Review article Immunity by ubiquitylation: a reversible process of modification
Yun-Cai Liu, Josef Penninger and Michael Karin Nature Reviews Immunology5, 941–952
(December 2005); doi:10.1038/nri1731
| Summary | Full Text (HTML / PDF) |
letter Deficiency of UBR1, a ubiquitin ligase of the N-end rule pathway, causes pancreatic dysfunction, malformations and mental retardation (Johanson-Blizzard syndrome)
Martin Zenker, Julia Mayerle, Markus M Lerch, Andreas Tagariello, Klaus Zerres, Peter R Durie, Matthias Beier, Georg Hülskamp, Celina Guzman, Helga Rehder, Frits A Beemer, Ben Hamel, Philippe Vanlieferinghen, Ruth Gershoni-Baruch, Marta W Vieira, Miroslav Dumic, Ron Auslender, Vera L Gil-da-Silva-Lopes, Simone Steinlicht, Manfred Rauh, Stavit A Shalev, Christian Thiel, Andreas Winterpacht, Yong Tae Kwon, Alexander Varshavsky and André Reis Nature Genetics37, 1345–1350
(December 2005); doi:10.1038/ng1681
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letter The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation
Karthik B. Jeganathan, Liviu Malureanu and Jan M. van Deursen Nature438, 1036–1039
(15 December 2005); doi:10.1038/nature04221
| First Paragraph | Full Text (HTML / PDF) |
article Regulation of Notch signalling by non-visual β-arrestin
Ashim Mukherjee, Alexey Veraksa, Andreas Bauer, Carine Rosse, Jacques Camonis and Spyros Artavanis-Tsakonas Nature Cell Biology7, 1191–1201
(December 2005); doi:10.1038/ncb1327
| Abstract | Full Text (HTML/PDF) |
news and views Receptor regulation: β-arrestin moves up a notch
Sudha K. Shenoy & Robert J. Lefkowitz Nature Cell Biology7, 1159–1161
(December 2005); doi:10.1038/ncb1205-1059
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brief communication The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone
Anna-Kaisa Anttonen, Ibrahim Mahjneh, Riikka H Hämäläinen, Clotilde Lagier-Tourenne, Outi Kopra, Laura Waris, Mikko Anttonen, Tarja Joensuu, Hannu Kalimo, Anders Paetau, Lisbeth Tranebjaerg, Denys Chaigne, Michel Koenig, Orvar Eeg-Olofsson, Bjarne Udd, Mirja Somer, Hannu Somer and Anna-Elina Lehesjoki Nature Genetics37, 1309–1311
(December 2005); doi:10.1038/ng1677
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brief communication Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy
Jan Senderek, Michael Krieger, Claudia Stendel, Carsten Bergmann, Markus Moser, Nico Breitbach-Faller, Sabine Rudnik-Schöneborn, Astrid Blaschek, Nicole I Wolf, Inga Harting, Kathryn North, Janine Smith, Francesco Muntoni, Martin Brockington, Susana Quijano-Roy, Francis Renault, Ralf Herrmann, Linda M Hendershot, J Michael Schröder, Hanns Lochmüller, Haluk Topaloglu, Thomas Voit, Joachim Weis, Friedrich Ebinger and Klaus Zerres Nature Genetics37, 1312–1314
(December 2005); doi:10.1038/ng1678
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news and views SILencing misbehaving proteins
Huda Y Zoghbi Nature Genetics37, 1302–1303
(December 2005); doi:10.1038/ng1205-1302
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November
review article Lysosomes and autophagy in cell death control
Guido Kroemer and Marja Jäättelä Nature Reviews Cancer5, 886–897
(November 2005); doi:10.1038/nrc1738
| Summary | Full Text (HTML / PDF) |
news and views Autophagy: to die or not to die
Myrto Raftopoulou Nature Cell Biology7, 1056
(November 2005); doi:10.1038/ncb1105-1056
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letter Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival
Elizabeth Allen, Jianqing Ding, Wei Wang, Suneet Pramanik, Jonathan Chou, Vincent Yau and Yanmin Yang Nature438, 224–228
(10 November 2005); doi:10.1038/nature04256
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article Dopamine covalently modifies and functionally inactivates parkin
