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Research library: Membrane receptors/Ligands

2006: December | November | October | September | August | July | June | May | April | March | February | January

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letter
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Rongsheng Jin, Andreas Rummel, Thomas Binz and Axel T. Brunger
Nature 444, 1092–1095
(21 December 2006); doi:10.1038/nature05387
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letter
Structural basis of cell surface receptor recognition by botulinum neurotoxin B
Qing Chai, Joseph W. Arndt, Min Dong, William H. Tepp, Eric A. Johnson, Edwin R. Chapman and Raymond C. Stevens
Nature 444, 1096–1100
(21 December 2006); doi:10.1038/nature05411
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review
Membrane-protein topology
Gunnar von Heijne
Nature Reviews Molecular Cell Biology 7, 909–918
(December 2006); doi:10.1038/nrm2063
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review
Tuning inflammation and immunity by chemokine sequestration: decoys and more
Alberto Mantovani, Raffaella Bonecchi and Massimo Locati
Nature Reviews Immunology 7, 907–918
(December 2006); doi:10.1038/nri1964
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news and analysis
Panitumumab
Leonard Saltz, Chris Easley and Peter Kirkpatrick
Nature Reviews Drug Discovery 5, 987–988
(December 2006); doi:10.1038/nrd2204
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article
A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans
David Biron, Mayumi Shibuya, Christopher Gabel, Sara M Wasserman, Damon A Clark, Adam Brown, Piali Sengupta & Aravinthan D T Samuel
Nature Neuroscience 9, 1499–1505
(December 2006); doi:10.1038/nn1796
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article
Dynorphin A activates bradykinin receptors to maintain neuropathic pain
Josephine Lai, Miaw-Chyi Luo, Qingmin Chen, Shouwu Ma, Luis R Gardell, Michael H Ossipov & Frank Porreca
Nature Neuroscience 9, 1534–1540
(December 2006); doi:10.1038/nn1804
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article
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
Karin Loser, Annette Mehling, Stefanie Loeser, Jenny Apelt, Annegret Kuhn, Stephan Grabbe, Thomas Schwarz, Josef M Penninger & Stefan Beissert
Nature Medicine 12, 1372–1379
(December 2006); doi:10.1038/nm1518
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news and views
Skin controls immune regulators
Tomoyuki Yamaguchi & Shimon Sakaguchi
Nature Medicine 12, 1358–1359
(December 2006); doi:10.1038/nm1206-1358
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letter
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Itaru Urakawa, Yuji Yamazaki, Takashi Shimada, Kousuke Iijima, Hisashi Hasegawa, Katsuya Okawa, Toshiro Fujita, Seiji Fukumoto and Takeyoshi Yamashita
Nature 444, 770–774
(7 December 2006); doi:10.1038/nature05315
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article
The P2Y12 receptor regulates microglial activation by extracellular nucleotides
Sharon E Haynes, Gunther Hollopeter, Guang Yang, Dana Kurpius, Michael E Dailey, Wen-Biao Gan & David Julius
Nature Neuroscience 9, 1512–1519
(December 2006); doi:10.1038/nn1805
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news and views
Triggering the brain's pathology sensor
Helmut Kettenmann
Nature Neuroscience 9, 1463–1464
(December 2006); doi:10.1038/nn1206-1463
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article
Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs
Attila Mócsai, Clare L Abram, Zoltán Jakus, Yongmei Hu, Lewis L Lanier & Clifford A Lowell
Nature Immunology 7, 1326–1333
(December 2006); doi:10.1038/ni1407
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news and views
Integrins and ITAMs: more than just good neighbors
Mark L Kahn & Gary A Koretzky
Nature Immunology 7, 1286–1288
(December 2006); doi:10.1038/ni1206-1286
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letter
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
Alastair M. Hosie, Megan E. Wilkins, Helena M. A. da Silva and Trevor G. Smart
Nature 444, 486–489
(23 November 2006); doi:10.1038/nature05324
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review
Toll-like receptors in systemic autoimmune disease
Ann Marshak-Rothstein
Nature Reviews Immunology 6, 823–835
(November 2006); doi:10.1038/nri1957
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article
