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Research library: Membrane receptors
2004: December
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December
letters to nature
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
Jianhang Jia, Chao Tong, Bing Wang, Liping Luo and Jin Jiang
Nature 432, 1045–1050
(23 December 2004); doi:10.1038/nature03179
| First Paragraph | Full Text (HTML / PDF) |
letter
Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling
Toshihiko Toyofuku, Hong Zhang, Atsushi Kumanogoh, Noriko Takegahara, Masanori Yabuki, Koichiro Harada, Masatsugu Hori and Hitoshi Kikutani
Nature Cell Biology 6, 1204–1211
(December 2004); doi:10.1038/ncb1193
| First Paragraph | Full Text (HTML/PDF) |
news and views
Invasive growth: A two-way street for semaphorin signalling
Paolo M. Comoglio, Luca Tamagnone and Silvia Giordano
Nature Cell Biology 6, 1155–1157
(December 2004); doi:10.1038/ncb1204-1155
| Full Text (HTML/PDF) |
perspectives
Timeline: Gefitinib — a novel targeted approach to treating cancer
Roy S. Herbst, Masahiro Fukuoka and José Baselga
Nature Reviews Cancer 4, 956–965
(December 2004); doi:10.1038/nrc1506
| Abstract | Full Text (HTML / PDF) |
review article
Making sense of it all: bacterial chemotaxis
George H. Wadhams and Judith P. Armitage
Nature Reviews Molecular Cell Biology 5, 1024–1037
(December 2004); doi:10.1038/nrm1524
| Abstract | Full Text (HTML / PDF) |
review article
War and peace at mucosal surfaces
Philippe J. Sansonetti
Nature Reviews Immunology 4, 953–964
(December 2004); doi:10.1038/nri1499
| Abstract | Full Text (HTML / PDF) |
article
Insulin regulation of heart function in aging fruit flies
Robert J Wessells, Erin Fitzgerald, James R Cypser, Marc Tatar and Rolf Bodmer
Nature Genetics 36, 1275–1281
(December 2004); doi:10.1038/ng1476
| Abstract | Full Text (HTML/PDF) |
research article
Lack of interferon response in animals to naked siRNAs
Jeremy D Heidel, Siwen Hu, Xian Fang Liu, Timothy J Triche and Mark E Davis
Nature Biotechnology 22, 1579–1582
(December 2004); doi:10.1038/nbt1038
| First Paragraph | Full Text (HTML/PDF) |
research article
Antisense and siRNA as agonists of Toll-like receptors
Sudhir Agrawal and Ekambar R Kandimalla
Nature Biotechnology 22, 1533–1537
(December 2004); doi:10.1038/nbt1042
| Abstract | Full Text (HTML/PDF) |
review article
Development of TGF-β signalling inhibitors for cancer therapy
Jonathan M. Yingling, Kerry L. Blanchard and J. Scott Sawyer
Nature Reviews Drug Discovery 3, 1011–1022
(December 2004); doi:10.1038/nrd1580
| Abstract | Full Text (HTML / PDF) |
article
Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming
Alfonso Martín-Fontecha, Lindy L Thomsen, Sara Brett, Craig Gerard, Martin Lipp, Antonio Lanzavecchia and Federica Sallusto
Nature Immunology 5, 1260–1265
(December 2004); doi:10.1038/ni1138
| Abstract | Full Text (HTML/PDF) |
review article
Consequences of regulated pre-mRNA splicing in the immune system
Kristen W. Lynch
Nature Reviews Immunology 4, 931–940
(December 2004); doi:10.1038/nri1497
| Summary | Full Text (HTML / PDF) |
article
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
Tian Wang, Terrence Town, Lena Alexopoulou, John F Anderson, Erol Fikrig and Richard A Flavell
Nature Medicine 10, 1366–1373
(December 2004); doi:10.1038/nm1140
| Abstract | Full Text (HTML/PDF) |
news and views
West Nile virus: crossing the blood-brain barrier
Michael S Diamond and Robyn S Klein
Nature Medicine 10, 1294–1295
(December 2004); doi:10.1038/nm1204-1294
| Full Text (HTML/PDF) |
review article
Netrin-1 and its receptors in tumorigenesis
Hirofumi Arakawa
Nature Reviews Cancer 4, 978–987
(December 2004); doi:10.1038/nrc1504
| Summary | Full Text (HTML / PDF) |
review article
Receptor trafficking and synaptic plasticity
Graham L. Collingridge , John T. R. Isaac and Yu Tian Wang
Nature Reviews Neuroscience 5, 952–962
(December 2004); doi:10.1038/nrn1556
| Summary | Full Text (HTML / PDF) |
article
Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin
Kara S Giddings, Ji Zhao, Peter J Sims and Rodney K Tweten
Nature Structural and Molecular Biology 11, 1173–1178
(December 2004); doi:10.1038/nsmb862
| Abstract | Full Text (HTML/PDF) |
news and views
A bacterial big-MAC attack
Ioan Iacovache and F Gisou van der Goot
Nature Structural and Molecular Biology 11, 1163–1164
(December 2004); doi:10.1038/nsmb1204-1163
| Full Text (HTML/PDF) |
November
article
Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors
Ioannis Tassiulas, Xiaoyu Hu, Hao Ho, Yogita Kashyap, Paul Paik, Yongmei Hu, Clifford A Lowell and Lionel B Ivashkiv
Nature Immunology 5, 1181–1189
(November 2004); doi:10.1038/ni1126
| Abstract | Full Text (HTML/PDF) |
news and views
From plankton to pathogen recognition
Robert L Modlin and Genhong Cheng
Nature Medicine 10, 1173–1174
(November 2004); doi:10.1038/nm1104-1173
| Full Text (HTML/PDF) |
article
Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
Simon D Bamforth, José Bragança, Cassandra R Farthing, Jürgen E Schneider, Carol Broadbent, Anna C Michell, Kieran Clarke, Stefan Neubauer, Dominic Norris, Nigel A Brown, Robert H Anderson and Shoumo Bhattacharya
Nature Genetics 36, 1189–1196
(November 2004); doi:10.1038/ng1446
| Abstract | Full Text (HTML/PDF) |
letter
Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity
Ramu A Subbramanian, Chikaya Moriya, Kristi L Martin, Fred W Peyerl, Atsuhiko Hasegawa, Akira Naoi, Heng Chhay, Patrick Autissier, Darci A Gorgone, Michelle A Lifton, Kristine Kuus-Reichel, Jörn E Schmitz, Norman L Letvin and Marcelo J Kuroda
Nature Biotechnology 22, 1429–1434
(December 2004); doi:10.1038/nbt1024
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
A FADD-dependent innate immune mechanism in mammalian cells
Siddharth Balachandran, Emmanuel Thomas and Glen N. Barber
Nature 432, 401–405
(18 November 2004); doi:10.1038/nature03124
| First Paragraph | Full Text (HTML / PDF) |
review article
Clinical strategies for expansion of haematopoietic stem cells
Brian P. Sorrentino
Nature Reviews Immunology 4, 878–888
(November 2004); doi:10.1038/nri1487
| Abstract | Full Text (HTML / PDF) |
letter
TCR affinity and negative regulation limit autoimmunity
Matthew A Gronski, Jonathan M Boulter, Demetrius Moskophidis, Linh T Nguyen, Kaisa Holmberg, Alisha R Elford, Elissa K Deenick, Hee O Kim, Josef M Penninger, Bernhard Odermatt, Awen Gallimore, Nicholas R J Gascoigne and Pamela S Ohashi
Nature Medicine 10, 1234–1239
(November 2004); doi:10.1038/nm1114
| First Paragraph | Full Text (HTML/PDF) |
article
Hedgehog signaling from the ZLI regulates diencephalic regional identity
Clemens Kiecker and Andrew Lumsden
Nature Neuroscience 7, 1242–1249
(November 2004); doi:10.1038/nn1338
| Abstract | Full Text (HTML/PDF) |
brief communication
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
Giles S H Yeo, Chiao-Chien Connie Hung, Justin Rochford, Julia Keogh, Juliette Gray, Shoba Sivaramakrishnan, Stephen O'Rahilly and I Sadaf Farooqi
Nature Neuroscience 7, 1187–1189
(November 2004); doi:10.1038/nn1336
| First Paragraph | Full Text (HTML/PDF) |
article
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
Jürgen Soutschek, Akin Akinc, Birgit Bramlage, Klaus Charisse, Rainer Constien, Mary Donoghue, Sayda Elbashir, Anke Geick, Philipp Hadwiger, Jens Harborth, Matthias John, Venkitasamy Kesavan, Gary Lavine, Rajendra K. Pandey, Timothy Racie, Kallanthottathil G. Rajeev, Ingo Röhl, Ivanka Toudjarska, Gang Wang, Silvio Wuschko, David Bumcrot, Victor Koteliansky, Stefan Limmer, Muthiah Manoharan and Hans-Peter Vornlocher
