Research library: Proteolysis/Ubiquitination
2009:
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December
article
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
Joanna R. Morris et al.
Nature 462, 886–890
(17 December 2009); doi:10.1038/nature08593
| Summary | Full Text (HTML / PDF) |
letter
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
Yaron Galanty et al.
Nature 462, 935–939
(17 December 2009); doi:10.1038/nature08657
| Summary | Full Text (HTML / PDF) |
news and views
DNA Repair: A heavyweight joins the fray
Simon J. Boulton
Nature 462, 857–858
(17 December 2009); doi:10.1038/462857a
| Full Text (HTML / PDF) |
article
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4
Fuping You et al.
Nature Immunology 10, 1300–1308
(December 2009); doi:10.1038/ni.1815
| Summary | Full Text (HTML / PDF) |
brief communication
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
Yogesh Kulathu, Masato Akutsu, Anja Bremm, Kay Hofmann & David Komander
Nature Structural & Molecular Biology 16, 1328–1330
(December 2009); doi:10.1038/nsmb.1731
| Summary | Full Text (HTML / PDF) |
news and views
Ubiquitin linkages make a difference
Ivan Dikic & Volker Dötsch
Nature Structural & Molecular Biology 16, 1209–1210
(December 2009); doi:10.1038/nsmb1209-1209
| Full Text (HTML / PDF) |
article
Detection of sequential polyubiquitylation on a millisecond timescale
Nathan W. Pierce, Gary Kleiger, Shu-ou Shan & Raymond J. Deshaies
Nature 462, 615–619
(03 December 2009); doi:10.1038/nature08595
| Full Text (HTML / PDF) |
news and views
Cell biology: Stairway to the proteasome
Malavika Raman & J. Wade Harper
Nature 462, 585–586
(03 December 2009); doi:10.1038/462585a
| Full Text (HTML / PDF) |
November
letter
Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome
Jens F. Sundström et al.
Nature Cell Biology 11, 1347–1354
(2009) doi:10.1038/ncb1979
| Summary | Full Text (HTML / PDF) |
review
Building ubiquitin chains: E2 enzymes at work
Yihong Ye & Michael Rape
Nature Reviews Molecular Cell Biology 10, 755–764
(November 2009); doi:10.1038/nrm2780
| Summary | Full Text (HTML / PDF) |
article
The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
Teresa L M Thurston, Grigory Ryzhakov, Stuart Bloor, Natalia von Muhlinen & Felix Randow
Nature Immunology 10, 1215–1221
(November 2009); doi:10.1038/ni.1800
| Summary | Full Text (HTML / PDF) |
news and views
NDP52: the missing link between ubiquitinated bacteria and autophagy
Stanimir Ivanov & Craig R Roy
Nature Immunology 10, 1137–1139
(November 2009); doi:10.1038/ni1109-1137
| Full Text (HTML / PDF) |
scientific reports
Helicobacter pylori CagA activates NF-κB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination
Acacia Lamb et al.
EMBO Reports 10, 1242–1249
(November 2009); doi:10.1038/embor.2009.210
| Summary | Full Text (HTML / PDF) |
letter
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit
Mathew J. Garnett et al.
Nature Cell Biology 11, 1363–1369
(November 2009) doi:10.1038/ncb1983
| Summary | Full Text (HTML / PDF) |
review
Targeting proteins for degradation
Erin K Schrader, Kristine G Harstad & Andreas Matouschek
Nature Chemical Biology 5, 815–822
(November 2009); doi:10.1038/nchembio.250
| Summary | Full Text (HTML / PDF) |
October
article
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly
Masami Yamada et al.
Nature Medicine 15, 1202–1207
(October 2009); doi:10.1038/nm.2023
| Summary | Full Text (HTML / PDF) |
article
Structural and kinetic determinants of protease substrates
John C Timmer et al.
