Research library: Oncogenes/Tumor suppressors
2009:
| December
| November
| October
| September
| August
| July
| June
| May
| April
| March
| February
| January
Other Years: 2005 | 2006 | 2007 | 2008
December
letter
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
Ulrich Wellner et al.
Nature Cell Biology 11, 1487–1495
(December 2009); doi:10.1038/ncb1998
| Summary | Full Text (HTML / PDF) |
article
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Lenny Dang et al.
Nature 462, 739–744
(10 December 2009); doi:10.1038/nature08617
| Full Text (HTML / PDF) |
letter
Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region
Monica Gostissa et al.
Nature 462, 803–807
(10 December 2009); doi:10.1038/nature08633
| Full Text (HTML / PDF) |
letter
TAp63 induces senescence and suppresses tumorigenesis in vivo
Xuecui Guo et al.
Nature Cell Biology 11, 1451–1457
(December 2009); doi:10.1038/ncb1988
| Summary | Full Text (HTML / PDF) |
review
Awakening guardian angels: drugging the p53 pathway
Christopher J. Brown, Sonia Lain, Chandra S. Verma, Alan R. Fersht & David P. Lane
Nature Reviews Cancer 9, 862–873
(December 2009); doi:10.1038/nrc2763
| Summary | Full Text (HTML / PDF) |
November
letter
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Yingli Sun et al.
Nature Cell Biology 11, 1376–1382
(1 November 2009) doi:10.1038/ncb1982
| Summary | Full Text (HTML / PDF) |
news and views
Tip60-ing the balance in DSB repair
Wolfgang Fischle
Nature Cell Biology 11, 1279–1281
(November 2009); doi:10.1038/ncb1109-1279
| Full Text (HTML / PDF) |
letter
Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
Anne Goriely et al.
Nature Genetics 41, 1247–1252
(November 2009); doi:10.1038/ng.470
| Summary | Full Text (HTML / PDF) |
review
Emerging roles of E2Fs in cancer: an exit from cell cycle control
Hui-Zi Chen, Shih-Yin Tsai & Gustavo Leone
Nature Reviews Cancer 9, 785–797
(November 2009); doi:10.1038/nrc2696
| Summary | Full Text (HTML / PDF) |
review
p53 — a Jack of all trades but master of none
Melissa R. Junttila & Gerard I. Evan
Nature Reviews Cancer 9, 821–829
(November 2009); doi:10.1038/nrc2728
| Summary | Full Text (HTML / PDF) |
perspective
20 years studying p53 functions in genetically engineered mice
Lawrence A. Donehower & Guillermina Lozano
Nature Reviews Cancer 9, 831–841
(November 2009); doi:10.1038/nrc2731
| Summary | Full Text (HTML / PDF) |
scientific reports
RelA/p65 functions to maintain cellular senescence by regulating genomic stability and DNA repair
Jingxin Wang et al.
EMBO Reports 10, 1272–1278
(November 2009); doi:10.1038/embor.2009.197
| Summary | Full Text (HTML / PDF) |
letter
Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma
Etienne Meylan et al.
Nature 462, 104–107
(05 November 2009); doi:10.1038/nature08462
| Full Text (HTML / PDF) |
letter
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie et al.
Nature 462, 108–112
(05 November 2009); doi:10.1038/nature08460
| Full Text (HTML / PDF) |
news and views
Cancer: A tumour gene's fatal flaws
Julian Downward
Nature 462, 44–45
(05 November 2009); doi:10.1038/462044a
| Full Text (HTML / PDF) |
letter
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas
Adam J Bass et al.
Nature Genetics 41, 1238–1242
(November 2009); doi:10.1038/ng.465
| Summary | Full Text (HTML / PDF) |
October
review
When mutants gain new powers: news from the mutant p53 field
Ran Brosh & Varda Rotter
Nature Reviews Cancer 9, 701–713
(October 2009); doi:10.1038/nrc2693
| Summary | Full Text (HTML / PDF) |
article
Pten in stromal fibroblasts suppresses mammary epithelial tumours
Anthony J. Trimboli et al.