Nature 432, 173–178
(11 November 2004); doi:10.1038/nature03121
| Abstract | Full Text (HTML / PDF) |
article
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
Hong Wang, Hong Liao, Mahendar Ochani, Marilou Justiniani, Xinchun Lin, Lihong Yang, Yousef Al-Abed, Haichao Wang, Christine Metz, Edmund J Miller, Kevin J Tracey and Luis Ulloa
Nature Medicine 10, 1216–1221
(November 2004); doi:10.1038/nm1124
| Abstract | Full Text (HTML/PDF) |
article
Focal adhesion kinase in netrin-1 signaling
Xiu-rong Ren, Guo-li Ming, Yi Xie, Yan Hong, Dong-mei Sun, Zhong-qiu Zhao, Zhu Feng, Qiang Wang, Sangwoo Shim, Zhou-feng Chen, Hong-jun Song, Lin Mei and Wen-cheng Xiong
Nature Neuroscience 7, 1204–1212
(November 2004); doi:10.1038/nn1330
| Abstract | Full Text (HTML/PDF) |
article
Activation of FAK and Src are receptor-proximal events required for netrin signaling
Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, Jennifer Aurandt, Tang-Long Shen, Eric R Fearon, Jun-Lin Guan, Min Han, Yi Rao, Kyonsoo Hong and Kun-Liang Guan
Nature Neuroscience 7, 1213–1221
(November 2004); doi:10.1038/nn1329
| Abstract | Full Text (HTML/PDF) |
article
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attraction
Guofa Liu, Hilary Beggs, Claudia Jürgensen, Hwan-Tae Park, Hao Tang, Jessica Gorski, Kevin R Jones, Louis F Reichardt, Jane Wu and Yi Rao
Nature Neuroscience 7, 1222–1232
(November 2004); doi:10.1038/nn1331
| Abstract | Full Text (HTML/PDF) |
article
CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
Ciriana Orabona, Ursula Grohmann, Maria Laura Belladonna, Francesca Fallarino, Carmine Vacca, Roberta Bianchi, Silvia Bozza, Claudia Volpi, Benoît L Salomon, Maria Cristina Fioretti, Luigina Romani and Paolo Puccetti
Nature Immunology 5, 1134–1142
(November 2004); doi:10.1038/ni1124
| Abstract | Full Text (HTML/PDF) |
news and views
CD28-B7 bidirectional signaling: a two-way street to activation
Eric C Logue and William C Sha
Nature Immunology 5, 1103–1105
(November 2004); doi:10.1038/ni1104-1103
| Full Text (HTML/PDF) |
review article
Strategies to enhance T-cell reconstitution in immunocompromised patients
Marcel R. M. van den Brink, Önder Alpdogan and Richard L. Boyd
Nature Reviews Immunology 4, 856–867
(November 2004); doi:10.1038/nri1484
| Abstract | Full Text (HTML / PDF) |
article
Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
Jianxin Bao, Hana Lin, Yannan Ouyang, Debin Lei, Abdullah Osman, Tae-Wan Kim, Lin Mei, Penggao Dai, Kevin K Ohlemiller and Richard T Ambron
Nature Neuroscience 7, 1250–1258
(November 2004); doi:10.1038/nn1342
| Abstract | Full Text (HTML/PDF) |
article
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
Saumendra N Sarkar, Kristi L Peters, Christopher P Elco, Shuji Sakamoto, Srabani Pal and Ganes C Sen
Nature Structural and Molecular Biology 11, 1060–1067
(November 2004); doi:10.1038/nsmb847
| Abstract | Full Text (HTML/PDF) |
news and views
Another detour on the Toll road to the interferon antiviral response
John Hiscott
Nature Structural and Molecular Biology 11, 1028–1030
(November 2004); doi:10.1038/nsmb1104-1028
| Full Text (HTML/PDF) |
October
review article
Toll-like receptor control of the adaptive immune responses
Akiko Iwasaki and Ruslan Medzhitov
Nature Immunology 5, 987–995
(October 2004); doi:10.1038/ni1112
| Abstract | Full Text (HTML/PDF) |
article
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz and Jiang-Fan Chen
Nature Medicine 10, 1081–1087
(October 2004); doi:10.1038/nm1103
| Abstract | Full Text (HTML/PDF) |
news and views
Bone marrow spawns brain killers
Costantino Iadecola
Nature Medicine 10, 1044–1045
(October 2004); doi:10.1038/nm1004-1044
| Full Text (HTML/PDF) |
news and views
Antisense inhibition of reward learning
Gregory D Horwitz and Edward M Callaway
Nature Neuroscience 7, 1023–1024
(October 2004); doi:10.1038/nn1004-1023
| Full Text (HTML/PDF) |
article
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira
Nature Immunology 5, 1061–1068
(October 2004); doi:10.1038/ni1118
| Abstract | Full Text (HTML/PDF) |
news and views
A polarizing situation
Tasha N Sims and Michael L Dustin
Nature Immunology 5, 1012–1013
(October 2004); doi:10.1038/ni1004-1012
| Full Text (HTML/PDF) |
review article
Interplay of natural killer cells and their receptors with the adaptive immune response
David H Raulet
Nature Immunology 5, 996–1002
(October 2004); doi:10.1038/ni1114
| Abstract | Full Text (HTML/PDF) |
article
Aberrant cannabinoid signaling impairs oviductal transport of embryos
Haibin Wang, Yong Guo, Dingzhi Wang, Philip J Kingsley, Lawrence J Marnett, Sanjoy K Das, Raymond N DuBois and Sudhansu K Dey
Nature Medicine 10, 1074–1080
(October 2004); doi:10.1038/nm1104
| Abstract | Full Text (HTML/PDF) |
letter
A specific requirement for PDGF-C in palate formation and PDGFR-α signaling
Hao Ding, Xiaoli Wu, Hans Boström, Injune Kim, Nicole Wong, Bonny Tsoi, Meredith O'Rourke, Gou Young Koh, Philippe Soriano, Christer Betsholtz, Thomas C Hart, Mary L Marazita, L L Field, Patrick P L Tam and Andras Nagy
Nature Genetics 36, 1111–1116
(October 2004); doi:10.1038/ng1415
| First Paragraph | Full Text (HTML/PDF) |
news and views
Engineering sweet targets for magic bullets
Ten Feizi
Nature Biotechnology 22, 1244–1245
(October 2004); doi:10.1038/nbt1004-1244
| Full Text (HTML/PDF) |
review article
Bradykinin receptor ligands: therapeutic perspectives
François Marceau and Domenico Regoli
Nature Reviews Drug Discovery 3, 845–852
(October 2004); doi:10.1038/nrd1522
| Abstract | Full Text (HTML / PDF) |
article
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Leonardo H Travassos, Stephen E Girardin, Dana J Philpott, Didier Blanot, Marie-Anne Nahori, Catherine Werts and Ivo G Boneca
EMBO Reports 5, 1000–1006
(October 2004); doi:10.1038/sj.embor.7400248
| Abstract | Full Text (HTML/PDF) |
article
Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription
Holly Maier, Rachel Ostraat, Hua Gao, Scott Fields, Susan A Shinton, Kay L Medina, Tomokatsu Ikawa, Cornelis Murre, Harinder Singh, Richard R Hardy and James Hagman
Nature Immunology 5, 1069–1077
(October 2004); doi:10.1038/ni1119
| Abstract | Full Text (HTML/PDF) |
article
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
Jonathan C Poe, Yoko Fujimoto, Minoru Hasegawa, Karen M Haas, Ann S Miller, Isaac G Sanford, Cheryl B Bock, Manabu Fujimoto and Thomas F Tedder
Nature Immunology 5, 1078–1087
(October 2004); doi:10.1038/ni1121
| Abstract | Full Text (HTML/PDF) |
news and views
Unmasking connections in transmembrane immune signaling
Jamey D Marth
Nature Immunology 5, 1008–1010
(October 2004); doi:10.1038/ni1004-1008
| Full Text (HTML/PDF) |
review article
The complement system in regulation of adaptive immunity
Michael C Carroll
Nature Immunology 5, 981–986
(October 2004); doi:10.1038/ni1113
| Abstract | Full Text (HTML/PDF) |
review article
Mast-cell responses to pathogens
Jean S. Marshall
Nature Reviews Immunology 4, 787–799
(October 2004); doi:10.1038/nri1460
| Abstract | Full Text (HTML / PDF) |
article
Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans
Daniel L Chase, Judy S Pepper and Michael R Koelle
Nature Neuroscience 7, 1096–1103
(October 2004); doi:10.1038/nn1316
| Abstract | Full Text (HTML/PDF) |
news and views
Dopamine: should I stay or should I go now?
