letter Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection
Kenneth J Ritchie, Chang S Hahn, Keun Il Kim, Ming Yan, Dabralee Rosario, Li Li, Juan Carlos de la Torre and Dong-Er Zhang Nature Medicine10, 1374–1378
(December 2004); doi:10.1038/nm1133
| First Paragraph | Full Text (HTML/PDF) |
article Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain
E S Anton, H T Ghashghaei, Janet L Weber, Corey McCann, Tobias M Fischer, Isla D Cheung, Martin Gassmann, Albee Messing, Rudiger Klein, Markus H Schwab, K C Kent Lloyd and Cary Lai Nature Neuroscience7, 1319–1328
(December 2004); doi:10.1038/nn1345
| Abstract | Full Text (HTML/PDF) |
article Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
Antonio Moschetta, Angie L Bookout and David J Mangelsdorf Nature Medicine10, 1352–1358
(December 2004); doi:10.1038/nm1138
| Abstract | Full Text (HTML/PDF) |
news and views Chipping away at gallstones
Kerry B Goralski and Christopher J Sinal Nature Medicine10, 1301–1302
(December 2004); doi:10.1038/nm1204-1301
| Full Text (HTML/PDF) |
November
letter Cardiomyocyte-restricted peroxisome proliferator-activated receptor-δ deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
Lihong Cheng, Guoliang Ding, Qianhong Qin, Yao Huang, William Lewis, Nu He, Ronald M Evans, Michael D Schneider, Florence A Brako, Yan Xiao, Yuqing E Chen and Qinglin Yang Nature Medicine10, 1245–1250
(November 2004); doi:10.1038/nm1116
| First Paragraph | Full Text (HTML/PDF) |
article Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
Simon D Bamforth, José Bragança, Cassandra R Farthing, Jürgen E Schneider, Carol Broadbent, Anna C Michell, Kieran Clarke, Stefan Neubauer, Dominic Norris, Nigel A Brown, Robert H Anderson and Shoumo Bhattacharya Nature Genetics36, 1189–1196
(November 2004); doi:10.1038/ng1446
| Abstract | Full Text (HTML/PDF) |
article Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells
Matthew C Lorincz, David R Dickerson, Mike Schmitt and Mark Groudine Nature Structural and Molecular Biology11, 1068–1075
(November 2004); doi:10.1038/nsmb840
| Abstract | Full Text (HTML/PDF) |
technical report Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
Lene Uhrbom, Edward Nerio and Eric C Holland Nature Medicine10, 1257–1260
(November 2004); doi:10.1038/nm1120
| Abstract | Full Text (HTML/PDF) |
October
letters to nature MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Catherine M. Shachaf, Andrew M. Kopelman, Constadina Arvanitis, Åsa Karlsson, Shelly Beer, Stefanie Mandl, Michael H. Bachmann, Alexander D. Borowsky, Boris Ruebner, Robert D. Cardiff, Qiwei Yang, J. Michael Bishop, Christopher H. Contag and Dean W. Felsher Nature431, 1112–1117
(28 October 2004); doi:10.1038/nature03043
| First Paragraph | Full Text (HTML / PDF) |
article Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury
Liqun Yu, Zhihong Huang, Juliana Mariani, Yumei Wang, Michael Moskowitz and Jiang-Fan Chen Nature Medicine10, 1081–1087
(October 2004); doi:10.1038/nm1103
| Abstract | Full Text (HTML/PDF) |
news and views Bone marrow spawns brain killers
Costantino Iadecola Nature Medicine10, 1044–1045
(October 2004); doi:10.1038/nm1004-1044
| Full Text (HTML/PDF) |
letters to nature Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito , Atsushi Hirao, Fumio Arai, Sahoko Matsuoka, Keiyo Takubo, Isao Hamaguchi, Kana Nomiyama, Kentaro Hosokawa, Kazuhiro Sakurada, Naomi Nakagata, Yasuo Ikeda, Tak W. Mak and Toshio Suda Nature431, 997–1002
(21 October 2004); doi:10.1038/nature02989
| First Paragraph | Full Text (HTML / PDF) |
letter A specific requirement for PDGF-C in palate formation and PDGFR-α signaling
Hao Ding, Xiaoli Wu, Hans Boström, Injune Kim, Nicole Wong, Bonny Tsoi, Meredith O'Rourke, Gou Young Koh, Philippe Soriano, Christer Betsholtz, Thomas C Hart, Mary L Marazita, L L Field, Patrick P L Tam and Andras Nagy Nature Genetics36, 1111–1116
(October 2004); doi:10.1038/ng1415
| First Paragraph | Full Text (HTML/PDF) |
article Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway
Reiko Hanada, Hitoshi Teranishi, James Todd Pearson, Mamoru Kurokawa, Hiroshi Hosoda, Nobuhiro Fukushima, Yoshihiko Fukue, Ryota Serino, Hiroaki Fujihara, Yoichi Ueta, Masahito Ikawa, Masaru Okabe, Noboru Murakami, Mikiyasu Shirai, Hironobu Yoshimatsu, Kenji Kangawa and Masayasu Kojima Nature Medicine10, 1067–1073
