Research library: Membrane receptors/Ligands

2007: December | November | October | September | August | July | June | May | April | March | February | January

Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2008

December

letter
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
Miguel A. Sanjuan et al.
Nature 450, 1253–1257
(20 December 2007); doi:10.1038/nature06421
| Summary | Full Text (HTML / PDF) |

article
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage
Nicole C Kaneider et al.
Nature Immunology 8, 1303–1312
(December 2007); doi:10.1038/ni1525
| Summary | Full Text (HTML / PDF) |

letter
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes
Marta Fernández-Suárez et al.
Nature Biotechnology 25, 1483–1487
(December 2007); doi:10.1038/nbt1355
| Summary | Full Text (HTML / PDF) |

news and views
A monkey wrench in the kinase machine
Daniel J Leahy
Nature Structural & Molecular Biology 14, 1120–1121
(December 2007); doi:10.1038/nsmb1207-1120
| Full Text (HTML / PDF) |

scientific report
Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein
Ryosuke Usui, Masabumi Shibuya, Shun Ishibashi & Yoshiro Maru
EMBO Reports 8, 1155–1161
(December 2007); doi:10.1038/sj.embor.7401103
| Summary | Full Text (HTML / PDF) |

article
Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
Thierry Walzer et al.
Nature Immunology 8, 1337–1344
(December 2007); doi:10.1038/ni1523
| Summary | Full Text (HTML / PDF) |

review
Engulfment of apoptotic cells: signals for a good meal
Kodi S. Ravichandran & Ulrike Lorenz
Nature Reviews Immunology 7, 964–974
(December 2007); doi:10.1038/nri2214
| Summary | Full Text (HTML / PDF) |

review
Glutamate transporters: confining runaway excitation by shaping synaptic transmission
Anastassios V. Tzingounis & Jacques I. Wadiche
Nature Reviews Neuroscience 8, 935–947
(December 2007); doi:10.1038/nrn2274
| Summary | Full Text (HTML / PDF) |

scientific report
Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors
Emma Sandilands, Shiva Akbarzadeh, Anna Vecchione, David G McEwan, Margaret C Frame & John K Heath
EMBO Reports 8, 1162–1169
(December 2007); doi:10.1038/sj.embor.7401097
| Summary | Full Text (HTML / PDF) |

review
Cooperation of signalling pathways in embryonic mammary gland development
Gertraud W. Robinson
Nature Reviews Genetics 8, 963–972
(December 2007); doi:10.1038/nrg2227
| Summary | Full Text (HTML / PDF) |

review
Interferons at age 50: past, current and future impact on biomedicine
Ernest C. Borden et al.
Nature Reviews Drug Discovery 6, 975–990
(December 2007); doi:10.1038/nrd2422
| Summary | Full Text (HTML / PDF) |

November

letter
Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Xuewu Zhang, Kerry A. Pickin, Ron Bose, Natalia Jura, Philip A. Cole & John Kuriyan
Nature 450, 741–744
(29 November 2007); doi:10.1038/nature05998
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review
Extracellular control of TGFβ signalling in vascular development and disease
Peter ten Dijke & Helen M. Arthur
Nature Reviews Molecular Cell Biology 8, 857–869
(November 2007); doi:10.1038/nrm2262
| Summary | Full Text (HTML / PDF) |

article
COP9 signalosome subunit 8 is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence
Suchithra Menon, Hongbo Chi, Huiyong Zhang, Xing Wang Deng, Richard A Flavell & Ning Wei
Nature Immunology 8, 1236–1245
(November 2007); doi:10.1038/ni1514
| Summary | Full Text (HTML / PDF) |

article
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
Chengbin Wu et al.
Nature Biotechnology 25, 1290–1297
(November 2007); doi:10.1038/nbt1345
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news and views
Two heads are better than one
Sherie L Morrison
Nature Biotechnology 25, 1233–1234
(November 2007); doi:10.1038/nbt1107-1233
| Summary | Full Text (HTML / PDF) |

letter
Identification of Tim4 as a phosphatidylserine receptor
Masanori Miyanishi, Kazutoshi Tada, Masato Koike, Yasuo Uchiyama, Toshio Kitamura & Shigekazu Nagata
Nature 450, 435–439
(15 November 2007); doi:10.1038/nature06307
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letter
EphB–ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells
Carme Cortina et al.
Nature Genetics 39, 1376–1383
(November 2007); doi:10.1038/ng.2007.11
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article
Hedgehog regulates smoothened activity by inducing a conformational switch
Yun Zhao, Chao Tong & Jin Jiang
Nature 450, 252–258
(8 November 2007); doi:10.1038/nature06225
| Summary | Full Text (HTML / PDF) |

letter
An essential role for a CD36-related receptor in pheromone detection in Drosophila
Richard Benton, Kirsten S. Vannice & Leslie B. Vosshall
Nature 450, 289–293
(8 November 2007); doi:10.1038/nature06328
| Summary | Full Text (HTML / PDF) |

letter
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA
Di Yu et al.
Nature 450, 299–303
(8 November 2007); doi:10.1038/nature06253
| Summary | Full Text (HTML / PDF) |

article
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
Rossana Zaru, Natalia Ronkina, Matthias Gaestel, J Simon C Arthur & Colin Watts
Nature Immunology 8, 1227–1235
(November 2007); doi:10.1038/ni1517
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review
Common themes in the assembly and architecture of activating immune receptors
Matthew E. Call & Kai W. Wucherpfennig
Nature Reviews Immunology 7, 841–850
(November 2007); doi:10.1038/nri2186
| Summary | Full Text (HTML / PDF) |

review
Astrocyte metabolism and signaling during brain ischemia
David J Rossi, James D Brady & Claudia Mohr
Nature Neuroscience 10, 1377–1386
(November 2007); doi:10.1038/nn2004
| Summary | Full Text (HTML / PDF) |

perspective
Proteins, drug targets and the mechanisms they control: the simple truth about complex networks
Robyn P. Araujo, Lance A. Liotta & Emanuel F. Petricoin
Nature Reviews Drug Discovery 6, 871–880
(November 2007); doi:10.1038/nrd2381
| Summary | Full Text (HTML / PDF) |

scientific report
Rapid ligand-regulated gating kinetics of single inositol 1,4,5-trisphosphate receptor Ca²⁺ release channels
Don-On Daniel Mak, John E Pearson, King Pan Campion Loong, Suman Datta, Marisabel Fernández-Mongil & J Kevin Foskett
EMBO Reports 8, 1044–1051
(November 2007); doi:10.1038/sj.embor.7401087
| Summary | Full Text (HTML / PDF) |

review
Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance
Anita Q. Gomes, Daniel V. Correia & Bruno Silva-Santos
EMBO Reports 8, 1024–1030
(November 2007); doi:10.1038/sj.embor.7401090
| Summary | Full Text (HTML / PDF) |

