Research library: Proteolysis
2004: December
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December
letter
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection
Kenneth J Ritchie, Chang S Hahn, Keun Il Kim, Ming Yan, Dabralee Rosario, Li Li, Juan Carlos de la Torre and Dong-Er Zhang
Nature Medicine 10, 1374–1378
(December 2004); doi:10.1038/nm1133
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letter
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase
Takumi Kamura, Taichi Hara, Masaki Matsumoto, Noriko Ishida, Fumihiko Okumura, Shigetsugu Hatakeyama, Minoru Yoshida, Keiko Nakayama and Keiichi I. Nakayama
Nature Cell Biology 6, 1229–1235
(December 2004); doi:10.1038/ncb1194
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news and views
A second RING to destroy p27Kip1
Ludger Hengst
Nature Cell Biology 6, 1153–1155
(December 2004); doi:10.1038/ncb1204-1153
| Full Text (HTML/PDF) |
letters to nature
The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
Ryan T. Phan and Riccardo Dalla-Favera
Nature 432, 635–639
(02 December 2004); doi:10.1038/nature03147
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letter
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C
Dong Liu, Tong Cheng, Huang Guo, José A Fernández, John H Griffin, Xiaomei Song and Berislav V Zlokovic
Nature Medicine 10, 1379–1383
(December 2004); doi:10.1038/nm1122
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news and views
Combination stroke therapy: easy as APC?
Eng H Lo
Nature Medicine 10, 1295–1296
(December 2004); doi:10.1038/nm1204-1295
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November
meeting report
ZOMES III: the interface between signalling and proteolysis
Eric C. Chang and Claus Schwechheimer
EMBO reports 5, 1041–1045
(November 2004); doi:10.1038/sj.embor.7400275
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review article
Molecular mechanisms of caspase regulation during apoptosis
Stefan J. Riedl and Yigong Shi
Nature Reviews Molecular Cell Biology 5, 897–907
(November 2004); doi:10.1038/nrm1496
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review article
The emerging roles of human tissue kallikreins in cancer
Carla A. Borgoño and Eleftherios P. Diamandis
Nature Reviews Cancer 4, 876–890
(November 2004); doi:10.1038/nrc1474
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review article
Recombinant protein folding and misfolding in Escherichia coli
François Baneyx and Mirna Mujacic
Nature Biotechnology 22, 1399–1408
(November 2004); doi:10.1038/nbt1029
| Abstract | Full Text (HTML/PDF) |
October
letter
Calpain-mediated proteolysis of talin regulates adhesion dynamics
Santos J. Franco, Mary A. Rodgers, Benjamin J. Perrin, Jaewon Han, David A. Bennin, David R. Critchley and Anna Huttenlocher
Nature Cell Biology 6, 977–983
(October 2004); doi:10.1038/ncb1175
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September
article
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
Yanyan Hao, Keiko Sekine, Atsushi Kawabata, Hitoshi Nakamura, Toshiyasu Ishioka, Hirokazu Ohata, Ryohei Katayama, Chizuko Hashimoto, Xiaodong Zhang, Tetsuo Noda, Takashi Tsuruo and Mikihiko Naito
Nature Cell Biology 6, 849–860
(September 2004); doi:10.1038/ncb1159
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news and views
An Apollon vista of death and destruction
Seamus J. Martin
Nature Cell Biology 6, 804–806
(September 2004); doi:10.1038/ncb0904-804
| Full Text (HTML/PDF) |
review article
The SCF ubiquitin ligase: insights into a molecular machine
Timothy Cardozo and Michele Pagano
Nature Reviews Molecular Cell Biology 5, 739–751
(September 2004); doi:10.1038/nrm1471
| Abstract | Full Text (HTML / PDF) |
review article
E3 ubiquitin ligases as T cell anergy factors
Daniel L Mueller
Nature Immunology 5, 883–890
(September 2004); doi:10.1038/ni1106
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letters to nature
Structure of the ESCRT-II endosomal trafficking complex
Aitor Hierro, Ji Sun, Alexander S. Rusnak, Jaewon Kim, Gali Prag, Scott D. Emr and James H. Hurley
Nature 431, 221–226
(09 September 2004); doi:10.1038/nature02914
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letters to nature
Involvement of targeted proteolysis in plant genetic transformation by Agrobacterium
Tzvi Tzfira, Manjusha Vaidya and Vitaly Citovsky
Nature 431, 87–92
(02 September 2004); doi:10.1038/nature02857
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article
Serine protease inhibitor 2A is a protective factor for memory T cell development
