
Yongchang Chang and David S. Weiss
Nature Neuroscience 5, 1163–1168
(November 2002); doi:10.1038/nn926
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review article
The cellular and molecular basis of store-operated calcium entry
Kartik Venkatachalam, Damian B. van Rossum, Randen L. Patterson, Hong-Tao Ma and Donald L. Gill
Nature Cell Biology 4, E263
(November 2002); doi:10.1038/ncb1102-e263
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article
CTLA-4-Ig regulates tryptophan catabolism in vivo
Ursula Grohmann, Ciriana Orabona, Francesca Fallarino, Carmine Vacca, Filippo Calcinaro, Alberto Falorni, Paola Candeloro, Maria L. Belladonna, Roberta Bianchi, Maria C. Fioretti and Paolo Puccetti
Nature Immunology 3, 1097–1101
(November 2002); doi:10.1038/ni846
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news and views
When ligand becomes receptor—tolerance via B7 signaling on DCs
Erik B. Finger and Jeffrey A. Bluestone
Nature Immunology 3, 1056–1057
(November 2002); doi:10.1038/ni1102-1056
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review article
Lymphocide: cytokines and the control of lymphoid homeostasis
Annette R. Khaled and Scott K. Durum
Nature Reviews Immunology 2, 817–830
(November 2002); doi:10.1038/nri931
| Summary | Full Text (HTML / PDF) |
letter
A critical role for the protein tyrosine phosphatase receptor type Z in functional recovery from demyelinating lesions
Sheila Harroch, Glaucia C. Furtado, Wolfgang Brueck, Jack Rosenbluth, Juan Lafaille, Moses Chao, Joseph D. Buxbaum and Joseph Schlessinger
Nature Genetics 32, 411–414
(November 2002); doi:10.1038/ng1004
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brief communication
EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP
Fumitoshi Irie and Yu Yamaguchi
Nature Neuroscience 5, 1117–1118
(November 2002); doi:10.1038/nn964
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news and views
How ephrins sculpt dendritic spines
Nature Neuroscience 5, 1113
(November 2002); doi:10.1038/nn1102-1113
| Full Text (HTML/PDF) |
October
letters to nature
Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
Veronika Groh, Jennifer Wu, Cassian Yee and Thomas Spies
Nature 419, 734–738
(17 October 2002); doi:10.1038/nature01112
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news and views
Immunology: Catch us if you can
Wayne M. Yokoyama
Nature 419, 679–680
(17 October 2002); doi:10.1038/419679a
| Full Text (HTML / PDF) |
article
Staging and resetting T cell activation in SMACs
Benjamin A. Freiberg, Hannah Kupfer, William Maslanik, Joe Delli, John Kappler, Dennis M. Zaller and Abraham Kupfer
Nature Immunology 3, 911–917
(October 2002); doi:10.1038/ni836
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article
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Estefania Claudio, Keith Brown, Sun Park, Hongshan Wang and Ulrich Siebenlist
Nature Immunology 3, 958–965
(October 2002); doi:10.1038/ni842
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news and views
Gatekeeper mechanisms for immature B cells
Xiao-Hong Sun and Paul W. Kincade
Nature Immunology 3, 898–899
(October 2002); doi:10.1038/ni1002-898
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article
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
L E Nelson, T Z Guo, J Lu, C B Saper, N P Franks & M Maze
Nature Neuroscience 5, 979–984
(October 2002); doi:10.1038/nn913
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news and views
General anesthesia research: aroused from a deep sleep?
Neil L. Harrison
Nature Neuroscience 5, 928–929
(October 2002); doi:10.1038/nn1002-928
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review article
G-Protein-coupled receptor oligomerization and its potential for drug discovery
Susan R. George, Brian F. O'Dowd and Samuel P. Lee
Nature Reviews Drug Discovery 1, 808–820
(October 2002); doi:10.1038/nrd913
| Summary | Full Text (HTML/PDF) |
review article
Toll-like receptors as potential therapeutic targets for multiple diseases
Claudia Zuany-Amorim, John Hastewell and Christoph Walker
Nature Reviews Drug Discovery 1, 797–807
(October 2002); doi:10.1038/nrd914
| Summary | Full Text (HTML / PDF) |
letters to nature
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians
Francesc Cebrià, Chiyoko Kobayashi, Yoshihiko Umesono, Masumi Nakazawa, Katsuhiko Mineta, Kazuho Ikeo, Takashi Gojobori, Mari Itoh, Masanori Taira, Alejandro Sánchez Alvarado and Kiyokazu Agata
Nature 419, 620–624
(10 October 2002); doi:10.1038/nature01042
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letters to nature
Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2
Atsushi Kumanogoh, Satoko Marukawa, Kazuhiro Suzuki, Noriko Takegahara, Chie Watanabe, EweSeng Ch'ng, Isao Ishida, Harutoshi Fujimura, Saburo Sakoda, Kanji Yoshida and Hitoshi Kikutani
Nature 419, 629–633
(10 October 2002); doi:10.1038/nature01037
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article
Signal-dependent protection from apoptosis in mice expressing caspase-resistant Rb
B. Nelson Chau, Helena Lobo Borges, Tung-Ti Chen, Anja Masselli, Irina C. Hunton and Jean Y. J. Wang
Nature Cell Biology 4, 757–765
(October 2002); doi:10.1038/ncb853
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article
A GPI-linked isoform of the IgD receptor regulates resting B cell activation
Akanksha Chaturvedi, Zaved Siddiqui, Fahri Bayiroglu and Kanury V.S. Rao
Nature Immunology 3, 951–957
(October 2002); doi:10.1038/ni839
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article
Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation
