Research library: Proteolysis/Ubiquitination
2008:
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July
perspective
Revisiting the biological roles of PAI2 (SERPINB2) in cancer
David R. Croucher, Darren N. Saunders, Sergei Lobov & Marie Ranson
Nature Reviews Cancer 8, 535–545
(July 2008); doi:10.1038/nrc2400
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article
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Chengyu Liang et al.
Nature Cell Biology 10, 776–787
(July 2008); doi:10.1038/ncb1740
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news and views
UVRAG reveals its second nature
Karolina Peplowska, Margarita Cabrera & Christian Ungermann
Nature Cell Biology 10, 759–761
(July 2008); doi:10.1038/ncb0708-759
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review
Deubiquitylation and regulation of the immune response
Shao-Cong Sun
Nature Reviews Immunology 8, 501–511
(July 2008); doi:10.1038/nri2337
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June
letter
Substrate-targeting γ-secretase modulators
Thomas L. Kukar et al.
Nature 453, 925–929
(12 June 2008); doi:10.1038/nature07055
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news and views
Biochemistry: Molecular cloaking devices
Thomas Kodadek
Nature 453, 861–862
(12 June 2008); doi:10.1038/453861a
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letter
Yeast Ataxin-7 links histone deubiquitination with gene gating and mRNA export
Alwin Köhler, Maren Schneider, Ghislain G. Cabal, Ulf Nehrbass & Ed Hurt
Nature Cell Biology 10, 637–639
(June 2008); doi:10.1038/ncb1733
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review
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
David Frescas & Michele Pagano
Nature Reviews Cancer 8, 438–449
(June 2008); doi:10.1038/nrc2396
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article
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
Oliver Schilling & Christopher M Overall
Nature Biotechnology 26, 685–694
(June 2008); doi:10.1038/nbt1408
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news and views
Proteases' prime targets revealed
Scott L Diamond & Doron Greenbaum
Nature Biotechnology 26, 652–653
(June 2008); doi:10.1038/nbt0608-652
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article
The central unit within the 19S regulatory particle of the proteasome
Rina Rosenzweig et al.
Nature Structural & Molecular Biology 15, 573–580
(June 2008); doi:10.1038/nsmb.14272
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letter
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Austin R. Graves, Patricia K. Curran, Carolyn L. Smith & Joseph A. Mindell
Nature 453, 788–792
(5 June 2008); doi:10.1038/nature06907
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letter
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
Robert K. McGinty, Jaehoon Kim, Champak Chatterjee, Robert G. Roeder & Tom W. Muir
Nature 453, 812–816
(5 June 2008); doi:10.1038/nature06906
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article
The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein
Xudong Zhao et al.
Nature Cell Biology 10, 643–653
(June 2008); doi:10.1038/ncb1727
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review
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
David Frescas & Michele Pagano
Nature Reviews Cancer 8, 438–449
(June 2008); doi:10.1038/nrc2396
| Summary | Full Text (HTML / PDF) |
May
letter
Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease
Claudine Kraft, Anna Deplazes, Marc Sohrmann & Matthias Peter
Nature Cell Biology 10, 602–610
(May 2008); doi:10.1038/ncb1723
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news and views
Starved cells eat ribosomes
Hitoshi Nakatogawa & Yoshinori Ohsumi
Nature Cell Biology 10, 505–507
(May 2008); doi:10.1038/ncb0508-505
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article
Proteasome subunit Rpn13 is a novel ubiquitin receptor
Koraljka Husnjak et al.
Nature 453, 481–488
(22 May 2008); doi:10.1038/nature06926
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letter
Ubiquitin docking at the proteasome through a novel pleckstrin–homology domain interaction
Patrick Schreiner et al.
Nature 453, 548–552
(22 May 2008); doi:10.1038/nature06924
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news and views
Cell Biology: Two hands for degradation
Yasushi Saeki & Keiji Tanaka
Nature 453, 460–461
(22 May 2008); doi:10.1038/453460a
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article
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome
Rebecca Mathew, Klaus Hartmuth, Sina Möhlmann, Henning Urlaub, Ralf Ficner & Reinhard Lührmann
Nature Structural & Molecular Biology 14, 435–443
(May 2008); doi:10.1038/nsmb.1415
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article
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
Michael H. Tatham et al.
Nature Cell Biology 10, 538–546
(May 2008); doi:10.1038/ncb1716
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article
Arsenic degrades PML or PML-RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway
Valérie Lallemand-Breitenbach et al.
Nature Cell Biology 10, 547–555
(May 2008); doi:10.1038/ncb1717
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news and views
Marked for death
Kevin Petrie & Arthur Zelent
Nature Cell Biology 10, 507–509
(May 2008); doi:10.1038/ncb0508-507
| Full Text (HTML / PDF) |
article
A role for ubiquitin in the spliceosome assembly pathway
Priya Bellare, Eliza C Small, Xinhua Huang, James A Wohlschlegel, Jonathan P Staley & Erik J Sontheimer
Nature Structural & Molecular Biology 14, 444–451
(May 2008); doi:10.1038/nsmb.1401
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news and views
Modifications target spliceosome dynamics
Corina Maeder & Christine Guthrie
Nature Structural & Molecular Biology 14, 426–428
(May 2008); doi:10.1038/nsmb0508-426
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article
Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I
Tiziana Di Pucchio et al.
Nature Immunology 9, 551–557
(May 2008); doi:10.1038/ni.1602
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article
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation
Sven Burgdorf, Christian Schölz, Andreas Kautz, Robert Tampé & Christian Kurts
Nature Immunology 9, 558–566
(May 2008); doi:10.1038/ni.1601
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news and views
Cross-presentation: avoiding trafficking chaos?
