article NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway
Tiffany Horng, Jelena S Bezbradica & Ruslan Medzhitov Nature Immunology8, 1345–1352
(December 2007); doi:10.1038/ni1524
| Summary | Full Text (HTML / PDF) |
news and views Unexpected partnership between IL-15 and DAP10
Francesco Colucci Nature Immunology8, 1289–1291
(December 2007); doi:10.1038/ni1207-1289
| Full Text (HTML / PDF) |
perspective Role of autophagy in cancer
Robin Mathew, Vassiliki Karantza-Wadsworth & Eileen White Nature Reviews Cancer7, 961–967
(December 2007); doi:10.1038/nrc2254
| Summary | Full Text (HTML / PDF) |
November
letter mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
John T. Cunningham, Joseph T. Rodgers, Daniel H. Arlow, Francisca Vazquez, Vamsi K. Mootha & Pere Puigserver Nature450, 736–740
(29 November 2007); doi:10.1038/nature06322
| Summary | Full Text (HTML / PDF) |
article TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases
Janni Petersen & Paul Nurse Nature Cell Biology9, 1263–1272
(November 2007); doi:10.1038/ncb1646
| Summary | Full Text (HTML / PDF) |
news and views Holding back TOR advances mitosis
Thomas W. Sturgill & Michael N. Hall Nature Cell Biology9, 1221–1222
(November 2007); doi:10.1038/ncb1107-1221
| Summary | Full Text (HTML / PDF) |
article SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress
Yonghua Yang et al. Nature Cell Biology9, 1253–1262
(November 2007); doi:10.1038/ncb1645
| Summary | Full Text (HTML / PDF) |
review Astrocyte metabolism and signaling during brain ischemia
David J Rossi, James D Brady & Claudia Mohr Nature Neuroscience10, 1377–1386
(November 2007); doi:10.1038/nn2004
| Summary | Full Text (HTML / PDF) |
article Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate
Tomohiro Sawa et al. Nature Chemical Biology3, 727–735
(November 2007); doi:10.1038/nchembio.2007.33
| Summary | Full Text (HTML / PDF) |
October
news and views Where lies the blame for resistance-tumor or host?
Charles L Sawyers Nature Medicine13, 1144–1145
(October 2007); doi:10.1038/nm1007-1144
| Full Text (HTML / PDF) |
review ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
Benoît D'Autréaux & Michel B. Toledano Nature Reviews Molecular Cell Biology8, 813–824
(October 2007); doi:10.1038/nrm2256
| Summary | Full Text (HTML / PDF) |
letter Adaptive immune cells temper initial innate responses
Kwang Dong Kim et al. Nature Medicine13, 1248–1252
(October 2007); doi:10.1038/nm1633
| Summary | Full Text (HTML / PDF) |
news and views Not so fast: adaptive suppression of innate immunity
Noah W Palm & Ruslan Medzhitov Nature Medicine13, 1142–1144
(October 2007); doi:10.1038/nm1007-1142b
| Summary | Full Text (HTML / PDF) |
review Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Vittorio Calabrese, Cesare Mancuso, Menotti Calvani, Enrico Rizzarelli, D. Allan Butterfield & Anna Maria Giuffrida Stella Nature Reviews Neuroscience8, 766–775
(October 2007); doi:10.1038/nrn2214
| Summary | Full Text (HTML / PDF) |
review AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
D. Grahame Hardie Nature Reviews Molecular Cell Biology8, 774–785
(October 2007); doi:10.1038/nrm2249
| Summary | Full Text (HTML / PDF) |
review Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez & Ruth Lupu Nature Reviews Cancer7, 763–777
(October 2007); doi:10.1038/nrc2222
| Summary | Full Text (HTML / PDF) |
article Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells
Ryan T Phan, Masumichi Saito, Yukiko Kitagawa, Anthony R Means & Riccardo Dalla-Favera Nature Immunology8, 1132–1139
(October 2007); doi:10.1038/ni1508
| Summary | Full Text (HTML / PDF) |
September
perspective Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?