IGF-I specifically enhances axon outgrowth of corticospinal motor neurons
P Hande Özdinler & Jeffrey D Macklis
Nature Neuroscience 9, 1371–1381
(November 2006); doi:10.1038/nn1789
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article
RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development
Yi Gu, Hee-Don Chae, Jamie E Siefring, Aparna C Jasti, David A Hildeman & David A Williams
Nature Immunology 7, 1182–1190
(November 2006); doi:10.1038/ni1396
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letter
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Adam Friedman and Norbert Perrimon
Nature 444, 230–234
(09 November 2006); doi:10.1038/nature05280
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letter
Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor
air Ben-Chaim1, Baron Chanda, Nathan Dasca, Francisco Bezanilla, Itzchak Parnas and Hanna Parnas1
Nature 444, 106–109
(02 November 2006); doi:10.1038/nature05259
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review
The CARMA1 signalosome links the signalling machinery of adaptive and innate immunity in lymphocytes
David J. Rawlings, Karen Sommer and Miguel E. Moreno-García
Nature Reviews Immunology 6, 799–812
(November 2006); doi:10.1038/nri1944
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review
Receptor editing in lymphocyte development and central tolerance
David Nemazee
Nature Reviews Immunology 6, 728–740
(October 2006); doi:10.1038/nri1939
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article
Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport
Sara K Custer, Gwenn A Garden, Nishi Gill, Udo Rueb, Randell T Libby, Christian Schultz, Stephan J Guyenet, Thomas Deller, Lesnick E Westrum, Bryce L Sopher & Albert R La Spada
Nature Neuroscience 9, 1302–1311
(September 2006); doi:10.1038/nn1750
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news and views
Intercellular miscommunication in polyglutamine pathogenesis
Christopher A Ross & Don W Cleveland
Nature Neuroscience 9, 1205–1206
(September 2006); doi:10.1038/nn1006-1205
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perspective
Channelrhodopsin-2 and optical control of excitable cells
Feng Zhang, Li-Ping Wang, Edward S Boyden & Karl Deisseroth
Nature Methods 5, 785–792
(October 2006); doi:10.1038/nmeth936
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article
State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling
Mark Sevecka & Gavin MacBeath
Nature Methods 5, 825–831
(October 2006); doi:10.1038/nmeth931
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article
Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1
Kyung-Chul Choi, Youn Sook Lee, Seunghwan Lim, Hyo Kyoung Choi, Chang-Hun Lee, Eun-Kyung Lee, Suntaek Hong, In-Hoo Kim, Seong-Jin Kim & Seok Hee Park
Nature Immunology 7, 1057–1065
(2006); doi:10.1038/ni1383
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article
Focal adhesion kinase signaling at sites of integrin-mediated adhesion controls axon pathfinding
Estuardo Robles & Timothy M Gomez
Nature Neurology 9, 1274–1283
(2006); doi:10.1038/nn1762
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news and views
Complementary therapies for inflammation
Yi Wang
Nature Biotechnology 24, 1224–1226
(2006); doi:10.1038/nbt1006-1224
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news and views
Signalling platforms that modulate the inflammatory response: new targets for drug development
Christopher. A. McCulloch, Gregory P. Downey and Hani El-Gabalawy
Nature Reviews Drug Discovery 5, 864–876
(2006); doi:10.1038/nrd2109
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letter
Bidirectional control of CNS capillary diameter by pericytes
Claire M. Peppiatt, Clare Howarth, Peter Mobbs and David Attwell
Nature 443, 700–704
(12 October 2006); doi:10.1038/nature05193
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article
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
Michael Carty, Rory Goodbody, Martina Schröder, Julianne Stack, Paul N Moynagh & Andrew G Bowie
Nature Immunology 7, 1074–1081
(2006); doi:10.1038/ni1382
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news and views
DisSARMing Toll-like receptor signaling
Luke A J O'Neill
Nature Immunology 7, 1023–1025
(2006); doi:10.1038/ni1006-1023
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review
Receptor editing in lymphocyte development and central tolerance
David Nemazee
Nature Reviews Immunology 7, 728–740
(2006); doi:10.1038/nri1939
| Summary | Full Text (HTML / PDF) |

