Research library: Proteolysis
2003: December | November
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| August | July
| June | May
| April | March
| February | January
Other Years: 2002 |2004 | 2005 | 2006 | 2007 | 2008
December
letter
Securin and B-cyclin/CDK are the only essential targets of the APC
Brian R. Thornton and David P. Toczyski
Nature Cell Biology 5, 1090–1094
(December 2003); doi:10.1038/ncb1066
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perspectives
The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
Dieter A. Wolf, Chunshui Zhou and Susan Wee
Nature Cell Biology 5, 1029–1033
(December 2003); doi:10.1038/ncb1203-1029
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review article
Proteinase-activated receptors in the nervous system
Farshid Noorbakhsh , Nathalie Vergnolle , Morley D. Hollenberg and Christopher Power
Nature Reviews Neuroscience 4, 981–990
(December 2003); doi:10.1038/nrn1255
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review article
The diverse roles of ubiquitin and the 26S proteasome in the life of plants
James A. Sullivan, Ken Shirasu and Xing Wang Deng
Nature Reviews Genetics 4, 948–958
(December 2003); doi:10.1038/nrg1228
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November
letter
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases
Manabu Furukawa, Yizhou Joseph He, Christoph Borchers and Yue Xiong
Nature Cell Biology 5, 1001–1007
(November 2003); doi:10.1038/ncb1056
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news and views
BTB proteins as henchmen of Cul3-based ubiquitin ligases
Wilhelm Krek
Nature Cell Biology 5, 950–951
(November 2003); doi:10.1038/ncb1103-950
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article
HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation
Mariana Marin, Kristine M. Rose, Susan L. Kozak and David Kabat
Nature Medicine 9, 1398–1403
(November 2003); doi:10.1038/nm946
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letter
The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif
Ann M. Sheehy, Nathan C. Gaddis and Michael H. Malim
Nature Medicine 9, 1404–1407
(November 2003); doi:10.1038/nm945
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news and views
Tinged migration
Charlotte Schubert
Nature Medicine 9, 1355
(November 2003); doi:10.1038/nm1103-1355
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article
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
Jijie Chai, Nieng Yan, Jun R. Huh, Jia-Wei Wu, Wenyu Li, Bruce A. Hay and Yigong Shi
Nature Structural Biology 10, 892–898
(November 2003); doi:10.1038/nsb989
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letter
Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint
Leigh Ann A. Higa, Ivailo S. Mihaylov, Damon P. Banks, Jianyu Zheng and Hui Zhang
Nature Cell Biology 5, 1008–1015
(November 2003); doi:10.1038/ncb1061
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review article
Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover
Steven I. Reed
Nature Reviews Molecular Cell Biology 4, 855–864
(November 2003); doi:10.1038/nrm1246
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article
Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein
Paul G Corn, E Robert McDonald III, James G Herman and Wafik S El-Deiry
Nature Genetics 35, 229–237
(November 2003); doi:10.1038/ng1254
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letter
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice
Milagros Balbín, Antonio Fueyo, Angus M Tester, Alberto M Pendás, Ana S Pitiot, Aurora Astudillo, Christopher M Overall, Steven D Shapiro and Carlos López-Otín
Nature Genetics 35, 252–257
(November 2003); doi:10.1038/ng1249
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letters to nature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
Luca Busino, Maddalena Donzelli, Massimo Chiesa, Daniele Guardavaccaro, Dvora Ganoth, N. Valerio Dorrello, Avram Hershko, Michele Pagano and Giulio F. Draetta
Nature 426, 87–91
(06 November 2003); doi:10.1038/nature02082
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brief communication
Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1
Mary Herbert, Mark Levasseur, Hayden Homer, Katie Yallop, Alison Murdoch and Alex McDougall
Nature Cell Biology 5, 1023–1025
(November 2003); doi:10.1038/ncb1062
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article
Enhancement of CIITA transcriptional function by ubiquitin
Susanna F Greer, Eleni Zika, Brian Conti, Xin-Sheng Zhu and Jenny P-Y Ting
Nature Immunology 4, 1074–1082
(November 2003); doi:10.1038/ni985
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October
letter
A novel ubiquitin ligase is deficient in Fanconi anemia