Gareth R. John, Sai Latha Shankar, Bridget Shafit-Zagardo, Aldo Massimi, Sunhee C. Lee, Cedric S. Raine and Celia F. Brosnan
Nature Medicine 8, 1115–1121
(October 2002); doi:10.1038/nm781
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news and views
Myelin failure in multiple sclerosis: Breaking the spell of Notch
Reinhard Hohlfeld
Nature Medicine 8, 1075–1076
(October 2002); doi:10.1038/nm1002-1075
| Full Text (HTML/PDF) |
article
A transmembrane motif governs the surface trafficking of nicotinic acetylcholine receptors
Jun-Mei Wang, Lili Zhang, Yun Yao, Nitnara Viroonchatapan, Elizabeth Rothe and Zuo-Zhong Wang
Nature Neuroscience 5, 963–970
(October 2002); doi:10.1038/nn918
| Abstract | Full Text (HTML/PDF) |
review article
Structural biology of insulin and IGF1 receptors: implications for drug design
Pierre De Meyts and Jonathan Whittaker
Nature Reviews Drug Discovery 1, 769–783
(October 2002); doi:10.1038/nrd917
| Summary | Full Text (HTML / PDF) |
letters to nature
Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases
Wun Chey Sin, Kurt Haas, Edward S. Ruthazer and Hollis T. Cline
Nature 419, 475–480
(03 October 2002); doi:10.1038/nature00987
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letters to nature
Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex
Valentin I. Gordeliy, Jörg Labahn, Rouslan Moukhametzianov, Rouslan Efremov, Joachim Granzin, Ramona Schlesinger, Georg Büldt, Tudor Savopol, Axel J. Scheidig, Johann P. Klare and Martin Engelhard
Nature 419, 484–487
(03 October 2002); doi:10.1038/nature01109
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article
Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion
Jinseol Rhee, Najmus S. Mahfooz, Carlos Arregui, Jack Lilien, Janne Balsamo and Mark F.A. VanBerkum
Nature Cell Biology 4, 798–805
(October 2002); doi:10.1038/ncb858
| Abstract | Full Text (HTML/PDF) |
news and views
Robo is Abl to block N-Cadherin function
Mark M. Emerson and David Van Vactor
Nature Cell Biology 4, E227
(October 2002); doi:10.1038/ncb1002-e227
| Full Text (HTML/PDF) |
article
Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
Jeffrey C. Rathmell, Tullia Lindsten, Wei-Xing Zong, Ryan M. Cinalli and Craig B. Thompson
Nature Immunology 3, 932–939
(October 2002); doi:10.1038/ni834
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news and views
Bax and Bak: back-bone of T cell death
Philippe Bouillet and Andreas Strasser
Nature Immunology 3, 893–894
(October 2002); doi:10.1038/ni1002-893
| Full Text (HTML/PDF) |
review article
Regulation of mast-cell and basophil function and survival by IgE
Toshiaki Kawakami and Stephen J. Galli
Nature Reviews Immunology 2, 773–786
(October 2002); doi:10.1038/nri914
| Summary | Full Text (HTML / PDF) |
review article
Protein palmitoylation: a regulator of neuronal development and function
Alaa El-Din El-Husseini and David S. Bredt
Nature Reviews Neuroscience 3, 791–802
(October 2002); doi:10.1038/nrn940
| Summary | Full Text (HTML / PDF) |
September
review article
STATS: transcriptional control and biological impact
David E. Levy and J. E. Darnell Jr
Nature Reviews Molecular Cell Biology 3, 651–662
(September 2002); doi:10.1038/nrm909
| Summary | Full Text (HTML / PDF) |
perspectives
Timeline: Cyclic nucleotide research — still expanding after half a century
Joseph A. Beavo and Laurence L. Brunton
Nature Reviews Molecular Cell Biology 3, 710–718
(September 2002); doi:10.1038/nrm911
| Summary | Full Text (HTML / PDF) |
review article
Natural killer cell activation in mice and men: different triggers for similar weapons?
Francesco Colucci, James P. Di Santo and Paul J. Leibson
Nature Immunology 3, 807–813
(September 2002); doi:10.1038/ni0902-807
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review article
Natural killer cells and pregnancy
Ashley Moffett-King
Nature Reviews Immunology 2, 656–663
(September 2002); doi:10.1038/nri886
| Summary | Full Text (HTML / PDF) |
article
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4
Bruce D. Levy, George T. De Sanctis, Pallavi R. Devchand, Eugene Kim, Kate Ackerman, Birgitta A. Schmidt, Wojciech Szczeklik, Jeffrey M. Drazen and Charles N. Serhan
Nature Medicine 8, 1018–1023
(September 2002); doi:10.1038/nm748
| Abstract | Full Text (HTML/PDF) |
news and views
'Good' lipids for asthma
Marc Peters-Golden
Nature Medicine 8, 931–932
(September 2002); doi:10.1038/nm0902-931
| Full Text (HTML/PDF) |
article
Spatial memory dissociations in mice lacking GluR1
D. Reisel, D. M. Bannerman, W. B. Schmitt, R. M. J. Deacon, J. Flint, T. Borchardt, P. H. Seeburg and J. N. P. Rawlins
Nature Neuroscience 5, 868–873
(September 2002); doi:10.1038/nn910
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review article
Is there more to GABA than synaptic inhibition?
David F. Owens and Arnold R. Kriegstein
Nature Reviews Neuroscience 3, 715–727
(September 2002); doi:10.1038/nrn919
| Summary | Full Text (HTML / PDF) |
brief communication
The Semaphorin 4D receptor controls invasive growth by coupling with Met
Silvia Giordano, Simona Corso, Paolo Conrotto, Stefania Artigiani, Giorgio Gilestro, Davide Barberis, Luca Tamagnone and Paolo M. Comoglio
Nature Cell Biology 4, 720–724
(September 2002); doi:10.1038/ncb843
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review article
g-Secretase-mediated proteolysis in cell-surface-receptor signalling
Mark E. Fortini
Nature Reviews Molecular Cell Biology 3, 673–684
(September 2002); doi:10.1038/nrm910
| Summary | Full Text (HTML / PDF) |
perspectives
Signalling shortcuts: cell-surface receptors in the nucleus?