Ni Liu, Tiphanie Phillips, Manling Zhang, Yue Wang, Joseph T Opferman, Ramila Shah and Philip G Ashton–Rickardt
Nature Immunology 5, 919–926
(September 2004); doi:10.1038/ni1107
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article
An unstructured initiation site is required for efficient proteasome–mediated degradation
Sumit Prakash, Lin Tian, Kevin S Ratliff, Rebecca E Lehotzky and Andreas Matouschek
Nature Structural and Molecular Biology 11, 830–837
(September 2004); doi:10.1038/nsmb814
| Abstract | Full Text (HTML/PDF) |
news and views
Signaling degradation
Jon A Kenniston and Robert T Sauer
Nature Structural and Molecular Biology 11, 800–802
(September 2004); doi:10.1038/nsmb0904–800
| Full Text (HTML/PDF) |
August
letters to nature
Separase-mediated cleavage of cohesin at interphase is required for DNA repair
Koji Nagao, Yoh Adachi and Mitsuhiro Yanagida
Nature 430, 1044–1048
(26 August 2004); doi:10.1038/nature02803
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letters to nature
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Ingrid E. Wertz, Karen M. O'Rourke, Honglin Zhou, Michael Eby, L. Aravind, Somasekar Seshagiri, Ping Wu, Christian Wiesmann, Rohan Baker, David L. Boone, Averil Ma, Eugene V. Koonin and Vishva M. Dixit
Nature 430, 694–699
(05 August 2004); doi:10.1038/nature02794
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review article
Pathways towards and away from Alzheimer's disease
Mark P. Mattson
Nature 430, 631–639
(05 August 2004); doi:10.1038/nature02621
| Abstract | Full Text (HTML / PDF) |
review article
Matrix metalloproteinases as modulators of inflammation and innate immunity
William C. Parks , Carole L. Wilson and Yolanda S. López-Boado
Nature Reviews Immunology 4, 617–629
(August 2004); doi:10.1038/nri1418
| Abstract | Full Text (HTML / PDF) |
July
letter
Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain
Karin Flick, Ikram Ouni, James A. Wohlschlegel, Chrissy Capati, W. Hayes McDonald, John R. Yates 3rd and Peter Kaiser
Nature Cell Biology 6, 634–641
(July 2004); doi:10.1038/ncb1143
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news and views
Ubiquitin signalling: what's in a chain?
Mark Hochstrasser
Nature Cell Biology 6, 571–572
(July 2004); doi:10.1038/ncb0704-571
| Full Text (HTML/PDF) |
review article
Post-proteasomal antigen processing for major histocompatibility complex class I presentation
Kenneth L Rock, Ian A York and Alfred L Goldberg
Nature Immunology 5, 670–677
(July 2004); doi:10.1038/ni1089
| Abstract | Full Text (HTML/PDF) |
letters to nature
Drosophila long-term memory formation involves regulation of cathepsin activity
Daniel Comas, Florian Petit and Thomas Preat
Nature 430, 460–463
(22 July 2004); doi:10.1038/nature02726
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review article
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules
Colin Watts
Nature Immunology 5, 685–692
(July 2004); doi:10.1038/ni1088
| Abstract | Full Text (HTML/PDF) |
review article
Generation of major histocompatibility complex class I antigens: functional interplay between proteasomes and TPPII
Peter M Kloetzel
Nature Immunology 5, 661–669
(July 2004); doi:10.1038/ni1090
| Abstract | Full Text (HTML/PDF) |
review article
The cell biology of lysosomal storage disorders
Anthony H. Futerman and Gerrit van Meer
Nature Reviews Molecular Cell Biology 5, 554–565
(July 2004); doi:10.1038/nrm1423
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article
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid- peptides
Milla Koistinaho, Suizhen Lin, Xin Wu, Michail Esterman, Deanna Koger, Jeffrey Hanson, Richard Higgs, Feng Liu, Seema Malkani, Kelly R Bales & Steven M Paul
Nature Medicine 10, 719–726
(July 2004); doi:10.1038/nm1058
| Abstract |
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June
article
A membrane protein required for dislocation of misfolded proteins from the ER
Brendan N. Lilley and Hidde L. Ploegh
Nature 429, 834–840
(24 June 2004); doi:10.1038/nature02592
| Abstract | Full Text (HTML / PDF) |
article
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Yihong Ye, Yoko Shibata, Chi Yun, David Ron and Tom A. Rapoport
Nature 429, 841–847
(24 June 2004); doi:10.1038/nature02656
| Abstract | Full Text (HTML / PDF) |
news and views
Cell biology: A channel for protein waste
Randy Schekman
Nature 429, 817–818
(24 June 2004); doi:10.1038/429817a
| Full Text (HTML / PDF) |
perspectives
Opinion: γ-Secretase: proteasome of the membrane?