article
Identification of clonogenic common Flt3⁺M–CSFR⁺ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow
Nobuyuki Onai, Aya Obata-Onai, Michael A Schmid, Toshiaki Ohteki, David Jarrossay & Markus G Manz
Nature Immunology 8, 1207–1216
(November 2007); doi:10.1038/ni1518
| Summary | Full Text (HTML / PDF) |

article
Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo
Shalin H Naik et al.
Nature Immunology 8, 1217–1226
(November 2007); doi:10.1038/ni1522
| Summary | Full Text (HTML / PDF) |

news and views
Dendritic cell genealogy: a new stem or just another branch?
Miriam Merad & Florent Ginhoux
Nature Immunology 8, 1199–1201
(November 2007); doi:10.1038/ni1107-1199
| Summary | Full Text (HTML / PDF) |

article
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
Jantje M Gerdes et al.
Nature Genetics 39, 1350–1360
(November 2007); doi:10.1038/ng.2007.12
| Summary | Full Text (HTML / PDF) |

article
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
Pernille Jansen et al.
Nature Neuroscience 10, 1449–1457
(November 2007); doi:10.1038/nn2000
| Summary | Full Text (HTML / PDF) |

October

letter
Purine-mediated signalling triggers eye development
Karine Massé, Surinder Bhamra, Robert Eason, Nicholas Dale & Elizabeth A. Jones
Nature 449, 1058–1062
(25 October 2007); doi:10.1038/nature06189
| Summary | Full Text (HTML / PDF) |

review
Recent advances in antigen processing and presentation
Peter E Jensen
Nature Immunology 8, 1041–1048
(October 2007); doi:10.1038/ni1516
| Summary | Full Text (HTML / PDF) |

letter
Computational design of antibody-affinity improvement beyond in vivo maturation
Shaun M Lippow, K Dane Wittrup, & Bruce Tidor
Nature Biotechnology 25, 1171–1176
(October 2007); doi:10.1038/nbt1336
| Summary | Full Text (HTML / PDF) |

news and views
No free energy lunch
Brian K Shoichet
Nature Biotechnology 25, 1109–1110
(October 2007); doi:10.1038/nbt1007-1109
| Full Text (HTML / PDF) |

article
Helicobacter exploits integrin for type IV secretion and kinase activation
Terry Kwok et al.
Nature 449, 862–866
(18 October 2007); doi:10.1038/nature06187
| Summary | Full Text (HTML / PDF) |

news and views
Microbiology: Preparing the shot
Christof R. Hauck
Nature 449, 798–799
(18 October 2007); doi:10.1038/449798a
| Full Text (HTML / PDF) |

review
Genetic analysis of resistance to viral infection
Bruce Beutler et al.
Nature Reviews Immunology 7, 753–766
(October 2007); doi:10.1038/nri2174
| Summary | Full Text (HTML / PDF) |

letter
Adaptive immune cells temper initial innate responses
Kwang Dong Kim et al.
Nature Medicine 13, 1248–1252
(October 2007); doi:10.1038/nm1633
| Summary | Full Text (HTML / PDF) |

news and views
Not so fast: adaptive suppression of innate immunity
Noah W Palm & Ruslan Medzhitov
Nature Medicine 13, 1142–1144
(October 2007); doi:10.1038/nm1007-1142b
| Summary | Full Text (HTML / PDF) |

brief communication
Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors
Zhiqiang Chen, Sharon G Kujawa & William F Sewell
Nature Neuroscience 10, 1238–1240
(October 2007); doi:10.1038/nn1974
| Summary | Full Text (HTML / PDF) |

review
Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer
David R. Clemmons
Nature Reviews Drug Discovery 6, 821–833
(October 2007); doi:10.1038/nrd2359
| Summary | Full Text (HTML / PDF) |

article
E2–BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
Devin E Christensen, Peter S Brzovic & Rachel E Klevit
Nature Structural & Molecular Biology 14, 941–948
(October 2007); doi:10.1038/nsmb1295
| Summary | Full Text (HTML / PDF) |

article
'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
Jung-Hyun Park, Stanley Adoro, Philip J Lucas, Sophia D Sarafova, Amala S Alag, Loretta L Doan, Batu Erman, Xiaolong Liu, Wilfried Ellmeier, Remy Bosselut, Lionel Feigenbaum & Alfred Singer
Nature Immunology 8, 1049–1059
(October 2007); doi:10.1038/ni1512
| Summary | Full Text (HTML / PDF) |

news and views
CD8⁺ T cells are kept in tune by modulating IL-7 responsiveness
Juan Carlos Zúñiga-Pflücker
Nature Immunology 8, 1027–1028
(October 2007); doi:10.1038/ni1007-1027
| Full Text (HTML / PDF) |

article
Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors
David Soto, Ian D Coombs, Leah Kelly, Mark Farrant & Stuart G Cull-Candy
Nature Neuroscience 10, 1260–1267
(October 2007); doi:10.1038/nn1966
| Summary | Full Text (HTML / PDF) |

news and views
Two in one: dual function of an invertebrate antigen receptor
Thomas Boehm
Nature Immunology 8, 1031–1033
(October 2007); doi:10.1038/ni1007-1031
| Full Text (HTML / PDF) |

article
Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans
Cheryl Van Buskirk & Paul W Sternberg
Nature Neuroscience 10, 1300–1307
(October 2007); doi:10.1038/nn1981
| Summary | Full Text (HTML / PDF) |

September

letter
Structural basis of Dscam isoform specificity
Rob Meijers, Roland Puettmann-Holgado, Georgios Skiniotis, Jin-huan Liu, Thomas Walz, Jia-huai Wang & Dietmar Schmucker
Nature 449, 487–491
(27 September 2007); doi:10.1038/nature06147
| Summary | Full Text (HTML / PDF) |

brief communication
A concentration-dependent switch in the bacterial response to temperature
Hanna Salman & Albert Libchaber
Nature Cell Biology 9, 1098–1100
(September 2007); doi:10.1038/ncb1632
| Summary | Full Text (HTML / PDF) |

news and views
Turning to the cold
Victor Sourjik & Ned S. Wingreen
Nature Cell Biology 9, 1029–1031
(September 2007); doi:10.1038/ncb0907-1029
| Summary | Full Text (HTML / PDF) |

perspective
Promiscuity and the single receptor: NKG2D
Robert A. Eagle & John Trowsdale
Nature Reviews Immunology 7, 737–744
(September 2007); doi:10.1038/nri2144
| Summary | Full Text (HTML / PDF) |

review
Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease
Stephen D. Miller, Danielle M. Turley & Joseph R. Podojil
Nature Reviews Immunology 7, 665–677
(September 2007); doi:10.1038/nri2153
| Summary | Full Text (HTML / PDF) |

