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Research library: Structures

2002: December | November | October | September | August | July | June | May | April | March | February | January

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letter
Structural characterization of a proline-driven conformational switch within the Itk SH2 domain
Robert J. Mallis, Kristine N. Brazin, D. Bruce Fulton and Amy H. Andreotti
Nature Structural Biology 9, 900–905
(December 2002); doi:10.1038/nsb864
| First Paragraph | Full Text (HTML/PDF) |

article
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
Jay Groppe, Jason Greenwald, Ezra Wiater, Joaquin Rodriguez-Leon, Aris N. Economides, Witek Kwiatkowski, Markus Affolter, Wylie W. Vale, Juan Carlos Izpisua Belmonte and Senyon Choe
Nature 420, 636–642
(12 December 2002); doi:10.1038/nature01245
| Summary | Full Text (HTML / PDF) |

news and views
On the wings of inhibition
Jeffrey L. Wrana
Growth factors regulate cell behaviour, and are kept in check by inhibitors. The structure of a complex of two such proteins shows that they form back-to-back butterflies, with the inhibitor's wings stretching to embrace its partner.
Nature 420, 613–614
(12 December 2002); doi:10.1038/420613a
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letters to nature
Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand
Ivan Bosanac, Jean-René Alattia, Tapas K. Mal, Jenny Chan, Susanna Talarico, Frances K. Tong, Kit I. Tong, Fumio Yoshikawa, Teiichi Furuichi, Miwako Iwai, Takayuki Michikawa, Katsuhiko Mikoshiba and Mitsuhiko Ikura
Nature AOP published online 17 November 2002; doi:10.1038/nature01268
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letter
Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP
Jing Yang, Peter Cron, Valerie M. Good, Vivienne Thompson, Brian A. Hemmings and David Barford
Nature Structural Biology 9, 940–944
(December 2002); doi:10.1038/nsb870
| First Paragraph | Full Text (HTML/PDF) |

original paper
Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases
Akhilesh Pandey, Blagoy Blagoev, Irina Kratchmarova, Minerva Fernandez, Mogens Nielsen, Troels Zakarias Kristiansen, Osamu Ohara, Alexandre V Podtelejnikov, Serge Roche, Harvey F Lodish & Matthias Mann
Oncogene 21, 8029–8036
(14 November 2002); doi:10.1038/sj.onc.1205988
| Abstract |

letters to nature
Structure of a protein determined by solid-state magic-angle-spinning NMR spectroscopy
Federica Castellani, Barth van Rossum, Annette Diehl, Mario Schubert, Kristina Rehbein and Hartmut Oschkinat
Nature 420, 98–102
(07 November 2002); doi:10.1038/nature01070
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article
Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism
Yongchang Chang and David S. Weiss
Nature Neuroscience 5, 1163–1168
(November 2002); doi:10.1038/nn926
| Abstract | Full Text (HTML/PDF) |

news and views
Spotlight on receptor/transducer interaction
John Spudich
Nature Structural Biology 9, 797–799
(November 2002); doi:10.1038/nsb1102-797
| Full Text (HTML/PDF) |

letter
The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization
Genie C. Leung, John W. Hudson, Anna Kozarova, Alan Davidson, James W. Dennis and Frank Sicheri
Nature Structural Biology 9, 719–724
(October 2002); doi:10.1038/nsb848
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letters to nature
Reaction path of protein farnesyltransferase at atomic resolution
Stephen B. Long, Patrick J. Casey and Lorena S. Beese
Nature 419, 645–650
(10 October 2002); doi:10.1038/nature00986
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review article
Structural biology of insulin and IGF1 receptors: implications for drug design
Pierre De Meyts and Jonathan Whittaker
Nature Reviews Drug Discovery 1, 769–783
(October 2002); doi:10.1038/nrd917
| Summary | Full Text (HTML / PDF) |