article
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
Liming Pei, Hironori Waki, Bhavapriya Vaitheesvaran, Damien C Wilpitz, Irwin J Kurland & Peter Tontonoz
Nature Medicine 12, 1048–1055
(2006); doi:10.1038/nm1471
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letter
TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis
Carolyn G King, Takashi Kobayashi, Pedro J Cejas, Taesoo Kim, Kwiyeom Yoon, Gregory K Kim, Elise Chiffoleau, Somia P Hickman, Patrick T Walsh, Laurence A Turka & Yongwon Choi
Nature Medicine 12, 1088–1092
(2006); doi:10.1038/nm1449
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review
Mechanisms of cutaneous toxicities to EGFR inhibitors
Mario E. Lacouture
Nature Reviews Cancer 6, 803–812
(October 2006); doi:10.1038/nrc1970
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review
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
Kenya Honda and Tadatsugu Taniguchi
Nature Reviews Immunology 6, 644–658
(September 2006); doi:10.1038/nri1900
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letter
Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning
John A. D'Orazio, Tetsuji Nobuhisa, Rutao Cui, Michelle Arya, Malinda Spry, Kazumasa Wakamatsu, Vivien Igras, Takahiro Kunisada, Scott R. Granter, Emi K. Nishimura, Shosuke Ito and David E. Fisher
Nature 443, 340–344
(21 September 2006); doi:10.1038/nature05098
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letter
Structure of the insulin receptor ectodomain reveals a folded-over conformation
Neil M. McKern, Michael C. Lawrence, Victor A. Streltsov, Mei-Zhen Lou, Timothy E. Adams, George O. Lovrecz, Thomas C. Elleman, Kim M. Richards, John D. Bentley, Patricia A. Pilling, Peter A. Hoyne, Kellie A. Cartledge, Tam M. Pham, Jennifer L. Lewis, Sonia E. Sankovich, Violet Stoichevska, Elizabeth Da Silva, Christine P. Robinson, Maurice J. Frenkel, Lindsay G. Sparrow, Ross T. Fernley, V. Chandana Epa and Colin W. Ward
Nature 443, 218–221
(14 September 2006); doi:10.1038/nature05106
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opinion
Toll-like receptors as molecular switches
Nicholas J. Gay, Monique Gangloff and Alexander N. R. Weber
Nature Reviews Immunology 6, 693–698
(September 2006); doi:10.1038/nri1916
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article
Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth
Qiyu Feng, Dan Baird, Xu Peng, Jianbin Wang, Thi Ly, Jun-Lin Guan & Richard A. Cerione
Nature Cell Biology 8, 945–956
(September 2006); doi:10.1038/ncb1453
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news and views
Src transforms in a Cool way
Jeffrey R. Peterson & Jonathan Chernoff
Nature Cell Biology 8, 905–907
(September 2006); doi:10.1038/ncb0906-905
| Summary | Full Text (HTML / PDF) |

letter
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
Ayumu Tashiro, Vladislav M. Sandler, Nicolas Toni, Chunmei Zhao and Fred H. Gage
Nature 442, 929–933
(24 August 2006); doi:10.1038/nature05028
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article
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
Yisong Y Wan, Hongbo Chi, Min Xie, Michael D Schneider & Richard A Flavell
Nature Immunology 7, 851–858
(August 2006); doi:10.1038/ni1355
| Summary | Full Text (HTML / PDF) |

letter
ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
Nikos Tapinos, Makoto Ohnishi & Anura Rambukkana
Nature Medicine 12, 961–966
(August 2006); doi:10.1038/nm1433
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article
A second class of chemosensory receptors in the olfactory epithelium
Stephen D. Liberles and Linda B. Buck
Nature 442, 645–650
(10 August 2006); doi:10.1038/nature05066
| Summary | Full Text (HTML / PDF) |

news and views
Neuroscience: An extra dimension to olfaction
John Ngai
Nature 442, 637–638
(10 August 2006); doi:10.1038/nature05001
| Full Text (HTML / PDF) |

