article IKK mediates ischemia-induced neuronal death
Oliver Herrmann, Bernd Baumann, Rossana de Lorenzi, Sajjad Muhammad, Wen Zhang, Jens Kleesiek, Max Malfertheiner, Martin Köhrmann, Ioana Potrovita, Ira Maegele, Cordian Beyer, James R Burke, Mazahir T Hasan, Hermann Bujard, Thomas Wirth, Manolis Pasparakis and Markus Schwaninger Nature Medicine11, 1322–1329
(December 2005); doi:10.1038/nm1323
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letter Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
Iiris Hovatta, Richard S. Tennant, Robert Helton, Robert A. Marr, Oded Singer, Jeffrey M. Redwine, Julie A. Ellison, Eric E. Schadt, Inder M. Verma, David J. Lockhart and Carrolee Barlow Nature438, 662–666
(01 December 2005); doi:10.1038/nature04250
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review article Developmental Cell Biology: Cleavage Pattern and Emerging Asymmetry of the Mouse Embryo
Magdalena Zernicka-Goetz Nature Reviews Molecular Cell Biology6, 919–928
(December 2005); doi:10.1038/nrm1782
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November
letter Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice
Ikuhiro Okamoto, Danielle Arnaud, Patricia Le Baccon, Arie P. Otte, Christine M. Disteche, Philip Avner and Edith Heard Nature438, 369–373
(17 November 2005); doi:10.1038/nature04155
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review article Building the mammalian heart from two sources of myocardial cells
Margaret Buckingham, Sigolène Meilhac and Stéphane Zaffran Nature Reviews Genetics6, 826–837
(November 2005); doi:10.1038/nrg1710
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letter Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
Robert S Ohgami, Dean R Campagna, Eric L Greer, Brendan Antiochos, Alice McDonald, Jing Chen, John J Sharp, Yuko Fujiwara, Jane E Barker and Mark D Fleming Nature Genetics37, 1264–1269
(November 2005); doi:10.1038/ng1658
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news and views A ferrireductase fills the gap in the transferrin cycle
Andrew T McKie Nature Genetics37, 1159–1160
(November 2005); doi:10.1038/ng1105-1159
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technical report Second-generation shRNA libraries covering the mouse and human genome
Jose M Silva, Mamie Z Li, Ken Chang, Wei Ge, Michael C Golding, Richard J Rickles, Despina Siolas, Guang Hu, Patrick J Paddison, Michael R Schlabach, Nihar Sheth, Jeff Bradshaw, Julia Burchard, Amit Kulkarni, Guy Cavet, Ravi Sachidanandam, W Richard McCombie, Michele A Cleary, Stephen J Elledge and Gregory J Hannon Nature Genetics37, 1281–1288
(November 2005); doi:10.1038/ng1650
| Abstract
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October
article Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
Oded Singer, Robert A Marr, Edward Rockenstein, Leslie Crews, Nicole G Coufal, Fred H Gage, Inder M Verma and Eliezer Masliah Nature Neuroscience8, 1343–1349
(October 2005); doi:10.1038/nn1531
| Abstract | Full Text (HTML/PDF) |
September
brief communication PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
Domingo F Barber, Almira Bartolomé, Carmen Hernandez, Juana M Flores, Clara Redondo, Cristina Fernandez-Arias, Montserrat Camps, Thomas Rückle, Matthias K Schwarz, Santiago Rodríguez, Carlos Martinez-A, Dimitrios Balomenos, Christian Rommel and Ana C Carrera Nature Medicine11, 933–935
(September 2005); doi:10.1038/nm1291
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article Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
Montserrat Camps, Thomas Rückle, Hong Ji, Vittoria Ardissone, Felix Rintelen, Jeffrey Shaw, Chiara Ferrandi, Christian Chabert, Corine Gillieron, Bernard Françon, Thierry Martin, Denise Gretener, Dominique Perrin, Didier Leroy, Pierre-Alain Vitte, Emilio Hirsch, Matthias P Wymann, Rocco Cirillo, Matthias K Schwarz and Christian Rommel Nature Medicine11, 936–943
(September 2005); doi:10.1038/nm1284
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letter Genome-wide analysis of mouse transcripts using exon microarrays and factor graphs
Brendan J Frey, Naveed Mohammad, Quaid D Morris, Wen Zhang, Mark D Robinson, Sanie Mnaimneh, Richard Chang, Qun Pan, Eric Sat, Janet Rossant, Benoit G Bruneau, Jane E Aubin, Benjamin J Blencowe and Timothy R Hughes Nature Genetics37, 991–996
(September 2005); doi:10.1038/ng1630
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July
brief communication Loss of
mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal
achalasia Takaharu Taketomi, Daigo Yoshiga, Koji Taniguchi, Takashi
Kobayashi, Atsushi Nonami, Reiko Kato, Mika Sasaki, Atsuo Sasaki, Hitoshi
