Research library: Oncogenes/Tumor suppressors
2007:
December
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Other Years: 2005 | 2006 | 2008
December
letter
MUC1 oncoprotein activates the IκB kinase β complex and constitutive NF-κB signalling
Rehan Ahmad et al.
Nature Cell Biology 9, 1419–1427
(December 2007); doi:10.1038/ncb1661
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review
CHK2 kinase: cancer susceptibility and cancer therapy — two sides of the same coin?
Laurent Antoni, Nayanta Sodha, Ian Collins & Michelle D. Garrett
Nature Reviews Cancer 7, 925–936
(December 2007); doi:10.1038/nrc2251
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review
Oncogenes and tumour suppressors take on centrosomes
Kenji Fukasawa
Nature Reviews Cancer 7, 911–924
(December 2007); doi:10.1038/nrc2249
| Summary | Full Text (HTML / PDF) |
November
letter
p53 regulates maternal reproduction through LIF
Wenwei Hu, Zhaohui Feng, Angelika K. Teresky & Arnold J. Levine
Nature 450, 721–724
(29 November 2007); doi:10.1038/nature05993
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news and views
Reproduction: The unusual suspect
Colin L. Stewart
Nature 450, 619
(29 November 2007); doi:10.1038/450619a
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news and views
APC and colon cancer: two hits for one
Craig J Ceol, David Pellman & Leonard I Zon
Nature Medicine 13, 1286–1287
(November 2007); doi:10.1038/nm1107-1286
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article
STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression
Qian Zhang, Hong Y Wang, Xiaobin Liu & Mariusz A Wasik
Nature Medicine 13, 1341–1348
(November 2007); doi:10.1038/nm1659
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October
letter
An elaborate pathway required for Ras-mediated epigenetic silencing
Claude Gazin, Narendra Wajapeyee, Stephane Gobeil, Ching-Man Virbasius & Michael R. Green
Nature 449, 1073–1077
(25 October 2007); doi:10.1038/nature06251
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letter
Protein arginine-methyltransferase-dependent oncogenesis
Ngai Cheung, Li Chong Chan, Alex Thompson, Michael L Cleary & Chi Wai Eric So
Nature Cell Biology 9, 1208–1215
(October 2007); doi:10.1038/ncb1642
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article
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Laura Soucek, Elizabeth R Lawlor, Darya Soto, Ksenya Shchors, Lamorna Brown Swigart & Gerard I Evan
Nature Medicine 13, 1211–1218
(October 2007); doi:10.1038/nm1649
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perspective
Emerging roles of proteases in tumour suppression
Carlos López-Otín & Lynn M. Matrisian
Nature Reviews Cancer 7, 800–808
(October 2007); doi:10.1038/nrc2228
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article
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
Yoshinori Takahashi et al.
Nature Cell Biology 9, 1142–1151
(October 2007); doi:10.1038/ncb1634
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news and views
Shaping membranes into autophagosomes
Muriel Mari & Fulvio Reggiori
Nature Cell Biology 9, 1125–1127
(October 2007); doi:10.1038/ncb1007-1125
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article
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Li Ma, Julie Teruya-Feldstein & Robert A. Weinberg
Nature 449, 682–688
(11 October 2007); doi:10.1038/nature06174
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news and views
Cancer: Micromanagement of metastasis
Patricia S. Steeg
Nature 449, 671–673
(11 October 2007); doi:10.1038/449671a
| Full Text (HTML / PDF) |
letter
Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation
Xiaoling Tang, Sung-Wuk Jang, Xuerong Wang, Zhixue Liu, Scott M. Bahr, Shi-Yong Sun, Daniel Brat, David H. Gutmann & Keqiang Ye
Nature Cell Biology 9, 1199–1207
(October 2007); doi:10.1038/ncb1641
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article
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia
Teresa Palomero, Maria Luisa Sulis, Maria Cortina, Pedro J Real, Kelly Barnes, Maria Ciofani, Esther Caparros, Jean Buteau, Kristy Brown, Sherrie L Perkins, Govind Bhagat, Archana M Agarwal, Giuseppe Basso, Mireia Castillo, Satoru Nagase, Carlos Cordon-Cardo, Ramon Parsons, Juan Carlos Zúñiga-Pflücker, Maria Dominguez & Adolfo A Ferrando
Nature Medicine 13, 1203–1210
(October 2007); doi:10.1038/nm1636
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article
The prolyl isomerase Pin1 orchestrates p53 acetylation and dissociation from the apoptosis inhibitor iASPP
Fiamma Mantovani, Francesca Tocco, Javier Girardini, Paul Smith, Milena Gasco, Xin Lu, Tim Crook & Giannino Del Sal
Nature Structural & Molecular Biology 14, 912–920
(October 2007); doi:10.1038/nsmb1306
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news and views
Multienzyme assembly of a p53 transcription complex
Ted R Hupp & Malcolm Walkinshaw
Nature Structural & Molecular Biology 14, 885–887
(October 2007); doi:10.1038/nsmb1007-885
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news and views
Micromanaging metastasis
Alison Schuldt
Nature Cell Biology 9, 1121
(October 2007); doi:10.1038/ncb1007-1121
| Full Text (HTML / PDF) |
review
Lung cancer in never smokers — a different disease
Sophie Sun, Joan H. Schiller & Adi F. Gazdar
Nature Reviews Cancer 7, 778–790
(October 2007); doi:10.1038/nrc2190
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September
perspective
Cancer and ageing: convergent and divergent mechanisms
Manuel Serrano & Maria A. Blasco
Nature Reviews Molecular Cell Biology 8, 715–722
(September 2007); doi:10.1038/nrm2242
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review
Modelling breast cancer: one size does not fit all
Tracy Vargo-Gogola & Jeffrey M. Rosen
Nature Reviews Cancer 7, 659–672
(September 2007); doi:10.1038/nrc2193
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perspective
Patching the gaps in Hedgehog signalling
Rajat Rohatgi & Matthew P. Scott
Nature Cell Biology 9, 1005–1009
(September 2007); doi:10.1038/ncb435
| Summary | Full Text (HTML / PDF) |
August
letter
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response
Chiara Gorrini, Massimo Squatrito, Chiara Luise, Nelofer Syed, Daniele Perna, Landon Wark, Francesca Martinato, Domenico Sardella, Alessandro Verrecchia, Samantha Bennett, Stefano Confalonieri, Matteo Cesaroni, Francesco Marchesi, Milena Gasco, Eugenio Scanziani, Maria Capra, Sabine Mai, Paolo Nuciforo, Tim Crook, John Lough & Bruno Amati
Nature 448, 1063–1067
(30 August 2007); doi:10.1038/nature06055
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review
Filling out the Hippo pathway
Leslie J. Saucedo & Bruce A. Edgar
Nature Reviews Molecular Cell Biology 8, 613–621
(August 2007); doi:10.1038/nrm2221
| Summary | Full Text (HTML / PDF) |
letter
LKB1 modulates lung cancer differentiation and metastasis
Hongbin Ji et al.
Nature 448, 807–810
(16 August 2007); doi:10.1038/nature06030
| Summary | Full Text (HTML / PDF) |
article
PIM1-dependent phosphorylation of histone H3 at serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation
Alessio Zippo, Alessandra De Robertis, Riccardo Serafini & Salvatore Oliviero
Nature Cell Biology 9, 932–944
(August 2007); doi:10.1038/ncb1618
| Summary | Full Text (HTML / PDF) |
news and views
PIM1 and MYC: a changing relationship?