Alan Wells and Ulrich Marti
Nature Reviews Molecular Cell Biology 3, 697–702
(September 2002); doi:10.1038/nrm905
| Summary | Full Text (HTML / PDF) |
article
Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
Shogo Ishiuchi, Keisuke Tsuzuki, Yukari Yoshida, Nobuaki Yamada, Norikazu Hagimura, Haruo Okado, Akiko Miwa, Hideyuki Kurihara, Yoichi Nakazato, Masaru Tamura, Tomio Sasaki and Seiji Ozawa
Nature Medicine 8, 971–978
(September 2002); doi:10.1038/nm746
| Abstract | Full Text (HTML/PDF) |
news and views
Paving new pathways
Jeffrey D. Rothstein
Nature Medicine 8, 938–940
(September 2002); doi:10.1038/nm0902-938
| Full Text (HTML/PDF) |
brief communication
Differential regulation of synaptic and extra-synaptic NMDA receptors
Bo Li, Nansheng Chen, Tao Luo, Yo Otsu, Timothy H. Murphy and Lynn A. Raymond
Nature Neuroscience 5, 833–834
(September 2002); doi:10.1038/nn912
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review article
Excitatory actions of GABA during development: the nature of the nurture
Yehezkel Ben-Ari
Nature Reviews Neuroscience 3, 728–739
(September 2002); doi:10.1038/nrn920
| Summary | Full Text (HTML / PDF) |
progress
Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae
Tom H.M. Ottenhoff, Frank A.W. Verreck, Elgin G.R. Lichtenauer-Kaligis, Marieke A. Hoeve, Ozden Sanal and Jaap T. van Dissel
Nature Genetics 32, 97–105
(September 2002); doi:10.1038/ng0902-97
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article
Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells
Sanne Weijzen, Paola Rizzo, Mike Braid, Radhika Vaishnav, Suzanne M. Jonkheer, Andrei Zlobin, Barbara A. Osborne, Sridevi Gottipati, Jon C. Aster, William C. Hahn, Michael Rudolf, Kalliopi Siziopikou, W. Martin Kast and Lucio Miele
Nature Medicine 8, 979–986
(September 2002); doi:10.1038/nm754
| Abstract | Full Text (HTML/PDF) |
review article
Signalling: Seven-transmembrane receptors
Kristen L. Pierce, Richard T. Premont and Robert J. Lefkowitz
Nature Reviews Molecular Cell Biology 3, 639–650
(September 2002); doi:10.1038/nrm908
| Summary | Full Text (HTML / PDF) |
review article
Breaking the neuronal sphere: regulation of the actin cytoskeleton in neuritogenesis
Jorge Santos Da Silva and Carlos G. Dotti
Nature Reviews Neuroscience 3, 694–704
(September 2002); doi:10.1038/nrn918
| Abstract | Full Text (HTML/PDF) |
perspectives
Opinion: Beyond the role of glutamate as a neurotransmitter
Maiken Nedergaard, Takahiro Takano and Anker J. Hansen
Nature Reviews Neuroscience 3, 748–755
(September 2002); doi:10.1038/nrn916
| Summary | Full Text (HTML / PDF) |
August
letters to nature
T-cell engagement of dendritic cells rapidly rearranges MHC class II transport
Marianne Boes, Jan Cerny , Ramiro Massol, Marjolein Op den Brouw, Tom Kirchhausen, Jianzhu Chen and Hidde L. Ploegh
Nature 418, 983–988
(29 August 2002); doi:10.1038/nature01004
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letters to nature
Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane
Amy Chow, Derek Toomre, Wendy Garrett and Ira Mellman
Nature 418, 988–994
(29 August 2002); doi:10.1038/nature01006
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: Inside the professionals
Jonathan W. Yewdell and David C. Tscharke
Nature 418, 923–924
(29 August 2002); doi:10.1038/418923a
| Full Text (HTML / PDF) |
article
Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms
Zheng Xu and Arthur Weiss
Nature Immunology 3, 764–771
(August 2002); doi:10.1038/ni822
| Abstract | Full Text (HTML/PDF) |
article
Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
Lena Alexopoulou, Venetta Thomas, Markus Schnare, Yves Lobet, Juan Anguita, Robert T. Schoen, Ruslan Medzhitov, Erol Fikrig and Richard A. Flavell
Nature Medicine 8, 878–884
(August 2002); doi:10.1038/nm732
| Abstract | Full Text (HTML/PDF) |
article
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
Haidong Dong, Scott E. Strome, Diva R. Salomao, Hideto Tamura, Fumiya Hirano, Dallas B. Flies, Patrick C. Roche, Jun Lu, Gefeng Zhu, Koji Tamada, Vanda A. Lennon, Esteban Celis and Lieping Chen
Nature Medicine 8, 793–800
(August 2002); doi:10.1038/nm730
| Abstract | Full Text (HTML/PDF) |
news and views
Protect the killer: CTLs need defenses against the tumor
Gordon J. Freeman, Arlene H. Sharpe and Vijay K. Kuchroo
Nature Medicine 8, 787–789
(August 2002); doi:10.1038/nm0802-787
| Full Text (HTML/PDF) |
news and views
Two-shot cocktail: Adenosine, dopamine and a twist of βg
R. Adron Harris and Richard A. Morrisett
Nature Medicine 8, 777–779
(August 2002); doi:10.1038/nm0802-777
| Full Text (HTML/PDF) |
letters to nature
Patched acts catalytically to suppress the activity of Smoothened
J. Taipale, M. K. Cooper, T. Maiti and P. A. Beachy
Nature 418, 892–896
(22 August 2002); doi:10.1038/nature00989
| First Paragraph | Full Text (HTML / PDF) |
news and views
Immunology: A block at the toll gate
Tak W. Mak and Wen-Chen Yeh
Nature 418, 835–836
(22 August 2002); doi:10.1038/418835a
| Full Text (HTML / PDF) |
review article
Signal transduction and endocytosis: close encounters of many kinds
Alexander Sorkin and Mark von Zastrow
Nature Reviews Molecular Cell Biology 3, 600–614
(August 2002); doi:10.1038/nrm883
| Summary | Full Text (HTML / PDF) |
review article
Roles of Fc receptors in autoimmunity
Toshiyuki Takai
Nature Reviews Immunology 2, 580–592
(August 2002); doi:10.1038/nri856
| Summary | Full Text (HTML / PDF) |