letter
Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial
Sandeep T Patil, Lu Zhang, Ferenc Martenyi, Stephen L Lowe, Kimberley A Jackson, Boris V Andreev, Alla S Avedisova, Leonid M Bardenstein, Issak Y Gurovich, Margarita A Morozova, Sergey N Mosolov, Nikolai G Neznanov, Alexander M Reznik, Anatoly B Smulevich, Vladimir A Tochilov, Bryan G Johnson, James A Monn & Darryle D Schoepp
Nature Medicine 13, 1102–1107
(September 2007); doi:10.1038/nm1632
| Summary | Full Text (HTML / PDF) |

news and views
Schizophrenia drug says goodbye to dopamine
Daniel R Weinberger
Nature Medicine 13, 1018–1019
(September 2007); doi:10.1038/nm0907-1018
| Summary | Full Text (HTML / PDF) |

technical report
A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist
Ian R Wilkinson, Eric Ferrandis, Peter J Artymiuk, Marc Teillot, Chantal Soulard, Caroline Touvay, Sarbendra L Pradhananga, Sue Justice, Zida Wu, Kin C Leung, Christian J Strasburger, Jon R Sayers & Richard J Ross
Nature Medicine 13, 1108–1113
(September 2007); doi:10.1038/nm1610
| Summary | Full Text (HTML / PDF) |

article
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Christopher E Lowe, Jason D Cooper, Todd Brusko, Neil M Walker, Deborah J Smyth, Rebecca Bailey, Kirsi Bourget, Vincent Plagnol, Sarah Field, Mark Atkinson, David G Clayton, Linda S Wicker & John A Todd
Nature Genetics 39, 1074–1082
(September 2007); doi:10.1038/ng2102
| Summary | Full Text (HTML / PDF) |

article
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
Paul J Norman, Laurent Abi-Rached, Ketevan Gendzekhadze, Daniel Korbel, Michael Gleimer, Don Rowley, Dan Bruno, Christine V F Carrington, Dasdayanee Chandanayingyong, Yih-Hsin Chang, Catalina Crespí, Güher Saruhan-Direskeneli, Patricia A Fraser, Kamran Hameed, Giorgi Kamkamidze, Kwadwo A Koram, Zulay Layrisse, Nuria Matamoros, Joan Milà, Myoung Hee Park, Ramasamy M Pitchappan, D Dan Ramdath, Ming-Yuh Shiau, Henry A F Stephens, Siske Struik, David H Verity, Robert W Vaughan, Dolly Tyan, Ronald W Davis, Eleanor M Riley, Mostafa Ronaghi & Peter Parham
Nature Genetics 39, 1092–1099
(September 2007); doi:10.1038/ng2111
| Summary | Full Text (HTML / PDF) |

review
Long-term synaptic plasticity in hippocampal interneurons
Dimitri M. Kullmann & Karri P. Lamsa
Nature Reviews Neuroscience 8, 687–699
(September 2007); doi:10.1038/nrn2207
| Summary | Full Text (HTML / PDF) |

letter
Toll-like receptors modulate adult hippocampal neurogenesis
Asya Rolls, Ravid Shechter, Anat London, Yaniv Ziv, Ayal Ronen, Rinat Levy & Michal Schwartz
Nature Cell Biology 9, 1081–1088
(September 2007); doi:10.1038/ncb1629
| Summary | Full Text (HTML / PDF) |

news and views
Neural stem cells: guardians of the brain
Gianvito Martino & Stefano Pluchino
Nature Cell Biology 9, 1031–1034
(September 2007); doi:10.1038/ncb0907-1031
| Summary | Full Text (HTML / PDF) |

article
MicroRNA control of Nodal signalling
Graziano Martello, Luca Zacchigna, Masafumi Inui, Marco Montagner, Maddalena Adorno, Anant Mamidi, Leonardo Morsut, Sandra Soligo, Uyen Tran, Sirio Dupont, Michelangelo Cordenonsi, Oliver Wessely & Stefano Piccolo
Nature 449, 183–188
(13 September 2007); doi:10.1038/nature06100
| Summary | Full Text (HTML / PDF) |

article
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'
Dan Feng, Christopher J Bond, Lauren K Ely, Jennifer Maynard & K Christopher Garcia
Nature Immunology 8, 975–983
(2007); doi:10.1038/ni1502
| Summary | Full Text (HTML / PDF) |

article
MALT1 directs B cell receptor-induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit
Uta Ferch, Christian Meyer zum Büschenfelde, Andreas Gewies, Elmar Wegener, Sandra Rauser, Christian Peschel, Daniel Krappmann & Jürgen Ruland
Nature Immunology 8, 984–991
(2007); doi:10.1038/ni1493
| Summary | Full Text (HTML / PDF) |

article
Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Lionel Apetoh, François Ghiringhelli, Antoine Tesniere, Michel Obeid, Carla Ortiz, Alfredo Criollo, Grégoire Mignot, M Chiara Maiuri, Evelyn Ullrich, Patrick Saulnier, Huan Yang, Sebastian Amigorena, Bernard Ryffel, Franck J Barrat, Paul Saftig, Francis Levi, Rosette Lidereau, Catherine Nogues, Jean-Paul Mira, Agnès Chompret, Virginie Joulin, Françoise Clavel-Chapelon, Jean Bourhis, Fabrice André, Suzette Delaloge, Thomas Tursz, Guido Kroemer & Laurence Zitvogel
Nature Medicine 13, 1050–1059
(2007); doi:10.1038/nm1622
| Summary | Full Text (HTML / PDF) |

article
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Eugene A Podrez, Tatiana V Byzova, Maria Febbraio, Robert G Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J Finton, Brian R Curtis, Juhua Chen, Renliang Zhang, Roy L Silverstein & Stanley L Hazen
Nature Medicine 13, 1086–1095
(2007); doi:10.1038/nm1626
| Summary | Full Text (HTML / PDF) |

news and views
The clot thickens-oxidized lipids and thrombosis
Shaun P Jackson & Anna C Calkin
Nature Medicine 13, 1015–1016
(2007); doi:10.1038/nm0907-1015
| Full Text (HTML / PDF) |

article
Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila
Krisztina Foltenyi, Ralph J Greenspan & John W Newport
Nature Neuroscience 10, 1160–1167
(2007); doi:10.1038/nn1957
| Summary | Full Text (HTML / PDF) |

news and views
Soporific signaling: how flies sleep through the night
Christopher S Colwell
Nature Neuroscience 10, 1079–1080
(2007); doi:10.1038/nn0907-1079
| Full Text (HTML / PDF) |

review
Endocrine regulation of ageing
Steven J. Russell & C. Ronald Kahn
Nature Reviews Molecular Cell Biology 8, 681–691
(September 2007); doi:10.1038/nrm2234
| Summary | Full Text (HTML / PDF) |

article
Crystal structure of the IL-15–IL-15Rα complex, a cytokine-receptor unit presented in trans
Mami Chirifu, Chiharu Hayashi, Teruya Nakamura, Sachiko Toma, Tsuyoshi Shuto, Hirofumi Kai, Yuriko Yamagata, Simon J Davis & Shinji Ikemizu
Nature Immunology 8, 1001–1007
(September 2007); doi:10.1038/ni1492
| Summary | Full Text (HTML / PDF) |

letter
RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Vivek Shukla, Xavier Coumoul, Rui-Hong Wang, Hyun-Seok Kim & Chu-Xia Deng
Nature Genetics 39, 1145–1150
(September 2007); doi:10.1038/ng2096
| Summary | Full Text (HTML / PDF) |

news and views
Cancer drugs to treat birth defects
Andrew O M Wilkie
Nature Genetics 39, 1057–1059
(September 2007); doi:10.1038/ng0907-1057
| Full Text (HTML / PDF) |

review
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Jürgen Wess, Richard M. Eglen & Dinesh Gautam
Nature Reviews Drug Discovery 6, 721–733
(September 2007); doi:10.1038/nrd2379
| Summary | Full Text (HTML / PDF) |