Marco Giorgio, Mirella Trinei, Enrica Migliaccio & Pier Giuseppe Pelicci Nature Reviews Molecular Cell Biology8, 722–728
(September 2007); doi:10.1038/nrm2240
| Summary | Full Text (HTML / PDF) |
article The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers
Liyong Zhang, Michael S Anglesio, Maureen O'Sullivan, Fan Zhang, Ge Yang, Renu Sarao, Mai P Nghiem, Shane Cronin, Hiromitsu Hara, Nataliya Melnyk, Liheng Li, Teiji Wada, Peter P Liu, Jason Farrar, Robert J Arceci, Poul H Sorensen & Josef M Penninger Nature Medicine13, 1060–1069
(September 2007); doi:10.1038/nm1621
| Summary | Full Text (HTML / PDF) |
review Self-eating and self-killing: crosstalk between autophagy and apoptosis
M. Chiara Maiuri, Einat Zalckvar, Adi Kimchi & Guido Kroemer Nature Reviews Molecular Cell Biology8, 741–752
(September 2007); doi:10.1038/nrm2239
| Summary | Full Text (HTML / PDF) |
article Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Eugene A Podrez, Tatiana V Byzova, Maria Febbraio, Robert G Salomon, Yi Ma, Manojkumar Valiyaveettil, Eugenia Poliakov, Mingjiang Sun, Paula J Finton, Brian R Curtis, Juhua Chen, Renliang Zhang, Roy L Silverstein & Stanley L Hazen Nature Medicine13, 1086–1095
(2007); doi:10.1038/nm1626
| Summary | Full Text (HTML / PDF) |
news and views The clot thickens-oxidized lipids and thrombosis
Shaun P Jackson & Anna C Calkin Nature Medicine13, 1015–1016
(2007); doi:10.1038/nm0907-1015
| Full Text (HTML / PDF) |
article MRE11—RAD50—NBS1 and ATM function as co-mediators of TRF1 in telomere length control
Yili Wu, Shujie Xiao & Xu-Dong Zhu Nature Structural & Molecular Biology14, 832–840
(2007); doi:10.1038/nsmb1286
| Summary | Full Text (HTML / PDF) |
letter The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun
Ryo Koyama-Nasu, Gregory David & Naoko Tanese Nature Cell Biology9, 1074–1080
(September 2007); doi:10.1038/ncb1628
| Summary | Full Text (HTML / PDF) |
scientific report The Arabidopsis TOR kinase links plant growth, yield, stress resistance and mRNA translation
Dorothée Deprost, Lei Yao, Rodnay Sormani, Manon Moreau, Guillaume Leterreux, Maryse Nicolaï, Magali Bedu, Christophe Robaglia & Christian Meyer EMBO Reports8, 864–870
(September 2007); doi:10.1038/nchembio.2007.19
| Summary | Full Text (HTML / PDF) |
August
article The Smc5–Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus
Jordi Torres-Rosell, Ivana Sunjevaric, Giacomo De Piccoli, Meik Sacher, Nadine Eckert-Boulet, Robert Reid, Stefan Jentsch, Rodney Rothstein, Luis Aragón & Michael Lisby Nature Cell Biology9, 923–931
(August 2007); doi:10.1038/ncb1619
| Summary | Full Text (HTML / PDF) |
review Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
Csaba Szabó, Harry Ischiropoulos & Rafael Radi Nature Reviews Drug Discovery6, 662–680
(August 2007); doi:10.1038/nrd2222
| Summary | Full Text (HTML / PDF) |
July
letter DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Akinori Takaoka, ZhiChao Wang, Myoung Kwon Choi, Hideyuki Yanai, Hideo Negishi, Tatsuma Ban, Yan Lu, Makoto Miyagishi, Tatsuhiko Kodama, Kenya Honda, Yusuke Ohba & Tadatsugu Taniguchi Nature448, 501–505
(26 July 2007); doi:10.1038/nature06013