Nature 461, 1084–1091
(22 October 2009); doi:10.1038/nature08486
| Full Text (HTML / PDF) |
review
The expanding universe of p53 targets
Daniel Menendez, Alberto Inga & Michael A. Resnick
Nature Reviews Cancer 9, 724–737
(October 2009); doi:10.1038/nrc2730
| Summary | Full Text (HTML / PDF) |
letter
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
Yvonne Begus-Nahrmann et al.
Nature Genetics 41, 1138–1143
(October 2009); doi:10.1038/ng.426
| Summary | Full Text (HTML / PDF) |
letter
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
Yaroslava Ruzankina et al.
Nature Genetics 41, 1144–1149
(October 2009); doi:10.1038/ng.441
| Summary | Full Text (HTML / PDF) |
article
An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression
Jay S Desgrosellier et al.
Nature Medicine 15, 1163–1169
(October 2009); doi:10.1038/nm.2009
| Summary | Full Text (HTML / PDF) |
review
Tumour suppression by p53: a role for the DNA damage response?
David W. Meek
Nature Reviews Cancer 9, 714–723
(October 2009); doi:10.1038/nrc2716
| Summary | Full Text (HTML / PDF) |
review
p53 and E2f: partners in life and death
Shirley Polager & Doron Ginsberg
Nature Reviews Cancer 9, 738–748
(October 2009); doi:10.1038/nrc2718
| Summary | Full Text (HTML / PDF) |
perspective
The first 30 years of p53: growing ever more complex
Arnold J. Levine & Moshe Oren
Nature Reviews Cancer 9, 749–758
(October 2009); doi:10.1038/nrc2723
| Summary | Full Text (HTML / PDF) |
article
Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling
Anne-Marie Martinez et al.
Nature Genetics 41, 1076–1082
(October 2009); doi:10.1038/ng.414
| Summary | Full Text (HTML / PDF) |
review
p53 and metabolism
Karen H. Vousden & Kevin M. Ryan
Nature Reviews Cancer 9, 691–700
(October 2009); doi:10.1038/nrc2715
| Summary | Full Text (HTML / PDF) |
letter
A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling
Anne-Kathrin Classen, Brandon D Bunker, Kieran F Harvey, Thomas Vaccari & David Bilder
Nature Genetics 41, 1150–1155
(October 2009); doi:10.1038/ng.445
| Summary | Full Text (HTML / PDF) |
September
article
A luminal epithelial stem cell that is a cell of origin for prostate cancer
Xi Wang et al.
Nature 461, 495–500
(24 September 2009); doi:10.1038/nature08361
| Full Text (HTML / PDF) |
letter
A dimerization-dependent mechanism drives RAF catalytic activation
Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois, Frank Sicheri & Marc Therrien
Nature 461, 542–545
(24 September 2009); doi:10.1038/nature08314
| Full Text (HTML / PDF) |
letter
p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Kaori Fujita et al.
Nature Cell Biology 11, 1135–1142
(September 2009); doi:10.1038/ncb1928
| Summary | Full Text (HTML / PDF) |
letter
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras
Jennifer O. Lauchle et al.
Nature 461, 411–414
(17 September 2009); doi:10.1038/nature08279
| Full Text (HTML / PDF) |
letter
Axin determines cell fate by controlling the p53 activation threshold after DNA damage
Qinxi Li et al.
Nature Cell Biology 11, 1128–1134
(September 2009); doi:10.1038/ncb1927
| Summary | Full Text (HTML / PDF) |
letter
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
Zachary T. Schafer et al.
Nature 461, 109–113
(03 September 2009); doi:10.1038/nature08268
| Full Text (HTML / PDF) |
news and views
Cancer: The fat and the furious
Eyal Gottlieb
Nature 461, 44–45
(03 September 2009); doi:10.1038/461044a
| Full Text (HTML / PDF) |
August
letter
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
Hyenjong Hong et al.
Nature 460, 1132–1135
(27 August 2009); doi:10.1038/nature08235
| Full Text (HTML / PDF) |
letter
The Ink4/Arf locus is a barrier for iPS cell reprogramming
Han Li et al.
Nature 460, 1136–1139
(27 August 2009); doi:10.1038/nature08290
| Full Text (HTML / PDF) |
letter
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
Teruhisa Kawamura et al.
