review Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
Robert E W Hancock & Hans-Georg Sahl Nature Biotechnology24, 1551–1557
(December 2006); doi:10.1038/nbt1267
| Summary | Full Text (HTML / PDF) |
review Protozoan encounters with Toll-like receptor signalling pathways: implications for host parasitism
Ricardo T. Gazzinelli and Eric Y. Denkers Nature Reviews Immunology6, 895–906
(December 2006); doi:10.1038/nri1978
| Summary | Full Text (HTML / PDF) |
November
letter Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein
Changjiang Dong, Konstantinos Beis , Jutta Nesper, Anne L. Brunkan-LaMontagne, Bradley R. Clarke, Chris Whitfield and James H. Naismith Nature444, 226–229
(09 November 2006); doi:10.1038/nature05267
| First Paragraph | Full Text (HTML / PDF) |
article Interleukin-10 determines viral clearance or persistence in vivo
David G Brooks, Matthew J Trifilo, Kurt H Edelmann, Luc Teyton, Dorian B McGavern & Michael B A Oldstone Nature Medicine12, 1301–1309
(November 2006); doi:10.1038/nm1492
| Summary | Full Text (HTML / PDF) |
October
article AB5 subtilase cytotoxin inactivates the endoplasmic reticulum chaperone BiP
Adrienne W. Paton, Travis Beddoe, Cheleste M. Thorpe, James C. Whisstock, Matthew C. J. Wilce, Jamie Rossjohn, Ursula M. Talbot and James C. Paton Nature443, 548–552
(05 October 2006); doi:10.1038/nature05124
| Summary | Full Text (HTML / PDF) |
September
letter PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Cheryl L. Day, Daniel E. Kaufmann, Photini Kiepiela, Julia A. Brown, Eshia S. Moodley, Sharon Reddy, Elizabeth W. Mackey, Joseph D. Miller, Alasdair J. Leslie, Chantal DePierres, Zenele Mncube, Jaikumar Duraiswamy, Baogong Zhu, Quentin Eichbaum, Marcus Altfeld, E. John Wherry, Hoosen M. Coovadia, Philip J. R. Goulder, Paul Klenerman, Rafi Ahmed, Gordon J. Freeman and Bruce D. Walker Nature443, 350–354
(21 September 2006); doi:10.1038/nature05115
| Summary | Full Text (HTML / PDF) |
article The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design
Rupert J. Russell, Lesley F. Haire, David J. Stevens, Patrick J. Collins, Yi Pu Lin, G. Michael Blackburn, Alan J. Hay, Steven J. Gamblin and John J. Skehel Nature443, 45–49
(7 September 2006); doi:10.1038/nature05114
| Summary | Full Text (HTML / PDF) |
news and views Structural biology: Antiviral drugs fit for a purpose
Ming Luo Nature443, 37–38
(7 September 2006); doi:10.1038/nature05003
| Full Text (HTML / PDF) |
article CFTR regulates phagosome acidification in macrophages and alters bactericidal activity
Anke Di, Mary E. Brown, Ludmila V. Deriy, Chunying Li, Frances L. Szeto, Yimei Chen, Ping Huang, Jiankun Tong, Anjaparavanda P. Naren, Vytautas Bindokas, H. Clive Palfrey & Deborah J. Nelson Nature Cell Biology8, 933–934
(20 August 2006); doi:10.1038/ncb1456
| Summary | Full Text (HTML / PDF) |
news and views CFTR: helping to acidify macrophage lysosomes
Joel Swanson Nature Cell Biology8, 908–909
(2006); doi:10.1038/ncb0906-908
| Summary | Full Text (HTML / PDF) |
August
letter Signal sequence directs localized secretion of bacterial surface proteins
Fredric Carlsson, Margaretha Stålhammar-Carlemalm, Klas Flärdh, Charlotta Sandin, Eric Carlemalm and Gunnar Lindahl Nature442, 943–946
(24 August 2006); doi:10.1038/nature05021
| First Paragraph | Full Text (HTML / PDF) |
letter ErbB2 receptor tyrosine kinase signaling mediates early demyelination induced by leprosy bacilli
Nikos Tapinos, Makoto Ohnishi & Anura Rambukkana Nature Medicine12, 961–966
(August 2006); doi:10.1038/nm1433