| Summary | Full Text (HTML / PDF) |
news and views Immunology: Sensing the enemy within
Hongbo Chi & Richard A. Flavell Nature448, 422–423
(26 July 2007); doi:10.1038/448423a
| Full Text (HTML / PDF) |
letter An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum
Samuel J. Fountain, Katie Parkinson, Mark T. Young, Lishuang Cao, Christopher R. L. Thompson & R. Alan North Nature448, 200–203
(12 July 2007); doi:10.1038/nature05926
| Summary | Full Text (HTML / PDF) |
review Signal integration in the endoplasmic reticulum unfolded protein response
David Ron & Peter Walter Nature Reviews Molecular Cell Biology8, 519–529
(July 2007); doi:10.1038/nrm2199
| Summary | Full Text (HTML / PDF) |
review The multifunctional nucleolus
François-Michel Boisvert, Silvana van Koningsbruggen, Joaquín Navascués & Angus I. Lamond Nature Reviews Molecular Cell Biology8, 574–585
(July 2007); doi:10.1038/nrm2184
| Summary | Full Text (HTML / PDF) |
perspective Lessons from 50 years of SOS DNA-damage-induced mutagenesis
Katharina Schlacher & Myron F. Goodman Nature Reviews Molecular Cell Biology8, 587–594
(July 2007); doi:10.1038/nrm2198
| Summary | Full Text (HTML / PDF) |
June
article TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
Ahjoku Amadi-Obi, Cheng-Rong Yu, Xuebin Liu, Rashid M Mahdi, Grace Levy Clarke, Robert B Nussenblatt, Igal Gery, Yun Sang Lee & Charles E Egwuagu Nature Medicine13, 711–718
(June 2007); doi:10.1038/nm1585
| Summary | Full Text (HTML / PDF) |
letter Mast cells promote atherosclerosis by releasing proinflammatory cytokines
Jiusong Sun, Galina K Sukhova, Paul J Wolters, Min Yang, Shiro Kitamoto, Peter Libby, Lindsey A MacFarlane, Jon Mallen-St Clair & Guo-Ping Shi Nature Medicine13, 719–724
(June 2007); doi:10.1038/nm1601
| Summary | Full Text (HTML / PDF) |
article The redox-switch domain of Hsp33 functions as dual stress sensor
Marianne Ilbert, Janina Horst, Sebastian Ahrens, Jeannette Winter, Paul C F Graf, Hauke Lilie & Ursula Jakob Nature Structural & Molecular Biology14, 556–563
(June 2007); doi:10.1038/nsmb1244
| Summary | Full Text (HTML / PDF) |
letter RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
Nicholas Yagoda, Moritz von Rechenberg, Elma Zaganjor, Andras J. Bauer, Wan Seok Yang, Daniel J. Fridman, Adam J. Wolpaw, Inese Smukste, John M. Peltier, J. Jay Boniface, Richard Smith, Stephen L. Lessnick, Sudhir Sahasrabudhe & Brent R. Stockwell Nature447, 865–869
(14 June 2007); doi:10.1038/nature05859
| Summary | Full Text (HTML / PDF) |
article Two neurons mediate diet-restriction-induced longevity in C. elegans
Nicholas A. Bishop & Leonard Guarente Nature447, 545–549
(31 May 2007); doi:10.1038/nature05904
| Summary | Full Text (HTML / PDF) |
article PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans
Siler H. Panowski, Suzanne Wolff, Hugo Aguilaniu, Jenni Durieux & Andrew Dillin Nature447, 550–555
(31 May 2007); doi:10.1038/nature05837
| Summary | Full Text (HTML / PDF) |
article The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors
Hiromitsu Hara, Chitose Ishihara, Arata Takeuchi, Takayuki Imanishi, Liquan Xue, Stephan W Morris, Masanori Inui, Toshiyuki Takai, Akira Shibuya, Shinobu Saijo, Yoichiro Iwakura, Naohito Ohno, Haruhiko Koseki, Hiroki Yoshida, Josef M Penninger & Takashi Saito Nature Immunology8, 619–629
(June 2007); doi:10.1038/ni1466
| Summary | Full Text (HTML / PDF) |
news and views All roads lead to CARD9
Marco Colonna Nature Immunology8, 554–555
(June 2007); doi:10.1038/ni0607-554
| Summary | Full Text (HTML / PDF) |
May
article OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Irina V. Kovtun, Yuan Liu, Magnar Bjoras, Arne Klungland, Samuel H. Wilson & Cynthia T. McMurray Nature447, 447–452
(24 May 2007); doi:10.1038/nature05778
| Summary | Full Text (HTML / PDF) |
letter Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases
G. C. Fox, M. Shafiq, D. C. Briggs, P. P. Knowles, M. Collister, M. J. Didmon, V. Makrantoni, R. J. Dickinson, S. Hanrahan, N. Totty, M. J. R. Stark, S. M. Keyse & N. Q. McDonald Nature447, 487–492
(24 May 2007); doi:10.1038/nature05804
| Summary | Full Text (HTML / PDF) |
article Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2
Suntaek Hong, Seunghwan Lim, Allen G Li, Chan Lee, Youn Sook Lee, Eun-Kyung Lee, Seok Hee Park, Xiao-Jing Wang & Seong-Jin Kim Nature Immunology8, 504–513
(May 2007); doi:10.1038/ni1451
| Summary | Full Text (HTML / PDF) |
news and views Smads keep TABs on inflammation
Rashu B Seth & Zhijian J Chen Nature Immunology8, 477–478
(May 2007); doi:10.1038/ni0507-477
| Summary | Full Text (HTML / PDF) |
article A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses
Annick Mayor, Fabio Martinon, Thibaut De Smedt, Virginie Pétrilli & Jürg Tschopp Nature Immunology8, 497–503
(May 2007); doi:10.1038/ni1459
| Summary | Full Text (HTML / PDF) |
progress Manipulation of host Kruppel-like factor (KLF) function by exotoxins from diverse bacterial pathogens
Eoin O'Grady, Heidi Mulcahy, Claire Adams, John P. Morrissey & Fergal O'Gara Nature Reviews Microbiology5, 337–341
(May 2007); doi:10.1038/nrmicro1641
| Summary | Full Text (HTML / PDF) |
essay Trawling for treasure: tales of T-bet
Laurie H Glimcher Nature Immunology8, 448–450
(May 2007); doi:10.1038/ni0507-448
| Summary | Full Text (HTML / PDF) |
letter Molecular imaging of hydrogen peroxide produced for cell signaling
Evan W Miller, Orapim Tulyathan, Ehud Y Isacoff & Christopher J Chang Nature Chemical Biology3, 263–267
(May 2007); doi:10.1038/nchembio871
| Summary | Full Text (HTML / PDF) |
news and views Measuring H2O2 produced in response to cell surface receptor activation
Sue Goo Rhee Nature Chemical Biology3, 244–246
(May 2007); doi:10.1038/nchembio0507-244
| Summary | Full Text (HTML / PDF) |
April
review Peptidoglycan recognition proteins: pleiotropic sensors and effectors of antimicrobial defences
Julien Royet & Roman Dziarski Nature Reviews Microbiology5, 264–277
(April 2007); doi:10.1038/nrmicro1620
| Summary | Full Text (HTML / PDF) |
article HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
Spencer J. Collis, Louise J. Barber, Allison J. Clark, Julie S. Martin, Jordan D. Ward & Simon J. Boulton Nature Cell Biology9, 391–401
(April 2007); doi:10.1038/ncb1555