Nature 460, 1140–1144
(27 August 2009); doi:10.1038/nature08311
| Full Text (HTML / PDF) |
letter
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Jochen Utikal et al.
Nature 460, 1145–1148
(27 August 2009); doi:10.1038/nature08285
| Full Text (HTML / PDF) |
letter
A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
Rosa M. Marión et al.
Nature 460, 1149–1153
(27 August 2009); doi:10.1038/nature08287
| Full Text (HTML / PDF) |
news and views
Stem cells: The promises and perils of p53
Valery Krizhanovsky & Scott W. Lowe
Nature 460, 1085–1086
(27 August 2009); doi:10.1038/4601085a
| Full Text (HTML / PDF) |
perspective
Crosstalk of Notch with p53 and p63 in cancer growth control
G. Paolo Dotto
Nature Reviews Cancer 9, 587–595
(August 2009); doi:10.1038/nrc2675
| Summary | Full Text (HTML / PDF) |
article
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling
Sari Tuupanen et al.
Nature Genetics 41, 885–890
(August 2009); doi:10.1038/ng.406
| Summary | Full Text (HTML / PDF) |
brief communication
The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
Mark M Pomerantz et al.
Nature Genetics 41, 882–884
(August 2009); doi:10.1038/ng.403
| Summary | Full Text (HTML / PDF) |
news and views
Elucidating the role of 8q24 in colorectal cancer
Olivier Harismendy & Kelly A. Frazer
Nature Genetics 41, 868–869
(August 2009); doi:10.1038/ng0809-868
| Full Text (HTML / PDF) |
letter
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
Masashi Sanada et al.
Nature 460, 904–908
(13 August 2009); doi:10.1038/nature08240
| Full Text (HTML / PDF) |
news and views
Cancer: More than kin and less than kind
Kevin Shannon & Mignon Loh
Nature 460, 804–807
(13 August 2009); doi:10.1038/460804a
| Full Text (HTML / PDF) |
July
letter
Acquired mutations in TET2 are common in myelodysplastic syndromes
Saskia M C Langemeijer et al.
Nature Genetics 41, 838–842
(July 2009); doi:10.1038/ng.391
| Summary | Full Text (HTML / PDF) |
news and views
TET2 mutations in myelodysplasia and myeloid malignancies
Charles G Mullighan
Nature Genetics 41, 766–767
(July 2009); doi:10.1038/ng0709-766
| Full Text (HTML / PDF) |
letter
Modulation of microRNA processing by p53
Hiroshi I. Suzuki et al.
Nature 460, 529–533
(23 July 2009); doi:10.1038/nature08199
| Full Text (HTML / PDF) |
news and views
Cancer: Three birds with one stone
Franck Toledo & Boris Bardot
Nature 460, 466–467
(23 July 2009); doi:10.1038/460466a
| Full Text (HTML / PDF) |
article
A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma
Hayriye V Erkizan et al.
Nature Medicine 15, 750–756
(July 2009); doi:10.1038/nm.1983
| Summary | Full Text (HTML / PDF) |
review
Genetic prognostic and predictive markers in colorectal cancer
Axel Walther et al.
Nature Reviews Cancer 9, 489–499
(July 2009); doi:10.1038/nrc2645
| Summary | Full Text (HTML / PDF) |
June
article
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer
Kenneth L. Scott et al.
Nature 459, 1085–1090
(25 June 2009); doi:10.1038/nature08109
| Full Text (HTML / PDF) |
letter
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
Kwan-Hyuck Baek et al.
Nature 459, 1126–1130
(25 June 2009); doi:10.1038/nature08062
| Full Text (HTML / PDF) |
article
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
Shu-Ping Wang et al.
