Research library: Structures

2004: December | November | October | September | August | July | June | May | April | March | February | January

Other Years: 2002 |2003 | 2005 | 2006 | 2007 | 2008

December

news and views
Progressing actin: Formin as a processive elongation machine
David R. Kovar and Thomas D. Pollard
Nature Cell Biology 6, 1158–1159
(December 2004); doi:10.1038/ncb1204-1158
| Full Text (HTML/PDF) |

review article
The complex architecture of oxygenic photosynthesis
Nathan Nelson and Adam Ben-Shem
Nature Reviews Molecular Cell Biology 5, 971–982
(December 2004); doi:10.1038/nrm1525
| Abstract | Full Text (HTML / PDF) |

research article
Baculovirus expression system for heterologous multiprotein complexes
Imre Berger, Daniel J Fitzgerald and Timothy J Richmond
Nature Biotechnology 22, 1583–1587
(December 2004); doi:10.1038/nbt1036
| First Paragraph | Full Text (HTML/PDF) |

news and views
Baculovirus solves a complex problem
Polly Roy
Nature Biotechnology 22, 1527–1528
(December 2004); doi:10.1038/nbt1204-1527
| Full Text (HTML/PDF) |

article
Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs
Peter J Mikulecky, Meenakshi K Kaw, Cristin C Brescia, Jennifer C Takach, Darren D Sledjeski and Andrew L Feig
Nature Structural and Molecular Biology 11, 1206–1214
(December 2004); doi:10.1038/nsmb858
| Abstract | Full Text (HTML/PDF) |

news and views
Rec-ing DNA
Michelle Montoya
Nature Structural and Molecular Biology 11, 1162
(December 2004); doi:10.1038/nsmb1204-1162
| Full Text (HTML/PDF) |

article
Three-chromophore FRET microscopy to analyze multiprotein interactions in living cells
Emilia Galperin, Vladislav V Verkhusha and Alexander Sorkin
Nature Methods 1, 209–217
(December 2004); doi:10.1038/nmeth720
| Abstract | Full Text (HTML/PDF) |

article
Structural basis for the assembly of a nuclear export complex
Yoshiyuki Matsuura and Murray Stewart
Nature 432, 872–877
(16 December 2004); doi:10.1038/nature03144
| Abstract | Full Text (HTML / PDF) |

news and views
Cell biology: Popping out of the nucleus
André Hoelz and Günter Blobel
Nature 432, 815–816
(16 December 2004); doi:10.1038/432815a
| Full Text (HTML / PDF) |

news and views
A new harvest of fluorescent proteins
George H Patterson
Nature Biotechnology 22, 1524–1525
(December 2004); doi:10.1038/nbt1204-1524
| Full Text (HTML/PDF) |

article
TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells
David P. Corey , Jaime García-Añoveros, Jeffrey R. Holt, Kelvin Y. Kwan , Shuh-Yow Lin , Melissa A. Vollrath , Andrea Amalfitano, Eunice L.-M. Cheung, Bruce H. Derfler, Anne Duggan, Gwénaëlle S. G. Géléoc, Paul A. Gray, Matthew P. Hoffman, Heidi L. Rehm, Daniel Tamasauskas and Duan-Sun Zhang
Nature 432, 723–730
(09 December 2004); doi:10.1038/nature03066
| Abstract | Full Text (HTML / PDF) |

news and views
Hearing: Channel at the hair's end
Jonathan Ashmore
Nature 432, 685–686
(09 December 2004); doi:10.1038/432685a
| Full Text (HTML / PDF) |

article
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
Jeffrey F Ohren, Huifen Chen, Alexander Pavlovsky, Christopher Whitehead, Erli Zhang, Peter Kuffa, Chunhong Yan, Patrick McConnell, Cindy Spessard, Craig Banotai, W Thomas Mueller, Amy Delaney, Charles Omer, Judith Sebolt-Leopold, David T Dudley, Iris K Leung, Cathlin Flamme, Joseph Warmus, Michael Kaufman, Stephen Barrett, Haile Tecle and Charles A Hasemann
Nature Structural and Molecular Biology 11, 1192–1197
(December 2004); doi:10.1038/nsmb859
| Abstract | Full Text (HTML/PDF) |

letters to nature
Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating
Alexander Fotin, Yifan Cheng, Nikolaus Grigorieff, Thomas Walz, Stephen C. Harrison and Tomas Kirchhausen
Nature 432, 649–653
(02 December 2004); doi:10.1038/nature03078
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cell biology: Clathrin's Achilles' ankle
Frances M. Brodsky
Nature 432, 568–569
(02 December 2004); doi:10.1038/432568a
| Full Text (HTML / PDF) |