letter
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor
Thomas G. Davies, Johanne Bentley, Christine E. Arris, F. Thomas Boyle, Nicola J. Curtin, Jane A. Endicott, Ashleigh E. Gibson, Bernard T. Golding, Roger J. Griffin, Ian R. Hardcastle, Philip Jewsbury, Louise N. Johnson, Veronique Mesguiche, David R. Newell, Martin E.M. Noble, Julie A. Tucker, Lan Wang and Hayley J. Whitfield
Nature Structural Biology 9, 745–749
(October 2002); doi:10.1038/nsb842
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letters to nature
Molecular basis of transmembrane signalling by sensory rhodopsin II-transducer complex
Valentin I. Gordeliy, Jörg Labahn, Rouslan Moukhametzianov, Rouslan Efremov, Joachim Granzin, Ramona Schlesinger, Georg Büldt, Tudor Savopol, Axel J. Scheidig, Johann P. Klare and Martin Engelhard
Nature 419, 484–487
(03 October 2002); doi:10.1038/nature01109
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review article
The spindle checkpoint: structural insights into dynamic signalling
Andrea Musacchio and Kevin G. Hardwick
Nature Reviews Molecular Cell Biology 3, 731–741
(October 2002); doi:10.1038/nrm929
| Summary | Full Text (HTML / PDF) |

article
Structure of the Sec23/24-Sar1 pre-budding complex of the COPII vesicle coat
Xiping Bi, Richard A. Corpina and Jonathan Goldberg
Nature 419, 271–277
(19 September 2002); doi:10.1038/nature01040
| Summary | Full Text (HTML / PDF) |

article
Open channel structure of MscL and the gating mechanism of mechanosensitive channels
Eduardo Perozo, D. Marien Cortes, Pornthep Sompornpisut, Anna Kloda and Boris Martinac
Nature 418, 942–948
(29 August 2002); doi:10.1038/nature00992
| Summary | Full Text (HTML / PDF) |

news and views
A P-type ion pump at work
C. Roy D. Lancaster
Nature Structural Biology 9, 643–645
(September 2002); doi:10.1038/nsb0902-643
| Full Text (HTML/PDF) |

letter
Structure and catalytic mechanism of the E. coli chemotaxis phosphatase CheZ
Rui Zhao, Edward J. Collins, Robert B. Bourret and Ruth E. Silversmith
Nature Structural Biology 9, 570–575
(August 2002); doi:10.1038/nsb816
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news and views
Last, but not least
Philip Matsumura
Nature Structural Biology 9, 563–564
(August 2002); doi:10.1038/nsb0802-563
| Full Text (HTML/PDF) |

letters to nature
Mechanism of magnesium activation of calcium-activated potassium channels
Jingyi Shi, Gayathri Krishnamoorthy, Yanwu Yang, Lei Hu, Neha Chaturvedi, Dina Harilal, Jun Qin and Jianmin Cui
Nature 418, 876–880
(22 August 2002); doi:10.1038/nature00941
| First Paragraph | Full Text (HTML / PDF) |

article
Disulfide exchange in domain 2 of CD4 is required for entry of HIV-1
Lisa J. Matthias, Patricia T.W. Yam, Xing-Mai Jiang, Nick Vandegraaff, Peng Li, Pantelis Poumbourios, Neil Donoghue and Philip J. Hogg
Nature Immunology 3, 727–732
(August 2002); doi:10.1038/ni815
| Abstract | Full Text (HTML/PDF) |

news and views
HIV entry: are all receptors created equal?
Mark A. Goldsmith and Robert W. Doms
Nature Immunology 3, 709–710
(August 2002); doi:10.1038/ni819
| Full Text (HTML/PDF) |

article
Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains
Stephan D. Gadola, Nathan R. Zaccai, Karl Harlos, Dawn Shepherd, Julio C. Castro-Palomino, Gerd Ritter, Richard R. Schmidt, E. Yvonne Jones and Vincenzo Cerundolo
Nature Immunology 3, 721–726
(August 2002); doi:10.1038/ni821
| Abstract | Full Text (HTML/PDF) |

news and views
The CD1b structure: antigen presentation adapts to a high-fat diet
Kayvan R. Niazi, Steven A. Porcelli and Robert L. Modlin
Nature Immunology 3, 703–704
(August 2002); doi:10.1038/ni0802-703
| Full Text (HTML/PDF) |

article
Structural changes in the calcium pump accompanying the dissociation of calcium
Chikashi Toyoshima and Hiromi Nomura
Nature 418, 605–611
(8 August 2002); doi:10.1038/nature00944
| Summary | Full Text (HTML / PDF) |

news and views
Structural biology: Calcium callisthenics
N. Michael Green and David H. MacLennan The Ca2+-ATPase is one of the best characterized of the pumps that move ions across cell membranes. The latest snapshot of the pump in another of its many conformations is a major step in understanding its dynamics.
Nature 418, 598–599
(8 August 2002); doi:10.1038/418598b
| Full Text (HTML / PDF) |