Nature Structural & Molecular Biology 16, 1101–1108
(October 2009); doi:10.1038/nsmb.1668
| Summary | Full Text (HTML / PDF) |
letter
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint
Marina Melixetian, Ditte Kjærsgaard Klein, Claus Storgaard Sørensen & Kristian Helin
Nature Cell Biology 11, 1247–1253
(October 2009); doi:10.1038/ncb1969
| Summary | Full Text (HTML / PDF) |
review
Ubiquitin-binding domains — from structures to functions
Ivan Dikic, Soichi Wakatsuki & Kylie J. Walters
Nature Reviews Molecular Cell Biology 10, 659–671
(October 2009); doi:10.1038/nrm2767
| Summary | Full Text (HTML / PDF) |
article
Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
Mikyoung Chang, Wei Jin & Shao-Cong Sun
Nature Immunology 10, 1089–1095
(October 2009); doi:10.1038/ni.1777
| Summary | Full Text (HTML / PDF) |
article
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Shih-Min A. Huang et al.
Nature 461, 614–620
(01 October 2009); doi:10.1038/nature08356
| Full Text (HTML / PDF) |
news and views
Drug discovery: Propping up a destructive regime
Randall T. Peterson
Nature 461, 599–600
(01 October 2009); doi:10.1038/461599a
| Full Text (HTML / PDF) |
September
review
Endocytosis and signalling: intertwining molecular networks
Alexander Sorkin & Mark von Zastrow
Nature Reviews Molecular Cell Biology 10, 609–622
(September 2009); doi:10.1038/nrm2748
| Summary | Full Text (HTML / PDF) |
review
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
Paul Saftig & Judith Klumperman
Nature Reviews Molecular Cell Biology 10, 623–635
(September 2009); doi:10.1038/nrm2745
| Summary | Full Text (HTML / PDF) |
article
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis
Tatsukata Kawagoe et al.
Nature Immunology 10, 965–972
(September 2009); doi:10.1038/ni.1771
| Summary | Full Text (HTML / PDF) |
letter
Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like
Hyunju Ro & Igor B. Dawid
Nature Cell Biology 11, 1121–1127
(September 2009); doi:10.1038/ncb1926
| Summary | Full Text (HTML / PDF) |
article
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9
Firaz Mohideen et al.
Nature Structural & Molecular Biology 16, 945–952
(September 2009); doi:10.1038/nsmb.1648
| Summary | Full Text (HTML / PDF) |
letter
Direct activation of protein kinases by unanchored polyubiquitin chains
Zong-Ping Xia et al.
Nature 461, 114–119
(03 September 2009); doi:10.1038/nature08247
| Full Text (HTML / PDF) |
August
review
Breaking the chains: structure and function of the deubiquitinases
David Komander, Michael J. Clague & Sylvie Urbé
Nature Reviews Molecular Cell Biology 10, 550–563
(August 2009); doi:10.1038/nrm2731
| Summary | Full Text (HTML / PDF) |
article
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains
Joshua J Sims, Aydin Haririnia, Bryan C Dickinson, David Fushman & Robert E Cohen
Nature Structural & Molecular Biology 16,
doi:10.1038/nsmb.1637
| Summary | Full Text (HTML / PDF) |
letter
XIAP discriminates between type I and type II FAS-induced apoptosis
Philipp J. Jost et al.
Nature 460, 1035–1039
(20 August 2009); doi:10.1038/nature08229
| Full Text (HTML / PDF) |
letter
Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation
Dirk Siepe & Stefan Jentsch
Nature Cell Biology 11, 967–972
(August 2009); doi:10.1038/ncb1908
| Summary | Full Text (HTML / PDF) |
perspective
An additional role for SUMO in ubiquitin-mediated proteolysis
Marie-Claude Geoffroy & Ronald T. Hay
Nature Reviews Molecular Cell Biology 10, 564–568
(August 2009); doi:10.1038/nrm2707
| Summary | Full Text (HTML / PDF) |
review
Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases
Janine Kirstein, Noël Molière, David A. Dougan & Kürşad Turgay
Nature Reviews Microbiology 7, 589–599
(August 2009); doi:10.1038/nrmicro2185
| Summary | Full Text (HTML / PDF) |
July
review
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa, Kuninori Suzuki, Yoshiaki Kamada & Yoshinori Ohsumi
Nature Reviews Molecular Cell Biology 10, 458–467
(July 2009); doi:10.1038/nrm2708
| Summary | Full Text (HTML / PDF) |
letter
OsHAL3 mediates a new pathway in the light-regulated growth of rice
Shi-Yong Sun et al.