August

article
Plasma membrane nanoswitches generate high-fidelity Ras signal transduction
Tianhai Tian, Angus Harding, Kerry Inder, Sarah Plowman, Robert G. Parton & John F. Hancock
Nature Cell Biology 9, 905–914
(August 2007); doi:10.1038/ncb1615
| Summary | Full Text (HTML / PDF) |

news and views
Nanoclusters digitize Ras signalling
Anne K. Kenworthy
Nature Cell Biology 9, 875–877
(August 2007); doi:10.1038/ncb0807-875
| Summary | Full Text (HTML / PDF) |

review
B-cell anergy: from transgenic models to naturally occurring anergic B cells?
John C. Cambier, Stephen B. Gauld, Kevin T. Merrell & Barbara J. Vilen
Nature Reviews Immunology 7, 633–643
(August 2007); doi:10.1038/nri2133
| Summary | Full Text (HTML / PDF) |

review
Molecular mechanisms of CD4⁺ T-cell anergy
C. Garrison Fathman & Neil B. Lineberry
Nature Reviews Immunology 7, 599–609
(August 2007); doi:10.1038/nri2131
| Summary | Full Text (HTML / PDF) |

review
Angiogenesis in brain tumours
Rakesh K. Jain, Emmanuelle di Tomaso, Dan G. Duda, Jay S. Loeffler, A. Gregory Sorensen & Tracy T. Batchelor
Nature Reviews Neuroscience 8, 610–622
(August 2007); doi:10.1038/nrn2175
| Summary | Full Text (HTML / PDF) |

review
Initiation to end point: the multiple roles of fibroblast growth factors in neural development
Ivor Mason
Nature Reviews Neuroscience 8, 583–596
(August 2007); doi:10.1038/nrn2189
| Summary | Full Text (HTML / PDF) |

article
Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse
Danielle L Graham, Scott Edwards, Ryan K Bachtell, Ralph J DiLeone, Maribel Rios & David W Self
Nature Neuroscience 10, 1029–1037
(August 2007); doi:10.1038/nn1929
| Summary | Full Text (HTML / PDF) |

news and views
A role for BDNF in cocaine reward and relapse
Geoffrey Schoenbaum, Thomas A Stalnaker & Yavin Shaham
Nature Neuroscience 10, 935–936
(August 2007); doi:10.1038/nn0807-935
| Summary | Full Text (HTML / PDF) |

brief communication
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai–Barrow and facio–oculo–acoustico–renal syndromes
Sibel Kantarci, Lihadh Al-Gazali, R Sean Hill, Dian Donnai, Graeme C M Black, Eric Bieth, Nicolas Chassaing, Didier Lacombe, Koen Devriendt, Ahmad Teebi, Maria Loscertales, Caroline Robson, Tianming Liu, David T MacLaughlin, Kristin M Noonan, Meaghan K Russell, Christopher A Walsh, Patricia K Donahoe & Barbara R Pober
Nature Genetics 39, 957–959
(August 2007); doi:10.1038/ng2063
| Summary | Full Text (HTML / PDF) |

July

article
MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
Laura Fontana, Elvira Pelosi, Paolo Greco, Serena Racanicchi, Ugo Testa, Francesca Liuzzi, Carlo M. Croce, Ercole Brunetti, Francesco Grignani & Cesare Peschle
Nature Cell Biology 9, 775–787
(July 2007); doi:10.1038/ncb1613
| Summary | Full Text (HTML / PDF) |

article
α₁β₁ integrin is crucial for accumulation of epidermal T cells and the development of psoriasis
Curdin Conrad, Onur Boyman, Giulia Tonel, Adrian Tun-Kyi, Ute Laggner, Antonin de Fougerolles, Victor Kotelianski, Humphrey Gardner & Frank O Nestle
Nature Medicine 13, 836–842
(July 2007); doi:10.1038/nm1605
| Summary | Full Text (HTML / PDF) |

news and views
The problem with upward mobility
Johann E Gudjonsson & James T Elder
Nature Medicine 13, 786–787
(July 2007); doi:10.1038/nm0707-786
| Summary | Full Text (HTML / PDF) |

letter
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
David J Hunter, Peter Kraft, Kevin B Jacobs, David G Cox, Meredith Yeager, Susan E Hankinson, Sholom Wacholder, Zhaoming Wang, Robert Welch, Amy Hutchinson, Junwen Wang, Kai Yu, Nilanjan Chatterjee, Nick Orr, Walter C Willett, Graham A Colditz, Regina G Ziegler, Christine D Berg, Saundra S Buys, Catherine A McCarty, Heather Spencer Feigelson, Eugenia E Calle, Michael J Thun, Richard B Hayes, Margaret Tucker, Daniela S Gerhard, Joseph F Fraumeni, Jr, Robert N Hoover, Gilles Thomas & Stephen J Chanock
Nature Genetics 39, 870–874
(July 2007); doi:10.1038/ng2075
| Summary | Full Text (HTML / PDF) |

news and views
ENCODE and our very busy genome
Steven Henikoff
Nature Genetics 39, 817–818
(July 2007); doi:10.1038/ng0707-817
| Summary | Full Text (HTML / PDF) |

article
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
Nitin Agarwal, Pal Pacher, Irmgard Tegeder, Fumimasa Amaya, Cristina E Constantin, Gary J Brenner, Tiziana Rubino, Christoph W Michalski, Giovanni Marsicano, Krisztina Monory, Ken Mackie, Claudiu Marian, Sandor Batkai, Daniela Parolaro, Michael J Fischer, Peter Reeh, George Kunos, Michaela Kress, Beat Lutz, Clifford J Woolf & Rohini Kuner
Nature Neuroscience 10, 870–879
(July 2007); doi:10.1038/nn1916
| Summary | Full Text (HTML / PDF) |

review
The contribution of immunology to the rational design of novel antibacterial vaccines
Stefan H.E. Kaufmann
Nature Reviews Microbiology 5, 491–504
(July 2007); doi:10.1038/nrmicro1688
| Summary | Full Text (HTML / PDF) |

