letter Regulation of osteoclast differentiation and function by the CaMK-CREB pathway
Kojiro Sato, Ayako Suematsu, Tomoki Nakashima, Sayaka Takemoto-Kimura, Kazuhiro Aoki, Yasuyuki Morishita, Hiroshi Asahara, Keiichi Ohya, Akira Yamaguchi, Toshiyuki Takai, Tatsuhiko Kodama, Talal A Chatila, Haruhiko Bito & Hiroshi Takayanagi Nature Medicine12, 1410–1416
(December 2006); doi:10.1038/nm1515
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letter v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation
Seoung-Hoon Lee, Jaerang Rho, Daewon Jeong, Jai-Yoon Sul, Taesoo Kim, Nacksung Kim, Ju-Seob Kang, Takeshi Miyamoto, Toshio Suda, Sun-Kyeong Lee, Robert J Pignolo, Boguslawa Koczon-Jaremko, Joseph Lorenzo & Yongwon Choi Nature Medicine12, 1403–1409
(December 2006); doi:10.1038/nm1514
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letter Bace1 modulates myelination in the central and peripheral nervous system
Xiangyou Hu, Caitlin W Hicks, Wanxia He, Philip Wong, Wendy B Macklin, Bruce D Trapp & Riqiang Yan Nature Neuroscience9, 1520–1525
(December 2006); doi:10.1038/nn1797
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review Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
Franck Toledo and Geoffrey M. Wahl Nature Reviews Cancer6, 906–923
(December 2006); doi:10.1038/nrc2012
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letter BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing
Kunikazu Tsuji, Amitabha Bandyopadhyay, Brian D Harfe, Karen Cox, Sanjeev Kakar, Louis Gerstenfeld, Thomas Einhorn, Clifford J Tabin & Vicki Rosen Nature Genetics38, 1424–1429
(December 2006); doi:10.1038/ng1916
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November
article BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm
Valerie Gouon-Evans, Lise Boussemart, Paul Gadue, Dirk Nierhoff, Christoph I Koehler, Atsushi Kubo, David A Shafritz & Gordon Keller Nature Biotechnology24, 1402–1411
(November 2006); doi:10.1038/nbt1258
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article Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
Marc Veldhoen, Richard J Hocking, Richard A Flavell & Brigitta Stockinger Nature Immunology7, 1151–1156
(November 2006); doi:10.1038/ni1391
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October
letter Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus
Kevin Lee, JaeWook Jeong, Inseok Kwak, Cheng-Tai Yu, Beate Lanske, Desi W Soegiarto, Rune Toftgard, Ming-Jer Tsai, Sophia Tsai, John P Lydon & Francesco J DeMayo Nature Genetics38, 1204–1209
(September 2006); doi:10.1038/ng1874
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September
review Model organisms: The mighty mouse: genetically engineered mouse models in cancer drug development
Norman E. Sharpless and Ronald A. DePinho Nature Reviews Drug Discovery7, 741–754
(September 2006); doi:10.1038/nrd2110
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letter The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
M. A. Christophorou, I. Ringshausen, A. J. Finch, L. Brown Swigart and G. I. Evan Nature443, 214–217
(14 September 2006); doi:10.1038/nature05077
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letter Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
Manuela Pellegrini, Arkady Celeste, Simone Difilippantonio, Rong Guo, Weidong Wang, Lionel Feigenbaum and André Nussenzweig Nature443, 222–225
(14 September 2006); doi:10.1038/nature05112
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August
article Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
Pengyuan Liu, Yian Wang, Haris Vikis, Anna Maciag, Daolong Wang, Yan Lu, Yan Liu & Ming You Nature Genetics38, 888–895
(10 August 2006); doi:10.1038/ng1849
| Summary | Full Text (HTML / PDF) |
review Regulation of cardiac hypertrophy by intracellular signalling pathways
Joerg Heineke and Jeffery D. Molkentin Nature Reviews Molecular Cell Biology7, 589–600
(August 2006); doi:10.1038/nrm1983
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article Genome-wide genetic association of complex traits in heterogeneous stock mice
William Valdar, Leah C Solberg, Dominique Gauguier, Stephanie Burnett, Paul Klenerman, William O Cookson, Martin S Taylor, J Nicholas P Rawlins, Richard Mott & Jonathan Flint Nature Genetics38, 879–887
(August 2006); doi:10.1038/ng1840
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July
letter A germline-specific class of small RNAs binds mammalian Piwi proteins
Angélique Girard, Ravi Sachidanandam, Gregory J. Hannon and Michelle A. Carmell Nature442, 199–202
(13 July 2006); doi:10.1038/nature04917
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letter A novel class of small RNAs bind to MILI protein in mouse testes
Alexei Aravin , Dimos Gaidatzis, Sébastien Pfeffer, Mariana Lagos-Quintana, Pablo Landgraf, Nicola Iovino, Patricia Morris, Michael J. Brownstein, Satomi Kuramochi-Miyagawa, Toru Nakano, Minchen Chien, James J. Russo, Jingyue Ju, Robert Sheridan, Chris Sander, Mihaela Zavolan and Thomas Tuschl Nature442, 203–207
(13 July 2006); doi:10.1038/nature04916