Matthew J LaVoie, Beth L Ostaszewski, Andreas Weihofen, Michael G Schlossmacher and Dennis J Selkoe Nature Medicine11, 1214–1221
(November 2005); doi:10.1038/nm1314
| Abstract | Full Text (HTML/PDF) |
news and views Neurons inflict self-harm
Mark R Cookson Nature Medicine11, 1159–1161
(November 2005); doi:10.1038/nm1105-1159
| Full Text (HTML/PDF) |
letter A putative stimulatory role for activator turnover in gene expression
J. Russell Lipford, Geoffrey T. Smith, Yong Chi and Raymond J. Deshaies Nature438, 113–116
(03 November 2005); doi:10.1038/nature04098
| First Paragraph | Full Text (HTML / PDF) |
October
letter A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes
Yuko Hirano, Klavs B. Hendil, Hideki Yashiroda, Shun-ichiro Iemura, Ryoichi Nagane, Yusaku Hioki, Tohru Natsume, Keiji Tanaka and Shigeo Murata Nature437, 1381–1385
(27 October 2005); doi:10.1038/nature04106
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letter Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation
June-Tai Wu, Hsiu-Chen Lin, Yen-Chen Hu and Cheng-Ting Chien Nature Cell Biology7, 1014–1020
(October 2005); doi:10.1038/ncb1301
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article Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines
Andreas Martin, Tania A. Baker and Robert T. Sauer Nature437, 1115–1120
(20 October 2005); doi:10.1038/nature04031
| Abstract | Full Text (HTML / PDF) |
letter Ubx2 links the Cdc48 complex to ER-associated protein degradation
Oliver Neuber, Ernst Jarosch, Corinna Volkwein, Jan Walter and Thomas Sommer Nature Cell Biology7, 993–998
(October 2005); doi:10.1038/ncb1298
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letter Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation
Christian Schuberth and Alexander Buchberger Nature Cell Biology7, 999–1006
(October 2005); doi:10.1038/ncb1299
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article 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
Masahiro Waza, Hiroaki Adachi, Masahisa Katsuno, Makoto Minamiyama, Chen Sang, Fumiaki Tanaka, Akira Inukai, Manabu Doyu and Gen Sobue Nature Medicine11, 1088–1095
(October 2005); doi:10.1038/nm1298
| Abstract | Full Text (HTML/PDF) |
article The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashi and Alexander Varshavsky Nature437, 981–986
(13 October 2005); doi:10.1038/nature04027
| Abstract | Full Text (HTML / PDF) |
letter Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation
Nadine R. Rauh, Andreas Schmidt, Jenny Bormann, Erich A. Nigg and Thomas U. Mayer Nature437, 1048–1052
(13 October 2005); doi:10.1038/nature04093
| First Paragraph | Full Text (HTML / PDF) |
news and views Targeting toxic proteins for turnover
Albert R La Spada and Patrick Weydt Nature Medicine11, 1052–1053
(October 2005); doi:10.1038/nm1005-1052
| Full Text (HTML/PDF) |
September
letter A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
Gabriel Pascual, Amy L. Fong, Sumito Ogawa, Amir Gamliel, Andrew C. Li, Valentina Perissi, David W. Rose, Timothy M. Willson, Michael G. Rosenfeld and Christopher K. Glass Nature437, 759–763
(29 September 2005); doi:10.1038/nature03988
| First Paragraph | Full Text (HTML / PDF) |
letter The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair
Wendy L Bridge, Cassandra J Vandenberg, Roger J Franklin and Kevin Hiom Nature Genetics37, 953–957
(September 2005); doi:10.1038/ng1627
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letter A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M
Amom Ruhikanta Meetei, Annette L Medhurst, Chen Ling, Yutong Xue, Thiyam Ramsing Singh, Patrick Bier, Jurgen Steltenpool, Stacie Stone, Inderjeet Dokal, Christopher G Mathew, Maureen Hoatlin, Hans Joenje, Johan P de Winter and Weidong Wang Nature Genetics37, 958–963