review
The perfect mix: recent progress in adjuvant research
Bruno Guy
Nature Reviews Microbiology 5, 505–517
(July 2007); doi:10.1038/nrmicro1681
| Summary | Full Text (HTML / PDF) |

article
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation
Ammar H Hawasli, David R Benavides, Chan Nguyen, Janice W Kansy, Kanehiro Hayashi, Pierre Chambon, Paul Greengard, Craig M Powell, Donald C Cooper & James A Bibb
Nature Neuroscience 10, 880–886
(July 2007); doi:10.1038/nn1914
| Summary | Full Text (HTML / PDF) |

news and views
Bypassing interneurons: inhibition in neocortex
Barry W Connors & Scott J Cruikshank
Nature Neuroscience 10, 808–810
(July 2007); doi:10.1038/nn0707-808
| Summary | Full Text (HTML / PDF) |

letter
The menthol receptor TRPM8 is the principal detector of environmental cold
Diana M. Bautista, Jan Siemens, Joshua M. Glazer, Pamela R. Tsuruda, Allan I. Basbaum, Cheryl L. Stucky, Sven-Eric Jordt & David Julius
Nature 448, 204–208
(12 July 2007); doi:10.1038/nature05910
| Summary | Full Text (HTML / PDF) |

review
Life and death in peripheral T cells
Peter H. Krammer, Rüdiger Arnold & Inna N. Lavrik
Nature Reviews Immunology 7, 532–542
(July 2007); doi:10.1038/nri2115
| Summary | Full Text (HTML / PDF) |

technical report
From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
Peer Wulff, Thomas Goetz, Elli Leppä, Anni-Maija Linden, Massimiliano Renzi, Jerome D Swinny, Olga Y Vekovischeva, Werner Sieghart, Peter Somogyi, Esa R Korpi, Mark Farrant & William Wisden
Nature Neuroscience 10, 923–929
(July 2007); doi:10.1038/nn1927
| Summary | Full Text (HTML / PDF) |

letter
CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Natalie A. Borg, Kwok S. Wun, Lars Kjer-Nielsen, Matthew C. J. Wilce, Daniel G. Pellicci, Ruide Koh, Gurdyal S. Besra, Mandvi Bharadwaj, Dale I. Godfrey, James McCluskey & Jamie Rossjohn
Nature 448, 44–49
(5 July 2007); doi:10.1038/nature05907
| Summary | Full Text (HTML / PDF) |

news and views
Immunology: How a T cell sees sugar
D. Branch Moody
Nature 448, 36–37
(5 July 2007); doi:10.1038/nature05890
| Full Text (HTML / PDF) |

article
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
Eicke Latz, Anjali Verma, Alberto Visintin, Mei Gong, Cherilyn M Sirois, Dionne C G Klein, Brian G Monks, C James McKnight, Marc S Lamphier, W Paul Duprex, Terje Espevik & Douglas T Golenbock
Nature Immunology 8, 772–779
(July 2007); doi:10.1038/ni1479
| Summary | Full Text (HTML / PDF) |

news and views
TLRs bent into shape
You-Me Kim, Melanie M Brinkmann & Hidde L Ploegh
Nature Immunology 8, 675–677
(July 2007); doi:10.1038/ni0707-675
| Summary | Full Text (HTML / PDF) |

review
Control points in NKT-cell development
Dale I. Godfrey & Stuart P. Berzins
Nature Reviews Immunology 7, 505–518
(July 2007); doi:10.1038/nri2116
| Summary | Full Text (HTML / PDF) |

June

review
TGFβ signalling in control of T-cell-mediated self-reactivity
Yuri P Rubtsov & Alexander Y Rudensky
Nature Reviews Immunology 7, 443–453
(June 2007); doi:10.1038/nri2095
| Summary | Full Text (HTML / PDF) |

article
Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages
Sushil Kumar Pathak, Sanchita Basu, Kunal Kumar Basu, Anirban Banerjee, Shresh Pathak, Asima Bhattacharyya, Tsuneyasu Kaisho, Manikuntala Kundu & Joyoti Basu
Nature Immunology 8, 610–618
(June 2007); doi:10.1038/ni1468
| Summary | Full Text (HTML / PDF) |

news and views
HER3 and mutant EGFR meet MET
Carlos L Arteaga
Nature Medicine 13, 675–677
(June 2007); doi:10.1038/nm0607-675
| Summary | Full Text (HTML / PDF) |

brief communication
Environmental enrichment in adulthood promotes amblyopia recovery through a reduction of intracortical inhibition
Alessandro Sale, José Fernando Maya Vetencourt, Paolo Medini, Maria Cristina Cenni, Laura Baroncelli, Roberto De Pasquale & Lamberto Maffei
Nature Neuroscience 10, 679–681
(June 2007); doi:10.1038/nn1899
| Summary | Full Text (HTML / PDF) |

review
NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders
C. Geoffrey Lau & R. Suzanne Zukin
Nature Reviews Neuroscience 8, 413–426
(June 2007); doi:10.1038/nrn2153
| Summary | Full Text (HTML / PDF) |

news and views
Membrane proteins up for grabs
Gunnar von Heijne
Nature Biotechnology 25, 646–647
(June 2007); doi:10.1038/nbt0607-646
| Summary | Full Text (HTML / PDF) |

letter
Chemical sensing of DNT by engineered olfactory yeast strain
Venkat Radhika, Tassula Proikas-Cezanne, Muralidharan Jayaraman, Djamila Onesime, Ji Hee Ha & Danny N Dhanasekaran
Nature Chemical Biology 3, 325–330
(June 2007); doi:10.1038/nchembio882
| Summary | Full Text (HTML / PDF) |

news and views
Smells like bread
David R Walt
Nature Chemical Biology 3, 306–307
(June 2007); doi:10.1038/nchembio0607-306
| Full Text (HTML / PDF) |

review
Molecular regulation of angiogenesis and lymphangiogenesis
Ralf H. Adams & Kari Alitalo
Nature Reviews Molecular Cell Biology 8, 464–478
(June 2007); doi:10.1038/nrm2183
| Summary | Full Text (HTML / PDF) |

letter
Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists
Rebecca A Buonpane, Hywyn R O Churchill, Beenu Moza, Eric J Sundberg, Marnie L Peterson, Patrick M Schlievert & David M Kranz
Nature Medicine 13, 725–729
(June 2007); doi:10.1038/nm1584
| Summary | Full Text (HTML / PDF) |

review
SOCS proteins, cytokine signalling and immune regulation
Akihiko Yoshimura, Tetsuji Naka & Masato Kubo
Nature Reviews Immunology 7, 454–465
(June 2007); doi:10.1038/nri2093
| Summary | Full Text (HTML / PDF) |

article
Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover
Germán Szapiro & Boris Barbour
Nature Neuroscience 10, 735–742
(June 2007); doi:10.1038/nn1907
| Summary | Full Text (HTML / PDF) |

article
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Hiromitsu Hara, Chitose Ishihara, Arata Takeuchi, Takayuki Imanishi, Liquan Xue, Stephan W Morris, Masanori Inui, Toshiyuki Takai, Akira Shibuya, Shinobu Saijo, Yoichiro Iwakura, Naohito Ohno, Haruhiko Koseki, Hiroki Yoshida, Josef M Penninger & Takashi Saito
Nature Immunology 8, 619–629
(June 2007); doi:10.1038/ni1466
| Summary | Full Text (HTML / PDF) |

news and views
All roads lead to CARD9
Marco Colonna
Nature Immunology 8, 554–555
(June 2007); doi:10.1038/ni0607-554
| Summary | Full Text (HTML / PDF) |

news and views
A sugar-coated switch for cellular growth and arrest
Naoyuki Taniguchi
Nature Chemical Biology 3, 307–309
(June 2007); doi:10.1038/nchembio0607-307
| Summary | Full Text (HTML / PDF) |