| Summary | Full Text (HTML / PDF) |
review Bacterial elicitation and evasion of plant innate immunity
Robert B. Abramovitch, Jeffrey C. Anderson and Gregory B. Martin Nature Review Molecular Cell Biology7, 601–611
(10 August 2006); doi:10.1038/nrm1984
| Summary | Full Text (HTML / PDF) |
article Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity
Olaf Gross, Andreas Gewies, Katrin Finger, Martin Schäfer, Tim Sparwasser, Christian Peschel, Irmgard Förster and Jürgen Ruland Nature442, 651–656
(10 August 2006); doi:10.1038/nature04926
| Summary | Full Text (HTML / PDF) |
July
letter Strategies for mitigating an influenza pandemic
Neil M. Ferguson, Derek A. T. Cummings, Christophe Fraser, James C. Cajka, Philip C. Cooley and Donald S. Burke Nature442, 448–452
(27 July 2006); doi:10.1038/nature04795
| First Paragraph | Full Text (HTML / PDF) |
letter Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript
A. Gupta, J. J. Gartner, P. Sethupathy, A. G. Hatzigeorgiou and N. W. Fraser Nature442, 82–85
(06 July 2006); doi:10.1038/nature04836
| First Paragraph | Full Text (HTML / PDF) |
June
article Distribution and three-dimensional structure of AIDS virus envelope spikes
Ping Zhu, Jun Liu, Julian Bess Jr, Elena Chertova, Jeffrey D. Lifson, Henry Grisé, Gilad A. Ofek, Kenneth A. Taylor and Kenneth H. Roux Nature441, 847–852
(15 June 2006); doi:10.1038/nature04817
| Summary | Full Text (HTML / PDF) |
news and views Structural biology: Images from the surface of HIV
Dennis R. Burton Nature441, 817–818
(15 June 2006); doi:10.1038/441817a
| Full Text (HTML / PDF) |
article Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1ß via Ipaf
Edward A Miao, Celia M Alpuche-Aranda, Monica Dors, April E Clark, Martin W Bader, Samuel I Miller and Alan Aderem Nature Immunology7, 569–575
(June 2006); doi:10.1038/ni1344
| First Paragraph | Full Text (HTML / PDF) |
article Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1ß in salmonella-infected macrophages
Luigi Franchi, Amal Amer, Mathilde Body-Malapel, Thirumala-Devi Kanneganti, Nesrin Özören, Rajesh Jagirdar, Naohiro Inohara, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P Grant and Gabriel Núñez Nature Immunology7, 576–582
(June 2006); doi:10.1038/ni1346
| First Paragraph | Full Text (HTML / PDF) |
article Lysophospholipid sensing triggers secretion of flagellin from pathogenic salmonella
Naeha Subramanian and Ayub Qadri Nature Immunology7, 583–589
(June 2006); doi:10.1038/ni1336
| First Paragraph | Full Text (HTML / PDF) |
news and views Cytosolic detection of flagellin: a deadly twist
Craig R Roy and Dario S Zamboni Nature Immunology7, 549–551
(08 June 2006); doi:10.1038/ni0606-549
| First Paragraph | Full Text (HTML / PDF) |
letter The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity
Jean-Marc Jacque and Mario Stevenson Nature441, 641–645
(01 June 2006); doi:10.1038/nature04682
| First Paragraph | Full Text (HTML / PDF) |
news and views Virology: HIV goes nuclear
Min Li and Robert Craigie Nature441, 581–582
(01 June 2006); doi:10.1038/441581a
| Full Text (HTML / PDF) |
May
letter Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang, Stephen M. Soisson, Katherine Young, Wesley Shoop, Srinivas Kodali, Andrew Galgoci, Ronald Painter, Gopalakrishnan Parthasarathy, Yui S. Tang, Richard Cummings, Sookhee Ha, Karen Dorso, Mary Motyl, Hiranthi Jayasuriya, John Ondeyka, Kithsiri Herath, Chaowei Zhang, Lorraine Hernandez, John Allocco, Ángela Basilio, José R. Tormo, Olga Genilloud, Francisca Vicente, Fernando Pelaez, Lawrence Colwell, Sang Ho Lee, Bruce Michael, Thomas Felcetto, Charles Gill, Lynn L. Silver, Jeffery D. Hermes, Ken Bartizal, John Barrett, Dennis Schmatz, Joseph W. Becker, Doris Cully and Sheo B. Singh Nature441, 358–361