letter
Mesodermal Wnt2b signalling positively regulates liver specification
Elke A. Ober, Heather Verkade, Holly A. Field and Didier Y. R. Stainier
Nature 442, 688–691
(10 August 2006); doi:10.1038/nature04888
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article
The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl–Crk pathway
Nicole K. Noren, Gabriele Foos, Craig A. Hauser & Elena B. Pasquale
Nature Cell Biology 8, 815–825
(10 August 2006); doi:10.1038/ncb1438
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news and views
Eph tumour suppression: the dark side of Gleevec
Jean Y. J. Wang
Nature Cell Biology 8, 785–786
(10 August 2006); doi:10.1038/ncb0806-785
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review
P2X receptors as cell-surface ATP sensors in health and disease
Baljit S. Khakh and R. Alan North
Nature 442, 527–532
(02 August 2006); doi:10.1038/nature04886
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article
JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport
Gerardo Morfini, Gustavo Pigino, Györgyi Szebenyi, Yimei You, Sarah Pollema & Scott T Brady
Nature Neuroscience 9, 907–916
(June 2006); doi:10.1038/nn1717
| Summary | Full Text (HTML / PDF) |

article
Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation
Seiichi Kuwajima, Taku Sato, Kazuto Ishida, Hiroyuki Tada, Hiroyuki Tezuka & Toshiaki Ohteki
Nature Immunology 7, 740–746
(July 2006); doi:10.1038/ni1348
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news and views
Division of labor and cooperation between dendritic cells
Bali Pulendran
Nature Immunology 7, 699–700
(July 2006); doi:10.1038/ni0706-699
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article
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Betty Y Y Tam, Kevin Wei, John S Rudge, Jana Hoffman, Joceyln Holash, Sang-ki Park, Jenny Yuan, Colleen Hefner, Cecile Chartier, Jeng-Shin Lee, Shelly Jiang, Nihar R Niyak, Frans A Kuypers, Lisa Ma, Uma Sundram, Grace Wu, Joseph A Garcia, Stanley L Schrier, Jacquelyn J Maher, Randall S Johnson, George D Yancopoulos, Richard C Mulligan & Calvin J Kuo
Nature Medicine 7, 793–800
(July 2006); doi:10.1038/nm1428
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news and views
VEGF inhibitors make blood
Christian Fischer, Peter Carmeliet & Edward M Conway
Nature Medicine 7, 732–734
(July 2006); doi:10.1038/nm0706-732
| Summary | Full Text (HTML / PDF) |

letter
Altered neuregulin 1-erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia
Chang-Gyu Hahn, Hoau-Yan Wang, Dan-Sung Cho, Konrad Talbot, Raquel E Gur, Wade H Berrettini, Kalindi Bakshi, Joshua Kamins, Karin E Borgmann-Winter, Steven J Siegel, Robert J Gallop & Steven E Arnold
Nature Medicine 442, 824–828
(July 2006); doi:10.1038/nm1418
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news and views
Schizophrenia: signals from the other side
Gerald D Fischbach
Nature Medicine 7, 734–1735
(July 2006); doi:10.1038/nm0706-734
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review
EGF-ERBB signalling: towards the systems level
Ami Citri and Yosef Yarden
Nature Reviews Molecular Cell Biology 7, 505–516
(July 2006); doi:10.1038/nrm1962
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article
Fas ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity
Veronika Groh, Kimberly Smythe, Zhenpeng Dai & Thomas Spies
Nature Immunology 7, 755–762
(28 May 2006); doi:10.1038/ni1350
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article
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia, Brendan W Wren, Peter Mullany, Neil F Fairweather, Nigel Minton, Richard Stabler, Nicholas R Thomson, Adam P Roberts, Ana M Cerdeño-Tárraga, Hongmei Wang, Matthew TG Holden, Anne Wright, Carol Churcher, Michael A Quail, Stephen Baker, Nathalie Bason, Karen Brooks, Tracey Chillingworth, Ann Cronin, Paul Davis, Linda Dowd, Audrey Fraser, Theresa Feltwell, Zahra Hance, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Mark Simmonds, Kim Stevens, Louise Unwin, Sally Whithead, Bruno Dupuy, Gordon Dougan, Bart Barrell & Julian Parkhill
Nature Genetics 38, 779–786
(25 June 2006); doi:10.1038/ng1830
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review
Intracellular pattern recognition receptors in the host response
Etienne Meylan, Jürg Tschopp and Michael Karin
Nature 442, 39–44
(06 July 2006); doi:10.1038/nature04946
| Summary | Full Text (HTML / PDF) |