Amom Ruhikanta Meetei, Johan P de Winter, Annette L Medhurst, Michael Wallisch, Quinten Waisfisz, Henri J van de Vrugt, Anneke B Oostra, Zhijiang Yan, Chen Ling, Colin E Bishop, Maureen E Hoatlin, Hans Joenje and Weidong Wang
Nature Genetics 35, 165–170
(October 2003); doi:10.1038/ng1241
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news and views
FANCL, as in ligase
Markus Grompe
Nature Genetics 35, 113–114
(October 2003); doi:10.1038/ng1003-113
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news and views
Cdc34: cycling on and off the SCF
Lionel Pintard and Matthias Peter
Nature Cell Biology 5, 856–857
(October 2003); doi:10.1038/ncb1003-856
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letter
Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
Xiaoying Wang, Sun-Ryung Lee, Ken Arai, Seong-Ryong Lee, Kiyoshi Tsuji, G William Rebeck and Eng H Lo
Nature Medicine 9, 1313–1317
(October 2003); doi:10.1038/nm926
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letters to nature
Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice
Julie M. Jones, Pinaki Datta, Srinivasa M. Srinivasula, Weizhen Ji, Sanjeev Gupta, ZhiJia Zhang, Erika Davies, György Hajnóczky, Thomas L. Saunders, Margaret L. Van Keuren, Teresa Fernandes-Alnemri, Miriam H. Meisler and Emad S. Alnemri
Nature 425, 721–727
(16 October 2003); doi:10.1038/nature02052
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article
Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity
Minna Woo, Razqallah Hakem, Caren Furlonger, Anne Hakem, Gordon S. Duncan, Takehiko Sasaki, Denis Bouchard, Liwei Lu, Gillian E. Wu, Christopher J. Paige and Tak W. Mak
Nature Immunology 4, 1016–1022
(October 2003); doi:10.1038/ni976
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September
letters to nature
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
Adeela Kamal, Lia Thao, John Sensintaffar, Lin Zhang, Marcus F. Boehm, Lawrence C. Fritz and Francis J. Burrows
Nature 425, 407–410
(25 September 2003); doi:10.1038/nature01913
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news and views
Cancer: The rules of attraction
Len Neckers and Yong-Sok Lee
Nature 425, 357–359
(25 September 2003); doi:10.1038/425357a
| Full Text (HTML / PDF) |
review article
Nuclear and unclear functions of SUMO
Jacob-S. Seeler and Anne Dejean
Nature Reviews Molecular Cell Biology 4, 690–699
(September 2003); doi:10.1038/nrm1200
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letters to nature
The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase
Lionel Pintard, John H. Willis, Andrew Willems, Jacque-Lynne F. Johnson, Martin Srayko, Thimo Kurz, Sarah Glaser, Paul E. Mains, Mike Tyers, Bruce Bowerman and Matthias Peter
Nature 425, 311–316
(18 September 2003); doi:10.1038/nature01959
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letters to nature
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
Lai Xu, Yue Wei, Jerome Reboul, Philippe Vaglio, Tae-Ho Shin, Marc Vidal, Stephen J. Elledge and J. Wade Harper
Nature 425, 316–321
(18 September 2003); doi:10.1038/nature01985
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news and views
Tag, you're degraded
Evelyn Jabri
Nature Structural Biology 10, 676
(September 2003); doi:10.1038/nsb0903-676
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research article
Phosphospecific proteolysis for mapping sites of protein phosphorylation
Zachary A. Knight, Birgit Schilling, Richard H. Row, Denise M. Kenski, Bradford W. Gibson and Kevan M. Shokat
Nature Biotechnology 21, 1047–1054
(September 2003); doi:10.1038/nbt863
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letters to nature
Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation
Philipp Stelter and Helle D. Ulrich
Nature 425, 188–191
(11 September 2003); doi:10.1038/nature01965
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research article
Engineering of a macromolecular scaffold to develop specific protease inhibitors
A. Allart Stoop and Charles S. Craik
Nature Biotechnology 21, 1063–1068
(September 2003); doi:10.1038/nbt860
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news and views
Two hands (or four) are better than one
Ben M. Dunn and Jörg Bungert
Nature Biotechnology 21, 1019–1021
(September 2003); doi:10.1038/nbt0903-1019
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letter
Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase
Kathleen F. Benson, Feng-Qian Li, Richard E. Person, Dalila Albani, Zhijun Duan, Jeremy Wechsler, Kimberly Meade-White, Kayleen Williams, Gregory M. Acland, Glenn Niemeyer, Clinton D. Lothrop and Marshall Horwitz
Nature Genetics 35, 90–96
(September 2003); doi:10.1038/ng1224