brief communication
Hormonally regulated α4β2d GABAA receptors are a target for alcohol
Inger Sundstrom-Poromaa, Deborah H. Smith, Qi Hua Gong, Thomas N. Sabado, Xinshe Li, Adam Light, Martin Wiedmann, Keith Williams and Sheryl S. Smith
Nature Neuroscience 5, 721–722
(August 2002); doi:10.1038/nn888
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letters to nature
Distalization of the Drosophila leg by graded EGF-receptor activity
Gerard Campbell
Nature 418, 781–785
(15 August 2002); doi:10.1038/nature00971
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news and views
Developmental biology: Signalling legacies
Richard S. Mann and Fernando Casares
Nature 418, 737–739
(15 August 2002); doi:10.1038/418737a
| Full Text (HTML / PDF) |
article
EphrinA1-induced cytoskeletal re-organization requires FAK and p130cas
Nigel Carter, Tetsuya Nakamoto, Hisamaru Hirai and Tony Hunter
Nature Cell Biology 4, 565–573
(August 2002); doi:10.1038/ncb823
| Abstract | Full Text (HTML/PDF) |
brief communication
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
José G. Abreu, Nan I. Ketpura, Bruno Reversade and E. M. De Robertis
Nature Cell Biology 4, 599–604
(August 2002); doi:10.1038/ncb826
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article
Self-inhibition of olfactory bulb neurons
T. Caitlin Smith and Craig E. Jahr
Nature Neuroscience 5, 760–766
(August 2002); doi:10.1038/nn882
| Abstract | Full Text (HTML/PDF) |
review article
Endogenous kynurenines as targets for drug discovery and development
Trevor W. Stone and L. Gail Darlington
Nature Reviews Drug Discovery 1, 609–620
(August 2002); doi:10.1038/nrd870
| Summary | Full Text (HTML / PDF) |
article
A nonredundant role for the adapter protein Shc in thymic T cell development
Li Zhang, Victoria Camerini, Timothy P. Bender and Kodi S. Ravichandran
Nature Immunology 3, 749–755
(August 2002); doi:10.1038/ni820
| Abstract | Full Text (HTML/PDF) |
news and views
Shc: a dominant player after ten seasons
Ed Palmer
Nature Immunology 3, 710–711
(August 2002); doi:10.1038/ni0802-710
| Full Text (HTML/PDF) |
review article
The unconventional lifestyle of NKT Cells
Mitchell Kronenberg and Laurent Gapin
Nature Reviews Immunology 2, 557–568
(August 2002); doi:10.1038/nri854
| Abstract | Full Text (HTML/PDF) |
Original Paper
A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death
Castro-Obregón S., del Rio G., Chen S.F., Swanson R.A., Frankowski H., Rao R.V., Stoka V., Vesce S., Nicholls D.G. and Bredesen D.E.
Cell Death and Differentiation 9, 807–817
(August 2002); doi:10.1038/sj.cdd.4401035
| Abstract |
letter
Two-step binding mechanism for T-cell receptor recognition of peptide-MHC
Lawren C. Wu, Delphine S. Tuot, Daniel S. Lyons, K. Christopher Garcia and Mark M. Davis
Nature 418, 552–556
(1 August 2002); doi:10.1038/nature00920
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article
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
Douglas A. Kuperman, Xiaozhu Huang, Laura L. Koth, Grace H. Chang, Gregory M. Dolganov, Zhou Zhu, Jack A. Elias, Dean Sheppard and David J. Erle
Nature Medicine 8, 885–889
(August 2002); doi:10.1038/nm734
| Abstract | Full Text (HTML/PDF) |
article
Rapid recruitment of NMDA receptor transport packets to nascent synapses
Philip Washbourne, Jennie E. Bennett and A. Kimberley McAllister
Nature Neuroscience 5, 751–759
(August 2002); doi:10.1038/nn883
| Abstract | Full Text (HTML/PDF) |
July
article
Human epithelial cells trigger dendritic cell-mediated allergic inflammation by producing TSLP
Vassili Soumelis, Pedro A. Reche, Holger Kanzler, Wei Yuan, Gina Edward, Bernhart Homey, Michel Gilliet, Steve Ho, Svetlana Antonenko, Annti Lauerma, Kathleen Smith, Daniel Gorman, Sandra Zurawski, Jon Abrams, Satish Menon, Terri McClanahan, Rene de Waal-Malefyt, Fernando Bazan, Robert A. Kastelein and Yong-Jun Liu
Nature Immunology 3, 673–680
(July 2002); doi:10.1038/ni805
| Abstract | Full Text (HTML/PDF) |
news and views
TSLP: finally in the limelight
Warren J. Leonard
Nature Immunology 3, 605–607
(July 2002); doi:10.1038/ni0702-605
| Full Text (HTML/PDF) |
article
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
Yoshinori Nagai, Sachiko Akashi, Masakazu Nagafuku, Masato Ogata, Yoichiro Iwakura, Shizuo Akira, Toshio Kitamura, Atsushi Kosugi, Masao Kimoto and Kensuke Miyake
Nature Immunology 3, 667–672
(July 2002); doi:10.1038/ni809
| Abstract | Full Text (HTML/PDF) |
review article
VAV proteins as signal integrators for multi-subunit immune-recognition receptors
Martin Turner and Daniel D. Billadeau
Nature Reviews Immunology 2, 476–486
(July 2002); doi:10.1038/nri840
| Abstract | Full Text (HTML/PDF) |
article
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Kazumasa Miyawaki, Yuichiro Yamada, Nobuhiro Ban, Yu Ihara, Katsushi Tsukiyama, Heying Zhou, Shimpei Fujimoto, Akira Oku, Kinsuke Tsuda, Shinya Toyokuni, Hiroshi Hiai, Wataru Mizunoya, Tohru Fushiki, Jens Juul Holst, Mitsuhiro Makino, Akira Tashita, Yukari Kobara, Yoshiharu Tsubamoto, Takayoshi Jinnouchi, Takahito Jomori and Yutaka Seino
Nature Medicine 8, 738–742
(July 2002); doi:10.1038/nm727
| Abstract | Full Text (HTML/PDF) |
letter to nature
TRPV3 is a calcium-permeable temperature-sensitive cation channel
Haoxing Xu, I. Scott Ramsey, Suhas A. Kotecha, Magdalene M. Moran, Jayhong A. Chong, Deborah Lawson, Pei Ge, Jeremiah Lilly, Inmaculada Silos-Santiago, Yu Xie, Peter S. DiStefano, Rory Curtis and David E. Clapham