article
AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc
Vikram R Rao, Sean A Pintchovski, Jeannie Chin, Carol L Peebles, Siddhartha Mitra & Steven Finkbeiner
Nature Neuroscience 7, 887–895
(July 2006); doi:10.1038/nn1708
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review article
Therapeutic potential of Toll-like receptor 9 activation
Arthur M. Krieg
Nature Reviews Drug Discovery 5, 471–484
(June 2006); doi:10.1038/nrd2059
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letter
Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis
Noriko Takegahara, Hyota Takamatsu, Toshihiko Toyofuku, Tohru Tsujimura, Tatsusada Okuno, Kazunori Yukawa, Masayuki Mizui, Midori Yamamoto, Durbaka V.R. Prasad, Kazuhiro Suzuki, Masaru Ishii, Kenta Terai, Masayuki Moriya, Yuji Nakatsuji, Saburo Sakoda, Shintaro Sato, Shizuo Akira, Kiyoshi Takeda, Masanori Inui, Toshiyuki Takai, Masahito Ikawa, Masaru Okabe, Atsushi Kumanogoh & Hitoshi Kikutani
Nature Cell Biology 8, 615 - 622
(June 2006); doi:10.1038/ncb1416
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news and views
Semaphorin pathways orchestrate osteogenesis
Luca Tamagnone & Silvia Giordano
Nature Cell Biology 8, 545 - 547
(June 2006); doi:10.1038/ncb0606-545
| Summary | Full Text (HTML / PDF) |

news and views
TGF-ß, a 'double agent' in the immune pathology war
Daniel J Cua & Robert A Kastelein
Nature Immunology 7, 557 - 559
(June 2006); doi:10.1038/ni0606-557
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letter
Social interactions among epithelial cells during tracheal branching morphogenesis
Amin S. Ghabrial and Mark A. Krasnow
Nature 441, 746–749
(08 June 2006); doi:10.1038/nature04829
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review article
The SIRP family of receptors and immune regulation
A. Neil Barclay and Marion H. Brown
(June 2006); doi:10.1038/nri1859
| Summary | Full Text (HTML / PDF) |

news and views
Predictable trends in protein noise
Craig R Roy and Dario S Zamboni
Nature Genetics 38, 610–611
(June 2006); doi:10.1038/ng0606-610
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article
Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O
Takafumi Shintani, Masaru Ihara, Hiraki Sakuta, Hiroo Takahashi, Ikuko Watakabe and Masaharu Noda
Nature Neuroscience 9, 761–769
(08 June 2006); doi:10.1038/nn1697
| First Paragraph | Full Text (HTML / PDF) |

letter
Syndecan-4 regulates non-canonical Wnt signalling and is essential for convergent and extension movements in Xenopus embryos
Rosana Muñoz, Mauricio Moreno, Carlos Oliva, Claudio Orbenes & Juan Larraín
Nature Cell Biology 8, 492–500
(May 2006); doi:10.1038/ncb1399
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article
The thioredoxin-related redox-regulating protein nucleoredoxin inhibits Wnt–ß–catenin signalling through Dishevelled
Yosuke Funato, Tatsuo Michiue, Makoto Asashima & Hiroaki Miki
Nature Cell Biology 8, 501–508
(May 2006); doi:10.1038/ncb1405
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article
Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1
Roi Gazit, Raizy Gruda, Moran Elboim, Tal I Arnon, Gil Katz, Hagit Achdout, Jacob Hanna, Udi Qimron, Guy Landau, Evgenia Greenbaum, Zichria Zakay-Rones, Angel Porgador & Ofer Mandelboim
Nature Immunology 7, 517–523
(May 2006); doi:10.1038/ni1322
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news and views
Natural cytotoxicity receptors: influenza virus in the spotlight
Thomas Spies & Veronika Groh
Nature Immunology 7, 443–444
(May 2006); doi:10.1038/ni0506-443
| Summary | Full Text (HTML / PDF) |