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article
Pulling geometry defines the mechanical resistance of a β-sheet protein
David J. Brockwell, Emanuele Paci, Rebecca C. Zinober, Godfrey S. Beddard, Peter D. Olmsted, D. Alastair Smith, Richard N. Perham and Sheena E. Radford
Nature Structural Biology 10, 731–737
(September 2003); doi:10.1038/nsb968
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article
The mechanical stability of ubiquitin is linkage dependent
Mariano Carrion-Vazquez, Hongbin Li, Hui Lu, Piotr E. Marszalek, Andres F. Oberhauser and Julio M. Fernandez
Nature Structural Biology 10, 738–743
(September 2003); doi:10.1038/nsb965
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news and views
Finding a protein's Achilles heel
Andreas Matouschek and Carlos Bustamante
Nature Structural Biology 10, 674–676
(September 2003); doi:10.1038/nsb0903-674
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August
letters to nature
Suppression of CED-3-independent apoptosis by mitochondrial βNAC in Caenorhabditis elegans
Tim A. Bloss, Eric S. Witze and Joel H. Rothman
Nature 424, 1066–1071
(28 August 2003); doi:10.1038/nature01920
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news and views
Cell biology: Tumour jailbreak
Kenneth M. Yamada
Nature 424, 889–890
(21 August 2003); doi:10.1038/424889a
| Full Text (HTML / PDF) |
letters to nature
CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members
Eirini Trompouki, Eudoxia Hatzivassiliou, Theodore Tsichritzis, Hannah Farmer, Alan Ashworth and George Mosialos
Nature 424, 793–796
(14 August 2003); doi:10.1038/nature01803
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letters to nature
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
Thijn R. Brummelkamp, Sebastian M. B. Nijman, Annette M. G. Dirac and René Bernards
Nature 424, 797–801
(14 August 2003); doi:10.1038/nature01811
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letters to nature
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
Andrew Kovalenko Christine Chable-Bessia, Giuseppina Cantarella, Alain Israël, David Wallach & Gilles Courtois
Nature 424, 801–805
(14 August 2003); doi:10.1038/nature01802
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news and views
Signal transduction: Aspirin, ubiquitin and cancer
Keith D. Wilkinson
Nature 424, 738–739
(14 August 2003); doi:10.1038/424738a
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article
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
Erik Sahai and Christopher J. Marshall
Nature Cell Biology 5, 711–719
(August 2003); doi:10.1038/ncb1019
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news and views
New dimensions in cell migration
Donna J. Webb and Alan F. Horwitz
Nature Cell Biology 5, 690–692
(August 2003); doi:10.1038/ncb0803-690
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research article
A transgenic mouse model of the ubiquitin/proteasome system
Kristina Lindsten, Victoria Menéndez-Benito, Maria G Masucci and Nico P Dantuma
Nature Biotechnology 21, 897–902
(August 2003); doi:10.1038/nbt851
| Abstract | Full Text (HTML/PDF) |
July
letter
Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation
Min Jung Kim, Bum-Joon Park, Young-Sun Kang, Hyoung June Kim, Jae-Hyun Park, Jung Woo Kang, Sang Won Lee, Jung Min Han, Han-Woong Lee and Sunghoon Kim
Nature Genetics 34, 330–336
(July 2003); doi:10.1038/ng1182
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review article
Molecular mechanisms of glioma invasiveness: the role of proteases
Jasti S. Rao
Nature Reviews Cancer 3, 489–501
(July 2003); doi:10.1038/nrc1121
| Summary | Full Text (HTML / PDF) |
letter
Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23
Mickaël Cohen, Françoise Stutz, Naïma Belgareh, Rosine Haguenauer-Tsapis and Catherine Dargemont
Nature Cell Biology 5, 661–667
(July 2003); doi:10.1038/ncb1003
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June
news and views
The cutting edge of mitochondrial fusion
Michael P. Yaffe
Nature Cell Biology 5, 497–499
(June 2003); doi:10.1038/ncb0603-497b
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letters to nature
CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing
Weiwei Zhong, Hui Feng, Fernando E. Santiago and Edward T. Kipreos
Nature 423, 885–889
(19 June 2003); doi:10.1038/nature01747
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news and views
Cell cycle: Degradation ensures integrity
Anatoliy Li and J. Julian Blow
Nature 423, 818–819
(19 June 2003); doi:10.1038/423818b
| Full Text (HTML / PDF) |
article
Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo
Masato Kanemaki, Alberto Sanchez-Diaz, Agnieszka Gambus and Karim Labib
Nature 423, 720–725