Nature Cell Biology 11, 845–851
(July 2009); doi:10.1038/ncb1892
| Summary | Full Text (HTML / PDF) |
progress
Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis
K. Heran Darwin
Nature Reviews Microbiology 7, 485–491
(July 2009); doi:10.1038/nrmicro2148
| Summary | Full Text (HTML / PDF) |
letter
A conserved ubiquitination pathway determines longevity in response to diet restriction
Andrea C. Carrano, Zheng Liu, Andrew Dillin & Tony Hunter
Nature 460, 396–399
(16 July 2009); doi:10.1038/nature08130
| Full Text (HTML / PDF) |
article
The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon
Chen Wang et al.
Nature Immunology 10, 744–752
(July 2009); doi:10.1038/ni.1742
| Summary | Full Text (HTML / PDF) |
June
article
Ube3a is required for experience-dependent maturation of the neocortex
Koji Yashiro et al.
Nature Neuroscience 12, 777–783
(June 2009); doi:10.1038/nn.2327
| Summary | Full Text (HTML / PDF) |
article
E2 interaction and dimerization in the crystal structure of TRAF6
Qian Yin et al.
Nature Structural & Molecular Biology 16, 658–666
(June 2009); doi:10.1038/nsmb.1605
| Summary | Full Text (HTML / PDF) |
review
Physiological functions of the HECT family of ubiquitin ligases
Daniela Rotin & Sharad Kumar
Nature Reviews Molecular Cell Biology 10, 398–409
(June 2009); doi:10.1038/nrm2690
| Summary | Full Text (HTML / PDF) |
article
Bacterial ubiquitin-like modifier Pup is deamidated and conjugated to substrates by distinct but homologous enzymes
Frank Striebel et al.
Nature Structural & Molecular Biology 16, 647–651
(June 2009); doi:10.1038/nsmb.1597
| Summary | Full Text (HTML / PDF) |
letter
Chaperone-mediated pathway of proteasome regulatory particle assembly
Jeroen Roelofs et al.
Nature 459, 861–865
(11 June 2009); doi:10.1038/nature08063
| Full Text (HTML / PDF) |
letter
Hexameric assembly of the proteasomal ATPases is templated through their C termini
Soyeon Park et al.
Nature 459, 866–870
(11 June 2009); doi:10.1038/nature08065
| Full Text (HTML / PDF) |
news and views
Cell biology: The proteasome assembly line
Kiran Madura
Nature 459, 787–788
(11 June 2009); doi:10.1038/459787a
| Full Text (HTML / PDF) |
review
The ubiquitin–26S proteasome system at the nexus of plant biology
Richard D. Vierstra
Nature Reviews Molecular Cell Biology 10, 385–397
(June 2009); doi:10.1038/nrm2688
| Summary | Full Text (HTML / PDF) |
review
Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms
Sinisa Urban
Nature Reviews Microbiology 7, 411–423
(June 2009); doi:10.1038/nrmicro2130
| Summary | Full Text (HTML / PDF) |
May
review
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
Brenda A. Schulman & J. Wade Harper
Nature Reviews Molecular Cell Biology 10, 319–331
(May 2009); doi:10.1038/nrm2673
| Summary | Full Text (HTML / PDF) |
article
Stability of surface NMDA receptors controls synaptic and behavioral adaptations to amphetamine
Li-Min Mao et al.