Erik M Jorgensen
Nature Neuroscience 7, 1019–1021
(October 2004); doi:10.1038/nn1004-1019
| Full Text (HTML/PDF) |
letters to nature
Hedgehog signalling in prostate regeneration, neoplasia and metastasis
Sunil S. Karhadkar, G. Steven Bova , Nadia Abdallah, Surajit Dhara, Dale Gardner, Anirban Maitra, John T. Isaacs, David M. Berman and Philip A. Beachy
Nature 431, 707–712
(07 October 2004); doi:10.1038/nature02962
| First Paragraph | Full Text (HTML / PDF) |
article
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
David L Boone, Emre E Turer, Eric G Lee, Regina-Celeste Ahmad, Matthew T Wheeler, Colleen Tsui, Paula Hurley, Marcia Chien, Sophia Chai, Osamu Hitotsumatsu, Elizabeth McNally, Cecile Pickart and Averil Ma
Nature Immunology 5, 1052–1060
(October 2004); doi:10.1038/ni1110
| Abstract | Full Text (HTML/PDF) |
news and views
DUBbing down innate immunity
Neal Silverman and Katherine Fitzgerald
Nature Immunology 5, 1010–1012
(October 2004); doi:10.1038/ni1004-1010
| Full Text (HTML/PDF) |
article
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
Jayati Sengupta, Jakob Nilsson, Richard Gursky, Christian M T Spahn, Poul Nissen and Joachim Frank
Nature Structural and Molecular Biology 11, 957–962
(October 2004); doi:10.1038/nsmb822
| Abstract | Full Text (HTML/PDF) |
article
In vitro selection and prediction of TIP47 protein-interaction interfaces
Alondra Schweizer Burguete, Pehr B Harbury and Suzanne R Pfeffer
Nature Methods 1, 55–60
(October 2004); doi:10.1038/nmeth702
| Abstract | Full Text (HTML/PDF) |
article
A role for the immunological synapse in lineage commitment of CD4 lymphocytes
Roberto A. Maldonado, Darrell J. Irvine, Robert Schreiber and Laurie H. Glimcher
Nature 431, 527–532
(30 September 2004); doi:10.1038/nature02916
| Abstract | Full Text (HTML / PDF) |
letters to nature
A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans
Christelle Gally, Stefan Eimer, Janet E. Richmond and Jean-Louis Bessereau
Nature 431, 578–582
(30 September 2004); doi:10.1038/nature02893
| First Paragraph | Full Text (HTML / PDF) |
brief communication
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker, Andy Barthorpe, Matthew Blow, Lisa Brackenbury, Adam Butler, Oliver Clarke, Jennifer Cole, Ed Dicks, Angus Dike, Anja Drozd, Ken Edwards, Simon Forbes, Rebecca Foster, Kristian Gray, Chris Greenman, Kelly Halliday, Katy Hills, Vivienne Kosmidou, Richard Lugg, Andy Menzies, Janet Perry, Robert Petty, Keiran Raine, Lewis Ratford, Rebecca Shepherd, Alexandra Small, Yvonne Stephens, Calli Tofts, Jennifer Varian, Sofie West, Sara Widaa, Andrew Yates, Francis Brasseur, Colin S. Cooper, Adrienne M. Flanagan, Margaret Knowles, Suet Y. Leung, David N. Louis, Leendert H. J. Looijenga, Bruce Malkowicz, Marco A. Pierotti, Bin Teh, Georgia Chenevix-Trench, Barbara L. Weber, Siu T. Yuen, Grace Harris, Peter Goldstraw, Andrew G. Nicholson, P. Andrew Futreal, Richard Wooster and Michael R. Stratton
Nature 431, 525–526
(30 September 2004); doi:10.1038/431525b
| First Paragraph | Full Text (HTML / PDF) |
review article
Integrin signalling during tumour progression
Wenjun Guo and Filippo G. Giancotti
Nature Reviews Molecular Cell Biology 5, 816–826
(October 2004); doi:10.1038/nrm1490
| Abstract | Full Text (HTML / PDF) |
review article
PDZ domain proteins of synapses
Eunjoon Kim and Morgan Sheng
Nature Reviews Neuroscience 5, 771–781
(October 2004); doi:10.1038/nrn1517
| Abstract | Full Text (HTML / PDF) |
September
review article
T-cell trafficking in asthma: lipid mediators grease the way
Andrew D. Luster and Andrew M. Tager
Nature Reviews Immunology 4, 711–724
(September 2004); doi:10.1038/nri1438
| Abstract | Full Text (HTML / PDF) |
article
Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A
Jose R Conejo-Garcia, Fabian Benencia, Maria-Cecilia Courreges, Eugene Kang, Alisha Mohamed-Hadley, Ronald J Buckanovich, David O Holtz, Ann Jenkins, Hana Na, Lin Zhang, Daniel S Wagner, Dionyssios Katsaros, Richard Caroll and George Coukos
Nature Medicine 10, 950–958
(September 2004); doi:10.1038/nm1097
| Abstract | Full Text (HTML/PDF) |
news and views
Epithelial cells pay a Toll for protection
Warren Strober
Nature Medicine 10, 898–900
(September 2004); doi:10.1038/nm0904-898
| Full Text (HTML/PDF) |
news and views
From mRNA to tumor suppressor
Dan Mercola and John Welsh
Nature Genetics 36, 937–938
(September 2004); doi:10.1038/ng0904-937
| Full Text (HTML/PDF) |
review article
Molecular and neuronal substrates for general anaesthetics
Uwe Rudolph and Bernd Antkowiak
Nature Reviews Neuroscience 5, 709–720
(September 2004); doi:10.1038/nrn1496
| Abstract | Full Text (HTML / PDF) |
research article
Temporal analysis of phosphotyrosine-dependent signaling networks by quantitative proteomics
Blagoy Blagoev, Shao-En Ong, Irina Kratchmarova and Matthias Mann
Nature Biotechnology 22, 1139–1145
(September 2004); doi:10.1038/nbt1005
| First Paragraph | Full Text (HTML/PDF) |
news and views
Phosphoproteomics finds its timing
Sam A Johnson and Tony Hunter
Nature Biotechnology 22, 1093–1094
(September 2004); doi:10.1038/nbt0904-1093
| Full Text (HTML/PDF) |
review article
TCR ζ-chain downregulation: curtailing an excessive inflammatory immune response
Michal Baniyash
Nature Reviews Immunology 4, 675–687
(September 2004); doi:10.1038/nri1434
| Abstract | Full Text (HTML / PDF) |
news and views
From neurotoxin to neurotrophin
Christian Mirescu and Elizabeth Gould
Nature Neuroscience 7, 899–900
(September 2004); doi:10.1038/nn0904-899
| Full Text (HTML/PDF) |
brief communication
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Héctor G Pálmer, María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros and Alberto Muñoz
Nature Medicine 10, 917–919
(September 2004); doi:10.1038/nm1095
| First Paragraph | Full Text (HTML/PDF) |
letters to nature
Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein
Andreu Casali and Gary Struhl
Nature 431, 76–80
(02 September 2004); doi:10.1038/nature02835
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Netrin–1 controls colorectal tumorigenesis by regulating apoptosis
Laetitia Mazelin, Agnès Bernet, Christelle Bonod–Bidaud, Laurent Pays, Ségolène Arnaud, Christian Gespach, Dale E Bredesen, Jean–Yves Scoazec and Patrick Mehlen
Nature 431, 80–84
(02 September 2004); doi:10.1038/nature02788
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cancer: Cell survival guide
Eric R. Fearon and Kathleen R. Cho
Nature 431, 35–36
(02 September 2004); doi:10.1038/431035a
| Full Text (HTML / PDF) |
review article
Tolerance, not immunity, crucially depends on IL–2
Thomas R. Malek and Allison L. Bayer
Nature Reviews Immunology 4, 665–674
(September 2004); doi:10.1038/nri1435
| Summary | Full Text (HTML / PDF) |
perspectives
Opinion: Switching on kinases: oncogenic activation of BRAF and the PDGFR family
Nick J. Dibb, Stephen M. Dilworth and Clifford D. Mol
Nature Reviews Cancer 4, 718–727
(September 2004); doi:10.1038/nrc1434
| Summary | Full Text (HTML / PDF) |
letter
Nonsense–mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
Pia Huusko, Damaris Ponciano–Jackson, Maija Wolf, Jeff A Kiefer, David O Azorsa, Sukru Tuzmen, Don Weaver, Christiane Robbins, Tracy Moses, Minna Allinen, Sampsa Hautaniemi, Yidong Chen, Abdel Elkahloun, Mark Basik, G Steven Bova, Lukas Bubendorf, Alessandro Lugli, Guido Sauter, Johanna Schleutker, Hilmi Ozcelik, Sabine Elowe, Tony Pawson, Jeffrey M Trent, John D Carpten, Olli–P Kallioniemi and Spyro Mousses