Nature 418, 181–186
(11 July 2002); doi:10.1038/nature00882
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letter to nature
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
G. D. Smith, M. J. Gunthorpe, R. E. Kelsell, P. D. Hayes, P. Reilly, P. Facer, J. E. Wright, J. C. Jerman, J.-P. Walhin, L. Ooi, J. Egerton, K. J. Charles, D. Smart, A. D. Randall, P. Anand and J. B. Davis
Nature 418, 186–190
(11 July 2002); doi:10.1038/nature00894
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letter to nature
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
Tian H. Chi, Mimi Wan, Keji Zhao, Ichiro Taniuchi, Lei Chen, Dan R. Littman and Gerald R. Crabtree
Nature 418, 195–199
(11 July 2002); doi:10.1038/nature00876
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article
DARPP-32 and regulation of the ethanol sensitivity of NMDA receptors in the nucleus accumbens
R. E. Maldve, T. A. Zhang, K. Ferrani-Kile, S. S. Schreiber, M. J. Lippmann, G. L. Snyder, A. A. Fienberg, S. W. Leslie, R. A. Gonzales and R. A. Morrisett
Nature Neuroscience 5, 641–648
(July 2002); doi:10.1038/nn877
| Abstract | Full Text (HTML/PDF) |
news and views
NMDA receptors lose their inhibitions
David M. Lovinger
Nature Neuroscience 5, 614–616
(July 2002); doi:10.1038/nn0702-614
| Full Text (HTML/PDF) |
review article
BAFF: A fundamental survival factor for B cells
Fabienne Mackay and Jeffrey L. Browning
Nature Reviews Immunology 2, 465–475
(July 2002); doi:10.1038/nri844
| Abstract | Full Text (HTML/PDF) |
perspectives
Timeline: The strange case of the signal recognition particle
Karl S. Matlin
Nature Reviews Molecular Cell Biology 3, 538–542
(July 2002); doi:10.1038/nrm857
| Abstract | Full Text (HTML/PDF) |
review article
Mechanisms and functions of eph and ephrin signalling
Klas Kullander and Rüdiger Klein
Nature Reviews Molecular Cell Biology 3, 475–486
(July 2002); doi:10.1038/nrm856
| Abstract | Full Text (HTML/PDF) |
June
letter
VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism
Hans-Peter Gerber, Ajay K. Malik, Gregg P. Solar, Daniel Sherman, Xiao Huan Liang, Gloria Meng, Kyu Hong, James C. Marsters and Napoleone Ferrara
Nature 417, 954–958
(27 June 2002); doi:10.1038/nature00821
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commentary
Targeting the endocannabinoid system in cancer therapy: A call for further research
Maurizio Bifulco and Vincenzo Di Marzo
Nature Medicine 8, 547–550
(June 2002); doi:10.1038/nm0602-547
| Full Text (HTML/PDF) |
letter
Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy
Patrick Cossette, Lidong Liu, Katéri Brisebois, Haiheng Dong, Anne Lortie, Michel Vanasse, Jean-Marc Saint-Hilaire, Lionel Carmant, Andrei Verner, Wei-Yang Lu, Yu Tian Wang and Guy A. Rouleau
Nature Genetics 31, 184–189
(June 2002); doi:10.1038/ng885
| First Paragraph | Full Text (HTML/PDF) |
brief communication
Acute versus chronic NMDA receptor blockade and synaptic AMPA receptor delivery
J. Julius Zhu and Roberto Malinow
Nature Neuroscience 5, 513–514
(June 2002); doi:10.1038/nn850
| First Paragraph | Full Text (HTML/PDF) |
letter to nature
Regulation of AMPA receptor lateral movements
AREN J. BORGDORFF AND DANIEL CHOQUET
Nature 417, 649–653
(6 June 2002); doi:10.1038/nature00780
| First Paragraph | Full Text (HTML/PDF) |
news and views
Neurobiology: Glutamate receptors on the move
Morgan Sheng and Terunaga Nakagawa
Nature 417, 601–602
(6 June 2002); doi:10.1038/417601a
| Full Text (HTML/PDF) |
letter to nature
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
BINGYU MAO, WEI WU, GARY DAVIDSON, JOACHIM MARHOLD, MINGFA LI, BERNARD M. MECHLER, HAJO DELIUS, DANA HOPPE, PETER STANNEK, CARMEN WALTER, ANDREI GLINKA & CHRISTOF NIEHRS
Nature 417, 664–667
(6 June 2002); doi:10.1038/nature756
| First Paragraph | Full Text (HTML/PDF) |
article
LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
Helmut Butzkueven, Jian-Guo Zhang, Merja Soilu-Hanninen, Hubertus Hochrein, Fiona Chionh, Kylie A. Shipham, Ben Emery, Ann M. Turnley, Steven Petratos, Matthias Ernst, Perry F. Bartlett and Trevor J. Kilpatrick
Nature Medicine 8, 613–619
(June 2002); doi:10.1038/nm0602-613
| Abstract | Full Text (HTML/PDF) |
article
CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammation
Ralf A. Linker, Mathias Mäurer, Stefanie Gaupp, Rudolf Martini, Bettina Holtmann, Ralf Giess, Peter Rieckmann, Hans Lassmann, Klaus V. Toyka, Michael Sendtner and Ralf Gold
Nature Medicine 8, 620–624
(June 2002); doi:10.1038/nm0602-620
| Abstract | Full Text (HTML/PDF) |
article
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats
Silvana Obici, Zhaohui Feng, George Karkanias, Denis G. Baskin and Luciano Rossetti
Nature Neuroscience 5, 566–572
(June 2002); doi:10.1038/nn861
| Abstract | Full Text (HTML/PDF) |
article
A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor
Bo Yang, John D. Slonimsky and Susan J. Birren
Nature Neuroscience 5, 539–545
(June 2002); doi:10.1038/nn853
| Abstract | Full Text (HTML/PDF) |
news and views
Quick-change artist: from excitatory to inhibitory synapse in minutes
Story C. Landis
Nature Neuroscience 5, 503–504
(June 2002); doi:10.1038/nn0602-503
| Full Text (HTML/PDF) |
review article
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Avi Ashkenazi
Nature Reviews Cancer 2, 420–430
(June 2002); doi:10.1038/nrc821
| Abstract | Full Text (HTML/PDF) |