Jean-Francois Naud & Martin Eilers
Nature Cell Biology 9, 873–875
(August 2007); doi:10.1038/ncb0807-873
| Summary | Full Text (HTML / PDF) |
July
article
The ubiquitin-specific protease USP28 is required for MYC stability
Nikita Popov, Michael Wanzel, Mandy Madiredjo, Dong Zhang, Roderick Beijersbergen, Rene Bernards, Roland Moll, Stephen J. Elledge & Martin Eilers
Nature Cell Biology 9, 765–774
(July 2007); doi:10.1038/ncb1601
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news and views
MYC degradation: deubiquitinating enzymes enter the dance
Bruno Amati & Victor J. Sanchez-Arévalo Lobo
Nature Cell Biology 9, 729–731
(July 2007); doi:10.1038/ncb0707-729
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letter
Delayed ageing through damage protection by the Arf/p53 pathway
Ander Matheu, Antonio Maraver, Peter Klatt, Ignacio Flores, Isabel Garcia-Cao, Consuelo Borras, Juana M. Flores, Jose Viña, Maria A. Blasco & Manuel Serrano
Nature 448, 375–379
(19 July 2007); doi:10.1038/nature05949
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June
article
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
Vassiliki Theodorou, Melanie A Kimm, Mandy Boer, Lodewyk Wessels, Wendy Theelen, Jos Jonkers & John Hilkens
Nature Genetics 39, 759–769
(June 2007); doi:10.1038/ng2034
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article
Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation
Baisong Liao, Yan Hu & Gary Brewer
Nature Structural & Molecular Biology 14, 511–518
(June 2007); doi:10.1038/nsmb1249
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news and views
HER3 and mutant EGFR meet MET
Carlos L Arteaga
Nature Medicine 13, 675–677
(June 2007); doi:10.1038/nm0607-675
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progress
Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation
Leonardo Salmena & Pier Paolo Pandolfi
Nature Reviews Cancer 7, 409–413
(June 2007); doi:10.1038/nrc2145
| Summary | Full Text (HTML / PDF) |
letter
p73 supports cellular growth through c-Jun-dependent AP-1 transactivation
Faina Vikhanskaya, Wen Hong Toh, Iqbal Dulloo, Qiang Wu, Lakshmanane Boominathan, Huck Hui Ng, Karen H. Vousden & Kanaga Sabapathy
Nature Cell Biology 9, 698–706
(June 2007); doi:10.1038/ncb1598
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May
letter
p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
Hoseok Song, Monica Hollstein & Yang Xu
Nature Cell Biology 9, 573–580
(May 2007); doi:10.1038/ncb1571
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news and views
p53: a two-faced cancer gene
Michael B. Kastan & Elijahu Berkovich
Nature Cell Biology 9, 489–491
(May 2007); doi:10.1038/ncb0507-489
| Summary | Full Text (HTML / PDF) |
brief communication
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Idoya Lahortiga, Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink & Jan Cools
Nature Genetics 39, 593–595
(May 2007); doi:10.1038/ng2025
| Summary | Full Text (HTML / PDF) |
review
Genetic determinants of cancer metastasis
Don X. Nguyen & Joan Massagué
Nature Reviews Genetics 8, 341–352
(May 2007); doi:10.1038/nrg2101
| Summary | Full Text (HTML / PDF) |
scientific report
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs
Helmut Kae, Arjan Kortholt, Holger Rehmann, Robert H Insall, Peter J M Van Haastert, George B Spiegelman & Gerald Weeks
EMBO Reports 8, 477–482
(May 2007); doi:10.1038/sj.embor.7400936
| Summary | Full Text (HTML / PDF) |
review
Second generation inhibitors of BCR–ABL for the treatment of imatinib-resistant chronic myeloid leukaemia
Ellen Weisberg, Paul W. Manley, Sandra W. Cowan-Jacob, Andreas Hochhaus & James D. Griffin
Nature Reviews Cancer 7, 345–356