Nature Genetics 36, 979–983
(September 2004); doi:10.1038/ng1408
| First Paragraph | Full Text (HTML/PDF) |
article
Restructuring the neuronal stress response with anti–glucocorticoid gene delivery
D Kaufer, W O Ogle, Z S Pincus, K L Clark, A C Nicholas, K M Dinkel, T C Dumas, D Ferguson, A L Lee, M A Winters and R M Sapolsky
Nature Neuroscience 7, 947–953
(September 2004); doi:10.1038/nn1296
| Abstract | Full Text (HTML/PDF) |
August
letters to nature
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
Sirith Douma, Theo van Laar, John Zevenhoven, Ralph Meuwissen, Evert van Garderen and Daniel S. Peeper
Nature 430, 1034–1039
(26 August 2004); doi:10.1038/nature02765
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news and views
Anoikis: Cancer and the homeless cell
Lance A. Liotta and Elise Kohn
Nature 430, 973–974
(26 August 2004); doi:10.1038/430973a
| Full Text (HTML / PDF) |
letters to nature
Argos inhibits epidermal growth factor receptor signalling by ligand sequestration
Daryl E. Klein, Valerie M. Nappi, Gregory T. Reeves, Stanislav Y. Shvartsman and Mark A. Lemmon
Nature 430, 1040–1044
(26 August 2004); doi:10.1038/nature02840
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letter
The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor
Marcel Vergés, Frédéric Luton, Carmen Gruber, Frank Tiemann, Lorri G. Reinders, Lan Huang, Alma L. Burlingame, Carol R. Haft and Keith E. Mostov
Nature Cell Biology 6, 763–769
(August 2004); doi:10.1038/ncb1153
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news and views
Closing in on vertebrate planar polarity
John B. Wallingford
Nature Cell Biology 6, 687–689
(August 2004); doi:10.1038/ncb0804-687
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article
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
Sharon H Jackson, Satish Devadas, Jaeyul Kwon, Ligia A Pinto and Mark S Williams
Nature Immunology 5, 818–827
(August 2004); doi:10.1038/ni1096
| Abstract | Full Text (HTML/PDF) |
review article
Transmembrane adaptor proteins: organizers of immunoreceptor signalling
Václav Horejší, Weiguo Zhang and Burkhart Schraven
Nature Reviews Immunology 4, 603–616
(August 2004); doi:10.1038/nri1414
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article
P2X7 receptor inhibition improves recovery after spinal cord injury
Xiaohai Wang, Gregory Arcuino, Takahiro Takano, Jane Lin, Wei Guo Peng, Pinglan Wan, Pingjia Li, Qiwu Xu, Qing Song Liu, Steven A Goldman and Maiken Nedergaard
Nature Medicine 10, 821–827
(August 2004); doi:10.1038/nm1082
| Abstract | Full Text (HTML/PDF) |
article
The type 1 equilibrative nucleoside transporter regulates ethanol intoxication and preference
Doo-Sup Choi, Maria-Grazia Cascini, William Mailliard, Hannah Young, Peter Paredes, Thomas McMahon, Ivan Diamond, Antonello Bonci and Robert O Messing
Nature Neuroscience 7, 855–861
(August 2004); doi:10.1038/nn1288
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news and views
Last call for adenosine transporters
Roberto I Melendez and Peter W Kalivas
Nature Neuroscience 7, 795–796
(August 2004); doi:10.1038/nn0804-795
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article
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
Julie Kniazeff, Anne-Sophie Bessis, Damien Maurel, Hervé Ansanay, Laurent Prézeau and Jean-Philippe Pin
Nature Structural and Molecular Biology 11, 706–713
(August 2004); doi:10.1038/nsmb794
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news and views
Toward understanding GPCR dimers
Charles Parnot and Brian Kobilka
Nature Structural and Molecular Biology 11, 691–692
(August 2004); doi:10.1038/nsmb0804-691
| Full Text (HTML/PDF) |
letters to nature
Chemical remodelling of cell surfaces in living animals
Jennifer A. Prescher, Danielle H. Dube and Carolyn R. Bertozzi
Nature 430, 873–877
(19 August 2004); doi:10.1038/nature02791
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news and views
Chemical biology: Hitting the sweet spot
David A. Tirrell
Nature 430, 837
(19 August 2004); doi:10.1038/430837a
| Full Text (HTML / PDF) |
letters to nature
SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans
Hongkyun Kim, Matthew J. Rogers, Janet E. Richmond and Steven L. McIntire
Nature 430, 891–896
(19 August 2004); doi:10.1038/nature02798
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letters to nature
Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel
Cecilia Bouzat, Fernanda Gumilar, Guillermo Spitzmaul, Hai-Long Wang, Diego Rayes, Scott B. Hansen, Palmer Taylor and Steven M. Sine
Nature 430, 896–900
(19 August 2004); doi:10.1038/nature02753
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letters to nature
Crystal structure of a complex between anthrax toxin and its host cell receptor
Eugenio Santelli, Laurie A. Bankston, Stephen H. Leppla and Robert C. Liddington
Nature 430, 905–908
(19 August 2004); doi:10.1038/nature02763
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news and views
Structural biology: Anthrax hijacks host receptor
James G. Bann and Scott J. Hultgren
Nature 430, 843–844
(19 August 2004); doi:10.1038/430843a
| Full Text (HTML / PDF) |
letter
The neurotrophin-receptor-related protein NRH1 is essential for convergent extension movements
Noriaki Sasai, Yoko Nakazawa, Tomoko Haraguchi and Yoshiki Sasai
Nature Cell Biology 6, 741–748
(August 2004); doi:10.1038/ncb1158
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article
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
Tomohiro Watanabe, Atsushi Kitani, Peter J Murray and Warren Strober
Nature Immunology 5, 800–808
(August 2004); doi:10.1038/ni1092
| Abstract | Full Text (HTML/PDF) |
news and views
How NOD-ing off leads to Crohn disease
Luke A J O'Neill
Nature Immunology 5, 776–778
(August 2004); doi:10.1038/ni0804-776
| Full Text (HTML/PDF) |
letters to nature
Reaction mechanism determines NMDA receptor response to repetitive stimulation
Gabriela Popescu, Antoine Robert, James R. Howe and Anthony Auerbach
Nature 430, 790–793
(12 August 2004); doi:10.1038/nature02775
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letter
RGM and its receptor neogenin regulate neuronal survival
Eiji Matsunaga, Servane Tauszig-Delamasure, Philippe P. Monnier, Bernhard K. Mueller, Stephen M. Strittmatter, Patrick Mehlen and Alain Chédotal
Nature Cell Biology 6, 749–755
(August 2004); doi:10.1038/ncb1157
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CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse
Qi-Jing Li, Aaron R Dinner, Shuyan Qi, Darrell J Irvine, Johannes B Huppa, Mark M Davis and Arup K Chakraborty
Nature Immunology 5, 791–799
(August 2004); doi:10.1038/ni1095
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news and views
Self help for T cells
Eric Hailman and Paul M Allen
Nature Immunology 5, 780–781
(August 2004); doi:10.1038/ni0804-780
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news and views
Type 1 diabetes: focus on prevention
Harald von Boehmer
Nature Medicine 10, 783–784
(August 2004); doi:10.1038/nm0804-783
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letter
Heterozygous TGFBR2 mutations in Marfan syndrome