News and Views
MAPping p38 binding interactions
Elizabeth H. Cox
Nature Structural Biology 9, 569
(August 2002); doi:10.1038/nsb0802-569
| Full Text (HTML/PDF) |

letter
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair
Karl-Peter Hopfner, Lisa Craig, Gabriel Moncalian, Robert A. Zinkel, Takehiko Usui, Barbara A. L. Owen, Annette Karcher, Brendan Henderson, Jean-Luc Bodmer, Cynthia T. McMurray, James P. Carney, John H. J. Petrini and John A. Tainer
Nature 418, 562–566
(1 August 2002); doi:10.1038/nature00922
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letters to nature
Distinct molecular mechanism for initiating TRAF6 signalling
Hong Ye, Joseph R. Arron, Betty Lamothe, Maurizio Cirilli, Takashi Kobayashi, Nirupama K. Shevde, Deena Segal, Oki K. Dzivenu, Masha Vologodskaia, Mijung Yim, Khoi Du, Sujay Singh, J. Wesley Pike, Bryant G. Darnay, Yongwon Choi and Hao Wu
Nature 418, 443–447
(25 July 2002); doi:10.1038/nature00888
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letter
Structural basis for the accessory protein recruitment by the γ-adaptin ear domain
Terukazu Nogi, Yoko Shiba, Masato Kawasaki, Tomoo Shiba, Naohiro Matsugaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Hiroyuki Takatsu, Kazuhisa Nakayama and Soichi Wakatsuki
Nature Structural Biology 9, 527–531
(July 2002); doi:10.1038/nsb808
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letter
Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism
Yukio Kato, Saurav Misra, Rosa Puertollano, James H. Hurley and Juan S. Bonifacino
Nature Structural Biology 9, 532–536
(July 2002); doi:10.1038/nsb807
| First Paragraph | Full Text (HTML/PDF) |

letter to nature
NMR analysis of a 900K GroEL-GroES complex
Jocelyne Fiaux, Eric B. Bertelsen, Arthur L. Horwich and Kurt Wüthrich
Nature 418, 207–211
(11 July 2002); doi:10.1038/nature00860
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insight: review article
The involvement of RNA in ribosome function
Peter B. Moore and Thomas A. Steitz
Nature 418, 229–235
(11 July 2002); doi:10.1038/418229a
| Summary | Full Text (HTML/PDF) |

review article
Roles of heparan-sulphate glycosaminoglycans in cancer
Ram Sasisekharan, Zachary Shriver, Ganesh Venkataraman and Uma Narayanasami
Nature Reviews Cancer 2, 521–528
(July 2002); doi:10.1038/nrc842
| Abstract | Full Text (HTML/PDF) |

letter
Structure of human phosphatidylcholine transfer protein in complex with its ligand
Steven L. Roderick, Wayne W. Chan, Diana S. Agate, Laurence R. Olsen, Matt W. Vetting, K.R. Rajashankar and David E. Cohen
Nature Structural Biology 9, 507–511
(July 2002); doi:10.1038/nsb812
| First Paragraph | Full Text (HTML/PDF) |

letter
Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA
Rong-guang Zhang, Terina Pappas, Jennifer L. Brace, Paula C. Miller, Tim Oulmassov, John M. Molyneaux, John C. Anderson, James K. Bashkin, Stephen C. Winans and Andrzej Joachimiak
Nature 417, 971–974
(27 June 2002); doi:10.1038/nature00833
| First Paragraph | Full Text (HTML/PDF) |

letter
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
Wai-Ching Hon, Michael I. Wilson, Karl Harlos, Timothy D. W. Claridge, Christopher J. Schofield, Christopher W. Pugh, Patrick H. Maxwell, Peter J. Ratcliffe, David I. Stuart and E. Yvonne Jones
Nature 417, 975–978
(27 June 2002); doi:10.1038/nature00767
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article
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors
Jason T. Snyder, David K. Worthylake, Kent L. Rossman, Laurie Betts, Wendy M. Pruitt, David P. Siderovski, Channing J. Der and John Sondek
Nature Structural Biology 9, 468–475
(June 2002); doi:10.1038/nsb796
| Abstract | Full Text (HTML/PDF) |