article
Metabolic biotinylation of cell surface receptors for in vivo imaging
Bakhos A Tannous, Jan Grimm, Katherine F Perry, John W Chen, Ralph Weissleder & Xandra O Breakefield
Nature Methods 3, 391–396
(May 2006); doi:10.1038/nmeth875
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article
Endocytosis and synaptic removal of NR3A–containing NMDA receptors by PACSIN1/syndapin1
Isabel Pérez–Otaño, Rafael Luján, Steven J Tavalin, Markus Plomann, Jan Modregger, Xiao–Bo Liu, Edward G Jones, Stephen F Heinemann, Donald C Lo, Michael D Ehlers
Nature Neuroscience 9, 611–621
(May 2006); doi:10.1038/nn1680
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article
Clearing obsolete NMDA receptors
Annette Markus
Nature Neuroscience 9, 598
(May 2006); doi:10.1038/nn0506-598
| Summary | Full Text (HTML / PDF) |

review
Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling
Richard D. Hayward, John M. Leong, Vassilis Koronakis, Kenneth G. Campellone
Nature Reviews Microbiology 4, 429–435
(May 2006); doi:10.1038/nrmicro1391
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article
NKG2D–mediated signaling requires a DAP10–bound Grb2–Vav1 intermediate and phosphatidylinositol–3–kinase in human natural killer cells
Jadee L Upshaw, Laura N Arneson, Renee A Schoon, Christopher J Dick, Daniel D Billadeau & Paul J Leibson
Nature Immunology 7, 524–532
(May 2006); doi:10.1038/ni1325
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article
Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane
Guillermo A Yudowski, Manojkumar A Puthenveedu & Mark von Zastrow
Nature Neuroscience 9, 622–627
(May 2006); doi:10.1038/nn1679
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letter
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
Ingvar Ferby, Markus Reschke, Oliver Kudlacek, Pjotr Knyazev, Guido Pantè, Kerstin Amann, Wolfgang Sommergruber, Norbert Kraut, Axel Ullrich, Reinhard Fässler & Rüdiger Klein
Nature Medicine 12, 568–573
(May 2006) | doi:10.1038/nm1401
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review article
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia
Clemens Grabher, Harald von Boehmer and A. Thomas Look
Nature Reviews Cancer 6, 347–359
(May 2006); doi:10.1038/nrc1880
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article
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
Jodie L Babitt, Franklin W Huang, Diedra M Wrighting, Yin Xia, Yisrael Sidis, Tarek A Samad, Jason A Campagna, Raymond T Chung, Alan L Schneyer, Clifford J Woolf, Nancy C Andrews & Herbert Y Lin
Nature Genetics 38, 531–539
(May 2006) | doi:10.1038/ng1777
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news and views
Iron metabolism meets signal transduction
Gregory J Anderson & David M Frazer
Nature Genetics 38, 503–503
(May 2006) | doi:10.1038/ng0506-503
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brief communication
Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation
Karen Plant, Kenneth A Pelkey, Zuner A Bortolotto, Daiju Morita, Akira Terashima, Chris J McBain, Graham L Collingridge & John T R Isaac
Nature Neuroscience 9, 602–604
(May 2006) | doi:10.1038/nn1678
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news and views
LTP: AMPA receptors trading places
Julie A Kauer & Robert C Malenka
Nature Neuroscience 9, 593–594
(May 2006) | doi:10.1038/nn0506-593
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Synaptic scaling mediated by glial TNF-α
David Stellwagen and Robert C. Malenka
Nature 440, 1054–1059
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Early hematopoietic lineage restrictions directed by Ikaros
Toshimi Yoshida, Samuel Yao-Ming Ng, Juan Carlos Zuniga-Pflucker & Katia Georgopoulos
Nature Immunology 7, 382–391
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Hematopoiesis flies high with Ikaros
Stephen T Smale & Kenneth Dorshkind
Nature Immunology 7, 367–369
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UNC-6/Netrin induces neuronal asymmetry and defines the site of axon formation
Carolyn E Adler, Richard D Fetter & Cornelia I Bargmann
Nature Neuroscience 9, 511 - 518
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IkB kinase-a is critical for interferon-α production induced by Toll-like receptors 7 and 9
Katsuaki Hoshino, Takahiro Sugiyama, Mitsuru Matsumoto, Takashi Tanaka, Masuyoshi Saito, Hiroaki Hemmi, Osamu Ohara, Shizuo Akira and Tsuneyasu Kaisho
Nature 440, 949–953