Raphael Kopan and Ma. Xenia G. Ilagan
Nature Reviews Molecular Cell Biology 5, 499–504
(June 2004); doi:10.1038/nrm1406
| Abstract | Full Text (HTML / PDF) |
news and views
Targeting tumors: seeing the light
Charlotte Schubert
Nature Medicine 10, 580
(June 2004); doi:10.1038/nm0604-580
| Full Text (HTML/PDF) |
news and views
Cutting into innate immunity
Astar Winoto
Nature Immunology 5, 563–564
(June 2004); doi:10.1038/ni0604-563
| Full Text (HTML/PDF) |
research article
Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors
Peter M Smith-Jones, David B Solit, Timothy Akhurst, Farzana Afroze, Neal Rosen and Steven M Larson
Nature Biotechnology 22, 701–706
(June 2004); doi:10.1038/nbt968
| Abstract | Full Text (HTML/PDF) |
news and views
An image worth a thousand lives?
Lisa A Hammond, Sean X Cavanaugh and Charles R Thomas Jr
Nature Biotechnology 22, 677–678
(June 2004); doi:10.1038/nbt0604-677
| Full Text (HTML/PDF) |
May
article
Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
Mattias Belting, Michael I Dorrell, Staffan Sandgren, Edith Aguilar, Jasimuddin Ahamed, Andrea Dorfleutner, Peter Carmeliet, Barbara M Mueller, Martin Friedlander and Wolfram Ruf
Nature Medicine 10, 502–509
(May 2004); doi:10.1038/nm1037
| Abstract | Full Text (HTML/PDF) |
article
Communication between ClpX and ClpP during substrate processing and degradation
Shilpa A Joshi, Greg L Hersch, Tania A Baker and Robert T Sauer
Nature Structural and Molecular Biology 11, 404–411
(May 2004); doi:10.1038/nsmb752
| Abstract | Full Text (HTML/PDF) |
letters to nature
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
Maya Saleh, John P. Vaillancourt, Rona K. Graham, Matthew Huyck, Srinivasa M. Srinivasula, Emad S. Alnemri, Martin H. Steinberg, Vikki Nolan, Clinton T. Baldwin, Richard S. Hotchkiss, Timothy G. Buchman, Barbara A. Zehnbauer, Michael R. Hayden, Lindsay A. Farrer, Sophie Roy and Donald W. Nicholson
Nature 429, 75–79
(06 May 2004); doi:10.1038/nature02451
| First Paragraph | Full Text (HTML / PDF) |
news and views
Human genetics: An inflammatory issue
Kevin J. Tracey and H. Shaw Warren
Nature 429, 35–37
(06 May 2004); doi:10.1038/429035a
| Full Text (HTML / PDF) |
letters to nature
The ubiquitin ligase COP1 is a critical negative regulator of p53
David Dornan, Ingrid Wertz, Harumi Shimizu, David Arnott, Gretchen D. Frantz, Patrick Dowd, Karen O' Rourke, Hartmut Koeppen and Vishva M. Dixit
Nature 429, 86–92
(06 May 2004); doi:10.1038/nature02514
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article
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
Tsung-Hsien Chuang and Richard J Ulevitch
Nature Immunology 5, 495–502
(May 2004); doi:10.1038/ni1066
| Abstract | Full Text (HTML/PDF) |
review article
The proteasome: a suitable antineoplastic target
Julian Adams
Nature Reviews Cancer 4, 349–360
(May 2004); doi:10.1038/nrc1361
| Abstract | Full Text (HTML / PDF) |
April
perspectives
Opinion: The biogenesis of multivesicular endosomes
Jean Gruenberg and Harald Stenmark
Nature Reviews Molecular Cell Biology 5, 317–323
(April 2004); doi:10.1038/nrm1360
| Abstract | Full Text (HTML / PDF) |
letter
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
Giles D J Watts, Jill Wymer, Margaret J Kovach, Sarju G Mehta, Steven Mumm, Daniel Darvish, Alan Pestronk, Michael P Whyte and Virginia E Kimonis
Nature Genetics 36, 377–381
(April 2004); doi:10.1038/ng1332
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article
Structural basis of sugar-recognizing ubiquitin ligase
Tsunehiro Mizushima, Takeshi Hirao, Yukiko Yoshida, Soo Jae Lee, Tomoki Chiba, Kazuhiro Iwai, Yoshiki Yamaguchi, Koichi Kato, Tomitake Tsukihara and Keiji Tanaka
Nature Structural and Molecular Biology 11, 365–370
(April 2004); doi:10.1038/nsmb732
| Abstract | Full Text (HTML/PDF) |
article
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells
Elizabeth Yeh, Melissa Cunningham, Hugh Arnold, Dawn Chasse, Teresa Monteith, Giovanni Ivaldi, William C. Hahn, P. Todd Stukenberg, Shirish Shenolikar, Takafumi Uchida, Christopher M. Counter, Joseph R. Nevins, Anthony R. Means and Rosalie Sears