letter
The crystal structure of the mouse apoptosis-inducing factor AIF
María J. Maté, Miguel Ortiz-Lombardía, Brigitte Boitel, Ahmed Haouz, Diana Tello, Santos A. Susin, Josef Penninger, Guido Kroemer and Pedro M. Alzari
Nature Structural Biology 9, 442–446
(June 2002); doi:10.1038/nsb793
| First Paragraph | Full Text (HTML/PDF) |

letter
Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi
Wenyu Li, Srinivasa M. Srinivasula, Jijie Chai, Pingwei Li, Jia-Wei Wu, ZhiJia Zhang, Emad S. Alnemri & Yigong Shi
Nature Structural Biology 9, 436–441
(June 2002); doi:10.1038/nsb795
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news and views
Love it or cleave it: Tough choices in protein quality control
Michael R. Maurizi
Nature Structural Biology 9, 410–412
(June 2002); doi:10.1038/nsb0602-410
| Full Text (HTML/PDF) |

review article
Structural mechanisms of costimulation
Jean-Claude D. Schwartz, Xuewu Zhang, Stanley G. Nathenson and Steven C. Almo
Nature Immunology 3, 427–434
(May 2002); doi:10.1038/ni0502-427
| Abstract | Full Text (HTML/PDF) |

article
The open pore conformation of potassium channels
Youxing Jiang, Alice Lee, Jiayun Chen, Martine Cadene, Brian T. Chait and Roderick MacKinnon
Nature 417, 523–526
(May 2002); doi:10.1038/417523a
| Summary | Full Text (HTML/PDF) |

news and views
Ion channels: An open and shut case
Maria Schumacher and John P. Adelman
Nature 417, 501–502
(May 2002); doi:10.1038/417501a
| Full Text (HTML/PDF) |

article
Mechanism of glutamate receptor desensitization
Yu Sun, Rich Olson, Michelle Horning, Neali Armstrong, Mark Mayer and Eric Gouaux
Nature 417, 245–253
(May 2002); doi:10.1038/417245a
| Summary | Full Text (HTML/PDF) |

news and views
Ion channels: How to be desensitized
Christian Rosenmund and Michael Mansour
Nature 417, 238–239
(May 2002); doi:10.1038/417238a
| Full Text (HTML/PDF) |

news and views
Locked but not loaded
Elizabeth H. Cox
Nature Structural Biology 9, 325
(May 2002); doi:10.1038/nsb0502-325
| Full Text (HTML/PDF) |

letter
Structural determinants for GoLoco-induced inhibition of nucleotide release by Ga subunits
Randall J. Kimple, Michelle E. Kimple, Laurie Betts, John Sondek and David P. Siderovski
Nature 416, 878-881
(25 April 2002); doi:10.1038/416878a
| Abstract | Full Text (HTML/PDF) |

news and views
How calpain is activated by calcium
Ahmad Khorchid and Mitsuhiko Ikura
Nature Structural Biology 9, 239–241
(April 2002); doi:10.1038/nsb0402-239
| Full Text (HTML/PDF) |

letter
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
Christopher Pargellis, Liang Tong, Laurie Churchill, Pier F. Cirillo, Thomas Gilmore, Anne G. Graham, Peter M. Grob, Eugene R. Hickey, Neil Moss, Susan Pav and John Regan
Nature Structural Biology 9, 268–272
(April 2002); doi:10.1038/nsb770
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letter
Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase
Madhusudan, Pearl Akamine, Nguyen-Huu Xuong and Susan S. Taylor
Nature Structural Biology 9, 273–277
(April 2002); doi:10.1038/nsb780
| First Paragraph | Full Text (HTML/PDF) |

letter
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
Natalia Beglova, Stephen C. Blacklow, Junichi Takagi and Timothy A. Springer
Nature Structural Biology 9, 282–287
(April 2002); doi:10.1038/nsb779
| First Paragraph | Full Text (HTML/PDF) |

letter
Structural basis of BLyS receptor recognition
Deena A. Oren, Yuling Li, Yulia Volovik, Tina S. Morris, Chhaya Dharia, Kalyan Das, Olga Galperina, Reiner Gentz and Eddy Arnold
Nature Structural Biology 9, 288–292
(April 2002); doi:10.1038/nsb769
| Abstract | Full Text (HTML/PDF) |