review article
Suppressors of cytokine signalling (SOCS) in the immune system
Warren S. Alexander
Nature Reviews Immunology 2, 410–416
(June 2002); doi:10.1038/nri818
| Abstract | Full Text (HTML/PDF) |
review article
Oestrogen as a neuroprotective hormone
Christian Behl
Nature Reviews Neuroscience 3, 433–442
(June 2002); doi:10.1038/nrn846
| Abstract | Full Text (HTML/PDF) |
May
article
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
Giles E. Hardingham, Yuko Fukunaga and Hilmar Bading
Nature Neuroscience 5, 405–414
(May 2002); doi:10.1038/nn835
| Abstract | Full Text (HTML/PDF) |
news and views
What a privilege to reside at the synapse: NMDA receptor signaling to CREB
Antonella Riccio and David D. Ginty
Nature Neuroscience 5, 389–390
(May 2002); doi:10.1038/nn0502-389
| Full Text (HTML/PDF) |
review article
Regulation of B-cell signal transduction by adaptor proteins
Tomohiro Kurosaki
Nature Reviews Immunology 2, 354–363
(May 2002); doi:10.1038/nri801
| Abstract | Full Text (HTML/PDF) |
review article
Structural mechanisms of costimulation
Jean-Claude D. Schwartz, Xuewu Zhang, Stanley G. Nathenson and Steven C. Almo
Nature Immunology 3, 427–434
(May 2002); doi:10.1038/ni0502-427
| Abstract | Full Text (HTML/PDF) |
letter
β-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass
Rohit N. Kulkarni, Martin Holzenberger, David Q. Shih, Umut Ozcan, Markus Stoffel, Mark A. Magnuson and C. Ronald Kahn
Nature Genetics 31, 111–115
(May 2002); doi:10.1038/ng872
| First Paragraph | Full Text (HTML/PDF) |
news and views
A role for Toll in autoimmunity
Arthur M. Krieg
Nature Immunology 3, 423–424
(May 2002); doi:10.1038/ni0502-423
| Full Text (HTML/PDF) |
article
The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells
Cory L. Ahonen, Eric M. Manning, Loren D. Erickson, Brian P. O'Connor, Evan F. Lind, Steven S. Pullen, Marilyn R. Kehry and Randolph J. Noelle
Nature Immunology 3, 451–456
(May 2002); doi:10.1038/ni792
| Abstract | Full Text (HTML/PDF) |
brief communication
Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis
Susan C. Shih, David J. Katzmann, Joshua D. Schnell and Myra Sutanto
Nature Cell Biology 4, 389–393
(May 2002); doi:10.1038/ncb790
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article
A critical role for the cytoplasmic tail of pTα in T lymphocyte development
Iannis Aifantis, Christine Borowski, Fotini Gounari, H. Daniel Lacorazza and Janko Nikolich-Zugich
Nature Immunology 3, 483–488
(May 2002); doi:10.1038/ni779
| Abstract | Full Text (HTML/PDF) |
article
Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene
Fotini Gounari, Iannis Aifantis, Colin Martin, Hans-Joerg Fehling, Sonja Hoeflinger, Philip Leder, Harald von Boehmer and Boris Reizis
Nature Immunology 3, 489–496
(May 2002); doi:10.1038/ni778
| Abstract | Full Text (HTML/PDF) |
news and views
A new spin on an unusual tail
Nigel Killeen
Nature Immunology 3, 419–421
(May 2002); doi:10.1038/ni0502-419
| Full Text (HTML/PDF) |
article
A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response
Rafaèle Tordjman, Yves Lepelletier, Valérie Lemarchandel, Marie Cambot, Philippe Gaulard, Olivier Hermine and Paul-Henri Roméo
Nature Immunology 3, 477–482
(May 2002); doi:10.1038/ni789
| Abstract | Full Text (HTML/PDF) |
news and views
Neuropilin-1: another neuronal molecule in the "immunological synapse"
Christoph Wülfing and Fabio Rupp
Nature Immunology 3, 418–419
(May 2002); doi:10.1038/ni0502-418
| Full Text (HTML/PDF) |
news and views
Nicotinic receptors: Addiction's smoking gun?
Ann E. Kelley
Nature Medicine 8, 447–449
(May 2002); doi:10.1038/nm0502-447
| Full Text (HTML/PDF) |
article
ErbB2 is essential in the prevention of dilated cardiomyopathy
Steven A. Crone, You-Yang Zhao, Lian Fan, Yusu Gu, Susumu Minamisawa, Yang Liu, Kirk L. Peterson, Ju Chen, Ronald Kahn, Gianluigi Condorelli, John Ross Jr, Kenneth R. Chien and Kuo-Fen Lee
Nature Medicine 8, 459–465
(May 2002); doi:10.1038/nm0502-459
| Abstract | Full Text (HTML/PDF) |
review article
THE GDNF FAMILY: SIGNALLING, BIOLOGICAL FUNCTIONS AND THERAPEUTIC VALUE
Matti S. Airaksinen and Mart Saarma
Nature Reviews Neuroscience 3, 383–394
(May 2002); doi:10.1038/nrn812
| Abstract | Full Text (HTML/PDF) |
April
article
Cooperation between independent hippocampal synapses is controlled by glutamate uptake
Nina Arnth-Jensen, Denis Jabaudon and Massimo Scanziani
Nature Neuroscience 5, 325–331
(April 2002); doi:10.1038/nn825
| Abstract | Full Text (HTML/PDF) |
news and views
A broad view of glutamate spillover
Jeffrey S. Diamond
Nature Neuroscience 5, 291–292
(April 2002); doi:10.1038/nn0402-291
| Full Text (HTML/PDF) |
article
Human Toll-like receptor 4 recognizes host-specific LPS modifications
Adeline M. Hajjar, Robert K. Ernst and Jeff H. Tsai, Christopher B. Wilson and Samuel I. Miller
Nature Immunology 3, 354–359
(April 2002); doi:10.1038/ni777
| Abstract | Full Text (HTML/PDF) |
review article
REGULATED TRANSPORT OF THE GLUCOSE TRANSPORTER GLUT4
Nia J. Bryant, Roland Govers and David E. James
Nature Reviews Molecular Cell Biology 3, 267–277
(April 2002); doi:10.1038/nrm782
| Abstract | Full Text (HTML/PDF) |
commentary
Networks and crosstalk: integrin signalling spreads
Martin A. Schwartz and Mark H. Ginsberg
Nature Cell Biology 4, E65
(April 2002); doi:10.1038/ncb0402-e65
| Full Text (HTML/PDF) |
news and views
E-cadherin and Hakai: signalling, remodeling or destruction?