Sudhir Pai Kasturi & Bali Pulendran
Nature Immunology 9, 461–463
(May 2008); doi:10.1038/ni0508-461
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April
article
TRIM30α negatively regulates TLR-mediated NF-κB activation by targeting TAB2 and TAB3 for degradation
Mude Shi et al.
Nature Immunology 9, 369–377
(April 2008); doi:10.1038/ni1577
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news and views
TRIM-ing down Tolls
Andrew G Bowie
Nature Immunology 9, 348–350
(April 2008); doi:10.1038/ni0408-348
| Full Text (HTML / PDF) |
letter
Securin regulates entry into M-phase by modulating the stability of cyclin B
Petros Marangos & John Carroll
Nature Cell Biology 10, 445–451
(April 2008); doi:10.1038/ncb1707
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news and views
Securin' M-phase entry
Mark J. Solomon & Janet L. Burton
Nature Cell Biology 10, 381–383
(April 2008); doi:10.1038/ncb0408-381
| Full Text (HTML / PDF) |
news and views Q&A
Cell biology: SUMO
Erik Meulmeester & Frauke Melchior
Nature 452, 709–711
(10 April 2008); doi:10.1038/452709a
| Full Text (HTML / PDF) |
March
review
Apoptosis: controlled demolition at the cellular level
Rebecca C. Taylor, Sean P. Cullen & Seamus J. Martin
Nature Reviews Molecular Cell Biology 9, 231–241
(March 2008); doi:10.1038/nrm2312
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article
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
K Venuprasad et al.
Nature Immunology 9, 245–253
(March 2008); doi:10.1038/ni1564
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article
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
Noula Shembade et al.
Nature Immunology 9, 254–262
(March 2008); doi:10.1038/ni1563
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news and views
Itching to end NF-κB
Vigo Heissmeyer & Anjana Rao
Nature Immunology 9, 227–229
(March 2008); doi:10.1038/ni0308-227
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letter
Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
Yasuhiko Kawasaki et al.
Nature Medicine 14, 331–336
(March 2008); doi:10.1038/nm1723
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news and views
Taking two cuts at pain
Simon Beggs & Michael W Salter
Nature Medicine 14, 243–244
(March 2008); doi:10.1038/nm0308-243
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letter
Control of chromosome stability by the β-TrCP–REST–Mad2 axis
Daniele Guardavaccaro et al.
Nature 452, 365–369
(20 March 2008); doi:10.1038/nature06641
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letter
SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation
Thomas F. Westbrook et al.
Nature 452, 370–374
(20 March 2008); doi:10.1038/nature06780
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article
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum
Shirin Arastu-Kapur et al.
Nature Chemical Biology 4, 203–213
(March 2008); doi:10.1038/nchembio.70
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news and views
Arresting malaria parasite egress from infected red blood cells
Marcus C S Lee & David A Fidock
Nature Chemical Biology 4, 161–162
(March 2008); doi:10.1038/nchembio0308-161
| Full Text (HTML / PDF) |
article
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-κB inhibitor A20
Beatrice Coornaert et al.
Nature Immunology 9, 263–271
(March 2008); doi:10.1038/ni1561
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article
The proteolytic activity of the paracaspase MALT1 is key in T cell activation
Fabien Rebeaud et al.
Nature Immunology 9, 272–281
(March 2008); doi:10.1038/ni1568
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news and views
Finally, MALT1 is a protease!
Linda M McAllister-Lucas & Peter C Lucas
Nature Immunology 9, 231–233
(March 2008); doi:10.1038/ni0308-231
| Full Text (HTML / PDF) |
letter
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons
Jyh-Rong Chao, Evan Parganas, Kelli Boyd, Cheol Yi Hong, Joseph T. Opferman & James N. Ihle
Nature 452, 98–102
(6 March 2008); doi:10.1038/nature06604
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article
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2
Danny T Huang, Min Zhuang, Olivier Ayrault & Brenda A Schulman
Nature Structural & Molecular Biology 15, 280–287
(March 2008); doi:10.1038/nsmb.1387
| Summary | Full Text (HTML / PDF) |
February
brief communication
Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF
Tomoya Matsumoto et al.
Nature Neuroscience 11, 131–133
(February 2008); doi:10.1038/nn2038
| Summary | Full Text (HTML / PDF) |
article
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
Nature Cell Biology 10, 138–148
(February 2008); doi:10.1038/ncb1676
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news and views
ERK and MDM2 prey on FOXO3a
Wensheng Yang, Nathan G. Dolloff & Wafik S. El-Deiry
Nature Cell Biology 10, 125–126
(February 2008); doi:10.1038/ncb0208-125
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article
Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes
Andreas Martin, Tania A Baker & Robert T Sauer
Nature Structural & Molecular Biology 15, 139–145
(February 2008); doi:10.1038/nsmb.1380
| Summary | Full Text (HTML / PDF) |
review
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
Markus Welcker & Bruce E. Clurman
Nature Reviews Cancer 8, 83–93
(February 2008); doi:10.1038/nrc2290
| Summary | Full Text (HTML / PDF) |
January
letter
Coordinated regulation of Arabidopsisthaliana development by light and gibberellins
Suhua Feng et al.
Nature 451, 475–479
(24 January 2008); doi:10.1038/nature06448
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article
Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase
Jianbo Diao, Ying Zhang, Jon M Huibregtse, Daoguo Zhou & Jue Chen
Nature Structural & Molecular Biology 15, 65–70
(January 2008); doi:10.1038/nsmb1346
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