(May 2007); doi:10.1038/nrc2126
| Summary | Full Text (HTML / PDF) |
letter
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Madhu S Kumar, Jun Lu, Kim L Mercer, Todd R Golub & Tyler Jacks
Nature Genetics 39, 673–677
(May 2007); doi:10.1038/ng2003
| Summary | Full Text (HTML / PDF) |
news and views
MicroRNAs as tumor suppressors
Scott M Hammond
Nature Genetics 39, 582–583
(May 2007); doi:10.1038/ng0507-582
| Summary | Full Text (HTML / PDF) |
scientific report
Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating the physical association of Tak1–IKK
Xuefeng Wu & Shao-Cong Sun
EMBO Reports 8, 510–515
(May 2007); doi:10.1038/sj.embor.7400931
| Summary | Full Text (HTML / PDF) |
scientific report
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
Wilfredo Cosme-Blanco, Mei-Feng Shen, Alexander J F Lazar, Sen Pathak, Guillermina Lozano, Asha S Multani & Sandy Chang
EMBO Reports 8, 497–503
(May 2007); doi:10.1038/sj.embor.7400937
| Summary | Full Text (HTML / PDF) |
letter
Chemical genetics reveals a complex functional ground state of neural stem cells
Phedias Diamandis, Jan Wildenhain, Ian D Clarke, Adrian G Sacher, Jeremy Graham, David S Bellows, Erick K M Ling, Ryan J Ward, Leanne G Jamieson, Mike Tyers and Peter B Dirks
Nature Chemical Biology 3, 268–273
(May 2007); doi:10.1038/nchembio873
| Summary | Full Text (HTML / PDF) |
news and views
Chemical probes of neural stem cell self-renewal
Mark Mercola
Nature Chemical Biology 3, 246–247
(May 2007); doi:10.1038/nchembio0507-246
| Summary | Full Text (HTML / PDF) |
article
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
Christopher J. Sarkisian, Blaine A. Keister, Douglas B. Stairs, Robert B. Boxer, Susan E. Moody & Lewis A. Chodosh
Nature Cell Biology 9, 493–505
(May 2007); doi:10.1038/ncb1567
| Summary | Full Text (HTML / PDF) |
April
article
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
Yuko Matsumoto, Hiroyuki Marusawa, Kazuo Kinoshita, Yoko Endo, Tadayuki Kou, Toshiyuki Morisawa, Takeshi Azuma, Il-Mi Okazaki, Tasuku Honjo & Tsutomu Chiba
Nature Medicine 13, 470–476
(April 2007); doi:10.1038/nm1566
| Summary | Full Text (HTML / PDF) |
news and views
Providing AID to p53 mutagenesis
Shigeo Takaishi & Timothy C Wang
Nature Medicine 13, 404–406
(April 2007); doi:10.1038/nm0407-404
| Summary | Full Text (HTML / PDF) |
letter
An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation
Sunita Kumari, Anthony Bugaut, Julian L Huppert and Shankar Balasubramanian
Nature Chemical Biology 3, 218–221
(April 2007); doi:10.1038/nchembio864
| Summary | Full Text (HTML / PDF) |
news and views
The rule of four
Bruce A Armitage
Nature Chemical Biology 3, 203–204
(April 2007); doi:10.1038/nchembio0407-203
| Summary | Full Text (HTML / PDF) |
review
The impact of translocations and gene fusions on cancer causation
Felix Mitelman, Bertil Johansson & Fredrik Mertens
Nature Reviews Cancer 7, 233–245
(April 2007); doi:10.1038/nrc2091
| Summary | Full Text (HTML / PDF) |
letter
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53
Stephanie Carter, Oliver Bischof, Anne Dejean & Karen H. Vousden
Nature Cell Biology 9, 428–435
(April 2007); doi:10.1038/ncb1562
| Summary | Full Text (HTML / PDF) |
review
p53 in health and disease
Karen H. Vousden & David P. Lane
Nature Reviews Molecular Cell Biology 8, 275–283
(April 2007); doi:10.1038/nrm2147
| Summary | Full Text (HTML / PDF) |
letter
Myc deletion rescues Apc deficiency in the small intestine
Owen J. Sansom, Valerie S. Meniel, Vanesa Muncan, Toby J. Phesse, Julie A. Wilkins, Karen R. Reed, J. Keith Vass, Dimitris Athineos, Hans Clevers & Alan R. Clarke
Nature 446, 676–679
(5 April 2007); doi:10.1038/nature05674
| Summary | Full Text (HTML / PDF) |