Nature Cell Biology 11, 694–704
(June 2009); doi:10.1038/ncb1875
| Summary | Full Text (HTML / PDF) |
review
p21 in cancer: intricate networks and multiple activities
Tarek Abbas & Anindya Dutta
Nature Reviews Cancer 9, 400–414
(June 2009); doi:10.1038/nrc2657
| Summary | Full Text (HTML / PDF) |
progress
New insights into the aetiology of colorectal cancer from genome-wide association studies
Albert Tenesa & Malcolm G. Dunlop
Nature Reviews Genetics 10, 353–358
(June 2009); doi:10.1038/nrg2574
| Summary | Full Text (HTML / PDF) |
review
The biology of ovarian cancer: new opportunities for translation
Robert C. Bast, Bryan Hennessy & Gordon B. Mills
Nature Reviews Cancer 9, 415–428
(June 2009); doi:10.1038/nrc2644
| Summary | Full Text (HTML / PDF) |
letter
Frequent inactivation of A20 in B-cell lymphomas
Motohiro Kato et al.
Nature 459, 712–716
(04 June 2009); doi:10.1038/nature07969
| Full Text (HTML / PDF) |
letter
Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma
Mara Compagno et al.
Nature 459, 717–721
(04 June 2009); doi:10.1038/nature07968
| Full Text (HTML / PDF) |
review
High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
Jaap Kool & Anton Berns
Nature Reviews Cancer 9, 389–399
(June 2009); doi:10.1038/nrc2647
| Summary | Full Text (HTML / PDF) |
perspective
Facilitating replication under stress: an oncogenic function of MYC?
Steffi Herold, Barbara Herkert & Martin Eilers
Nature Reviews Cancer 9, 441–444
(June 2009); doi:10.1038/nrc2640
| Summary | Full Text (HTML / PDF) |
May
article
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
Chunyan Tian et al.
Nature Cell Biology 11, 580–591
(May 2009); doi:10.1038/ncb1864
| Summary | Full Text (HTML / PDF) |
perspective
The ups and downs of p53: understanding protein dynamics in single cells
Eric Batchelor, Alexander Loewer & Galit Lahav
Nature Reviews Cancer 9, 371–377
(May 2009); doi:10.1038/nrc2604
| Summary | Full Text (HTML / PDF) |
article
BrafV600E cooperates with Pten loss to induce metastatic melanoma
David Dankort et al.
Nature Genetics 41, 544–552
(May 2009); doi:10.1038/ng.356
| Summary | Full Text (HTML / PDF) |
perspective
Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours
Amy Brock, Hannah Chang & Sui Huang
Nature Reviews Genetics 10, 336–342
(May 2009); doi:10.1038/nrg2556
| Summary | Full Text (HTML / PDF) |
technical report
Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens
Alice C Fan et al.
Nature Medicine 15, 566–571
(May 2009); doi:10.1038/nm.1903
| Summary | Full Text (HTML / PDF) |
letter
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
Brett S Carver et al.
Nature Genetics 41, 619–624
(May 2009); doi:10.1038/ng.370
| Summary | Full Text (HTML / PDF) |
brief communication
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
Jennifer C King et al.
Nature Genetics 41, 524–526
(May 2009); doi:10.1038/ng.371
| Summary | Full Text (HTML / PDF) |
news and views
TMPRSS2-ERG and PTEN loss in prostate cancer
Jeremy A Squire
Nature Genetics 41, 509–510
(May 2009); doi:10.1038/ng0509-509
| Full Text (HTML / PDF) |
perspective
Tumour necrosis factor and cancer
Frances Balkwill
Nature Reviews Cancer 9, 361–371
(May 2009); doi:10.1038/nrc2628
| Summary | Full Text (HTML / PDF) |
April
letter
Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction
Stefano Fumagalli et al.
Nature Cell Biology 11, 501–508
(April 2009); doi:10.1038/ncb1858
| Summary | Full Text (HTML / PDF) |
letter
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms
Amy V Jones et al.
Nature Genetics 41, 446–449
(April 2009); doi:10.1038/ng.334
| Summary | Full Text (HTML / PDF) |
letter
A common JAK2 haplotype confers susceptibility to myeloproliferative neoplasms
Damla Olcaydu et al.
Nature Genetics 41, 450–454
(April 2009); doi:10.1038/ng.341
| Summary | Full Text (HTML / PDF) |
letter
A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms
Outi Kilpivaara et al.