Nature Neuroscience 12, 602–610
(May 2009); doi:10.1038/nn.2300
| Summary | Full Text (HTML / PDF) |
article
Molecular mimicry of SUMO promotes DNA repair
John Prudden, J Jefferson P Perry, Andrew S Arvai, John A Tainer & Michael N Boddy
Nature Structural & Molecular Biology 16, 509–516
(May 2009); doi:10.1038/nsmb.1582
| Summary | Full Text (HTML / PDF) |
April
scientific report
Phosphorylation of NF-κB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination
Hui Geng et al.
EMBO Reports 10, 381–386
(April 2009); doi:10.1038/embor200910
| Summary | Full Text (HTML / PDF) |
article
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
Subbareddy Maddika & Junjie Chen
Nature Cell Biology 11, 409–419
(April 2009); doi:10.1038/ncb1848
| Summary | Full Text (HTML / PDF) |
news and views
Targeting protein ubiquitylation: DDB1 takes its RING off
Sarah Jackson & Yue Xiong
Nature Cell Biology 11, 379–381
(April 2009); doi:10.1038/ncb0409-379
| Full Text (HTML / PDF) |
article
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction
Daming Gao et al.
Nature Cell Biology 11, 397–408
(April 2009); doi:10.1038/ncb1847
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB
Hui-Kuan Lin et al.
Nature Cell Biology 11, 420–432
(April 2009); doi:10.1038/ncb1849
| Summary | Full Text (HTML / PDF) |
news and views
Skp2: caught in the Akt
Karin Ecker & Ludger Hengst
Nature Cell Biology 11, 377–379
(April 2009); doi:10.1038/ncb1859
| Full Text (HTML / PDF) |
March
review
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
Luigi Franchi, Tatjana Eigenbrod, Raúl Muñoz-Planillo & Gabriel Nuñez
Nature Immunology 10, 241–247
(March 2009); doi:10.1038/ni.1703
| Summary | Full Text (HTML / PDF) |
article
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc
Hugh K Arnold, Xiaoli Zhang, Colin J Daniel, Deanne Tibbitts, Julie Escamilla-Powers, Amy Farrell, Sara Tokarz, Charlie Morgan & Rosalie C Sears
The EMBO Journal 28, 500–512
(March 2009); doi:10.1038/emboj.2008.279
| Summary | Full Text (HTML / PDF) |
article
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling
Noula Shembade, Kislay Parvatiyar, Nicole S Harhaj & Edward W Harhaj
The EMBO Journal 28, 513–522
(March 2009); doi:10.1038/emboj.2008.285
| Summary | Full Text (HTML / PDF) |
article
Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death
Theocharis Panaretakis et al.
The EMBO Journal 28, 578–590
(March 2009); doi:10.1038/emboj.2009.1
| Summary | Full Text (HTML / PDF) |
letter
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA
Sebastian Leidel et al.
Nature 458, 228–232
(12 March 2009); doi:10.1038/nature07643
| Summary | Full Text (HTML / PDF) |
letter
The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways
Masashi Kajiro et al.
Nature Cell Biology 11, 312–319
(March 2009); doi:10.1038/ncb1839
| Summary | Full Text (HTML / PDF) |
news and views
Breast cancer quality control
Cam Patterson & Sarah Ronnebaum
Nature Cell Biology 11, 239–241
(March 2009); doi:10.1038/ncb0309-239
| Full Text (HTML / PDF) |
February
review
Molecular mechanisms of proteasome assembly
Shigeo Murata, Hideki Yashiroda & Keiji Tanaka
Nature Reviews Molecular Cell Biology 10, 104–115
(February 2009); doi:10.1038/nrm2630
| Summary | Full Text (HTML / PDF) |
article
Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3
Sokol V Todi et al.
The EMBO Journal 28, 372–382
(February 2009); doi:10.1038/emboj.2008.289
| Summary | Full Text (HTML / PDF) |
article
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
Anatoly Nikolaev, Todd McLaughlin, Dennis D. M. O'Leary & Marc Tessier-Lavigne
Nature 457, 981–989
(19 February 2009); doi:10.1038/nature07767
| Summary | Full Text (HTML / PDF) |
news and views
Neuroscience: Good and bad cell death
Donald W. Nicholson
Nature 457, 970–971
(19 February 2009); doi:10.1038/457970a
| Full Text (HTML / PDF) |
article
Nuclear signalling by tumour-associated antigen EpCAM
Dorothea Maetzel et al.