May

letter
The neural progenitor-specifying activity of FoxG1 is antagonistically regulated by CKI and FGF
Tarik Regad, Martin Roth, Nicholas Bredenkamp, Nicola Illing & Nancy Papalopulu
Nature Cell Biology 9, 531–540
(May 2007); doi:10.1038/ncb1573
| Summary | Full Text (HTML / PDF) |

article
Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
Alexandre Bonnin, Masaaki Torii, Lilly Wang, Pasko Rakic & Pat Levitt
Nature Neuroscience 10, 588–597
(May 2007); doi:10.1038/nn1896
| Summary | Full Text (HTML / PDF) |

news and views
Serotonin guides the way
Noah Gray
Nature Neuroscience 10, 542
(May 2007); doi:10.1038/nn0507-542
| Summary | Full Text (HTML / PDF) |

review
More than one reason to rethink the use of peptides in vaccine design
Anthony W. Purcell, James McCluskey & Jamie Rossjohn
Nature Reviews Drug Discovery 6, 404–414
(May 2007); doi:10.1038/nrd2224
| Summary | Full Text (HTML / PDF) |

review
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
Luke A. J. O'Neill & Andrew G. Bowie
Nature Reviews Immunology 7, 353–364
(May 2007); doi:10.1038/nri2079
| Summary | Full Text (HTML / PDF) |

review
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
Roberto Baccala, Kasper Hoebe, Dwight H Kono, Bruce Beutler & Argyrios N Theofilopoulos
Nature Methods 13, 543–551
(May 2007); doi:10.1038/nm1590
| Summary | Full Text (HTML / PDF) |

review
Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists
Holger Kanzler, Franck J Barrat, Edith M Hessel & Robert L Coffman
Nature Methods 13, 552–559
(May 2007); doi:10.1038/nm1589
| Summary | Full Text (HTML / PDF) |

review
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
Arpad Szallasi, Daniel N. Cortright, Charles A. Blum & Samer R. Eid
Nature Reviews Drug Discovery 6, 357–372
(May 2007); doi:10.1038/nrd2280
| Summary | Full Text (HTML / PDF) |

article
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
Jane Tian, Ana Maria Avalos, Su-Yau Mao, Bo Chen, Kannaki Senthil, Herren Wu, Peggy Parroche, Stacey Drabic, Douglas Golenbock, Cherilyn Sirois, Jing Hua, Ling Ling An, Laurent Audoly, Greg La Rosa, Angelika Bierhaus, Peter Naworth, Ann Marshak-Rothstein, Mary K Crow, Katherine A Fitzgerald, Eicke Latz, Peter A Kiener & Anthony J Coyle
Nature Immunology 8, 487–496
(May 2007); doi:10.1038/ni1457
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news and views
TLR9 and DNA 'feel' RAGE
Arthur M Krieg
Nature Immunology 8, 475–477
(May 2007); doi:10.1038/ni0507-475
| Summary | Full Text (HTML / PDF) |

review
New developments in Fc_εRI regulation, function and inhibition
Stefan Kraft & Jean-Pierre Kinet
Nature Reviews Immunology 7, 365–378
(May 2007); doi:10.1038/nri2072
| Summary | Full Text (HTML / PDF) |

article
TRPC channels promote cerebellar granule neuron survival
Yichang Jia, Jian Zhou, Yilin Tai & Yizheng Wang
Nature Neuroscience 10, 559–567
(May 2007); doi:10.1038/nn1870
| Summary | Full Text (HTML / PDF) |

news and views
Something old, something new: BDNF-induced neuron survival requires TRPC channel function
Wayne S Sossin & Philip A Barker
Nature Neuroscience 10, 537–538
(May 2007); doi:10.1038/nn0507-537
| Summary | Full Text (HTML / PDF) |

review
Transcriptional regulation of vertebrate axon guidance and synapse formation
Franck Polleux, Gulayse Ince-Dunn & Anirvan Ghosh
Nature Reviews Neuroscience 8, 331–340
(May 2007); doi:10.1038/nrn2118
| Summary | Full Text (HTML / PDF) |

April

letter
Opioids block long-term potentiation of inhibitory synapses
Fereshteh S. Nugent, Esther C. Penick & Julie A. Kauer
Nature 446, 1086–1090
(26 April 2007); doi:10.1038/nature05726
| Summary | Full Text (HTML / PDF) |

letter
UDP acting at P2Y₆ receptors is a mediator of microglial phagocytosis
Schuichi Koizumi, Yukari Shigemoto-Mogami, Kaoru Nasu-Tada, Yoichi Shinozaki, Keiko Ohsawa, Makoto Tsuda, Bhalchandra V. Joshi, Kenneth A. Jacobson, Shinichi Kohsaka & Kazuhide Inoue
Nature 446, 1091–1095
(26 April 2007); doi:10.1038/nature05704
| Summary | Full Text (HTML / PDF) |

news and views
Neuroscience: The brain's garbage men
Helmut Kettenmann
Nature 446, 987–989
(26 April 2007); doi:10.1038/nature05713
| Summary | Full Text (HTML / PDF) |

perspective
Angiogenesis: an organizing principle for drug discovery?
Judah Folkman
Nature Reviews Drug Discovery 6, 273–286
(April 2007); doi:10.1038/nrd2115
| Summary | Full Text (HTML / PDF) |

letter
A stepwise mechanism for acetylcholine receptor channel gating
Prasad Purohit, Ananya Mitra & Anthony Auerbach
Nature 446, 930–933
(19 April 2007); doi:10.1038/nature05721
| Summary | Full Text (HTML / PDF) |

review
Siglecs and their roles in the immune system
Paul R. Crocker, James C. Paulson & Ajit Varki
Nature Reviews Immunology 7, 255–266
(April 2007); doi:10.1038/nri2056
| Summary | Full Text (HTML / PDF) |

