news and views PTPN22 and autoimmune disease
Katherine A Siminovitch Nature Genetics36, 1248–1249
(December 2004); doi:10.1038/ng1204-1248
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article Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress
Norbert Frey, Tomasa Barrientos, John M Shelton, Derk Frank, Hartmut Rütten, Doris Gehring, Christian Kuhn, Matthias Lutz, Beverly Rothermel, Rhonda Bassel-Duby, James A Richardson, Hugo A Katus, Joseph A Hill and Eric N Olson Nature Medicine10, 1336–1343
(December 2004); doi:10.1038/nm1132
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article Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice
Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda and Iichiro Shimomura Nature Medicine10, 1208–1215
(November 2004); doi:10.1038/nm1117
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news and views Turning up the heat in the fat cell
Domenico Accili and Luca Valenti Nature Medicine10, 1168–1169
(November 2004); doi:10.1038/nm1104-1168
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review article Oncogenic mechanisms of the Helicobacter pylori CagA protein
Masanori Hatakeyama Nature Reviews Cancer4, 688–694
(September 2004); doi:10.1038/nrc1433
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article Control of vesicle fusion by a tyrosine phosphatase
Huong Huynh, Nunzio Bottini, Scott Williams, Vera Cherepanov, Lucia Musumeci, Kan Saito, Shane Bruckner, Eric Vachon, Xiaodong Wang, Joshua Kruger, Chung-Wai Chow, Maurizio Pellecchia, Edvard Monosov, Peter A. Greer, William Trimble, Gregory P. Downey and Tomas Mustelin Nature Cell Biology6, 831–839
(September 2004); doi:10.1038/ncb1164
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August
article Allosteric inhibition of protein tyrosine phosphatase 1B
Christian Wiesmann, Kenneth J Barr, Jenny Kung, Jiang Zhu, Daniel A Erlanson, Wang Shen, Bruce J Fahr, Min Zhong, Lisa Taylor, Mike Randal, Robert S McDowell and Stig K Hansen Nature Structural and Molecular Biology11, 730–737
(August 2004); doi:10.1038/nsmb803
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article Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation
Toshiyuki Araki, M Golam Mohi, Fraz A Ismat, Roderick T Bronson, Ifor R Williams, Jeffery L Kutok, Wentian Yang, Lily I Pao, D Gary Gilliland, Jonathan A Epstein and Benjamin G Neel Nature Medicine10, 849–857
(August 2004); doi:10.1038/nm1084
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letters to nature Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5
Yongliang Zhang, Joseph N. Blattman, Norman J. Kennedy, Julie Duong, Thang Nguyen, Ying Wang, Roger J. Davis, Philip D. Greenberg, Richard A. Flavell and Chen Dong Nature430, 793–797
(12 August 2004); doi:10.1038/nature02764
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letter The CDC-14 phosphatase controls developmental cell-cycle arrest in C. elegans
R. Mako Saito, Audrey Perreault, Bethan Peach, John S. Satterlee and Sander van den Heuvel Nature Cell Biology6, 777–783
(August 2004); doi:10.1038/ncb1154
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news and views Developmental quiescence: Cdc14 moonlighting in G1
Edward T. Kipreos Nature Cell Biology6, 693–695
(August 2004); doi:10.1038/ncb0804-693
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July
June
letters to nature Structural basis of protein phosphatase 1 regulation
Mohammed Terrak, Frederic Kerff, Knut Langsetmo, Terence Tao and Roberto Dominguez Nature429, 780–784
(17 June 2004); doi:10.1038/nature02582
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news and views Cdc14 phosphatase resolves the rDNA segregation delay
Gislene Pereira and Elmar Schiebel Nature Cell Biology6, 473–475
(June 2004); doi:10.1038/ncb0604-473
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May
April
brief communication A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
Nunzio Bottini, Lucia Musumeci, Andres Alonso, Souad Rahmouni, Konstantina Nika, Masoud Rostamkhani, James MacMurray, Gian Franco Meloni, Paola Lucarelli, Maurizio Pellecchia, George S Eisenbarth, David Comings and Tomas Mustelin Nature Genetics36, 337–338
(April 2004); doi:10.1038/ng1323
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meeting report Calcineurin: a central controller of signalling in eukaryotes
José Aramburu, Joseph Heitman & Gerald R. Crabtree EMBO reports11, 343–348
(April 2004); doi:10.1038/sj.embor.7400133
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article A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
Elizabeth Yeh, Melissa Cunningham, Hugh Arnold, Dawn Chasse, Teresa Monteith, Giovanni Ivaldi, William C. Hahn, P. Todd Stukenberg, Shirish Shenolikar, Takafumi Uchida, Christopher M. Counter, Joseph R. Nevins, Anthony R. Means and Rosalie Sears Nature Cell Biology6, 308–318
(April 2004); doi:10.1038/ncb1110
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news and views PINning down the c-Myc oncoprotein
David Dominguez-Sola and Riccardo Dalla-Favera Nature Cell Biology6, 288–289
(April 2004); doi:10.1038/ncb0404-288
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article Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p19Arf pathway
Dmitry V Bulavin, Crissy Phillips, Bonnie Nannenga, Oleg Timofeev, Larry A Donehower, Carl W Anderson, Ettore Appella and Albert J Fornace Jr. Nature Genetics36, 343–350
(April 2004); doi:10.1038/ng1317
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news and views Wip-ing out cancer
René Bernards Nature Genetics36, 319–320
(April 2004); doi:10.1038/ng0404-319
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March
article Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Vigo Heissmeyer, Fernando Macián, Sin-Hyeog Im, Rajat Varma, Stefan Feske, K Venuprasad, Hua Gu, Yun-Cai Liu, Michael L Dustin and Anjana Rao Nature Immunology5, 255–265
(March 2004); doi:10.1038/ni1047
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news and views Behind the scenes of anergy: a tale of three E3s
Matti Davis and Yinon Ben-Neriah Nature Immunology5, 238–240
(March 2004); doi:10.1038/ni0304-238
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February
January
letter An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans
Kiyoji Nishiwaki, Yukihiko Kubota, Yuko Chigira, Samir Kumar Roy, Maho Suzuki, Mara Schvarzstein, Yoshifumi Jigami, Naoki Hisamoto and Kunihiro Matsumoto Nature Cell Biology6, 31–37
(January 2004); doi:10.1038/ncb1079
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news and views Sweet control of cell migration, cytokinesis and organogenesis
Benjamin Podbilewicz Nature Cell Biology6, 9–11
(January 2004); doi:10.1038/ncb0104-9
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