(September 2005); doi:10.1038/ng1626
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brief communication The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia
Orna Levran, Claire Attwooll, Rashida T Henry, Kelly L Milton, Kornelia Neveling, Paula Rio, Sat Dev Batish, Reinhard Kalb, Eunike Velleuer, Sandra Barral, Jurg Ott, John Petrini, Detlev Schindler, Helmut Hanenberg and Arleen D Auerbach Nature Genetics37, 931–933
(September 2005); doi:10.1038/ng1624
| First Paragraph | Full Text (HTML/PDF) |
letter The most infectious prion protein particles
Jay R. Silveira, Gregory J. Raymond, Andrew G. Hughson, Richard E. Race, Valerie L. Sim, Stanley F. Hayes and Byron Caughey Nature437, 257–261
(08 September 2005); doi:10.1038/nature03989
| First Paragraph | Full Text (HTML / PDF) |
August
article Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach
Alexandre Lautrette, Shunqiang Li, Rohia Alili, Susan W Sunnarborg, Martine Burtin, David C Lee, Gérard Friedlander and Fabiola Terzi Nature Medicine11, 867–874
(August 2005); doi:10.1038/nm1275
| Abstract | Full Text (HTML/PDF) |
review article The yin and yang of neurotrophin action
Bai Lu, Petti T. Pang and Newton H. Woo Nature Reviews Neuroscience6, 603–614
(August 2005); doi:10.1038/nrn1726
| Abstract | Full Text (HTML / PDF) |
review article Ubiquitin and ubiquitin-like proteins as multifunctional signals
Rebecca L. Welchman, Colin Gordon and R. John Mayer Nature Reviews Molecular Cell Biology6, 599–609
(August 2005); doi:10.1038/nrm1700
| Abstract | Full Text (HTML / PDF) |
July
letter MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
Jidong Liu, Marco Antonio Valencia-Sanchez, Gregory J. Hannon and Roy Parker Nature Cell Biology7, 719–723
(July 2005); doi:10.1038/ncb1274
| First Paragraph | Full Text (HTML/PDF) |
news and views RNAi and the P-body connection
John J. Rossi Nature Cell Biology7, 643–644
(July 2005); doi:10.1038/ncb0705-643
| Full Text (HTML/PDF) |
letter SUMO-modified PCNA recruits
Srs2 to prevent recombination during S phase Boris Pfander ,
George-Lucian Moldovan , Meik Sacher , Carsten Hoege and Stefan Jentsch
Nature436, 428–433 (21 July 2005);
doi:10.1038/nature03665 | First Paragraph |
Full Text (HTML /
PDF) |
article S-nitrosylated
GAPDH initiates apoptotic cell death by nuclear translocation following Siah1
binding Makoto R. Hara, Nishant Agrawal, Sangwon F. Kim, Matthew B.
Cascio, Masahiro Fujimuro, Yuji Ozeki, Masaaki Takahashi, Jaime H. Cheah,
Stephanie K. Tankou, Lynda D. Hester, Christopher D. Ferris, S. Diane Hayward,
Solomon H. Snyder and Akira Sawa Nature Cell Biology7,
665–674 (July 2005); doi:10.1038/ncb1268 | Abstract | Full Text (HTML/PDF)
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news and views A central role
for S-nitrosylation in apoptosis Moran Benhar and Jonathan S.
Stamler Nature Cell Biology7, 645–646 (July 2005);
doi:10.1038/ncb0705-645 | Full Text
(HTML/PDF) |
letter The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
Monica Dentice, Amitabha Bandyopadhyay, Balázs Gereben, Isabelle Callebaut, Marcelo A. Christoffolete, Brian W. Kim, Sahar Nissim, Jean-Paul Mornon, Ann Marie Zavacki, Anikó Zeöld, Luciane P. Capelo, Cyntia Curcio-Morelli, Rogério Ribeiro, John W. Harney, Clifford J. Tabin and Antonio C. Bianco Nature Cell Biology7, 698–705
(July 2005); doi:10.1038/ncb1272
| First Paragraph | Full Text (HTML/PDF) |
news and views Huntingtin and the vicious circle
Jack Horne Nature Cell Biology7, 650
(July 2005); doi:10.1038/ncb0705-650
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review article AAA+ proteins: have engine, will work
Phyllis I. Hanson and Sidney W. Whiteheart Nature Reviews Molecular Cell Biology6, 519–529
(July 2005); doi:10.1038/nrm1684
| Summary | Full Text (HTML / PDF) |
June