Nature Cell Biology 11, 162–171
(February 2009); doi:10.1038/ncb1824
| Summary | Full Text (HTML / PDF) |
letter
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
Shigeru Oshima et al.
Nature 457, 906–909
(12 February 2009); doi:10.1038/nature07575
| Summary | Full Text (HTML / PDF) |
article
Polyubiquitin substrates allosterically activate their own degradation by the 26S proteasome
Dawadschargal Bech-Otschir et al.
Nature Structural & Molecular Biology 16, 219–225
(February 2009); doi:10.1038/nsmb.1547
| Summary | Full Text (HTML / PDF) |
news and views
Involvement of linear polyubiquitylation of NEMO in NF- κB activation
Fuminori Tokunaga et al.
Nature Cell Biology 11, 123–132
(February 2009); doi:10.1038/ncb1821
| Summary | Full Text (HTML / PDF) |
news and views
Linear polyubiquitylation: the missing link in NF–κB signalling
Arthur L. Haas
Nature Cell Biology 11, 116–118
(February 2009); doi:10.1038/ncb0209-116
| Full Text (HTML / PDF) |
January
letter
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
Marco A. Calzado, Laureano de la Vega, Andreas Möller, David D. L. Bowtell & M. Lienhard Schmitz
Nature Cell Biology 11, 85–91
(January 2009); doi:10.1038/ncb1816
| Summary | Full Text (HTML / PDF) |
article
Histone H3 tail clipping regulates gene expression
Helena Santos-Rosa et al.
Nature Structural & Molecular Biology 16, 17–22
(January 2009); doi:10.1038/nsmb.1534
| Summary | Full Text (HTML / PDF) |
brief communication
Peptidase substrates via global peptide profiling
Debarati M Tagore et al.
Nature Chemical Biology 5, 23–25
(January 2009); doi:10.1038/nchembio.126
| Summary | Full Text (HTML / PDF) |
news and views
Metabolomics cuts to the chase to chase the cuts
Matthew Bogyo
Nature Chemical Biology 5, 5–6
(January 2009); doi:10.1038/nchembio0109-5
| Full Text (HTML / PDF) |
article
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
Koichi Kobayashi, Min Luo, Yue Zhang, David C. Wilkes, Gaoxiang Ge, Thomas Grieskamp, Chikaomi Yamada, Ting-Chun Liu, Guorui Huang, Craig T. Basson, Andreas Kispert, Daniel S. Greenspan & Thomas N. Sato
Nature Cell Biology 11, 46–55
(January 2009); doi:10.1038/ncb1811
| Summary | Full Text (HTML / PDF) |
news and views
sFRPs: a declaration of (Wnt) independence
Elisha Nathan & Eldad Tzahor
Nature Cell Biology 11, 13
(January 2009); doi:10.1038/ncb0109-13
| Full Text (HTML / PDF) |
article
Proteolysis of NF-κB1 p105 is essential for T cell antigen receptor–induced proliferation
Srividya Sriskantharajah et al.
Nature Immunology 10, 38–47
(January 2009); doi:10.1038/ni.1685
| Summary | Full Text (HTML / PDF) |
article
Substrate selection by the proteasome during degradation of protein complexes
Sumit Prakash, Tomonao Inobe, Ace Joseph Hatch & Andreas Matouschek
Nature Chemical Biology 5, 29–36
(January 2009); doi:10.1038/nchembio.130
| Summary | Full Text (HTML / PDF) |
news and views
The proteasome makes sense of mixed signals
Thomas J Wandless
Nature Chemical Biology 5, 3–4
(January 2009); doi:10.1038/nchembio0109-3
| Full Text (HTML / PDF) |
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