Takeshi Mizuguchi, Gwenaëlle Collod-Beroud, Takushi Akiyama, Marianne Abifadel, Naoki Harada, Takayuki Morisaki, Delphine Allard, Mathilde Varret, Mireille Claustres, Hiroko Morisaki, Makoto Ihara, Akira Kinoshita, Koh-ichiro Yoshiura, Claudine Junien, Tadashi Kajii, Guillaume Jondeau, Tohru Ohta, Tatsuya Kishino, Yoichi Furukawa, Yusuke Nakamura, Norio Niikawa, Catherine Boileau and Naomichi Matsumoto
Nature Genetics 36, 855–860
(August 2004); doi:10.1038/ng1392
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news and views
TGFβ signaling in health and disease
Rosemary J Akhurst
Nature Genetics 36, 790–792
(August 2004); doi:10.1038/ng0804-790
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letter
Neogenin mediates the action of repulsive guidance molecule
Srikanth Rajagopalan, Lutz Deitinghoff, Denise Davis, Sabine Conrad, Thomas Skutella, Alain Chedotal, Bernhard K. Mueller and Stephen M. Strittmatter
Nature Cell Biology 6, 756–762
(August 2004); doi:10.1038/ncb1156
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article
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Marisa I Gómez, Aram Lee, Bharat Reddy, Amanda Muir, Grace Soong, Allyson Pitt, Ambrose Cheung and Alice Prince
Nature Medicine 10, 842–848
(August 2004); doi:10.1038/nm1079
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news and views
Staphylococcal protein A inflames the lungs
Birgitta Henriques Normark, Staffan Normark and Anna Norrby-Teglund
Nature Medicine 10, 780–781
(August 2004); doi:10.1038/nm0804-780
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Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions
Takaki Komiyama, John R Carlson and Liqun Luo
Nature Neuroscience 7, 819–825
(August 2004); doi:10.1038/nn1284
| Abstract | Full Text (HTML/PDF) |
July
news and views
Neurobiology: Odorant receptors make scents
Rainer W. Friedrich
Nature 430, 511–512
(29 July 2004); doi:10.1038/430511a
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review article
Hyaluronan: from extracellular glue to pericellular cue
Bryan P. Toole
Nature Reviews Cancer 4, 528–539
(July 2004); doi:10.1038/nrc1391
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letter
A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone
Christine Dos Santos, Laurent Essioux, Cécile Teinturier, Maïté Tauber, Vincent Goffin and Pierre Bougnères
Nature Genetics 36, 720–724
(July 2004); doi:10.1038/ng1379
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Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR
Yuan Guo, Hadar Feinberg, Edward Conroy, Daniel A Mitchell, Richard Alvarez, Ola Blixt, Maureen E Taylor, William I Weis and Kurt Drickamer
Nature Structural and Molecular Biology 11, 591–598
(July 2004); doi:10.1038/nsmb784
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brief communication
Evolutionary genetics: Ambiguous role of CCR5 in Y. pestis infection
Stephen J. Elvin, E. Diane Williamson, Joanne C. Scott, Jeremy N. Smith, Guillermo Pérez de Lema, Silvia Chilla, Paul Clapham, Klaus Pfeffer, Detlef Schlöndorff and Bruno Luckow
Nature 430, 606–31
(22 July 2004); doi:10.1038/nature02822
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Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice
Stacey R Dillon, Cindy Sprecher, Angela Hammond, Janine Bilsborough, Maryland Rosenfeld-Franklin, Scott R Presnell, Harald S Haugen, Mark Maurer, Brandon Harder, Janet Johnston, Susan Bort, Sherri Mudri, Joseph L Kuijper, Tom Bukowski, Pamela Shea, Dennis L Dong, Maria Dasovich, Francis J Grant, Luann Lockwood, Steven D Levin, Cosette LeCiel, Kim Waggie, Heather Day, Stavros Topouzis, Janet Kramer, Rolf Kuestner, Zhi Chen, Don Foster, Julia Parrish-Novak and Jane A Gross
Nature Immunology 5, 752–760
(July 2004); doi:10.1038/ni1084
| Abstract | Full Text (HTML/PDF) |
perspectives
Landmark: The road to Toll
Bruno Lemaitre
Nature Reviews Immunology 4, 521–527
(July 2004); doi:10.1038/nri1390
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letter
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
Jane K Howard, Belinda J Cave, Laura J Oksanen, Iphigenia Tzameli, Christian Bjørbæk and Jeffrey S Flier
Nature Medicine 10, 734–738
(July 2004); doi:10.1038/nm1072
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letter
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
Hiroyuki Mori, Reiko Hanada, Toshikatsu Hanada, Daisuke Aki, Ryuichi Mashima, Hitomi Nishinakamura, Takehiro Torisu, Kenneth R Chien, Hideo Yasukawa and Akihiko Yoshimura
Nature Medicine 10, 739–743
(July 2004); doi:10.1038/nm1071
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review article
Toll-like receptor signalling
Shizuo Akira and Kiyoshi Takeda
Nature Reviews Immunology 4, 499–511
(July 2004); doi:10.1038/nri1391
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review article
Insulin-like growth factors and neoplasia
Michael N. Pollak, Eva S. Schernhammer and Susan E. Hankinson
Nature Reviews Cancer 4, 505–518
(July 2004); doi:10.1038/nrc1387
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Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
Zeev Pancer, Chris T. Amemiya, Götz R. A. Ehrhardt, Jill Ceitlin, G. Larry Gartland and Max D. Cooper
Nature 430, 174–180
(08 July 2004); doi:10.1038/nature02740
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news and views
Immunology: Another manifestation of GOD
Martin F. Flajnik
Nature 430, 157–158
(08 July 2004); doi:10.1038/430157a
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letters to nature
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkBζ
Masahiro Yamamoto, Soh Yamazaki, Satoshi Uematsu, Shintaro Sato, Hiroaki Hemmi, Katsuaki Hoshino, Tsuneyasu Kaisho, Hirotaka Kuwata, Osamu Takeuchi, Koichiro Takeshige, Tatsuya Saitoh, Shoji Yamaoka, Naoki Yamamoto, Shunsuke Yamamoto, Tatsushi Muta, Kiyoshi Takeda and Shizuo Akira
Nature 430, 218–222
(08 July 2004); doi:10.1038/nature02738
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news and views
Immunology: Polarizing a T-cell response
Sophie M. Lehar and Michael J. Bevan
Nature 430, 150–151
(08 July 2004); doi:10.1038/430150a
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review
Inferences, questions and possibilities in Toll-like receptor signalling
Bruce Beutler
Nature 430, 257–263
(08 July 2004); doi:10.1038/nature02761
| Abstract | Full Text (HTML / PDF) |
letter
Phosphorylation of the enteropathogenic E. coli receptor by the Src-family kinase c-Fyn triggers actin pedestal formation
Neil Phillips, Richard D. Hayward and Vassilis Koronakis
Nature Cell Biology 6, 618–625
(July 2004); doi:10.1038/ncb1148
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review article
Therapeutics targeting the innate immune system
Richard J. Ulevitch
Nature Reviews Immunology 4, 512–520
(July 2004); doi:10.1038/nri1396
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brief communication
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Laurent Groc, Martin Heine, Laurent Cognet, Kieran Brickley, F Anne Stephenson, Brahim Lounis and Daniel Choquet
Nature Neuroscience 7, 695–696
(July 2004); doi:10.1038/nn1270
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Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone
Guy Cinamon, Mehrdad Matloubian, Matthew J Lesneski, Ying Xu, Caroline Low, Theresa Lu, Richard L Proia and Jason G Cyster
Nature Immunology 5, 713–720
(July 2004); doi:10.1038/ni1083
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news and views
Should we B-leavin' now?