letter The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae
Thimo Kurz, Nurhan Özlü, Fabian Rudolf, Sean M. O'Rourke, Brian Luke, Kay Hofmann, Anthony A. Hyman, Bruce Bowerman and Matthias Peter Nature435, 1257–1261
(30 June 2005); doi:10.1038/nature03662
| First Paragraph | Full Text (HTML/PDF) |
letter Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
George L. Sen and Helen M. Blau Nature Cell Biology7, 633–636
(June 2005); doi:10.1038/ncb1265
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news and views Transcription RINGs in repair
Mary Ann Osley Nature Cell Biology7, 553–555
(June 2005); doi:10.1038/ncb0605-553
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letter Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex
David Reverter and Christopher D. Lima Nature435, 687–692
(02 June 2005); doi:10.1038/nature03588
| First Paragraph | Full Text (HTML / PDF) |
May
article The F-box protein TIR1 is an auxin receptor
Nihal Dharmasiri, Sunethra Dharmasiri and Mark Estelle Nature435, 441–445
(26 May 2005); doi:10.1038/nature03543
| Summary | Full Text (HTML / PDF) |
article The Arabidopsis F-box protein TIR1 is an auxin receptor
Stefan Kepinski and Ottoline Leyser Nature435, 446–451
(26 May 2005); doi:10.1038/nature03542
| Summary | Full Text (HTML / PDF) |
news and views Plant biology: Auxin action
Judy Callis Nature435, 436–437
(26 May 2005); doi:10.1038/435436b
| Full Text (HTML / PDF) |
article A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
Carola G. Vinuesa, Matthew C. Cook, Constanza Angelucci, Vicki Athanasopoulos, Lixin Rui, Kim M. Hill, Di Yu, Heather Domaschenz, Belinda Whittle, Teresa Lambe, Ian S. Roberts, Richard R. Copley, John I. Bell, Richard J. Cornall and Christopher C. Goodnow Nature435, 452–458
(26 May 2005); doi:10.1038/nature03555
| Summary | Full Text (HTML / PDF) |
article Egr-2 and Egr-3 are negative regulators of T cell activation
Meredith Safford, Samuel Collins, Michael A Lutz, Amy Allen, Ching-Tai Huang, Jeanne Kowalski, Amanda Blackford, Maureen R Horton, Charles Drake, Ronald H Schwartz and Jonathan D Powell Nature Immunology6, 472–480
(May 2005); doi:10.1038/ni1193
| Abstract | Full Text (HTML/PDF) |
April
letter CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability
Susan Wee, Rory K. Geyer, Takashi Toda and Dieter A. Wolf Nature Cell Biology7, 387–391
(April 2005); doi:10.1038/ncb1241
| First Paragraph | Full Text (HTML/PDF) |
article The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle
Marion Schmidt, Wilhelm Haas, Bernat Crosas, Patricia G Santamaria, Steven P Gygi, Thomas Walz and Daniel Finley Nature Structural and Molecular Biology12, 294–303
(April 2005); doi:10.1038/nsmb914
| Abstract | Full Text (HTML/PDF) |
news and views Staufen does double duty
Erika L Meyer and Elizabeth R Gavis Nature Structural and Molecular Biology12, 291–292
(April 2005); doi:10.1038/nsmb0405-291
| Full Text (HTML/PDF) |
letters to nature Structure of the apoptotic protease-activating factor 1 bound to ADP
Stefan J. Riedl, Wenyu Li, Yang Chao, Robert Schwarzenbacher and Yigong Shi Nature434, 926–933
(14 April 2005); doi:10.1038/nature03465
| First Paragraph | Full Text (HTML / PDF) |
review article IAPs, RINGs and ubiquitylation
David L. Vaux and John Silke Nature Reviews Molecular Cell Biology6, 287–297
(April 2005); doi:10.1038/nrm1621
| Summary | Full Text (HTML / PDF) |
research article Pulse proteolysis: A simple method for quantitative determination of protein stability and ligand binding
Chiwook Park and Susan Marqusee Nature Methods2, 207–212
(March 2005); doi:10.1038/nmeth740
| Abstract | Full Text (HTML/PDF) |
March
letters to nature Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p
Daisuke Izawa, Masuo Goto, Akira Yamashita, Hiroyuki Yamano and Masayuki Yamamoto Nature434, 529–533