article
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen R Clark, Adrienne C Ma, Samantha A Tavener, Braedon McDonald, Zahra Goodarzi, Margaret M Kelly, Kamala D Patel, Subhadeep Chakrabarti, Erin McAvoy, Gary D Sinclair, Elizabeth M Keys, Emma Allen-Vercoe, Rebekah DeVinney, Christopher J Doig, Francis H Y Green & Paul Kubes
Nature Medicine 13, 463–469
(April 2007); doi:10.1038/nm1565
| Summary | Full Text (HTML / PDF) |

news and views
Netting bacteria in sepsis
Constantin Urban & Arturo Zychlinsky
Nature Medicine 13, 403–404
(April 2007); doi:10.1038/nm0407-403
| Summary | Full Text (HTML / PDF) |

letter
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
Chiea C Khor, Stephen J Chapman, Fredrik O Vannberg, Aisling Dunne, Caroline Murphy, Edmund Y Ling, Angela J Frodsham, Andrew J Walley, Otto Kyrieleis, Amir Khan, Christophe Aucan, Shelley Segal, Catrin E Moore, Kyle Knox, Sarah J Campbell, Christian Lienhardt, Anthony Scott, Peter Aaby, Oumou Y Sow, Robert T Grignani, Jackson Sillah, Giorgio Sirugo, Nobert Peshu, Thomas N Williams, Kathryn Maitland, Robert J O Davies, Dominic P Kwiatkowski, Nicholas P Day, Djamel Yala, Derrick W Crook, Kevin Marsh, James A Berkley, Luke A J O'Neill & Adrian V S Hill
Nature Genetics 39, 523–528
(April 2007); doi:10.1038/ng1976
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article
Reversal of neurosteroid effects at α4β2_δ GABA_A receptors triggers anxiety at puberty
Hui Shen, Qi Hua Gong, Chiye Aoki, Maoli Yuan, Yevgeniy Ruderman, Michael Dattilo, Keith Williams & Sheryl S Smith
Nature Neuroscience 10, 469–477
(April 2007); doi:10.1038/nn1868
| Summary | Full Text (HTML / PDF) |

news and views
GABA receptors make teens resistant to input
Margaret M McCarthy
Nature Neuroscience 10, 397–399
(April 2007); doi:10.1038/nn0407-397
| Summary | Full Text (HTML / PDF) |

review
Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences
Julien Royet & Roman Dziarski
Nature Reviews Microbiology 5, 264–277
(April 2007); doi:10.1038/nrmicro1620
| Summary | Full Text (HTML / PDF) |

brief communication
Subunit counting in membrane-bound proteins
Maximilian H Ulbrich & Ehud Y Isacoff
Nature Methods 4, 319–321
(April 2007); doi:10.1038/nmeth1024
| Summary | Full Text (HTML / PDF) |

article
Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
Jimmy A Blair, Daniel Rauh, Charles Kung, Cai-Hong Yun, Qi-Wen Fan, Haridas Rode, Chao Zhang, Michael J Eck, William A Weiss and Kevan M Shokat
Nature Chemical Biology 3, 229–238
(April 2007); doi:10.1038/nchembio866
| Summary | Full Text (HTML / PDF) |

letter
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
Matthew J. Evans, Thomas von Hahn, Donna M. Tscherne, Andrew J. Syder, Maryline Panis, Benno Wölk, Theodora Hatziioannou, Jane A. McKeating, Paul D. Bieniasz & Charles M. Rice
Nature 446, 801–805
(11 April 2007); doi:10.1038/nature05654
| Summary | Full Text (HTML / PDF) |

article
Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes
Jane A Skok, Ramiro Gisler, Maria Novatchkova, Deborah Farmer, Wouter de Laat & Meinrad Busslinger
Nature Immunology 8, 378–387
(April 2007); doi:10.1038/ni1448
| Summary | Full Text (HTML / PDF) |

article
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor
Lu Deng, Ries J Langley, Patrick H Brown, Gang Xu, Leslie Teng, Qian Wang, Monica I Gonzales, Glenda G Callender, Michael I Nishimura, Suzanne L Topalian & Roy A Mariuzza
Nature Immunology 8, 398–408
(April 2007); doi:10.1038/ni1447
| Summary | Full Text (HTML / PDF) |

review
Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
Kirsty C. Newman & Eleanor M. Riley
Nature Reviews Immunology 7, 279–291
(April 2007); doi:10.1038/nri2057
| Summary | Full Text (HTML / PDF) |

article
Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons
Bryen A Jordan, Brian D Fernholz, Latika Khatri & Edward B Ziff
Nature Neuroscience 10, 427–435
(April 2007); doi:10.1038/nn1867
| Summary | Full Text (HTML / PDF) |

news and views
Synapses go nucle(ol)ar
Joel D Richter & Justin R Fallon
Nature Neuroscience 10, 399–400
(April 2007); doi:10.1038/nn0407-399
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March

letter
Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis
Henrique Veiga-Fernandes, Mark C. Coles, Katie E. Foster, Amisha Patel, Adam Williams, Dipa Natarajan, Amanda Barlow, Vassilis Pachnis & Dimitris Kioussis
Nature 446, 547–551
(29 March 2007); doi:10.1038/nature05597
| Summary | Full Text (HTML / PDF) |

review
Epidermal growth factor receptor mutations in lung cancer
Sreenath V. Sharma, Daphne W. Bell, Jeffrey Settleman & Daniel A. Haber
Nature Reviews Cancer 7, 169–181
(March 2007); doi:10.1038/nrc2088
| Summary | Full Text (HTML / PDF) |

article
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis
Sofi G Julien, Nadia Dubé, Michelle Read, Janice Penney, Marilene Paquet, Yongxin Han, Brian P Kennedy, William J Muller & Michel L Tremblay
Nature Genetics 39, 338–346
(March 2007); doi:10.1038/ng1963
| Summary | Full Text (HTML / PDF) |

article
Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation
Inmaculada Segura, Clara L Essmann, Stefan Weinges & Amparo Acker-Palmer
Nature Neuroscience 10, 301–310
(March 2007); doi:10.1038/nn1858
| Summary | Full Text (HTML / PDF) |

review
Cooperation of Toll-like receptor signals in innate immune defence
Giorgio Trinchieri and Alan Sher
Nature Reviews Immunology 7, 179–190
(March 2007); doi:10.1038/nri2038
| Summary | Full Text (HTML / PDF) |

brief communication
Structure of a VEGF–VEGF receptor complex determined by electron microscopy
Claudia Ruch, Georgios Skiniotis, Michel O Steinmetz, Thomas Walz & Kurt Ballmer-Hofer
Nature Structural & Molecular Biology 14, 249–250
(March 2007); doi:10.1038/nsmb1202
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letter
Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses
Sheli R. Radoshitzky, Jonathan Abraham, Christina F. Spiropoulou, Jens H. Kuhn, Dan Nguyen, Wenhui Li, Jane Nagel, Paul J. Schmidt, Jack H. Nunberg, Nancy C. Andrews, Michael Farzan and Hyeryun Choe
Nature 446, 92–96
(1 March 2007); doi:10.1038/nature05539
| Summary | Full Text (HTML / PDF) |

article
GDNF and GFRα1 promote formation of neuronal synapses by ligand-induced cell adhesion
Fernanda Ledda, Gustavo Paratcha, Tatiana Sandoval-Guzmán & Carlos F Ibáñez
Nature Neuroscience 10, 293–300
(March 2007); doi:10.1038/nn1855
| Summary | Full Text (HTML / PDF) |

article
Glutamate exocytosis from astrocytes controls synaptic strength
Pascal Jourdain, Linda H Bergersen, Khaleel Bhaukaurally, Paola Bezzi, Mirko Santello, Maria Domercq, Carlos Matute, Fiorella Tonello, Vidar Gundersen & Andrea Volterra
Nature Neuroscience 10, 331–339
(March 2007); doi:10.1038/nn1849
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news and views
Astrocytes target presynaptic NMDA receptors to give synapses a boost
Rheinallt Parri & Vincenzo Crunelli
Nature Neuroscience 10, 271–273
(March 2007); doi:10.1038/nn0307-271
| Summary | Full Text (HTML / PDF) |