| Summary | Full Text (HTML / PDF) |
letter Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada & Shimon Sakaguchi Nature446, 685–689
(5 April 2007); doi:10.1038/nature05673
| Summary | Full Text (HTML / PDF) |
review Whatever turns you on: accessory-cell-dependent activation of NK cells by pathogens
Kirsty C. Newman & Eleanor M. Riley Nature Reviews Immunology7, 279–291
(April 2007); doi:10.1038/nri2057
| Summary | Full Text (HTML / PDF) |
article Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
James Jiayuan Tong, Samuel E Schriner, David McCleary, Brian J Day & Douglas C Wallace Nature Genetics39, 476–485
(April 2007); doi:10.1038/ng2004
| Summary | Full Text (HTML / PDF) |
March
letter p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
Masanori Sano, Tohru Minamino, Haruhiro Toko, Hideyuki Miyauchi, Masayuki Orimo, Yingjie Qin, Hiroshi Akazawa, Kaoru Tateno, Yosuke Kayama, Mutsuo Harada, Ippei Shimizu, Takayuki Asahara, Hirofumi Hamada, Shuhei Tomita, Jeffrey D. Molkentin, Yunzeng Zou and Issei Komuro Nature446, 444–448
(22 March 2007); doi:10.1038/nature05602
| Summary | Full Text (HTML / PDF) |
article Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4
Rudi Vennekens, Jenny Olausson, Marcel Meissner, Wilhelm Bloch, Ilka Mathar, Stephan E Philipp, Frank Schmitz, Petra Weissgerber, Bernd Nilius, Veit Flockerzi & Marc Freichel Nature Immunology8, 312–320
(March 2007); doi:10.1038/ni1441
| Summary | Full Text (HTML / PDF) |
letter Cross-talk and decision making in MAP kinase pathways
Megan N McClean, Areez Mody, James R Broach & Sharad Ramanathan Nature Genetics 39, 409–414
(March 2007); doi:10.1038/ng1957
| Summary | Full Text (HTML / PDF) |
news and views Shaping specificity in signaling networks
Réka Albert & Zoltán N Oltvai Nature Genetics 39, 286–287
(March 2007); doi:10.1038/ng0307-286
| Summary | Full Text (HTML / PDF) |
article The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
Youcun Qian, Caini Liu, Justin Hartupee, Cengiz Zubeyir Altuntas, Muhammet Fatih Gulen, Daniel Jane-wit, Jianhua Xiao, Yi Lu, Natalia Giltiay, Jinbo Liu, Tomasz Kordula, Qi-Wei Zhang, Bruce Vallance, Shadi Swaidani, Mark Aronica, Vincent K Tuohy, Thomas Hamilton & Xiaoxia Li Nature Immunology8, 247–256
(March 2007); doi:10.1038/ni1439
| Summary | Full Text (HTML / PDF) |
news and views Act1-ivating IL-17 inflammation
Christopher A Hunter Nature Immunology8, 232–234
(March 2007); doi:10.1038/ni0307-232
| Summary | Full Text (HTML / PDF) |
February
letter eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
Popi Syntichaki, Kostoula Troulinaki and Nektarios Tavernarakis Nature445, 922–926
(22 February 2007); doi:10.1038/nature05603
| First Paragraph | Full Text (HTML / PDF) |
letter A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction
Michiaki Kubo, Jun Hata, Toshiharu Ninomiya, Koichi Matsuda, Koji Yonemoto, Toshiaki Nakano, Tomonaga Matsushita, Keiko Yamazaki, Yozo Ohnishi, Susumu Saito, Takanari Kitazono, Setsuro Ibayashi, Katsuo Sueishi, Mitsuo Iida, Yusuke Nakamura & Yutaka Kiyohara Nature Genetics39, 212–217
(February 2007); doi:10.1038/ng1945
| Summary | Full Text (HTML / PDF) |
