Cell signaling research papers - Phosphatases - Signaling Update

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Research library: Phosphatases

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November

article
Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
Xue Li, Kenneth A. Oghi, Jie Zhang, Anna Krones, Kevin T. Bush, Christopher K. Glass, Sanjay K. Nigam, Aneel K. Aggarwal, Richard Maas, David W. Rose and Michael G. Rosenfeld
Nature 426, 247–254
(20 November 2003); doi:10.1038/nature02083
| Abstract | Full Text (HTML / PDF) |

letters to nature
Eyes absent represents a class of protein tyrosine phosphatases
Jayanagendra P. Rayapureddi, Chandramohan Kattamuri, Brian D. Steinmetz, Benjamin J. Frankfort, Edwin J. Ostrin, Graeme Mardon and Rashmi S. Hegde
Nature 426, 295–298
(20 November 2003); doi:10.1038/nature02093
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letters to nature
The transcription factor Eyes absent is a protein tyrosine phosphatase
Tina L. Tootle , Serena J. Silver , Erin L. Davies , Victoria Newman, Robert R. Latek, Ishara A. Mills, Jeremy D. Selengut, Beth E. W. Parlikar and Ilaria Rebay
Nature 426, 299–302
(20 November 2003); doi:10.1038/nature02097
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news and views
Signal transduction: An eye on organ development
Jonathan A. Epstein and Benjamin G. Neel
Nature 426, 238–239
(20 November 2003); doi:10.1038/426238a
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letters to nature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
Luca Busino, Maddalena Donzelli, Massimo Chiesa, Daniele Guardavaccaro, Dvora Ganoth, N. Valerio Dorrello, Avram Hershko, Michele Pagano and Giulio F. Draetta
Nature 426, 87–91
(06 November 2003); doi:10.1038/nature02082
| First Paragraph | Full Text (HTML / PDF) |

September

review article
Phosphatases in cell-matrix adhesion and migration
Melinda Larsen, Michel L. Tremblay and Kenneth M. Yamada
Nature Reviews Molecular Cell Biology 4, 700–711
(September 2003); doi:10.1038/nrm1199
| Abstract | Full Text (HTML / PDF) |

article
The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin
Sandra Ryeom, Rebecca J. Greenwald, Arlene H. Sharpe and Frank McKeon
Nature Immunology 4, 874–881
(September 2003); doi:10.1038/ni966
| Abstract | Full Text (HTML/PDF) |

news and views
Calcium-independent calcineurin regulation
Richard V. Parry and Carl H. June
Nature Immunology 4, 821–823
(September 2003); doi:10.1038/ni0903-821
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August

letters to nature
Feedback regulation of MAPK signalling by an RNA-binding protein
Reiko Sugiura, Ayako Kita, Yasuhito Shimizu, Hisato Shuntoh, Susie O. Sio and Takayoshi Kuno
Nature 424, 961–965
(21 August 2003); doi:10.1038/nature01907
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scientific report
Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo
Camilla Burnett and Ken Howard
EMBO reports 4, 793–799
(August 2003); doi:10.1038/sj.embor.embor900
| Abstract | Full Text (HTML/PDF) |

July

article
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
Norihiko Watanabe, Maya Gavrieli, John R Sedy, Jianfei Yang, Francesca Fallarino, Susan K Loftin, Michelle A Hurchla, Natalie Zimmerman, Julia Sim, Xingxing Zang, Theresa L Murphy, John H Russell, James P Allison and Kenneth M Murphy
Nature Immunology 4, 670–679
(July 2003); doi:10.1038/ni944
| Abstract | Full Text (HTML/PDF) |

news and views
More negative feedback?
Anthony J Coyle and Jose-Carlos Gutierrez-Ramos
Nature Immunology 4, 647–648
(July 2003); doi:10.1038/ni0703-647
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June

letter
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry
Dmitry V. Bulavin, Yuichiro Higashimoto, Zoya N. Demidenko, Sarah Meek, Paul Graves, Crissy Phillips, Hui Zhao, Sally A. Moody, Ettore Appella, Helen Piwnica-Worms and Albert J. Fornace Jr
Nature Cell Biology 5, 545–551
(June 2003); doi:10.1038/ncb994
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letters to nature
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate
Annette Salmeen, Jannik N. Andersen, Michael P. Myers, Tzu-Ching Meng, John A. Hinks, Nicholas K. Tonks and David Barford
Nature 423, 769–773
(12 June 2003); doi:10.1038/nature01680
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letters to nature
Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B
Rob L. M. van Montfort, Miles Congreve, Dominic Tisi, Robin Carr and Harren Jhoti
Nature 423, 773–777
(12 June 2003); doi:10.1038/nature01681
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article
A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting
Anja U Bräuer, Nicolai E Savaskan, Hartmut Kühn, Siegfried Prehn, Olaf Ninnemann and Robert Nitsch
Nature Neuroscience 6, 572–578
(June 2003); doi:10.1038/nn1052
| Abstract | Full Text (HTML/PDF) |