Ishibashi, Maiko Moriyama, Kei-ichiro Nakamura, Junji Nishimura and Akihiko
Yoshimura Nature Neuroscience8, 855–857 (July 2005);
doi:10.1038/nn1485 | First Paragraph | Full Text (HTML/PDF)
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article Blimp1 is a critical determinant of the germ cell lineage in mice
Yasuhide Ohinata , Bernhard Payer , Dónal O'Carroll , Katia Ancelin , Yukiko Ono , Mitsue Sano , Sheila C. Barton , Tetyana Obukhanych , Michel Nussenzweig , Alexander Tarakhovsky , Mitinori Saitou and M. Azim Surani Nature436, 207–213
(14 July 2005); doi:10.1038/nature03813
| Summary | Full Text (HTML / PDF) |
news and views A plague of autoantibodies
Vigo Heissmeyer, K Mark Ansel and Anjana Rao Nature Immunology6, 642–643
(July 2005); doi:10.1038/ni1214
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article Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig, and André Nussenzweig Nature Cell Biology7 675–685
(July 2005); doi:10.1038/ncb1270
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news and views Nbs1 moving up in the world
Elena S. Stavridi and Thanos D. Halazonetis Nature Cell Biology7, 648–650
(July 2005); doi:10.1038/ncb0705-648
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article Temporal dissection of p53 function in vitro and in vivo
Maria A Christophorou, Dionisio Martin-Zanca, Laura Soucek, Elizabeth R Lawlor, Lamorna Brown-Swigart, Emmy W Verschuren and Gerard I Evan Nature Genetics37, 718–726
(July 2005); doi:10.1038/ng1572
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June
article Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
Jessica A Hamerman, Nadia K Tchao, Clifford A Lowell and Lewis L Lanier Nature Immunology6, 579–586
(June 2005); doi:10.1038/ni1204
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review article Notch signaling in the mammalian central nervous system: insights from mouse mutants
Keejung Yoon and Nicholas Gaiano Nature Neuroscience8, 709–715
(June 2005); doi:10.1038/nn1475
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May
letter Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action
Emilie A Bard-Chapeau, Andrea L Hevener, Shinong Long, Eric E Zhang, Jerrold M Olefsky and Gen-Sheng Feng Nature Medicine11, 567–571
(May 2005); doi:10.1038/nm1227
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article Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
Kei Sakamoto, Afshan McCarthy, Darrin Smith, Kevin A Green, D Grahame Hardie, Alan Ashworth and Dario R Alessi The EMBO Journal24, 1810–1820
(May 2005); doi:10.1038/sj.emboj.7600667
| Abstract | Full Text (HTML/PDF) |
April
letter Chfr is required for tumor suppression and Aurora A regulation
Xiaochun Yu, Katherine Minter-Dykhouse, Liviu Malureanu, Wei-Meng Zhao, Dongwei Zhang, Carolin J Merkle, Irene M Ward, Hideyuki Saya, Guowei Fang, Jan van Deursen and Junjie Chen Nature Genetics37, 401–406
(April 2005); doi:10.1038/ng1538
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news and views MET orchestrates cancer and blood coagulation
Olga I Stenina and Edward F Plow Nature Medicine11, 376–377
(April 2005); doi:10.1038/nm0405-376
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article Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
Edward J McManus, Kei Sakamoto, Laura J Armit, Leah Ronaldson, Natalia Shpiro, Rodolfo Marquez and Dario R Alessi The EMBO Journal24, 1571–1583
(April 2005); doi:10.1038/7600633a
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article Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease
Jingmei Lin, Sanjeevkumar R Patel, Xu Cheng, Eun Ah Cho, Inna Levitan, Matthew Ullenbruch, Sem H Phan, John M Park and Gregory R Dressler Nature Medicine11, 387–393
(April 2005); doi:10.1038/nm1217
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news and views Setting a trap for tissue fibrosis
Eric G Neilson Nature Medicine11, 373–374
(April 2005); doi:10.1038/nm0405-373
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letters to nature IRF-7 is the master regulator of type-I interferon-dependent immune responses
Kenya Honda, Hideyuki Yanai, Hideo Negishi, Masataka Asagiri, Mitsuharu Sato, Tatsuaki Mizutani, Naoya Shimada, Yusuke Ohba, Akinori Takaoka, Nobuaki Yoshida and Tadatsugu Taniguchi Nature434, 772–777
(07 April 2005); doi:10.1038/nature03464
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letters to nature Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
Samira Saadoun, Marios C. Papadopoulos, Mariko Hara-Chikuma and A. S. Verkman Nature434, 786–792
(07 April 2005); doi:10.1038/nature03460
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letters to nature Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