Nature Cell Biology 6, 308–318
(April 2004); doi:10.1038/ncb1110
| Abstract | Full Text (HTML/PDF) |
news and views
PINning down the c-Myc oncoprotein
David Dominguez-Sola and Riccardo Dalla-Favera
Nature Cell Biology 6, 288–289
(April 2004); doi:10.1038/ncb0404-288
| Full Text (HTML/PDF) |
March
letter
Interactions of GGA3 with the ubiquitin sorting machinery
Rosa Puertollano and Juan S. Bonifacino
Nature Cell Biology 6, 244–251
(March 2004); doi:10.1038/ncb1106
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letter
GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network
Patricia M. Scott, Patricia S. Bilodeau, Olga Zhdankina, Stanley C. Winistorfer, Melissa J. Hauglund, Margaret M. Allaman, William R. Kearney, Andrew D. Robertson, Annette L. Boman and Robert C. Piper
Nature Cell Biology 6, 252–259
(March 2004); doi:10.1038/ncb1107
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news and views
GGAing ubiquitin to the endosome
Markus Babst
Nature Cell Biology 6, 175–177
(March 2004); doi:10.1038/ncb0304-175
| Full Text (HTML/PDF) |
letter
Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination
Anatoliy Li and J. Julian Blow
Nature Cell Biology 6, 260–267
(March 2004); doi:10.1038/ncb1100
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review article
Proteolysis within the membrane: rhomboids revealed
Matthew Freeman
Nature Reviews Molecular Cell Biology 5, 188–197
(March 2004); doi:10.1038/nrm1334
| Abstract | Full Text (HTML / PDF) |
article
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
Vigo Heissmeyer, Fernando Macián, Sin-Hyeog Im, Rajat Varma, Stefan Feske, K Venuprasad, Hua Gu, Yun-Cai Liu, Michael L Dustin and Anjana Rao
Nature Immunology 5, 255–265
(March 2004); doi:10.1038/ni1047
| Abstract | Full Text (HTML/PDF) |
news and views
Behind the scenes of anergy: a tale of three E3s
Matti Davis and Yinon Ben-Neriah
Nature Immunology 5, 238–240
(March 2004); doi:10.1038/ni0304-238
| Full Text (HTML/PDF) |
letters to nature
Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
Tarig Bashir, N. Valerio Dorrello, Virginia Amador, Daniele Guardavaccaro and Michele Pagano
Nature 428, 190–193
(11 March 2004); doi:10.1038/nature02330
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
Wenyi Wei, Nagi G. Ayad, Yong Wan, Guo-Jun Zhang, Marc W. Kirschner and William G. Kaelin Jr
Nature 428, 194–198
(11 March 2004); doi:10.1038/nature02381
| First Paragraph | Full Text (HTML / PDF) |
review article
Proteasomes and their kin: proteases in the machine age
Cecile M. Pickart and Robert E. Cohen
Nature Reviews Molecular Cell Biology 5, 177–187
(March 2004); doi:10.1038/nrm1336
| Abstract | Full Text (HTML / PDF) |
February
January
news and views
How resting T cells deMURR HIV infection
Warner C Greene
Nature Immunology 5, 18–19
(January 2004); doi:10.1038/ni0104-18
| Full Text (HTML/PDF) |
review article
Fluorescent probes for proteolysis: Tools for drug discovery
Jacques Neefjes and Nico P. Dantuma
Nature Reviews Drug Discovery 3, 58–69
(January 2004); doi:10.1038/nrd1282
| Abstract | Full Text (HTML / PDF) |
letter
An NDPase links ADAM protease glycosylation with organ morphogenesis in C. elegans
Kiyoji Nishiwaki, Yukihiko Kubota, Yuko Chigira, Samir Kumar Roy, Maho Suzuki, Mara Schvarzstein, Yoshifumi Jigami, Naoki Hisamoto and Kunihiro Matsumoto
Nature Cell Biology 6, 31–37
(January 2004); doi:10.1038/ncb1079
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news and views
Sweet control of cell migration, cytokinesis and organogenesis
Benjamin Podbilewicz
Nature Cell Biology 6, 9–11
(January 2004); doi:10.1038/ncb0104-9
| Full Text (HTML/PDF) |
article
Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization
and inhibition of p53
Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai, Zhi-Min Yuan, Jolanta Bondaruk,
Fumio Suzuki, Satoshi Fujii, Ralph B Arlinghaus, Bogdan A Czerniak and
Subrata Sen
Nature Genetics 36, 55–62
(January 2004); doi:10.1038/ng1279
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