May

review article
Sphingosine-1-phosphate: an enigmatic signalling lipid
Sarah Spiegel and Sheldon Milstien
Nature Reviews Molecular Cell Biology 4, 397–407
(May 2003); doi:10.1038/nrm1103
| Summary | Full Text (HTML / PDF) |

letter
EGFR activation coupled to inhibition of tyrosine phosphatases causes lateral signal propagation
Andrew R. Reynolds, Christian Tischer, Peter J. Verveer, Oliver Rocks and Philippe I. H. Bastiaens
Nature Cell Biology 5, 447–453
(May 2003); doi:10.1038/ncb981
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April

letters to nature
PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
Yuxin Yin, Yu-Xin Liu, Yan J. Jin, Eric J. Hall and J. Carl Barrett
Nature 422, 527–531
(03 April 2003); doi:10.1038/nature01519
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March

letter
A non-proteolytic function of separase links the onset of anaphase to mitotic exit
Matt Sullivan and Frank Uhlmann
Nature Cell Biology 5, 249–254
(March 2003); doi:10.1038/ncb940
| Abstract | Full Text (HTML/PDF) |

news and views
Multitasking at mitotic exit
Karen E. Ross and Orna Cohen-Fix
Nature Cell Biology 5, 188–190
(March 2003); doi:10.1038/ncb0303-188
| Full Text (HTML/PDF) |

letter
Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
Akihiro Fujikawa, Daisuke Shirasaka, Shoichi Yamamoto, Hiroyoshi Ota, Kinnosuke Yahiro, Masahide Fukada, Takafumi Shintani, Akihiro Wada, Nobuo Aoyama, Toshiya Hirayama, Hiroshi Fukamachi and Masaharu Noda
Nature Genetics 33, 375–381
(March 2003); doi:10.1038/ng1112
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news and views
Intoxicated cells and stomach ulcers
Richard M. Peek Jr.
Nature Genetics 33, 328–330
(March 2003); doi:10.1038/ng0303-328
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article
Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex
Gianluca Canettieri, Ianessa Morantte, Ernesto Guzmán, Hiroshi Asahara, Stephan Herzig, Scott D. Anderson, John R. Yates and III Marc Montminy
Nature Structural Biology 10, 175–181
(March 2003); doi:10.1038/nsb895
| Abstract | Full Text (HTML/PDF) |

news and views
The decline of induced transcription: a case of enzymatic symbiosis
Paolo Sassone-Corsi
Nature Structural Biology 10, 151–152
(March 2003); doi:10.1038/nsb0303-151
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article
TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways
Irena Štefanová, Bernhard Hemmer, Marco Vergelli, Roland Martin, William E. Biddison and Ronald N. Germain
Nature Immunology 4, 248–254
(March 2003); doi:10.1038/ni895
| Abstract | Full Text (HTML/PDF) |

news and views
Tuning the immune system: competing positive and negative feedback loops
Daniel L. Mueller
Nature Immunology 4, 210–211
(March 2003); doi:10.1038/ni0303-210
| Full Text (HTML/PDF) |

February

article
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling
Claudine Irles, Antony Symons, Frédérique Michel, Talitha R. Bakker, P. Anton van der Merwe and Oreste Acuto
Nature Immunology 4, 189–197
(February 2003); doi:10.1038/ni877
| Abstract | Full Text (HTML/PDF) |

review article
Tor signalling in bugs, brain and brawn
Estela Jacinto and Michael N. Hall
Nature Reviews Molecular Cell Biology 4, 117–126
(February 2003); doi:10.1038/nrm1018
| Summary | Full Text (HTML / PDF) |

January

article
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis
Michiko Shirane and Keiichi I. Nakayama
Nature Cell Biology 5, 28–37
(January 2003); doi:10.1038/ncb894
| Abstract | Full Text (HTML/PDF) |

news and views
Defying death: showing Bcl-2 the way home
Colin Adrain, Emma M. Creagh and Seamus J. Martin
Nature Cell Biology 5, 9–11
(January 2003); doi:10.1038/ncb0103-9a
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article
Tyrosine phosphorylation of VHR phosphatase by ZAP-70
Andres Alonso, Souad Rahmouni, Scott Williams, Marianne van Stipdonk, Lukasz Jaroszewski, Adam Godzik, Robert T. Abraham, Stephen P. Schoenberger and Tomas Mustelin
Nature Immunology 4, 44–48
(January 2003); doi:10.1038/ni856
| Abstract | Full Text (HTML/PDF) |

news and views
ZAP-ping T-cell activation
Sarah Greaves
Nature Cell Biology 5, 13
(January 2003); doi:10.1038/ncb0103-13
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article
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling
Surojit Paul, Angus C. Nairn, Ping Wang and Paul J. Lombroso
Nature Neuroscience 6, 34–42
(January 2003); doi:10.1038/nn989
| Abstract | Full Text (HTML/PDF) |