(24 March 2005); doi:10.1038/nature03406
| First Paragraph | Full Text (HTML / PDF) |
article A cytosolic pathway for MHC class II-restricted antigen processing that is proteasome and TAP dependent
Mona K Tewari, Gomathinayagam Sinnathamby, Deepa Rajagopal and Laurence C Eisenlohr Nature Immunology6, 287–294
(March 2005); doi:10.1038/ni1171
| Abstract | Full Text (HTML/PDF) |
article SUMO modification of the ubiquitin-conjugating enzyme E2-25K
Andrea Pichler, Puck Knipscheer, Edith Oberhofer, Willem J van Dijk, Roman Körner, Jesper Velgaard Olsen, Stefan Jentsch, Frauke Melchior and Titia K Sixma Nature Structural and Molecular Biology12, 264–269
(March 2005); doi:10.1038/nsmb903
| Abstract | Full Text (HTML/PDF) |
article Nucleotide-dependent substrate recognition by the AAA+ HslUV protease
Randall E Burton, Tania A Baker and Robert T Sauer Nature Structural and Molecular Biology12, 245–251
(March 2005); doi:10.1038/nsmb898
| Abstract | Full Text (HTML/PDF) |
article A new method for C-terminal sequence analysis in the proteomic era
Bart Samyn, Kjell Sergeant, Pedro Castanheira, Carlos Faro and Jozef Van Beeumen Nature Methods2, 193–200
(March 2005); doi:10.1038/nmeth738
| Abstract | Full Text (HTML/PDF) |
February
news and views ACEing GPI release
Satyajit Mayor Nature Structural and Molecular Biology12, 107–108
(February 2005); doi:10.1038/nsmb0205-107
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article Cathepsin L is required for endothelial progenitor cell-induced neovascularization
Carmen Urbich, Christopher Heeschen, Alexandra Aicher, Ken-ichiro Sasaki, Thomas Bruhl, Mohammad R Farhadi, Peter Vajkoczy, Wolf K Hofmann, Christoph Peters, Len A Pennacchio, Nasreddin D Abolmaali, Emmanouil Chavakis, Thomas Reinheckel, Andreas M Zeiher and Stefanie Dimmeler Nature Medicine11, 206–213
(February 2005); doi:10.1038/nm1182
| Abstract | Full Text (HTML/PDF) |
article Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi and Junji Takeda Nature Medicine11, 160–166
(February 2005); doi:10.1038/nm1179
| Abstract | Full Text (HTML/PDF) |
news and views ACE sets up fertilization
Pierre Corvol Nature Medicine11, 118–119
(February 2005); doi:10.1038/nm0205-118
| Full Text (HTML/PDF) |
article Specific and potent RNAi in the nucleus of human cells
G Brett Robb, Kirk M Brown, Jaspreet Khurana and Tariq M Rana Nature Structural and Molecular Biology12, 133–137
(February 2005); doi:10.1038/nsmb886
| Abstract | Full Text (HTML/PDF) |
January
article Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
Michael H Tatham, Suhkmann Kim, Ellis Jaffray, Jing Song, Yuan Chen and Ronald T Hay Nature Structural and Molecular Biology12, 67–74
(January 2005); doi:10.1038/nsmb878
| Abstract | Full Text (HTML/PDF) |
review article ADAMs: key components in EGFR signalling and development
Carl P. Blobel Nature Reviews Molecular Cell Biology6, 32–43
(January 2005); doi:10.1038/nrm1548
| Summary | Full Text (HTML / PDF) |
news and views Ub in charge: Regulating E2 enzyme nuclear import
Xiang-Dong Zhang and Michael J Matunis Nature Cell Biology7, 12–14
(January 2005); doi:10.1038/ncb0105-12
| Full Text (HTML/PDF) |
review article Function and regulation of cullin-RING ubiquitin ligases
Matthew D. Petroski and Raymond J. Deshaies Nature Reviews Molecular Cell Biology6, 9–20
(January 2005); doi:10.1038/nrm1547
| Summary | Full Text (HTML / PDF) |
article Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
Pascal Descargues, Céline Deraison, Chrystelle Bonnart, Maaike Kreft, Mari Kishibe, Akemi Ishida-Yamamoto, Peter Elias, Yann Barrandon, Giovanna Zambruno, Arnoud Sonnenberg and Alain Hovnanian Nature Genetics37, 56–65
(January 2005); doi:10.1038/ng1493
| Abstract | Full Text (HTML/PDF) |