article
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex
Ning Zheng, Brenda A. Schulman, Langzhou Song, Julie J. Miller, Philip D. Jeffrey, Ping Wang, Claire Chu, Deanna M. Koepp, Stephen J. Elledge, Michele Pagano, Ronald C. Conaway, Joan W. Conaway, J. Wade Harper and Nikola P. Pavletich
Nature 416, 703–709
(April 2002); doi:10.1038/416703a
| Summary | Full Text (HTML/PDF) |

letters to nature
Structural determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits
Randall J. Kimple, Michelle E. Kimple, Laurie Betts, John Sondek and David P. Siderovski
Nature 416, 878–881
(April 2002); doi:10.1038/416878a
| First Paragraph | Full Text (HTML/PDF) |

review article
PHOSPHOTYROSINE-BINDING DOMAINS IN SIGNAL TRANSDUCTION
Michael B. Yaffe
Nature Reviews Molecular Cell Biology 3, 177–186
(March 2002); doi:10.1038/nrm759
| Abstract | Full Text (HTML/PDF) |

letter
Structural basis for CDK6 activation by a virus-encoded cyclin
Ursula Schulze-Gahmen and Sung-Hou Kim
Nature Structural Biology 9, 177–181
(March 2002); doi:10.1038/nsb756
| First Paragraph | Full Text (HTML/PDF) |

letter
Crystal structure of the human TβR2 ectodomain-TGF-β3 complex
P. John Hart, Shashank Deep, Alexander B. Taylor, Zhanyong Shu, Cynthia S. Hinck and Andrew P. Hinck
Nature Structural Biology 9, 203–208
(March 2002); doi:10.1038/nsb766
| First Paragraph | Full Text (HTML/PDF) |

review article
ION CHANNEL STRUCTURE: THE STRUCTURE AND FUNCTION OF GLUTAMATE RECEPTOR ION CHANNELS
Dean R. Madden
Nature Reviews Neuroscience 3, 91–101
(February 2002); doi:10.1038/nrn725
| Abstract | Full Text (HTML/PDF) |

review article
ION CHANNEL STRUCTURE: EMERGING STRUCTURE OF THE NICOTINIC ACETYLCHOLINE RECEPTORS
Arthur Karlin
Nature Reviews Neuroscience 3, 102–114
(February 2002); doi:10.1038/nrn731
| Abstract | Full Text (HTML/PDF) |

review article
ION CHANNEL STRUCTURE: POTASSIUM CHANNEL STRUCTURES
Senyon Choe
Nature Reviews Neuroscience 3, 115–121
(February 2002); doi:10.1038/nrn727
| Abstract | Full Text (HTML/PDF) |

news and views
A GTPase gate for protein import into chloroplasts
Felix Kessler and Danny J. Schnell
Nature Structural Biology 9, 81–83
(February 2002); doi:10.1038/nsb0202-81
| Full Text (HTML/PDF) |

letter
Crystal structure of pea Toc34, a novel GTPase of the chloroplast protein translocon
Yuh-Ju Sun, Farhad Forouhar, Hsou-min Li, Shuh-Long Tu, Yi-Hong Yeh, Sen Kao, Hui-Lin Shr, Chia-Cheng Chou, Chinpan Chen and Chwan-Deng Hsiao
Nature Structural Biology 9, 95–100
(February 2002); doi:10.1038/nsb744
| First Paragraph | Full Text (HTML/PDF) |

letters to nature
RanGAP mediates GTP hydrolysis without an arginine finger
Michael J. Seewald, Carolin Körner, Alfred Wittinghofer and Ingrid R. Vetter
Nature 415, 662–666
(February 2002); doi:10.1038/415662a
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letters to nature
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
H. Eric Xu, Thomas B. Stanley, Valerie G. Montana, Millard H. Lambert, Barry G. Shearer, Jeffery E. Cobb, David D. McKee, Cristin M. Galardi, Kelli D. Plunket, Robert T. Nolte, Derek J. Parks, John T. Moore, Steven A. Kliewer, Timothy M. Willson and Julie B. Stimmel
Nature 415, 813–817
(February 2002); doi:10.1038/415813a
| First Paragraph | Full Text (HTML/PDF) |

letters to nature
Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains
Saurav Misra, Rosa Puertollano, Yukio Kato, Juan S. Bonifacino and James H. Hurley
Nature 415, 933–937
(February 2002); doi:10.1038/415933a
| First Paragraph | Full Text (HTML/PDF) |