Takashi Nakagawa , Shigeomi Shimizu, Tetsuya Watanabe, Osamu Yamaguchi, Kinya Otsu, Hirotaka Yamagata, Hidenori Inohara, Takeshi Kubo and Yoshihide Tsujimoto Nature434, 652–658
(31 March 2005); doi:10.1038/nature03317
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letters to nature Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
Christopher P. Baines, Robert A. Kaiser, Nicole H. Purcell, N. Scott Blair, Hanna Osinska, Michael A. Hambleton, Eric W. Brunskill, M. Richard Sayen, Roberta A. Gottlieb, Gerald W. Dorn II, Jeffrey Robbins and Jeffery D. Molkentin Nature434, 658–662
(31 March 2005); doi:10.1038/nature03434
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review article The promise of genetically engineered mice for cancer prevention studies
Jeffrey E. Green and Tamaro Hudson Nature Reviews Cancer5, 184–198
(March 2005); doi:10.1038/nrc1565
| Summary | Full Text (HTML / PDF) |
March
letters to nature The MET oncogene drives a genetic programme linking cancer to haemostasis
Carla Boccaccio, Gabriella Sabatino, Enzo Medico, Flavia Girolami, Antonia Follenzi, Gigliola Reato, Antonino Sottile, Luigi Naldini and Paolo M. Comoglio Nature434, 396–400
(17 March 2005); doi:10.1038/nature03357
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review article Expression and functions of neuronal gap junctions
Goran Söhl, Stephan Maxeiner and Klaus Willecke Nature Reviews Neuroscience6, 191–200
(March 2005); doi:10.1038/nrn1627
| Summary | Full Text (HTML / PDF) |
February
article IKK-β links inflammation to obesity-induced insulin resistance
Melek C Arkan, Andrea L Hevener, Florian R Greten, Shin Maeda, Zhi-Wei Li, Jeffrey M Long, Anthony Wynshaw-Boris, Giuseppe Poli, Jerrold Olefsky and Michael Karin Nature Medicine11, 191–198
(February 2005); doi:10.1038/nm1185
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article Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity
Mark W Sleeman, Katherine E Wortley, Ka-Man V Lai, Lori C Gowen, Jennifer Kintner, William O Kline, Karen Garcia, Trevor N Stitt, George D Yancopoulos, Stanley J Wiegand and David J Glass Nature Medicine11, 199–205
(February 2005); doi:10.1038/nm1178
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news and views Staying in SHIP shape
Stuart J Decker and Alan R Saltiel Nature Medicine11, 123–124
(February 2005); doi:10.1038/nm0205-123
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article Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice
Tohru Uchida, Takehiro Nakamura, Naoko Hashimoto, Tomokazu Matsuda, Ko Kotani, Hiroshi Sakaue, Yoshiaki Kido, Yoshitake Hayashi, Keiichi I Nakayama, Morris F White and Masato Kasuga Nature Medicine11, 175–182
(February 2005); doi:10.1038/nm1187
| Abstract | Full Text (HTML/PDF) |
article The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality
Thomas M Johnson, Ester M Hammond, Amato Giaccia and Laura D Attardi Nature Genetics37, 145–152
(February 2005); doi:10.1038/ng1498
| Abstract | Full Text (HTML/PDF) |
January
article Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model
Shigetoshi Sano, Keith Syson Chan, Steve Carbajal, John Clifford, Mary Peavey, Kaoru Kiguchi, Satoshi Itami, Brian J Nickoloff and John DiGiovanni Nature Medicine11, 43–49
(January 2005); doi:10.1038/nm1162
| Abstract | Full Text (HTML/PDF) |
news and views Psoriasis: more than skin deep
Mark R Pittelkow Nature Medicine11, 17–18
(January 2005); doi:10.1038/nm0105-17
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article Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
Pascal Descargues, Céline Deraison, Chrystelle Bonnart, Maaike Kreft, Mari Kishibe, Akemi Ishida-Yamamoto, Peter Elias, Yann Barrandon, Giovanna Zambruno, Arnoud Sonnenberg and Alain Hovnanian Nature Genetics37, 56–65
(January 2005); doi:10.1038/ng1493
| Abstract | Full Text (HTML/PDF) |
article An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis
Alejandro Sweet-Cordero, Sayan Mukherjee, Aravind Subramanian, Han You, Jeffrey J Roix, Christine Ladd-Acosta, Jill Mesirov, Todd R Golub and Tyler Jacks Nature Genetics37, 48–55
(January 2005); doi:10.1038/ng1490
| Abstract | Full Text (HTML/PDF) |
news and views Cross-species comparisons of cancer signaling
Thomas G Graeber and Charles L Sawyers Nature Genetics37, 7–8
(January 2005); doi:10.1038/ng0105-7
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article The invertor knock-in conditional chromosomal translocation mimic
Alan Forster, Richard Pannell, Lesley F Drynan, Rosalind Codrington, Angelika Daser, Markus Metzler, M Natividad Lobato and Terence H Rabbitts Nature Methods2, 27–30
(January 2005); doi:10.1038/nmeth727
| Abstract | Full Text (HTML/PDF) |