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June
article Ovulated oocytes in adult mice derive from non-circulating germ cells
Kevin Eggan, Sara Jurga, Roger Gosden, Irene M. Min and Amy J. Wagers Nature441, 1109–1114
(29 June 2006); doi:10.1038/nature04929
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letter Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, Shigeo Murata, Jun-ichi Iwata, Isei Tanida, Takashi Ueno, Masato Koike, Yasuo Uchiyama, Eiki Kominami and Keiji Tanaka Nature441, 880–884
(15 June 2006); doi:10.1038/nature04723
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letter Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara, Kenji Nakamura, Makoto Matsui, Akitsugu Yamamoto, Yohko Nakahara, Rika Suzuki-Migishima, Minesuke Yokoyama, Kenji Mishima, Ichiro Saito, Hideyuki Okano and Noboru Mizushima Nature441, 885–889
(15 June 2006); doi:10.1038/nature04724
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news and views Neurodegeneration: Good riddance to bad rubbish
Daniel J. Klionsky Nature441, 819–820
(15 June 2006); doi:10.1038/441819a
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May
letter Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways
Dirk Grimm, Konrad L. Streetz, Catherine L. Jopling, Theresa A. Storm, Kusum Pandey, Corrine R. Davis, Patricia Marion, Felix Salazar and Mark A. Kay Nature441, 537–541
(25 May 2006); doi:10.1038/nature04791
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letter Critical role for the p110α phosphoinositide–3–OH kinase in growth and metabolic regulation
Lazaros C. Foukas, Marc Claret, Wayne Pearce, Klaus Okkenhaug, Stephen Meek, Emma Peskett, Sara Sancho, Andrew J. H. Smith, Dominic J. Withers and Bart Vanhaesebroeck Nature441, 366–370
(18 May 2006); doi:10.1038/nature04694
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April
letter Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
Maya Saleh, John C. Mathison, Melissa K. Wolinski, Steve J. Bensinger, Patrick Fitzgerald, Nathalie Droin, Richard J. Ulevitch, Douglas R. Green and Donald W. Nicholson Nature440, 1064–1068
(20 April 2006); doi:10.1038/nature04656
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March
letter A specific amyloid-β protein assembly in the brain impairs memory
Sylvain Lesné, Ming Teng Koh, Linda Kotilinek, Rakez Kayed, Charles G. Glabe, Austin Yang, Michela Gallagher and Karen H. Ashe Nature440, 352–357
(16 March 2006); doi:10.1038/nature04533
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news and views Alzheimer's disease: A needle from the haystack
Richard Morris and Lennart Mucke Nature440, 284–285
(16 March 2006); doi:10.1038/440284a
| Full Text (HTML / PDF) |
February
letter Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1
Davide Gabellini, Giuseppe D'Antona, Maurizio Moggio, Alessandro Prelle, Chiara Zecca, Raffaella Adami, Barbara Angeletti, Patrizia Ciscato, Maria Antonietta Pellegrino, Roberto Bottinelli, Michael R. Green and Rossella Tupler Nature439, 973–977
(23 February 2006); doi:10.1038/nature04422
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article Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens
Julie Bakker, Christelle De Mees, Quentin Douhard, Jacques Balthazart, Philippe Gabant, Josiane Szpirer and Claude Szpirer Nature Neuroscience9, 220–226
(February 2006); doi:10.1038/nn1624
| Abstract | Full Text (HTML/PDF) |
news and views Defending the brain from estrogen
David A Puts, Cynthia L Jordan and S Marc Breedlove Nature Neuroscience9, 155–156
(February 2006); doi:10.1038/nn0206-155
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letter GABA regulates synaptic integration of newly generated neurons in the adult brain
Shaoyu Ge, Eyleen L. K. Goh, Kurt A. Sailor, Yasuji Kitabatake, Guo-li Ming and Hongjun Song Nature439, 589–593
(02 February 2006); doi:10.1038/nature04404
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article Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
Kazuko Koshiba-Takeuchi, Jun K Takeuchi, Eric P Arruda, Irfan S Kathiriya, Rong Mo, Chi-chung Hui, Deepak Srivastava and Benoit G Bruneau Nature Genetics38, 175–183
(February 2006); doi:10.1038/ng1707
| Abstract | Full Text (HTML/PDF) |
January
letter Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Mitsuhiro Watanabe, Sander M. Houten, Chikage Mataki, Marcelo A. Christoffolete, Brian W. Kim, Hiroyuki Sato, Nadia Messaddeq, John W. Harney, Osamu Ezaki, Tatsuhiko Kodama, Kristina Schoonjans, Antonio C. Bianco and Johan Auwerx Nature439, 484–489
(26 January 2006); doi:10.1038/nature04330
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letter Constant darkness is a circadian metabolic signal in mammals
Jianfa Zhang, Krista Kaasik, Michael R. Blackburn and Cheng Chi Lee Nature439, 340–343
(19 January 2006); doi:10.1038/nature04368
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letter Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells
Oleg O. Glebov, Nicholas A. Bright and Benjamin J. Nichols Nature Cell Biology8, 46–54
(January 2006); doi:10.1038/ncb1342
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