Nature Genetics 41, 455–459
(April 2009); doi:10.1038/ng.342
| Summary | Full Text (HTML / PDF) |
news and views
Somatic and germline genetics at the JAK2 locus
Peter J Campbell
Nature Methods 41, 385–386
(April 2009); doi:10.1038/ng0409-385
| Full Text (HTML / PDF) |
letter
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
Ping Gao et al.
Nature 458, 762–765
(09 April 2009); doi:10.1038/nature07823
| Summary | Full Text (HTML / PDF) |
letter
p53-cofactor JMY is a multifunctional actin nucleation factor
J. Bradley Zuchero, Amanda S. Coutts, Margot E. Quinlan, Nicholas B. La Thangue & R. Dyche Mullins
Nature Cell Biology 11, 451–459
(April 2009); doi:10.1038/ncb1852
| Summary | Full Text (HTML / PDF) |
news and views
Double JMY: making actin fast
David W. Roadcap & James E. Bear
Nature Cell Biology 11, 375–376
(April 2009); doi:10.1038/ncb0409-375
| Full Text (HTML / PDF) |
March
article
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
Hugh K Arnold, Xiaoli Zhang, Colin J Daniel, Deanne Tibbitts, Julie Escamilla-Powers, Amy Farrell, Sara Tokarz, Charlie Morgan & Rosalie C Sears
The EMBO Journal 28, 500–512
(March 2009); doi:10.1038/emboj.2008.279
| Summary | Full Text (HTML / PDF) |
letter
Transcriptome sequencing to detect gene fusions in cancer
Christopher A. Maher et al.
Nature 458, 97–101
(March 2009); doi:10.1038/nature07638
| Summary | Full Text (HTML / PDF) |
February
article
The tumor suppressor Pml regulates cell fate in the developing neocortex
Tarik Regad, Cristian Bellodi, Pierluigi Nicotera & Paolo Salomoni
Nature Neuroscience 12, 132–140
(February 2009); doi:10.1038/nn.2251
| Summary | Full Text (HTML / PDF) |
news and views
PML: a tumor suppressor essential for neocortical development
Karisa C Schreck & Nicholas Gaiano
Nature Neuroscience 12, 108–110
(February 2009); doi:10.1038/nn0209-108
| Full Text (HTML / PDF) |
review
p53 polymorphisms: cancer implications
Catherine Whibley, Paul D. P. Pharoah & Monica Hollstein
Nature Reviews Cancer 9, 95–107
(February 2009); doi:10.1038/nrc2584
| Summary | Full Text (HTML / PDF) |
article
The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer
Alessandra Rustighi et al.
Nature Cell Biology 11, 133–142
(February 2009); doi:10.1038/ncb1822
| Summary | Full Text (HTML / PDF) |
review
Senescence-messaging secretome: SMS-ing cellular stress
Thomas Kuilman & Daniel S. Peeper
Nature Reviews Cancer 9, 81–94
(February 2009); doi:10.1038/nrc2560
| Summary | Full Text (HTML / PDF) |
letter
Dynamic modularity in protein interaction networks predicts breast cancer outcome
Ian W Taylor et al.
Nature Biotechnology 27, 199–204
(February 2009); doi:10.1038/nbt.1522
| Summary | Full Text (HTML / PDF) |
January
letter
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Catherine D. Van Raamsdonk et al.
Nature 457, 599–602
(January 2009); doi:10.1038/nature07586
| Summary | Full Text (HTML / PDF) |
article
miR-29 miRNAs activate p53 by targeting p85α and CDC42
Seong-Yeon Park, Jung Hyun Lee, Minju Ha, Jin-Wu Nam & V Narry Kim
Nature Structural & Molecular Biology 16, 23–29
(January 2009); doi:10.1038/nsmb.1533
| Summary | Full Text (HTML / PDF) |
article
Cancer induction by restriction of oncogene expression to the stem cell compartment
María Pérez-Caro et al.
The EMBO Journal 28, 8–20
(January 2009); doi:10.1038/emboj.2008.253
| Summary | Full Text (HTML / PDF) |
letter
Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Sandra Rebouissou et al.
Nature 457, 200–204
(08 January 2009); doi:10.1038/nature07475
| Summary | Full Text (HTML / PDF) |
|