Michael D Gunn and Garnett Kelsoe
Nature Immunology 5, 703–704
(July 2004); doi:10.1038/ni0704-703
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CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals
Rémy Bosselut
Nature Reviews Immunology 4, 529–540
(July 2004); doi:10.1038/nri1392
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review article
Cancer and the chemokine network
Fran Balkwill
Nature Reviews Cancer 4, 540–550
(July 2004); doi:10.1038/nrc1388
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brief communication
Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
Laurent Groc, Martin Heine, Laurent Cognet, Kieran Brickley, F Anne Stephenson, Brahim Lounis and Daniel Choquet
Nature Neuroscience 7, 695–696
(July 2004); doi:10.1038/nn1270
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June
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A membrane protein required for dislocation of misfolded proteins from the ER
Brendan N. Lilley and Hidde L. Ploegh
Nature 429, 834–840
(24 June 2004); doi:10.1038/nature02592
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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Yihong Ye, Yoko Shibata, Chi Yun, David Ron and Tom A. Rapoport
Nature 429, 841–847
(24 June 2004); doi:10.1038/nature02656
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news and views
Cell biology: A channel for protein waste
Randy Schekman
Nature 429, 817–818
(24 June 2004); doi:10.1038/429817a
| Full Text (HTML / PDF) |
letters to nature
Rapid BDNF-induced retrograde synaptic modification in a developing retinotectal system
Jiu-lin Du and Mu-ming Poo
Nature 429, 878–883
(24 June 2004); doi:10.1038/nature02618
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Juxtamembrane autoinhibition in receptor tyrosine kinases
Stevan R. Hubbard
Nature Reviews Molecular Cell Biology 5, 464–471
(June 2004); doi:10.1038/nrm1399
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A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells
Wu-Shiun Hou and Luk Van Parijs
Nature Immunology 5, 583–589
(June 2004); doi:10.1038/ni1071
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news and views
Balancing life and death
Muriel Moser
Nature Immunology 5, 559–560
(June 2004); doi:10.1038/ni0604-559
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Exacerbated graft-versus-host disease in Pirb−/− mice
Akira Nakamura, Eiji Kobayashi and Toshiyuki Takai
Nature Immunology 5, 623–629
(June 2004); doi:10.1038/ni1074
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perspectives
Opinion: γ-Secretase: proteasome of the membrane?
Raphael Kopan and Ma. Xenia G. Ilagan
Nature Reviews Molecular Cell Biology 5, 499–504
(June 2004); doi:10.1038/nrm1406
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Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors
Yoshihiro Hayakawa, Stuart P Berzins, Nadine Y Crowe, Dale I Godfrey and Mark J Smyth
Nature Immunology 5, 590–596
(June 2004); doi:10.1038/ni1069
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article
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo
Katsuto Hozumi, Naoko Negishi, Daisuke Suzuki, Natsumi Abe, Yusuke Sotomaru, Norikazu Tamaoki, Carolina Mailhos, David Ish-Horowicz, Sonoko Habu and Michael J Owen
Nature Immunology 5, 638–644
(June 2004); doi:10.1038/ni1075
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perspectives
Opinion: Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses
Seung-Yong Seong and Polly Matzinger
Nature Reviews Immunology 4, 469–478
(June 2004); doi:10.1038/nri1372
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news and views
Targeting tumors: seeing the light
Charlotte Schubert
Nature Medicine 10, 580
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article
Dynein motors transport activated Trks to promote survival of target-dependent neurons
Heather M Heerssen, Maria F Pazyra and Rosalind A Segal
Nature Neuroscience 7, 596–604
(June 2004); doi:10.1038/nn1242
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review article
Modulation of signalling by Sprouty: a developing story
Hong Joo Kim and Dafna Bar-Sagi
Nature Reviews Molecular Cell Biology 5, 441–450
(June 2004); doi:10.1038/nrm1400
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article
Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells
Tetsuya Yamagata, Diane Mathis and Christophe Benoist
Nature Immunology 5, 597–605
(June 2004); doi:10.1038/ni1070
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news and views
Nondeletional pathways for the development of autoreactive thymocytes
Albert Bendelac
Nature Immunology 5, 557–558
(June 2004); doi:10.1038/ni0604-557
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brief communication
Frequency-dependent modulation of dopamine release by nicotine
Hui Zhang and David Sulzer
Nature Neuroscience 7, 581–582
(June 2004); doi:10.1038/nn1243
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brief communication
Nicotine amplifies reward-related dopamine signals in striatum
Margaret E Rice and Stephanie J Cragg
Nature Neuroscience 7, 583–584
(June 2004); doi:10.1038/nn1244
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perspectives
Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia
Gabriel Corfas, Kristine Roy and Joseph D Buxbaum
Nature Neuroscience 7, 575–580
(June 2004); doi:10.1038/nn1258
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Yunzeng Zou, Hiroshi Akazawa, Yingjie Qin, Masanori Sano, Hiroyuki Takano, Tohru Minamino, Noriko Makita, Koji Iwanaga, Weidong Zhu, Sumiyo Kudoh, Haruhiro Toko, Koichi Tamura, Minoru Kihara, Toshio Nagai, Akiyoshi Fukamizu, Satoshi Umemura, Taroh Iiri, Toshiro Fujita and Issei Komuro
Nature Cell Biology 6, 499–506
(June 2004); doi:10.1038/ncb1137
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review article
Mathematical and computational models of immune-receptor signalling
Byron Goldstein, James R. Faeder and William S. Hlavacek
Nature Reviews Immunology 4, 445–456
(June 2004); doi:10.1038/nri1374
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research article
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
Peter M Smith-Jones, David B Solit, Timothy Akhurst, Farzana Afroze, Neal Rosen and Steven M Larson
Nature Biotechnology 22, 701–706
(June 2004); doi:10.1038/nbt968
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news and views
An image worth a thousand lives?
Lisa A Hammond, Sean X Cavanaugh and Charles R Thomas Jr
Nature Biotechnology 22, 677–678
(June 2004); doi:10.1038/nbt0604-677
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May
news and views
A Bit-role for integrins in apoptosis
Dwayne G. Stupack and David A. Cheresh
Nature Cell Biology 6, 388–389
(May 2004); doi:10.1038/ncb0504-388
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Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
Juha-Pekka Himanen, Michael J Chumley, Martin Lackmann, Chen Li, William A Barton, Phillip D Jeffrey, Christopher Vearing, Detlef Geleick, David A Feldheim, Andrew W Boyd, Mark Henkemeyer and Dimitar B Nikolov
Nature Neuroscience 7, 501–509
(May 2004); doi:10.1038/nn1237
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news and views
Eph-ephrin promiscuity is now crystal clear
Elena B Pasquale
Nature Neuroscience 7, 417–418
(May 2004); doi:10.1038/nn0504-417
| Full Text (HTML/PDF) |
letters to nature
Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases
Letizia Lanzetti, Andrea Palamidessi, Liliana Areces, Giorgio Scita and Pier Paolo Di Fiore
Nature 429, 309–314
(20 May 2004); doi:10.1038/nature02542
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RIP1 is an essential mediator of Toll-like receptor 3-induced NF-κB activation
Etienne Meylan, Kim Burns, Kay Hofmann, Vincent Blancheteau, Fabio Martinon, Michelle Kelliher and Jürg Tschopp
Nature Immunology 5, 503–507
(May 2004); doi:10.1038/ni1061
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news and views
Toll signaling: RIPping off the TNF pathway
Gregory M Barton and Ruslan Medzhitov
Nature Immunology 5, 472–474
(May 2004); doi:10.1038/ni0504-472
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article
Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance
Yiping Yang, Ching-Tai Huang, Xiaopei Huang and Drew M Pardoll
Nature Immunology 5, 508–515
(May 2004); doi:10.1038/ni1059
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A single class II myosin modulates T cell motility and stopping, but not synapse formation
Jordan Jacobelli, Stephen A Chmura, Denis B Buxton, Mark M Davis and Matthew F Krummel
Nature Immunology 5, 531–538
(May 2004); doi:10.1038/ni1065
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review article
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity
Lieping Chen
Nature Reviews Immunology 4, 336–347
(May 2004); doi:10.1038/nri1349
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perspectives