(12 June 2003); doi:10.1038/nature01692
| Abstract | Full Text (HTML / PDF) |
perspectives
When ubiquitin meets ubiquitin receptors: a signalling connection
Pier Paolo Di Fiore , Simona Polo and Kay Hofmann
Nature Reviews Molecular Cell Biology 4, 491–497
(June 2003); doi:10.1038/nrm1124
| Summary | Full Text (HTML / PDF) |
May
letters to nature
Mitochondrial membrane remodelling regulated by a conserved rhomboid protease
G. Angus McQuibban, Saroj Saurya and Matthew Freeman
Nature 423, 537–541
(29 May 2003); doi:10.1038/nature01633
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letter
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
Kaisa Haglund, Sara Sigismund, Simona Polo, Iwona Szymkiewicz, Pier Paolo Di Fiore and Ivan Dikic
Nature Cell Biology 5, 461–466
(May 2003); doi:10.1038/ncb983
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review article
Cell death and immunity: The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal
Judy Lieberman
Nature Reviews Immunology 3, 361–370
(May 2003); doi:10.1038/nri1083
| Summary | Full Text (HTML / PDF) |
April
letter
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2
Koji Yamanaka, Haruto Ishikawa, Yuzuru Megumi, Fuminori Tokunaga, Masato Kanie, Tracey A. Rouault, Isao Morishima, Nagahiro Minato, Koichiro Ishimori and Kazuhiro Iwai
Nature Cell Biology 5, 336–340
(April 2003); doi:10.1038/ncb952
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article
Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2
Anje Cauwels, Ben Janssen, Anouk Waeytens, Claude Cuvelier and Peter Brouckaert
Nature Immunology 4, 387–393
(April 2003); doi:10.1038/ni914
| Abstract | Full Text (HTML/PDF) |
news and views
Caspase activation is not death
Jean-Luc Perfettini and Guido Kroemer
Nature Immunology 4, 308–310
(April 2003); doi:10.1038/ni0403-308
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March
letters to nature
The role of presenilin cofactors in the γ-secretase complex
Nobumasa Takasugi, Taisuke Tomita, Ikuo Hayashi, Makiko Tsuruoka, Manabu Niimura, Yasuko Takahashi, Gopal Thinakaran and Takeshi Iwatsubo
Nature 422, 438–441
(27 March 2003); doi:10.1038/nature01506
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news and views
Neurobiology: Ballads of a protein quartet
Mark P. Mattson
Nature 422, 385–387
(27 March 2003); doi:10.1038/422385a
| Full Text (HTML / PDF) |
research article
In situ assembly of enzyme inhibitors using extended tethering
Daniel A. Erlanson, Joni W. Lam, Christian Wiesmann, Tinh N. Luong, Robert L. Simmons, Warren L. DeLano, Ingrid C. Choong, Matthew T. Burdett, W. Michael Flanagan, Dennis Lee, Eric M. Gordon and Tom O'Brien
Nature Biotechnology 21, 308–314
(March 2003); doi:10.1038/nbt786
| Abstract | Full Text (HTML/PDF) |
review article
How the ubiquitin-proteasome system controls transcription
Masafumi Muratani and William P. Tansey
Nature Reviews Molecular Cell Biology 4, 192–201
(March 2003); doi:10.1038/nrm1049
| Summary | Full Text (HTML / PDF) |
February
perspectives
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
David J. Glass
Nature Cell Biology 5, 87–90
(February 2003); doi:10.1038/ncb0203-87
| Full Text (HTML/PDF) |
review article
NALPs: a novel protein family involved in inflammation
Jürg Tschopp, Fabio Martinon and Kimberly Burns
Nature Reviews Molecular Cell Biology 4, 95–104
(February 2003); doi:10.1038/nrm1019
| Summary | Full Text (HTML / PDF) |
January
letters to nature
Crystal structure of the human angiotensin-converting enzyme-lisinopril complex
Ramanathan Natesh, Sylva L. U. Schwager, Edward D. Sturrock and K. Ravi Acharya
Nature 421, 551–554
(30 January 2003); doi:10.1038/nature01370
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review article
Validating survivin as a cancer therapeutic target
Dario C. Altieri
Nature Reviews Cancer 3, 46–54
(January 2003); doi:10.1038/nrc968
| Summary | Full Text (HTML / PDF) |
news and views
Immunology: Mobilizing the army
Steven D. Shapiro
Nature 421, 223–224
(16 January 2003); doi:10.1038/421223a
| Full Text (HTML / PDF) |
article
Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins
Vikram Govind Panse, Bernhard Küster, Thomas Gerstberger and Ed Hurt
Nature Cell Biology 5, 21–27
(January 2003); doi:10.1038/ncb893
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article
Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
Hanne B. Rasmussen, Sven Branner, Finn C. Wiberg and Nicolai Wagtmann
Nature Structural Biology 10, 19–25
(January 2003); doi:10.1038/nsb882
| Abstract | Full Text (HTML/PDF) |
news and views
First bite
Mark D. Gorrell
Nature Structural Biology 10, 3–5
(January 2003); doi:10.1038/nsb0103-3
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