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review article
ITAM-mediated tonic signalling through pre-BCR and BCR complexes
John G. Monroe
Nature Reviews Immunology 4, 265–275
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A C. elegans stretch receptor neuron revealed by a mechanosensitive TRP channel homologue
Wei Li, Zhaoyang Feng, Paul W. Sternberg and X. Z. Shawn Xu
Nature 440, 684–687
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review article
CATERPILLERs, pyrin and hereditary immunological disorders
Jenny P.-Y. Ting, Daniel L. Kastner and Hal M. Hoffman
Nature Reviews Immunology 6, 183–195
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Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent
Fabiana S Machado, James E Johndrow, Lisia Esper, Alexandra Dias, Andre Bafica, Charles N Serhan & Julio Aliberti
Nature Medicine 12, 330–334
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Silencing of EphA3 through a cis interaction with ephrinA5
Ricardo F Carvalho, Martin Beutler, Katharine J M Marler, Bernd Knöll, Elena Becker-Barroso, R Heintzmann, Tony Ng & Uwe Drescher
Nature Neuroscience 9, 322–330
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Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2
Natalya V Serbina and Eric G Pamer
Nature Immunology 7, 311–317
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Adenosine receptors as therapeutic targets
Kenneth A. Jacobson and Zhan-Guo Gao
Nature Reviews Drug Discovery 5, 247–264
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research article
Neurotrophins mediate human embryonic stem cell survival
April D Pyle, Leslie F Lock and Peter J Donovan
Nature Biotechnology 24, 344–350
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CD30 is a survival factor and a biomarker for transformed human pluripotent stem cells
Daniella Herszfeld, Ernst Wolvetang, Emma Langton-Bunker, Tung-Liang Chung, Adam A Filipczyk, Souheir Houssami, Pegah Jamshidi, Karen Koh, Andrew L Laslett, Anna Michalska, Linh Nguyen, Benjamin E Reubinoff, Irene Tellis, Jonathan M Auerbach, Carol J Ording, Leendert H J Looijenga and Martin F Pera
Nature Biotechnology 24, 351–357
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cFLIP regulation of lymphocyte activation and development
Ralph C. Budd, Wen-Chen Yeh and Jürg Tschopp
Nature Reviews Immunology 6, 196–204
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Integrated signalling pathways for mast-cell activation
Alasdair M. Gilfillan and Christine Tkaczyk
Nature Reviews Immunology 6, 218–230
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Development of the signal in sensory rhodopsin and its transfer to the cognate transducer
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Nature 440, 115–119
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NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia
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Nature 439, 988–992
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Association of β-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
Yaya Wang, Yawei Tang, Lin Teng, Yalan Wu, Xiaohui Zhao and Gang Pei
Nature Immunology 7, 139–147
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Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling
Brian E Collins, Brian A Smith, Per Bengtson and James C Paulson
Nature Immunology 7, 199–206
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Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity
Takayuki Kawano, Josef Anrather, Ping Zhou, Laibaik Park, Gang Wang, Kelly A Frys, Alexander Kunz, Sunghee Cho, Marcello Orio and Costantino Iadecola
Nature Medicine 12, 225–229
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Retinoic acid receptor β2 promotes functional regeneration of sensory axons in the spinal cord
Liang-Fong Wong, Ping K Yip, Anna Battaglia, John Grist, Jonathan Corcoran, Malcolm Maden, Mimoun Azzouz, Susan M Kingsman, Alan J Kingsman, Nicholas D Mazarakis and Stephen B McMahon
Nature Neuroscience 9, 243–250
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Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
Stuart A. Lipton
Nature Reviews Drug Discovery 5, 160–170
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Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle
Marçal Vilar, Maribel Murillo-Carretero, Helena Mira, Kalle Magnusson, Valerie Besset and Carlos F Ibáñez
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The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1