Timeline: The discovery of receptor tyrosine kinases: targets for cancer therapy
Andreas Gschwind, Oliver M. Fischer and Axel Ullrich
Nature Reviews Cancer 4, 361–370
(May 2004); doi:10.1038/nrc1360
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letter
SUMO modification is required for in vivo Hox gene regulation by the Caenorhabditis elegans Polycomb group protein SOP-2
Hong Zhang, Gromoslaw A Smolen, Rachel Palmer, Andrea Christoforou, Sander van den Heuvel and Daniel A Haber
Nature Genetics 36, 507–511
(May 2004); doi:10.1038/ng1336
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brief communication
Circadian regulation of GABAA receptor function by CKIε-CKIδ in the rat suprachiasmatic nuclei
Ke Ning, Lei Li, Mingxia Liao, Baosong Liu, John G Mielke, Yonghong Chen, Ying Duan, Youssef H El-Hayek and Qi Wan
Nature Neuroscience 7, 489–490
(May 2004); doi:10.1038/nn1236
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TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
Carole Couillault, Nathalie Pujol, Jérôme Reboul, Laurence Sabatier, Jean-François Guichou, Yuji Kohara and Jonathan J Ewbank
Nature Immunology 5, 488–494
(May 2004); doi:10.1038/ni1060
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Dissecting worm immunity
Jonathan Hodgkin
Nature Immunology 5, 471–472
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Tlx3 and Tlx1 are post-mitotic selector genes determining glutamatergic over GABAergic cell fates
Leping Cheng, Akiko Arata, Rumiko Mizuguchi, Ying Qian, Asanka Karunaratne, Paul A Gray, Satoru Arata, Senji Shirasawa, Maxime Bouchard, Ping Luo, Chih-Li Chen, Meinrad Busslinger, Martyn Goulding, Hiroshi Onimaru and Qiufu Ma
Nature Neuroscience 7, 510–517
(May 2004); doi:10.1038/nn1221
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Tlx genes make an exciting choice
Stewart Anderson
Nature Neuroscience 7, 421–422
(May 2004); doi:10.1038/nn0504-421
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letters to nature
Mechanotransduction through growth-factor shedding into the extracellular space
Daniel J. Tschumperlin, Guohao Dai, Ivan V. Maly, Tadashi Kikuchi, Lily H. Laiho, Anna K. McVittie, Kathleen J. Haley, Craig M. Lilly, Peter T. C. So, Douglas A. Lauffenburger, Roger D. Kamm and Jeffrey M. Drazen
Nature 429, 83–86
(06 May 2004); doi:10.1038/nature02543
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article
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Tsung-Hsien Chuang and Richard J Ulevitch
Nature Immunology 5, 495–502
(May 2004); doi:10.1038/ni1066
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review article
The weight of leptin in immunity
Antonio La Cava and Giuseppe Matarese
Nature Reviews Immunology 4, 371–379
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article
Retrograde activation of presynaptic NMDA receptors enhances GABA release at cerebellar interneuron-Purkinje cell synapses
Ian C Duguid and Trevor G Smart
Nature Neuroscience 7, 525–533
(May 2004); doi:10.1038/nn1227
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Presynaptic NMDA receptors get into the act
Anastassios V Tzingounis and Roger A Nicoll
Nature Neuroscience 7, 419–420
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NMDA receptors, place cells and hippocampal spatial memory
Kazu Nakazawa , Thomas J. McHugh , Matthew A. Wilson and Susumu Tonegawa
Nature Reviews Neuroscience 5, 361–372
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Molecular recognition of BMP-2 and BMP receptor IA
Sascha Keller, Joachim Nickel, Jin-Li Zhang, Walter Sebald and Thomas D Mueller
Nature Structural and Molecular Biology 11, 481–488
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April
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Fas ligation on macrophages enhances IL-1R1-Toll-like receptor 4 signaling and promotes chronic inflammation
Yingyu Ma, Hongtao Liu, Hoang Tu-Rapp, Hans-Juergen Thiesen, Saleh M Ibrahim, Shawn M Cole and Richard M Pope
Nature Immunology 5, 380–387
(April 2004); doi:10.1038/ni1054
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Sporadic ALS: blame it on the editor
Stuart A Lipton
Nature Medicine 10, 347
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research article
Reversible site-selective labeling of membrane proteins in live cells
Emmanuel G Guignet, Ruud Hovius and Horst Vogel
Nature Biotechnology 22, 440–444
(April 2004); doi:10.1038/nbt954
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Finding needles in haystacks
Jonathan A Javitch
Nature Biotechnology 22, 394–396
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letters to nature
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges
Sarah M. Webster, Donato del Camino, John P. Dekker and Gary Yellen
Nature 428, 864–868
(22 April 2004); doi:10.1038/nature02468
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ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
Elizabeth K Brint, Damo Xu, Haiying Liu, Aisling Dunne, Andrew N J McKenzie, Luke A J O'Neill and Foo Y Liew
Nature Immunology 5, 373–379
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review article
Src kinases: a hub for NMDA receptor regulation
Michael W. Salter and Lorraine V. Kalia
Nature Reviews Neuroscience 5, 317–328
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brief communication
A receptor for green tea polyphenol EGCG
Hirofumi Tachibana, Kiyoshi Koga, Yoshinori Fujimura and Koji Yamada
Nature Structural and Molecular Biology 11, 380–381
(April 2004); doi:10.1038/nsmb743
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Shutting down Wnt signal-activated cancer
M Mark Taketo
Nature Genetics 36, 320–322
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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
Michelle R. Arkin and James A. Wells
Nature Reviews Drug Discovery 3, 301–317
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Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
Pietro G Andres, Kimberly C Howland, Ajay Nirula, Lawrence P Kane, Luke Barron, Douglas Dresnek, Ali Sadra, John Imboden, Arthur Weiss and Abul K Abbas
Nature Immunology 5, 435–442
(April 2004); doi:10.1038/ni1044
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perspectives
Timeline: Jurkat T cells and development of the T-cell receptor signalling paradigm
Robert T. Abraham and Arthur Weiss
Nature Reviews Immunology 4, 301–308
(April 2004); doi:10.1038/nri1330
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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Hiromu Suzuki, D Neil Watkins, Kam-Wing Jair, Kornel E Schuebel, Sanford D Markowitz, Wei Dong Chen, Theresa P Pretlow, Bin Yang, Yoshimitsu Akiyama, Manon van Engeland, Minoru Toyota, Takashi Tokino, Yuji Hinoda, Kohzoh Imai, James G Herman and Stephen B Baylin
Nature Genetics 36, 417–422
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March
letters to nature
Functional interactions between receptors in bacterial chemotaxis
Victor Sourjik and Howard C. Berg
Nature 428, 437–441
(25 March 2004); doi:10.1038/nature02406
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Interactions of GGA3 with the ubiquitin sorting machinery
Rosa Puertollano and Juan S. Bonifacino
Nature Cell Biology 6, 244–251
(March 2004); doi:10.1038/ncb1106
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GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network
Patricia M. Scott, Patricia S. Bilodeau, Olga Zhdankina, Stanley C. Winistorfer, Melissa J. Hauglund, Margaret M. Allaman, William R. Kearney, Andrew D. Robertson, Annette L. Boman and Robert C. Piper
Nature Cell Biology 6, 252–259
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GGAing ubiquitin to the endosome
Markus Babst
Nature Cell Biology 6, 175–177
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B cell receptor signal strength determines B cell fate
Stefano Casola, Kevin L Otipoby, Marat Alimzhanov, Sibille Humme, Nathalie Uyttersprot, Jeffery L Kutok, Michael C Carroll and Klaus Rajewsky
Nature Immunology 5, 317–327
(March 2004); doi:10.1038/ni1036
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Creation of AMPA-silent synapses in the neonatal hippocampus
Min-Yi Xiao, Pontus Wasling, Eric Hanse and Bengt Gustafsson
Nature Neuroscience 7, 236–243
(March 2004); doi:10.1038/nn1196
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Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
William Ju, Wade Morishita, Jennifer Tsui, Guido Gaietta, Thomas J Deerinck, Stephen R Adams, Craig C Garner, Roger Y Tsien, Mark H Ellisman and Robert C Malenka
Nature Neuroscience 7, 244–253
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Cancer: Dangerous liaisons
Allan Balmain and Rosemary J. Akhurst
Nature 428, 271–272
(18 March 2004); doi:10.1038/428271a
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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex
Sha Mi, Xinhua Lee, Zhaohui Shao, Greg Thill, Benxiu Ji, Jane Relton, Melissa Levesque, Norm Allaire, Steve Perrin, Bryan Sands, Thomas Crowell, Richard L Cate, John M McCoy and R Blake Pepinsky