(October 2004); doi:10.1038/nm1106
| Abstract | Full Text (HTML/PDF) |
letter BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-β-catenin signaling
Xi C He, Jiwang Zhang, Wei-Gang Tong, Ossama Tawfik, Jason Ross, David H Scoville, Qiang Tian, Xin Zeng, Xi He, Leanne M Wiedemann, Yuji Mishina and Linheng Li Nature Genetics36, 1117–1121
(October 2004); doi:10.1038/ng1430
| First Paragraph | Full Text (HTML/PDF) |
news and views Linking pathways in colorectal cancer
Gijs R van den Brink Nature Genetics36, 1038–1039
(October 2004); doi:10.1038/ng1004-1038
| Full Text (HTML/PDF) |
September
letters to nature Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice
Lina Kassar-Duchossoy, Barbara Gayraud-Morel, Danielle Gomès, Didier Rocancourt, Margaret Buckingham, Vasily Shinin and Shahragim Tajbakhsh Nature431, 466–471
(23 September 2004); doi:10.1038/nature02876
| First Paragraph | Full Text (HTML / PDF) |
letter Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse
Heather M Kulaga, Carmen C Leitch, Erica R Eichers, Jose L Badano, Alysa Lesemann, Bethan E Hoskins, James R Lupski, Philip L Beales, Randall R Reed and Nicholas Katsanis Nature Genetics36, 994–998
(September 2004); doi:10.1038/ng1418
| First Paragraph | Full Text (HTML/PDF) |
article Degenerate self-reactive human T-cell receptor causes spontaneous autoimmune disease in mice
Sonia Quaratino, Ester Badami, Yun Yun Pang, Istvan Bartok, Julian Dyson, Dimitris Kioussis, Marco Londei and Luigi Maiuri Nature Medicine10, 920–926
(September 2004); doi:10.1038/nm1092
| Abstract | Full Text (HTML/PDF) |
news and views Autoimmune hypothyroidism: T cells caught in the act
Sandra M McLachlan and Basil Rapoport Nature Medicine10, 895–896
(September 2004); doi:10.1038/nm0904-895
| Full Text (HTML/PDF) |
article Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
Tatiana V Petrova, Terhi Karpanen, Camilla Norrmén, Russell Mellor, Tomoki Tamakoshi, David Finegold, Robert Ferrell, Dontscho Kerjaschki, Peter Mortimer, Seppo Ylä-Herttuala, Naoyuki Miura and Kari Alitalo Nature Medicine10, 974–981
(September 2004); doi:10.1038/nm1094
| Abstract | Full Text (HTML/PDF) |
article Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
Fazilat F Mohammed, David S Smookler, Suzanne E M Taylor, Barbara Fingleton, Zamaneh Kassiri, Otto H Sanchez, Jane L English, Lynn M Matrisian, Billie Au, Wen-Chen Yeh and Rama Khokha Nature Genetics36, 969–977
(September 2004); doi:10.1038/ng1413
| Abstract | Full Text (HTML/PDF) |
news and views TIMP3 checks inflammation
Roy A Black Nature Genetics36, 934–935
(September 2004); doi:10.1038/ng0904-934
| Full Text (HTML/PDF) |
perspectives Opinion: Genetically modified mouse models for pharmacogenomic research
Stephen B. Liggett Nature Reviews Genetics5, 657–663
(September 2004); doi:10.1038/nrg1429
| Abstract | Full Text (HTML / PDF) |
article Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis
Martin C Herzig, David T Winkler, Patrick Burgermeister, Michelle Pfeifer, Esther Kohler, Stephen D Schmidt, Simone Danner, Dorothee Abramowski, Christine Stürchler-Pierrat, Kurt Bürki, Sjoerd G van Duinen, Marion L C Maat-Schieman, Matthias Staufenbiel, Paul M Mathews and Mathias Jucker Nature Neuroscience7, 954–960
(September 2004); doi:10.1038/nn1302
| Abstract | Full Text (HTML/PDF) |
news and views An animal model of vascular amyloidosis
Jorge Ghiso and Thomas Wisniewski Nature Neuroscience7, 902–904
(September 2004); doi:10.1038/nn0904-902
| Full Text (HTML/PDF) |
August
letter Mutagenic Insertion and Chromosome Engineering Resource (MICER)
David J Adams, Patrick J Biggs, Tony Cox, Rob Davies, Louise van der Weyden, Jos Jonkers, James Smith, Bob Plumb, Ruth Taylor, Ichiko Nishijima, Yuejin Yu, Jane Rogers and Allan Bradley Nature Genetics36, 867–871
(August 2004); doi:10.1038/ng1388
| First Paragraph | Full Text (HTML/PDF) |
July
review article Neonatal adaptive immunity comes of age
Becky Adkins, Claude Leclerc and Stuart Marshall-Clarke Nature Reviews Immunology4, 553–564
(July 2004); doi:10.1038/nri1394