Karuppiah Muthumani, Andrew Y. Choo, Wei-Xing Zong, Muniswamy Madesh, Daniel S. Hwang, Arumugam Premkumar, Khanh P. Thieu, Joann Emmanuel, Sanjeev Kumar, Craig B. Thompson and David B. Weiner
Nature Cell Biology 8, 170–179
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Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
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Nature Immunology 7, 165–172
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GABA regulates synaptic integration of newly generated neurons in the adult brain
Shaoyu Ge, Eyleen L. K. Goh, Kurt A. Sailor, Yasuji Kitabatake, Guo-li Ming and Hongjun Song
Nature 439, 589–593
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Regulation of ubiquitin-binding proteins by monoubiquitination
Daniela Hoeller, Nicola Crosetto, Blagoy Blagoev, Camilla Raiborg, Ritva Tikkanen, Sebastian Wagner, Katarzyna Kowanetz, Rainer Breitling, Matthias Mann, Harald Stenmark and Ivan Dikic
Nature Cell Biology 8, 163–169
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Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
Ashley Mansell, Rosealee Smith, Sarah L Doyle, Pearl Gray, Jennifer E Fenner, Peter J Crack, Sandra E Nicholson, Douglas J Hilton, Luke A J O'Neill and Paul J Hertzog
Nature Immunology 7, 148–155
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Mal-function of TLRs by SOCS
Takashi Kobayashi, Giichi Takaesu and Akihiko Yoshimura
Nature Immunology 7, 123–124
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Kinase cogs go forward and reverse in the Wnt signaling machine
Trevor Dale
Nature Structural and Molecular Biology 13, 9–11
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The RNA-binding protein FCA is an abscisic acid receptor
Fawzi A. Razem, Ashraf El-Kereamy, Suzanne R. Abrams and Robert D. Hill
Nature 439, 290–294
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review article
SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond
Gary A. Koretzky, Farhad Abtahian and Michael A. Silverman
Nature Reviews Immunology 6, 67–78
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Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Hans Häcker, Vanessa Redecke, Blagoy Blagoev, Irina Kratchmarova, Li-Chung Hsu, Gang G. Wang, Mark P. Kamps, Eyal Raz, Hermann Wagner, Georg Häcker, Matthias Mann and Michael Karin
Nature 439, 204–207
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Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Gagik Oganesyan, Supriya K. Saha, Beichu Guo, Jeannie Q. He, Arash Shahangian, Brian Zarnegar, Andrea Perry and Genhong Cheng
Nature 439, 208–211
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review article
Dectin-1: a signalling non-TLR pattern-recognition receptor
Gordon D. Brown
Nature Reviews Immunology 6, 33–43
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IL-13 signaling through the IL-13α2 receptor is involved in induction of TGF-β1 production and fibrosis
Stefan Fichtner-Feigl, Warren Strober, Koji Kawakami, Raj K Puri and Atsushi Kitani
Nature Medicine 12, 99–106
(January 2006); doi:10.1038/nm1332
| Abstract | Full Text (HTML/PDF) |

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Mechanistic basis of pre-T cell receptor–mediated autonomous signaling critical for thymocyte development
Sho Yamasaki, Eri Ishikawa, Machie Sakuma, Koji Ogata, Kumiko Sakata-Sogawa, Michio Hiroshima, David L Wiest, Makio Tokunaga and Takashi Saito
Nature Immunology 7, 67–75
(January 2006); doi:10.1038/ni1290
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review article
Immune regulation by SLAM family receptors and SAP-related adaptors
André Veillette
Nature Reviews Immunology 6, 56–66
(January 2006); doi:10.1038/nri1761
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ORL1 receptor-mediated internalization of N-type calcium channels
Christophe Altier, Houman Khosravani, Rhian M Evans, Shahid Hameed, Jean B Peloquin, Brian A Vartian, Lina Chen, Aaron M Beedle, Stephen S G Ferguson, Alexandre Mezghrani, Stefan J Dubel, Emmanuel Bourinet, John E McRory and Gerald W Zamponi
Nature Neuroscience 9, 31–40
(January 2006); doi:10.1038/nn1605
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Internalizing channels: a mechanism to control pain?
Diane Lipscombe and Jesica Raingo
Nature Neuroscience 9, 8–10
(January 2006); doi:10.1038/nn0106-8
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