(18 May 2006); doi:10.1038/nature04784
| First Paragraph | Full Text (HTML / PDF) |
review Exploiting pathogenic Escherichia coli to model transmembrane receptor signalling
Richard D. Hayward, John M. Leong, Vassilis Koronakis, Kenneth G. Campellone Nature Reviews Microbiology4, 429–435
(May 2006); doi:10.1038/nrmicro1391
| Summary | Full Text (HTML / PDF) |
April
letter Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
Maya Saleh, John C. Mathison, Melissa K. Wolinski, Steve J. Bensinger, Patrick Fitzgerald, Nathalie Droin, Richard J. Ulevitch, Douglas R. Green and Donald W. Nicholson Nature440, 1064–1068
(20 April 2006); doi:10.1038/nature04656
| First Paragraph | Full Text (HTML / PDF) |
review article Phenotypic variation in bacteria: the role of feedback regulation
Wiep Klaas Smits, Oscar P. Kuipers and Jan-Willem Veening Nature Reviews Microbiology4, 259–271
(April 2006); doi:10.1038/nrmicro1381
| Summary | Full Text (HTML / PDF) |
March
letter A P-type ATPase required for rice blast disease and induction of host resistance
Martin J. Gilbert, Christopher R. Thornton, Gavin E. Wakley and Nicholas J. Talbot Nature440, 535–539
(23 March 2006); doi:10.1038/nature04567
| First Paragraph | Full Text (HTML / PDF) |
letter An excitable gene regulatory circuit induces transient cellular differentiation
Gürol M. Süel, Jordi Garcia-Ojalvo, Louisa M. Liberman and Michael B. Elowitz Nature440, 545–550
(23 March 2006); doi:10.1038/nature04588
| First Paragraph | Full Text (HTML / PDF) |
letter Atomic structure of a Na+- and K+-conducting channel
Ning Shi, Sheng Ye, Amer Alam, Liping Chen and Youxing Jiang Nature440, 570–574
(23 March 2006); doi:10.1038/nature04508
| First Paragraph | Full Text (HTML/PDF) |
letter Membrane biology: Permutations of permeability
William N. Zagotta Nature440, 427–429
(23 March 2006); doi:10.1038/440427a
| Full Text (HTML/PDF) |
article Robust Salmonella metabolism limits possibilities for new antimicrobials
Daniel Becker, Matthias Selbach, Claudia Rollenhagen, Matthias Ballmaier, Thomas F. Meyer, Matthias Mann and Dirk Bumann Nature440, 303–307
(16 March 2006); doi:10.1038/nature04616
| Summary | Full Text (HTML / PDF) |
letter Cryopyrin activates the inflammasome in response to toxins and ATP
Sanjeev Mariathasan, David S. Weiss, Kim Newton, Jacqueline McBride, Karen O'Rourke, Meron Roose-Girma, Wyne P. Lee, Yvette Weinrauch, Denise M. Monack and Vishva M. Dixit Nature440, 228–232
(09 March 2006); doi:10.1038/nature04515
| First Paragraph | Full Text (HTML / PDF) |
letter Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
Thirumala-Devi Kanneganti, Nesrin Özören, Mathilde Body-Malapel, Amal Amer, Jong-Hwan Park, Luigi Franchi, Joel Whitfield, Winfried Barchet, Marco Colonna, Peter Vandenabeele, John Bertin, Anthony Coyle, Ethan P. Grant, Shizuo Akira and Gabriel Núñez Nature440, 233–236
(09 March 2006); doi:10.1038/nature04517
| First Paragraph | Full Text (HTML / PDF) |
review article N6-methyl-adenine: an epigenetic signal for DNA-protein interactions
Didier Wion and Josep Casadesús Nature Reviews Microbiology4, 183–192
(March 2006); doi:10.1038/nrmicro1350
| Abstract | Full Text (HTML/PDF) |
letter Development of the signal in sensory rhodopsin and its transfer to the cognate transducer