Nature Neuroscience 7, 221–228
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review article
Molecular mechanisms of taste-recognition memory
Federico Bermúdez-Rattoni
Nature Reviews Neuroscience 5, 209–217
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Cis association of Ly49A with MHC class I restricts natural killer cell inhibition
Marie-Agnés Doucey, Léonardo Scarpellino, Jacques Zimmer, Philippe Guillaume, Immanuel F Luescher, Claude Bron and Werner Held
Nature Immunology 5, 328–336
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Having it both ways: MHC recognition in cis and trans
Paul J Leibson and Larry R Pease
Nature Immunology 5, 237–238
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letters to nature
A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex
Sathees C. Raghavan, Patrick C. Swanson, Xiantuo Wu, Chih-Lin Hsieh and Michael R. Lieber
Nature 428, 88–93
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Molecular biology: Case of mistaken identity
Craig H. Bassing and Frederick W. Alt
Nature 428, 29–31
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Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo
Xiaolong Liu and Rémy Bosselut
Nature Immunology 5, 280–288
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review article
Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future
Eric Vivier and Nicolas Anfossi
Nature Reviews Immunology 4, 190–198
(March 2004); doi:10.1038/nri1306
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February
brief communication
Glutamate receptors: RNA editing and death of motor neurons
Yukio Kawahara, Kyoko Ito, Hui Sun, Hitoshi Aizawa, Ichiro Kanazawa and Shin Kwak
Nature 427, 801
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TLR9 signals after translocating from the ER to CpG DNA in the lysosome
Eicke Latz, Annett Schoenemeyer, Alberto Visintin, Katherine A Fitzgerald, Brian G Monks, Cathrine F Knetter, Egil Lien, Nadra J Nilsen, Terje Espevik and Douglas T Golenbock
Nature Immunology 5, 190–198
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Human antibody-Fc receptor interactions illuminated by crystal structures
Jenny M. Woof and Dennis R. Burton
Nature Reviews Immunology 4, 89–99
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The many important facets of T-cell repertoire diversity
Janko Nikolich-Zugich, Mark K. Slifka and Ilhem Messaoudi
Nature Reviews Immunology 4, 123–132
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Presynaptic ionotropic receptors and control of transmitter release
Holly S. Engelman and Amy B. MacDermott
Nature Reviews Neuroscience 5, 135–145
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Bi-directional effects of GABAB receptor agonists on the mesolimbic dopamine system
Hans G Cruz, Tatiana Ivanova, Marie-Louise Lunn, Markus Stoffel, Paul A Slesinger and Christian Lüscher
Nature Neuroscience 7, 153–159
(February 2004); doi:10.1038/nn1181
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Label-free detection becomes crystal clear
Paul S Cremer
Nature Biotechnology 22, 172–173
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Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death
Jagan R Muppidi and Richard M Siegel
Nature Immunology 5, 182–189
(February 2004); doi:10.1038/ni1024
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Right place, right time
Christopher J Froelich
Nature Immunology 5, 124–125
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Identification of amino acid residues crucial for chemokine receptor dimerization
Patricia Hernanz-Falcón, José Miguel Rodríguez-Frade, Antonio Serrano, David Juan, Antonio del Sol, Silvia F Soriano, Fernando Roncal, Lucio Gómez, Alfonso Valencia, Carlos Martínez-A and Mario Mellado
Nature Immunology 5, 216–223
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Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area
Steven R Laviolette, Roger A Gallegos, Steven J Henriksen and Derek van der Kooy
Nature Neuroscience 7, 160–169
(February 2004); doi:10.1038/nn1182
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Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction
Diane S Lidke, Peter Nagy, Rainer Heintzmann, Donna J Arndt-Jovin, Janine N Post, Hernan E Grecco, Elizabeth A Jares-Erijman and Thomas M Jovin
Nature Biotechnology 22, 198–203
(February 2004); doi:10.1038/nbt929
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Enlightened receptor dynamics
Gal Gur and Yosef Yarden
Nature Biotechnology 22, 169–170
(February 2004); doi:10.1038/nbt0204-169
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N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation
Naruhisa Ota, Tom J Brett, Theresa L Murphy, Daved H Fremont and Kenneth M Murphy
Nature Immunology 5, 208–215
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review article
Cytokine-receptor pairing: accelerating discovery of cytokine function
Don Foster, Julia Parrish-Novak, Brian Fox and Wenfeng Xu
Nature Reviews Drug Discovery 3, 160–170
(February 2004); doi:10.1038/nrd1305
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January
letters to nature
SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans
Yi Zheng, Jerry E. Mellem, Penelope J. Brockie, David M. Madsen and Andres V. Maricq
Nature 427, 451–457
(29 January 2004); doi:10.1038/nature02244
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letter
Mutant Frizzled 4 associated with vitreoretinopathy traps wild-type Frizzled in the endoplasmic reticulum by oligomerization
Ajamete Kaykas, Julia Yang-Snyder, Madeleine Héroux, Kavita V. Shah, Michel Bouvier and Randall T. Moon
Nature Cell Biology 6, 52–58
(January 2004); doi:10.1038/ncb1081
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review article
The GGA proteins: adaptors on the move
Juan S. Bonifacino
Nature Reviews Molecular Cell Biology 5, 23–32
(January 2004); doi:10.1038/nrm1279
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Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
Qiaojia Huang, Jianhua Yang, Yong Lin, Christopher Walker, Jinke Cheng, Zheng-gang Liu and Bing Su
Nature Immunology 5, 98–103
(January 2004); doi:10.1038/ni1014
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Molecular determinants of resistance to antiandrogen therapy
Charlie D Chen, Derek S Welsbie, Chris Tran, Sung Hee Baek, Randy Chen, Robert Vessella, Michael G Rosenfeld and Charles L Sawyers
Nature Medicine 10, 33–39
(January 2004); doi:10.1038/nm972
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news and views
Androgen receptor outwits prostate cancer drugs
John T Isaacs and William B Isaacs
Nature Medicine 10, 26–27
(January 2004); doi:10.1038/nm0104-26
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brief communication
Modifying quinolone antibiotics yields new anxiolytics
Timothy B C Johnstone, Derk J Hogenkamp, Leanne Coyne, Jiping Su, Robert F Halliwell, Minhtam B Tran, Ryan F Yoshimura, Wen-Yen Li, Jeff Wang and Kelvin W Gee
Nature Medicine 10, 31–32
(January 2004); doi:10.1038/nm967
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HTLV-1 sweet-talks its way into cells
Julie Overbaugh
Nature Medicine 10, 20–21
(January 2004); doi:10.1038/nm0104-20
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letter
The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
Ralph T. Böttcher, Nicolas Pollet, Hajo Delius and Christof Niehrs
Nature Cell Biology 6, 38–44
(January 2004); doi:10.1038/ncb1082
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THC: moderation during implantation
Daniele Piomelli
Nature Medicine 10, 19–20
(January 2004); doi:10.1038/nm0104-19
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review article
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Anthony W. Norman , Mathew T. Mizwicki and Derek P. G. Norman
Nature Reviews Drug Discovery 3, 27–41
(January 2004); doi:10.1038/nrd1283
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Substrate twinning activates the signal recognition particle and its receptor
Pascal F. Egea, Shu-ou Shan, Johanna Napetschnig, David F. Savage, Peter Walter and Robert M. Stroud
Nature 427, 215–221
(15 January 2004); doi:10.1038/nature02250
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The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens
You-Wen He, Hong Li, Jun Zhang, Chia-Lin Hsu, Emily Lin, Nu Zhang, Jian Guo, Katherine A Forbush and Michael J Bevan
Nature Immunology 5, 88–97
(January 2004); doi:10.1038/ni1021
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Mindin the fort
Christine McDonald and Gabriel Nuñez
Nature Immunology 5, 16–18
(January 2004); doi:10.1038/ni0104-16
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Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
Li Hua Wang, Xiao Yi Yang, Xiaohu Zhang, Kelly Mihalic, Ying-Xin Fan, Weihua Xiao, O M Zack Howard, Ettore Appella, And |