February

review
Interleukin-7 receptor expression: intelligent design
Renata Mazzucchelli and Scott K. Durum
Nature Reviews Immunology 7, 144–154
(February 2007); doi:10.1038/nri2023
| Summary | Full Text (HTML / PDF) |

perspective
Activating and inhibitory functions of DAP12
Isaiah R. Turnbull and Marco Colonna
Nature Reviews Immunology 7, 155–161
(February 2007); doi:10.1038/nri2014
| Summary | Full Text (HTML / PDF) |

letter
Angiotensin II type 1 receptor blockade attenuates TGF-β-induced failure of muscle regeneration in multiple myopathic states
Ronald D Cohn, Christel van Erp, Jennifer P Habashi, Arshia A Soleimani, Erin C Klein, Matthew T Lisi, Matthew Gamradt, Colette M ap Rhys, Tammy M Holm, Bart L Loeys, Francesco Ramirez, Daniel P Judge, Christopher W Ward & Harry C Dietz
Nature Medicine 13, 204–210
(February 2007); doi:10.1038/nm1536
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news and views
ACE inhibitor bulks up muscle
Jeffrey S Chamberlain
Nature Medicine 13, 125–126
(February 2007); doi:10.1038/nm0207-125
| Summary | Full Text (HTML / PDF) |

article
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Ekaterina Rogaeva, Yan Meng, Joseph H Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T Baldwin, Rong Cheng, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Kathryn L Lunetta, Raphaelle Pardossi-Piquard, Christopher Bohm, Yosuke Wakutani, L Adrienne Cupples, Karen T Cuenco, Robert C Green, Lorenzo Pinessi, Innocenzo Rainero, Sandro Sorbi, Amalia Bruni, Ranjan Duara, Robert P Friedland, Rivka Inzelberg, Wolfgang Hampe, Hideaki Bujo, You-Qiang Song, Olav M Andersen, Thomas E Willnow, Neill Graff-Radford, Ronald C Petersen, Dennis Dickson, Sandy D Der, Paul E Fraser, Gerold Schmitt-Ulms, Steven Younkin, Richard Mayeux, Lindsay A Farrer & Peter St George-Hyslop
Nature Genetics 39, 168–177
(February 2007); doi:10.1038/ng1943
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review
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Victor A. Derkach, Michael C. Oh, Eric S. Guire and Thomas R. Soderling
Nature Reviews Neuroscience 8, 101–113
(February 2007); doi:10.1038/nrn2055
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review
Imaging single events at the cell membrane
Jyoti K Jaiswal and Sanford M Simon
Nature Chemical Biology 3, 92–98
(February 2007); doi:10.1038/nchembio855
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January

article
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
Wing-Yu Fu, Yu Chen, Mustafa Sahin, Xiao-Su Zhao, Lei Shi, Jay B Bikoff, Kwok-On Lai, Wing-Ho Yung, Amy K Y Fu, Michael E Greenberg & Nancy Y Ip
Nature Neuroscience 10, 67–76
(January 2007); doi:10.1038/nn1811
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article
Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia
Tomas Vilimas, Joaquina Mascarenhas, Teresa Palomero, Malay Mandal, Silvia Buonamici, Fanyong Meng, Benjamín Thompson, Christina Spaulding, Sami Macaroun, Maria-Luisa Alegre, Barbara L Kee, Adolfo Ferrando, Lucio Miele & Iannis Aifantis
Nature Medicine 13, 70–77
(January 2007); doi:10.1038/nm1524
| Summary | Full Text (HTML / PDF) |

opinion
Chemoprevention of breast cancer with selective oestrogen-receptor modulators
V. Craig Jordan
Nature Reviews Cancer 7, 46–53
(January 2007); doi:10.1038/nrc2048
| Summary | Full Text (HTML / PDF) |

brief communication
Sensitive and specific method for detecting G protein-coupled receptor mRNAs
Arne Hansen, Yidong Chen, Jason M Inman, Quang N Phan, Zhi-Qing Qi, Charlie C Xiang, Miklos Palkovits, Natasha Cherman, Sergei A Kuznetsov, Pamela G Robey, Eva Mezey & Michael J Brownstein
Nature Methods 4, 35–37
(January 2007); doi:10.1038/nmeth977
| Summary | Full Text (HTML / PDF) |

letter
Dynein is required for receptor sorting and the morphogenesis of early endosomes
Owen J. Driskell, Aleksandr Mironov, Victoria J. Allan & Philip G. Woodman
Nature Cell Biology 9, 113–120
(January 2007); doi:10.1038/ncb1525
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article
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses
Jr-Wen Shui, Jonathan S Boomer, Jin Han, Jun Xu, Gregory A Dement, Guisheng Zhou & Tse-Hua Tan
Nature Immunology 8, 84–91
(January 2007); doi:10.1038/ni1416
| Summary | Full Text (HTML / PDF) |

article
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates
Scott J Russo, Carlos A Bolanos, David E Theobald, Nathan A DeCarolis, William Renthal, Arvind Kumar, Catharine A Winstanley, Nora E Renthal, Matthew D Wiley, David W Self, David S Russell, Rachael L Neve, Amelia J Eisch & Eric J Nestler
Nature Neuroscience 10, 93–99
(January 2007); doi:10.1038/nn1812
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Tolerance to opiate reward: role of midbrain IRS2-Akt pathway
Brandon K Harvey, Bruce T Hope & Yavin Shaham
Nature Neuroscience 10, 9–10
(January 2007); doi:10.1038/nn0107-9
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Two chemosensory receptors together mediate carbon dioxide detection in Drosophila
Walton D. Jones, Pelin Cayirlioglu, Ilona Grunwald Kadow and Leslie B. Vosshall
Nature 445, 86–90
(4 January 2007); doi:10.1038/nature05466
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Neurobiology: Scent secrets of insects
Rachel I. Wilson
Nature 445, 30–31
(4 January 2007); doi:10.1038/445030a
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