review
Hyperactive Ras in developmental disorders and cancer
Suzanne Schubbert, Kevin Shannon & Gideon Bollag
Nature Reviews Cancer 7, 295–308
(April 2007); doi:10.1038/nrc2109
| Summary | Full Text (HTML / PDF) |
article
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
James Jiayuan Tong, Samuel E Schriner, David McCleary, Brian J Day & Douglas C Wallace
Nature Genetics 39, 476–485
(April 2007); doi:10.1038/ng2004
| Summary | Full Text (HTML / PDF) |
March
letter
Tyrosine kinase receptor RET is a key regulator of Peyer's Patch organogenesis
Henrique Veiga-Fernandes, Mark C. Coles, Katie E. Foster, Amisha Patel, Adam Williams, Dipa Natarajan, Amanda Barlow, Vassilis Pachnis & Dimitris Kioussis
Nature 446, 547–551
(29 March 2007); doi:10.1038/nature05597
| Summary | Full Text (HTML / PDF) |
letter
14-3-3σ controls mitotic translation to facilitate cytokinesis
Erik W. Wilker, Marcel A. T. M. van Vugt, Steven A. Artim, Paul H. Huang, Christian P. Petersen, H. Christian Reinhardt, Yun Feng, Phillip A. Sharp, Nahum Sonenberg, Forest M. White and Michael B. Yaffe
Nature 446, 329–332
(15 March 2007); doi:10.1038/nature05584
| Summary | Full Text (HTML / PDF) |
news and views
Cell biology: Lost in mitotic translation
Anthony Wynshaw-Boris
Nature 446, 274–275
(15 March 2007); doi:10.1038/446274a
| Full Text (HTML / PDF) |
letter
A common coding variant in CASP8 is associated with breast cancer risk
Angela Cox et al.
Nature Genetics 39, 352 - 358
(March 2007); doi:10.1038/ng1981
| Summary | Full Text (HTML / PDF) |
article
Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility
Mingxuan Xia & Hartmut Land
Nature Biotechnology 14, 215 - 223
(March 2007); doi:10.1038/nsmb1208
| Summary | Full Text (HTML / PDF) |
February
article
PTEN-deficient intestinal stem cells initiate intestinal polyposis
Xi C He, Tong Yin, Justin C Grindley, Qiang Tian, Toshiro Sato, W Andy Tao, Raminarao Dirisina, Kimberly S Porter-Westpfahl, Mark Hembree, Teri Johnson, Leanne M Wiedemann, Terrence A Barrett, Leroy Hood, Hong Wu & Linheng Li
Nature Genetics 39, 189–198
(February 2007); doi:10.1038/ng1928
| Summary | Full Text (HTML / PDF) |
brief communication
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2
Bing Xia, Josephine C Dorsman, Najim Ameziane, Yne de Vries, Martin A Rooimans, Qing Sheng, Gerard Pals, Abdellatif Errami, Eliane Gluckman, Julian Llera, Weidong Wang, David M Livingston, Hans Joenje & Johan P de Winter
Nature Genetics 39, 159–161
(February 2007); doi:10.1038/ng1942
| Summary | Full Text (HTML / PDF) |
brief communication
Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer
Sarah Reid, Detlev Schindler, Helmut Hanenberg, Karen Barker, Sandra Hanks, Reinhard Kalb, Kornelia Neveling, Patrick Kelly, Sheila Seal, Marcel Freund, Melanie Wurm, Sat Dev Batish, Francis P Lach, Sevgi Yetgin, Heidemarie Neitzel, Hany Ariffin, Marc Tischkowitz, Christopher G Mathew, Arleen D Auerbach & Nazneen Rahman
Nature Genetics 39, 162–164
(February 2007); doi:10.1038/ng1947
| Summary | Full Text (HTML / PDF) |
brief communication
Fanconi anemia and breast cancer susceptibility
Ketan J Patel
Nature Genetics 39, 142–143
(February 2007); doi:10.1038/ng0207-142
| Summary | Full Text (HTML / PDF) |
January
review
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Hua Yu, Marcin Kortylewski and Drew Pardoll
Nature Reviews Immunology 7, 41–51
(January 2007); doi:10.1038/nri1995
| Summary | Full Text (HTML / PDF) |
review
Cancer phenomics: RET and PTEN as illustrative models
Kevin M. Zbuk and Charis Eng
Nature Reviews Cancer 7, 35–45
(January 2007); doi:10.1038/nrc2037
| Summary | Full Text (HTML / PDF) |
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