Rouslan Moukhametzianov , Johann P. Klare, Rouslan Efremov, Christian Baeken, Annika Göppner, Jörg Labahn, Martin Engelhard, Georg Büldt and Valentin I. Gordeliy Nature440, 115–119
(02 March 2006); doi:10.1038/nature04520
| First Paragraph | Full Text (HTML / PDF) |
review article Antiviral antibody responses: the two extremes of a wide spectrum
Lars Hangartner, Rolf M. Zinkernagel and Hans Hengartner Nature Reviews Immunology6, 231–243
(March 2006); doi:10.1038/nri1783
| Summary | Full Text (HTML / PDF) |
February
letter A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
Till S. Voss, Julie Healer, Allison J. Marty, Michael F. Duffy, Jennifer K. Thompson, James G. Beeson, John C. Reeder, Brendan S. Crabb and Alan F. Cowman Nature439, 1004–1008
(23 February 2006); doi:10.1038/nature04407
| First Paragraph | Full Text (HTML / PDF) |
letter Induction, suppression and requirement of RNA silencing pathways in virulent Agrobacterium tumefaciens infections
Patrice Dunoyer, Christophe Himber and Olivier Voinnet Nature Genetics38, 258–263
(February 2006); doi:10.1038/ng1722
| First Paragraph | Full Text (HTML/PDF) |
news and views Defense and counterdefense in the plant world
Peter M Waterhouse Nature Genetics38, 138–139
(February 2006); doi:10.1038/ng0206-138
| Full Text (HTML/PDF) |
article Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes
Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H Linde, Hannah S Hewitt, Kaori Sango, Margaret E Feeney, Marylyn M Addo, Mathias Lichterfeld, Matthew P Lahaie, Eunice Pae, Alysse G Wurcel, Timothy Roach, M Anne St John, Marcus Altfeld, Francesco M Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M Allen, James I Mullins, Bette T Korber, Philip J R Goulder, Bruce D Walker and Christian Brander Nature Immunology7, 173–178
(February 2006); doi:10.1038/ni1281
| Abstract | Full Text (HTML/PDF) |
article Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope
Astrid K N Iversen, Guillaume Stewart-Jones, Gerald H Learn, Natasha Christie, Christina Sylvester-Hviid, Andrew E Armitage, Rupert Kaul, Tara Beattie, Jean K Lee, Yanping Li, Pojchong Chotiyarnwong, Tao Dong, Xiaoning Xu, Mark A Luscher, Kelly MacDonald, Henrik Ullum, Bente Klarlund-Pedersen, Peter Skinhøj, Lars Fugger, Søren Buus, James I Mullins, E Yvonne Jones, P Anton van der Merwe and Andrew J McMichael Nature Immunology7, 179–189
(February 2006); doi:10.1038/ni1298
| Abstract | Full Text (HTML/PDF) |
news and views Crosscurrents in HIV-1 evolution
Joel N Blankson, Justin R Bailey and Robert F Siliciano Nature Immunology7, 121–122
(February 2006); doi:10.1038/ni0206-121
| Full Text (HTML/PDF) |
review article Pathogen-endoplasmic-reticulum interactions: in through the out door
Craig R. Roy, Suzana P. Salcedo and Jean-Pierre E. Gorvel Nature Reviews Immunology6, 136–147
(February 2006); doi:10.1038/nri1775
| Summary | Full Text (HTML / PDF) |
letter Quantitative imaging of Plasmodium transmission from mosquito to mammal
Rogerio Amino, Sabine Thiberge, Béatrice Martin, Susanna Celli, Spencer Shorte, Friedrich Frischknecht and Robert Ménard Nature Medicine12, 220–224
(February 2006); doi:10.1038/nm1350
| First Paragraph | Full Text (HTML/PDF) |
news and views Malaria parasites up close
Malcolm K Jones and Michael F Good Nature Medicine12, 170–171
(February 2006); doi:10.1038/nm0206-170
| Full Text (HTML/PDF) |
article Restoring function in exhausted CD8 T cells during chronic viral infection
Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman and Rafi Ahmed Nature439, 682–687
(09 February 2006); doi:10.1038/nature04444
| Summary | Full Text (HTML / PDF) |