| Abstract | Full Text (HTML / PDF) |
review article The cutting-edge of mammalian development; how the embryo makes teeth
Abigail Tucker and Paul Sharpe Nature Reviews Genetics5, 499–508
(July 2004); doi:10.1038/nrg1380
| Abstract | Full Text (HTML / PDF) |
letter Instability of Hes7 protein is crucial for the somite segmentation clock
Hiromi Hirata, Yasumasa Bessho, Hiroshi Kokubu, Yoshito Masamizu, Shuichi Yamada, Julian Lewis and Ryoichiro Kageyama Nature Genetics36, 750–754
(July 2004); doi:10.1038/ng1372
| First Paragraph | Full Text (HTML/PDF) |
June
article CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
Antoine Perchellet, Ingunn Stromnes, Jennifer M Pang and Joan Goverman Nature Immunology5, 606–614
(June 2004); doi:10.1038/ni1073
| Abstract | Full Text (HTML/PDF) |
news and views A mightier mouse with human adaptive immunity
Marie H Kosco-Vilbois Nature Biotechnology22, 684–685
(June 2004); doi:10.1038/nbt0604-684
| Full Text (HTML/PDF) |
May
article Analysis of regulatory CD8 T cells in Qa-1-deficient mice
Dan Hu, Koichi Ikizawa, Linrong Lu, Marie E Sanchirico, Mari L Shinohara and Harvey Cantor Nature Immunology5, 516–523
(May 2004); doi:10.1038/ni1063
| Abstract | Full Text (HTML/PDF) |
news and views Resurrecting CD8+ suppressor T cells
Leonard Chess and Hong Jiang Nature Immunology5, 469–471
(May 2004); doi:10.1038/ni0504-469
| Full Text (HTML/PDF) |
letter Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta
Takahisa Nakamura, Ryoji Yao, Takehiko Ogawa, Toru Suzuki, Chizuru Ito, Naoki Tsunekawa, Kimiko Inoue, Rieko Ajima, Takashi Miyasaka, Yutaka Yoshida, Atsuo Ogura, Kiyotaka Toshimori, Toshiaki Noce, Tadashi Yamamoto and Tetsuo Noda Nature Genetics36, 528–533
(May 2004); doi:10.1038/ng1344
| First Paragraph | Full Text (HTML/PDF) |
article Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice
Marcus Mall, Barbara R Grubb, Jack R Harkema, Wanda K O'Neal and Richard C Boucher Nature Medicine10, 487–493
(May 2004); doi:10.1038/nm1028
| Abstract | Full Text (HTML/PDF) |
news and views Finally, mice with CF lung disease
Raymond A Frizzell and Joseph M Pilewski Nature Medicine10, 452–454
(May 2004); doi:10.1038/nm0504-452
| Full Text (HTML/PDF) |
review article Experimental therapeutics in transgenic mouse models of Huntington's disease
M. Flint Beal and Robert J. Ferrante Nature Reviews Neuroscience5, 373–384
(May 2004); doi:10.1038/nrn1386
| Abstract | Full Text (HTML / PDF) |
April
brief communication Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease
Vicente E Torres, Xiaofang Wang, Qi Qian, Stefan Somlo, Peter C Harris, Vincent H Gattone and II Nature Medicine10, 363–364
(April 2004); doi:10.1038/nm1004
| First Paragraph | Full Text (HTML/PDF) |
March
article Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
Masamichi Yamamoto, Yukio Saijoh, Aitana Perea-Gomez, William Shawlot, Richard R. Behringer, Siew-Lan Ang, Hiroshi Hamada and Chikara Meno Nature428, 387–392
(25 March 2004); doi:10.1038/nature02418
| Abstract | Full Text (HTML / PDF) |
news and views Fragile fugue: p53 in aging, cancer and IGF signaling
Judith Campisi Nature Medicine10, 231–232
(March 2004); doi:10.1038/nm0304-231
| Full Text (HTML/PDF) |
February
January
technical report A transgenic mouse model for monitoring endoplasmic reticulum stress
Takao Iwawaki, Ryoko Akai, Kenji Kohno and Masayuki Miura Nature Medicine10, 98–102
(January 2004); doi:10.1038/nm970
| Abstract | Full Text (HTML/PDF) |
review article The human model: a genetic dissection of immunity to infection in natural conditions
Jean-Laurent Casanova and Laurent Abel Nature Reviews Immunology4, 55–66
(January 2004); doi:10.1038/nri1264
| Abstract | Full Text (HTML / PDF) |
letter Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
Geng Liu, John M Parant, Gene Lang, Patty Chau, Arturo Chavez-Reyes, Adel K El-Naggar, Asha Multani, Sandy Chang and Guillermina Lozano
Nature Genetics36, 63–68
(January 2004); doi:10.1038/ng1282
| First Paragraph | Full Text (HTML/PDF) |
news and views Conquering the complexity of p53
Laura D Attardi and Ronald A DePinho Nature Genetics36, 7–8
(January 2004); doi:10.1038/ng0104-7
| Full Text
(HTML/PDF) |