Salvatore Pece and J. Silvio Gutkind
Nature Cell Biology 4, E72
(April 2002); doi:10.1038/ncb0402-e72
| Full Text (HTML/PDF) |
news and views
Integrin regulation of growth factor receptors
Kenneth M. Yamada and Sharona Even-Ram
Nature Cell Biology 4, E75
(April 2002); doi:10.1038/ncb0402-e75
| Full Text (HTML/PDF) |
hypothesis
Sensing the environment: a historical perspective on integrin signal transduction
Cindy K. Miranti and Joan S. Brugge
Nature Cell Biology 4, E83
(April 2002); doi:10.1038/ncb0402-e83
| Abstract | Full Text (HTML/PDF) |
letters to nature
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4
Nobutaka Suzuki, Shinobu Suzuki, Gordon S. Duncan, Douglas G. Millar, Teiji Wada, Christine Mirtsos, Hidetoshi Takada, Andrew Wakeham, Annick Itie, Shyun Li, Josef M. Penninger, Holger Wesche, Pamela S. Ohashi, Tak W. Mak and Wen-Chen Yeh
Nature 416, 750–756
(April 2002); doi:10.1038/nature736
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news and views
Immunology: DNA drives autoimmunity
Carola G. Vinuesa and Christopher C. Goodnow
Nature 416, 595–598
(April 2002); doi:10.1038/416595a
| Full Text (HTML/PDF) |
article
Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
Elizabeth A. Leadbetter, Ian R. Rifkin, Andreas M. Hohlbaum, Britte C. Beaudette, Mark J. Shlomchik and Ann Marshak-Rothstein
Nature 416, 603–607
(April 2002); doi:10.1038/416603a
| Summary | Full Text (HTML/PDF) |
letters to nature
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
Marie Gottar, Vanessa Gobert, Tatiana Michel, Marcia Belvin, Geoffrey Duyk, Jules A. Hoffmann, Dominique Ferrandon and Julien Royet
Nature 416, 640–644
(April 2002); doi:10.1038/nature734
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letters to nature
Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
Mika Rämet, Pascal Manfruelli, Alan Pearson, Bernard Mathey-Prevot and R. Alan B. Ezekowitz
Nature 416, 644–648
(April 2002); doi:10.1038/nature735
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March
review article
ALLOSTERIC BINDING SITES ON CELL-SURFACE RECEPTORS: NOVEL TARGETS FOR DRUG DISCOVERY
Arthur Christopoulos
Nature Reviews Drug Discovery 1, 198–210
(March 2002); doi:10.1038/nrd746
| Abstract | Full Text (HTML/PDF) |
letter
A mutant PTH/PTHrP type I receptor in enchondromatosis
Sevan Hopyan, Nalan Gokgoz, Raymond Poon, Robert C. Gensure, Chunying Yu, William G. Cole, Robert S. Bell, Harald Jüppner, Irene L. Andrulis, Jay S. Wunder and Benjamin A. Alman
Nature Genetics 30, 306–310
(March 2002); doi:10.1038/ng844
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letter
Crystal structure of the human TβR2 ectodomain-TGF-β3 complex
P. John Hart, Shashank Deep, Alexander B. Taylor, Zhanyong Shu, Cynthia S. Hinck and Andrew P. Hinck
Nature Structural Biology 9, 203–208
(March 2002); doi:10.1038/nsb766
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letters to nature
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Xiaoming Li, Yili Yang and Jonathan D. Ashwell
Nature 416, 345–347
(March 2002); doi:10.1038/416345a
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letters to nature
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position
Karin Reif, Eric H. Ekland, Lars Ohl, Hideki Nakano, Martin Lipp, Reinhold Förster and Jason G. Cyster
Nature 416, 94–99
(March 2002); doi:10.1038/416094a
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news and views
Neurobiology: The bitter-sweet taste of amino acids
Lesley Anson
Nature 416, 136
(February 2002); doi:10.1038/416136b
| Full Text (HTML/PDF) |
news and views
Cell biology: A new view of photoreceptors
Franck Pichaud and Claude Desplan
Nature 416, 139–140
(February 2002); doi:10.1038/416139a
| Full Text (HTML/PDF) |
article
Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis
Milena Pellikka, Guy Tanentzapf, Madalena Pinto, Christian Smith, C. Jane McGlade, Donald F. Ready and Ulrich Tepass
Nature 416, 143–149
(March 2002); doi:10.1038/nature721
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letters to nature
Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres
Shayan Izaddoost, Sand-Chul Nam, Manzoor A. Bhat, Hugo J. Bellen & Kwang-Wook Choi
Nature 416, 178–182
(March 2002); doi:10.1038/nature720
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letters to nature
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
Philippe Soubeyran, Katarzyna Kowanetz, Iwona Szymkiewicz, Wallace Y. Langdon and Ivan Dikic
Nature 416, 183–187
(March 2002); doi:10.1038/416183a
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news and views
Signal transduction: Molecular ticket to enter cells
Shlomo Oved and Yosef Yarden
Nature 416, 133–136
(February 2002); doi:10.1038/416133a
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letters to nature
The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met
Annalisa Petrelli, Giorgio F. Gilestro, Stefania Lanzardo, Paolo M. Comoglio, Nicola Migone and Silvia Giordano
Nature 416, 187–190
(March 2002); doi:10.1038/416187a
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letters to nature
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi, Naohiro Inohara, Lorraine D. Hernandez, Jorge E. Galán, Gabriel Núñez, Charles A. Janeway, Ruslan Medzhitov and Richard A. Flavell
Nature 416, 194–199
(March 2002); doi:10.1038/416194a
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letters to nature
An amino-acid taste receptor
Greg Nelson, Jayaram Chandrashekar, Mark A. Hoon, Luxin Feng, Grace Zhao, Nicholas J. P. Ryba & Charles S. Zuker
Nature 416, 199–202
(March 2002); doi:10.1038/nature726
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February
review article
C-TYPE LECTIN RECEPTORS ON DENDRITIC CELLS AND LANGERHANS CELLS
Carl G. Figdor, Yvette van Kooyk and Gosse J. Adema
Nature Reviews Immunology 2, 77–84
(February 2002); doi:10.1038/nri723
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review article
CHEMOKINE RECEPTORS: MULTIFACETED THERAPEUTIC TARGETS
Amanda E. I. Proudfoot
Nature Reviews Immunology 2, 106–115
(February 2002); doi:10.1038/nri722
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review article
THE B7-CD28 SUPERFAMILY