news and views Immunology: Exhausted T cells perk up
Matthew A. Williams and Michael J. Bevan Nature439, 669–670
(09 February 2006); doi:10.1038/439669a
| Full Text (HTML / PDF) |
letter Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection
Koert J. Stittelaar, Johan Neyts, Lieve Naesens, Geert van Amerongen, Rob F. van Lavieren, Antonin Holý, Erik De Clercq, Hubert G. M. Niesters, Edwin Fries, Chantal Maas, Paul G. H. Mulder, Ben A. M. van der Zeijst and Albert D. M. E. Osterhaus Nature439, 745–748
(09 February 2006); doi:10.1038/nature04295
| First Paragraph | Full Text (HTML / PDF) |
letter ClpS is an essential component of the N-end rule pathway in Escherichia coli
A. Erbse, R. Schmidt, T. Bornemann, J. Schneider-Mergener, A. Mogk, R. Zahn, D. A. Dougan and B. Bukau Nature439, 753–756
(09 February 2006); doi:10.1038/nature04412
| First Paragraph | Full Text (HTML / PDF) |
letter The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1
Karuppiah Muthumani, Andrew Y. Choo, Wei-Xing Zong, Muniswamy Madesh, Daniel S. Hwang, Arumugam Premkumar, Khanh P. Thieu, Joann Emmanuel, Sanjeev Kumar, Craig B. Thompson and David B. Weiner Nature Cell Biology8, 170–179
(February 2006); doi:10.1038/ncb1352
| First Paragraph | Full Text (HTML/PDF) |
article Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity
Nicholas S Wilson, Georg M N Behrens, Rachel J Lundie, Christopher M Smith, Jason Waithman, Louise Young, Simon P Forehan, Adele Mount, Raymond J Steptoe, Ken D Shortman, Tania F de Koning-Ward, Gabrielle T Belz, Francis R Carbone, Brendan S Crabb, William R Heath and Jose A Villadangos Nature Immunology7, 165–172
(February 2006); doi:10.1038/ni1300
| Abstract | Full Text (HTML/PDF) |
news and views Youth has its privileges: maturation inhibits DC cross-priming
Heather D Hickman-Miller and Jonathan W Yewdell Nature Immunology7, 125–126
(February 2006); doi:10.1038/ni0206-125
| Full Text (HTML/PDF) |
article Replication fork reactivation downstream of a blocked nascent leading strand
Ryan C. Heller and Kenneth J. Marians Nature439, 557–562
(02 February 2006); doi:10.1038/nature04329
| Summary | Full Text (HTML / PDF) |
January
review article Signalling pathways and molecular interactions of NOD1 and NOD2
Warren Strober, Peter J. Murray, Atsushi Kitani and Tomohiro Watanabe Nature Reviews Immunology6, 9–20
(January 2006); doi:10.1038/nri1747
| Summary | Full Text (HTML / PDF) |
protocol Strategies for protein coexpression in Escherichia coli
Niraj H Tolia and Leemor Joshua-Tor Nature Methods3, 55–64
(January 2006); doi:10.1038/nmeth0106-55
| Full Text (HTML/PDF) |
letter Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
Hans Häcker, Vanessa Redecke, Blagoy Blagoev, Irina Kratchmarova, Li-Chung Hsu, Gang G. Wang, Mark P. Kamps, Eyal Raz, Hermann Wagner, Georg Häcker, Matthias Mann and Michael Karin Nature439, 204–207
(12 January 2006); doi:10.1038/nature04369
| First Paragraph | Full Text (HTML / PDF) |
letter Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
Gagik Oganesyan, Supriya K. Saha, Beichu Guo, Jeannie Q. He, Arash Shahangian, Brian Zarnegar, Andrea Perry and Genhong Cheng Nature439, 208–211
(12 January 2006); doi:10.1038/nature04374
| First Paragraph | Full Text (HTML / PDF) |
letter An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Deborah Palliser, Dipanjan Chowdhury, Qing-Yin Wang, Sandra J. Lee, Roderick T. Bronson, David M. Knipe and Judy Lieberman Nature439, 89–94
(05 January 2006); doi:10.1038/nature04263
| First Paragraph | Full Text (HTML / PDF) |