letters to nature
Structural basis for recognition of acidic-cluster dileucine sequence by GGA1
Tomoo Shiba, Hiroyuki Takatsu, Terukazu Nogi, Naohiro Matsugaki, Masato Kawasaki, Noriyuki Igarashi, Mamoru Suzuki, Ryuichi Kato, Thomas Earnest, Kazuhisa Nakayama and Soichi Wakatsuki
Nature 415, 937–941
(February 2002); doi:10.1038/415937a
| First Paragraph | Full Text (HTML/PDF) |

letter
The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin
Ikuko Hayashi, Kristiina Vuori and Robert C. Liddington
Nature Structural Biology 9, 101–106
(February 2002); doi:10.1038/nsb755
| First Paragraph | Full Text (HTML/PDF) |

letter
Loss of a metal-binding site in gelsolin leads to familial amyloidosis-Finnish type
Steven L. Kazmirski, Rivka L. Isaacson, Chahm An, Ashley Buckle, Christopher M. Johnson, Valerie Daggett and Alan R. Fersht
Nature Structural Biology 9, 112–116
(February 2002); doi:10.1038/nsb745
| First Paragraph | Full Text (HTML/PDF) |

letter
Structure of the Bcr-Abl oncoprotein oligomerization domain
Xun Zhao, Saghi Ghaffari, Harvey Lodish, Vladimir N. Malashkevich and Peter S. Kim
Nature Structural Biology 9, 117–120
(February 2002); doi:10.1038/nsb747
| First Paragraph | Full Text (HTML/PDF) |

article
SNARE assembly and disassembly exhibit a pronounced hysteresis
Dirk Fasshauer, Wolfram Antonin, Vinod Subramaniam and Reinhard Jahn
Nature Structural Biology 9, 144–151
(February 2002); doi:10.1038/nsb750
| Abstract | Full Text (HTML/PDF) |

article
Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin
Chester L. Drum, Shui-Zhong Yan, Joel Bard, Yue-Quan Shen, Dan Lu, Sandriyana Soelaiman, Zenon Grabarek, Andrew Bohm and Wei-Jen Tang
Nature 415, 396–402
(January 2002); doi:10.1038/415396a
| Summary | Full Text (HTML/PDF) |

news and views
Anthrax: A molecular full nelson
Robert C. Liddington,
Nature 415, 373–374
(January 2002); doi:10.1038/415373a
| Full Text (HTML/PDF) |

news and views
Degrading liaisons: Siah structure revealed
John C. Reed and Kathryn R. Ely
Nature Structural Biology 9, 8–10
(January 2002); doi:10.1038/nsb0102-8
| Full Text (HTML/PDF) |

article
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-α signaling
Michael W. Parker and David D. L. Bowtell
Nature Structural Biology 9, 68–75
(January 2002); doi:10.1038/nsb743
| Abstract | Full Text (HTML/PDF) |

letter
A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq
Alex U. Singer, Gary L. Waldo, T. Kendall Harden and John Sondek
Nature Structural Biology 9, 32–36
(January 2002); doi:10.1038/nsb731
| First Paragraph | Full Text (HTML/PDF) |

news and views
Bacterial behaviour: Function by serendipity
Dagmar Ringe
Nature 415, 488–489
(January 2002); doi:10.1038/415488b
| Full Text (HTML/PDF) |

news and views
Bacterial Esperanto
Stephen C. Winans
Nature Structural Biology 9, 83–84
(February 2002); doi:10.1038/nsb0202-83
| Full Text (HTML/PDF) |

letters to nature
Structural identification of a bacterial quorum-sensing signal containing boron
Xin Chen, Stephan Schauder, Noelle Potier, Alain Van Dorsselaer, István Pelczer, Bonnie L. Bassler and Frederick M. Hughson
Nature 415, 545–549
(January 2002); doi:10.1038/415545a
| First Paragraph | Full Text (HTML/PDF) |

article
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
Raimund Dutzler, Ernest B. Campbell, Martine Cadene, Brian T. Chait and Roderick MacKinnon
Nature 415, 287–294
(January 2002); doi:10.1038/415287a
| Summary | Full Text (HTML/PDF) |

news and views
Cell biology: Chloride channels are different
Thomas J. Jentsch
Nature 415, 276–277
(January 2002); doi:10.1038/415276a
| Full Text (HTML/PDF) |

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