Arlene H. Sharpe and Gordon J. Freeman
Nature Reviews Immunology 2, 116–126
(February 2002); doi:10.1038/nri727
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review article
ION CHANNEL STRUCTURE: EMERGING STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTORS
Arthur Karlin
Nature Reviews Neuroscience 3, 102–114
(February 2002); doi:10.1038/nrn731
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news and views
Tumor viral escape from inhibited T cells
Raymond M. Welsh, Susan E. Stepp, Eva Szomolanyi-Tsuda and Craig D. Peacock
Nature Immunology 3, 112–114
(February 2002); doi:10.1038/ni0202-112
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article
CD94-NKG2A receptors regulate antiviral CD8+ T cell responses
Janice M. Moser, James Gibbs, Peter E. Jensen and Aron E. Lukacher
Nature Immunology 3, 189–195
(February 2002); doi:10.1038/ni757
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news and views
Effector BCRs: inside information on IgG
Tim Manser
Nature Immunology 3, 114–116
(February 2002); doi:10.1038/ni0202-114
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article
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory
Stephen W. Martin and Christopher C. Goodnow
Nature Immunology 3, 182–188
(February 2002); doi:10.1038/ni752
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brief communication
Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling
Maximilian Fürthauer, Wei Lin, Siew-Lan Ang, Bernard Thisse and Christine Thisse
Nature Cell Biology 4, 170–174
(February 2002); doi:10.1038/ncb750
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article
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
Hiroaki Hemmi, Tsuneyasu Kaisho, Osamu Takeuchi, Shintaro Sato, Hideki Sanjo, Katsuaki Hoshino, Takao Horiuchi, Hideyuki Tomizawa, Kiyoshi Takeda and Shizuo Akira
Nature Immunology 3, 196–200
(February 2002); doi:10.1038/ni758
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news and views
New avenues for anti-inflammatory therapy
Charles R. Mackay
Nature Medicine 8, 117–118
(February 2002); doi:10.1038/nm0202-117
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article
CCL27-CCR10 interactions regulate T cell-mediated skin inflammation
Bernard Homey, Harri Alenius, Anja Müller, Hortensia Soto, Edward P. Bowman, Wei Yuan, Leslie McEvoy, Antti I. Lauerma, Till Assmann, Erich Bünemann, Maili Lehto, Henrik Wolff, David Yen, Heather Marxhausen, Wayne To, Jonathon Sedgwick, Thomas Ruzicka, Percy Lehmann and Albert Zlotnik
Nature Medicine 8, 157–165
(February 2002); doi:10.1038/nm0202-157
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letters to nature
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains
Saurav Misra, Rosa Puertollano, Yukio Kato, Juan S. Bonifacino and James H. Hurley
Nature 415, 933–937
(February 2002); doi:10.1038/415933a
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letters to nature
Structural basis for recognition of acidic-cluster dileucine sequence by GGA1
Tomoo Shiba, Hiroyuki Takatsu, Terukazu Nogi, Naohiro Matsugaki, Masato Kawasaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Thomas Earnest, Kazuhisa Nakayama and Soichi Wakatsuki
Nature 415, 937–941
(February 2002); doi:10.1038/415937a
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article
Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance
Jun Shimizu, Sayuri Yamazaki, Takeshi Takahashi, Yasumasa Ishida and Shimon Sakaguchi
Nature Immunology 3, 135–142
(February 2002); doi:10.1038/ni759
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January
news and views
Strabismus comes into focus
Jeffrey D. Axelrod
Nature Cell Biology 4, E6
(January 2002); doi:10.1038/ncb0102-e6
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article
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
Maiyon Park and Randall T. Moon
Nature Cell Biology 4, 20–25
(January 2002); doi:10.1038/ncb716
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commentary
Lymphatic endothelium: a new frontier of metastasis research
Marika J. Karkkainen, Taija Mäkinen and Kari Alitalo
Nature Cell Biology 4, E2
(January 2002); doi:10.1038/ncb0102-e2
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article
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells
Hassan Lemjabbar and Carol Basbaum
Nature Medicine 8, 41–46
(January 2002); doi:10.1038/nm0102-41
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article
Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes
H. Kropshofer, S. Spindeldreher, T. A. Röhn, N. Platania, C. Grygar, N. Daniel, A. Wölpl, H. Langen, V. Horejsi and A. B. Vogt
Nature Immunology 3, 61–68
(January 2002); doi:10.1038/ni750
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news and views
All peptide-MHC complexes are not created equal
Peter E. Jensen
Nature Immunology 3, 14–15
(January 2002); doi:10.1038/ni0102-14
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research article
Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRz /CD28 receptor
John Maher, Renier J. Brentjens, Gertrude Gunset, Isabelle Rivière and Michel Sadelain
Nature Biotechnology 20, 70–75
(January 2002); doi:10.1038/nbt0102-70
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article
Costimulation and endogenous MHC ligands contribute to T cell recognition
Christoph Wülfing, Cenk Sumen, Michael D. Sjaastad, Lawren C. Wu, Michael L. Dustin and Mark M. Davis
Nature Immunology 3, 42–47
(January 2002); doi:10.1038/ni741
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news and views
Self-help in T cell recognition?
Talitha R. Bakker and P. Anton van der Merwe
Nature Immunology 3, 11–12
(January 2002); doi:10.1038/ni0102-11
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news and views
CD8: from coreceptor to comodulator
Marc Bonneville and François Lang
Nature Immunology 3, 12–14
(January 2002); doi:10.1038/ni0102-12
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letters to nature
Inter-receptor communication through arrays of bacterial chemoreceptors
Jason E. Gestwicki and Laura L. Kiessling
Nature 415, 81–84
(January 2002); doi:10.1038/415081a
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