review article
The role of the unfolded protein response in tumour development: friend or foe?
Yanjun Ma and Linda M. Hendershot
Nature Reviews Cancer 4, 966–977
(December 2004); doi:10.1038/nrc1505
| Summary | Full Text (HTML / PDF) |

technical review
Light-activated ion channels for remote control of neuronal firing
Matthew Banghart, Katharine Borges, Ehud Isacoff, Dirk Trauner and Richard H Kramer
Nature Neuroscience 7, 1381–1386
(December 2004); doi:10.1038/nn1356
| Abstract | Full Text (HTML/PDF) |

news and views
A molecular light switch turns off neural activity
Cara Allen
Nature Neuroscience 7, 1291
(December 2004); doi:10.1038/nn1204-1291
| Full Text (HTML/PDF) |

review article
Making protein interactions druggable: targeting PDZ domains
Kumlesh K. Dev
Nature Reviews Drug Discovery 3, 1047–1056
(December 2004); doi:10.1038/nrd1578
| Summary | Full Text (HTML / PDF) |

article
Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin
Kara S Giddings, Ji Zhao, Peter J Sims and Rodney K Tweten
Nature Structural and Molecular Biology 11, 1173–1178
(December 2004); doi:10.1038/nsmb862
| Abstract | Full Text (HTML/PDF) |

article
Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Ming Lei, Elaine R Podell and Thomas R Cech
Nature Structural and Molecular Biology 11, 1223–1229
(December 2004); doi:10.1038/nsmb867
| Abstract | Full Text (HTML/PDF) |

news and views
A bacterial big-MAC attack
Ioan Iacovache and F Gisou van der Goot
Nature Structural and Molecular Biology 11, 1163–1164
(December 2004); doi:10.1038/nsmb1204-1163
| Full Text (HTML/PDF) |

November

review article
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
Dennis J. Selkoe
Nature Cell Biology 6, 1054–1061
(November 2004); doi:10.1038/ncb1104-1054
| Abstract | Full Text (HTML/PDF) |

letters to nature
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Yentram Huyen, Omar Zgheib, Richard A. DiTullio Jr, Vassilis G. Gorgoulis, Panayotis Zacharatos, Tom J. Petty, Emily A. Sheston, Hestia S. Mellert, Elena S. Stavridi and Thanos D. Halazonetis
Nature 432, 406–411
(18 November 2004); doi:10.1038/nature03114
| First Paragraph | Full Text (HTML / PDF) |

news and views
Structural biology: Ion pump in the movies
C. Roy D. Lancaster
Nature 432, 286–287
(18 November 2004); doi:10.1038/432286a
| Full Text (HTML / PDF) |

article
Structural basis for the control of translation initiation during stress
Antòn Vila-Sanjurjo, Barbara-S Schuwirth, Cathy W Hau and Jamie H D Cate
Nature Structural and Molecular Biology 11, 1054–1059
(November 2004); doi:10.1038/nsmb850
| Abstract | Full Text (HTML/PDF) |

news and views
The how and Y of cold shock
Daniel N Wilson and Knud H Nierhaus
Nature Structural and Molecular Biology 11, 1026–1028
(November 2004); doi:10.1038/nsmb1104-1026
| Full Text (HTML/PDF) |

article
Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex
Rhiannon R Penkert, Heather M DiVittorio and Kenneth E Prehoda
Nature Structural and Molecular Biology 11, 1122–1127
(November 2004); doi:10.1038/nsmb839
| Abstract | Full Text (HTML/PDF) |

article
Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks
Martin R. Singleton, Mark S. Dillingham, Martin Gaudier, Stephen C. Kowalczykowski and Dale B. Wigley
Nature 432, 187–193
(11 November 2004); doi:10.1038/nature02988
| Abstract | Full Text (HTML / PDF) |

news and views
DNA repair: Big engine finds small breaks
Anna Marie Pyle
Nature 432, 157–158
(11 November 2004); doi:10.1038/432157a
| Full Text (HTML / PDF) |

letters to nature
Processing of primary microRNAs by the Microprocessor complex
Ahmet M. Denli, Bastiaan B. J. Tops, Ronald H. A. Plasterk, René F. Ketting and Gregory J. Hannon
Nature 432, 231–235
(11 November 2004); doi:10.1038/nature03049
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
The Microprocessor complex mediates the genesis of microRNAs
Richard I. Gregory, Kai-ping Yan, Govindasamy Amuthan, Thimmaiah Chendrimada, Behzad Doratotaj, Neil Cooch and Ramin Shiekhattar
Nature 432, 235–240
(11 November 2004); doi:10.1038/nature03120
| First Paragraph | Full Text (HTML / PDF) |

review article
Recombinant protein folding and misfolding in Escherichia coli
François Baneyx and Mirna Mujacic
Nature Biotechnology 22, 1399–1408
(November 2004); doi:10.1038/nbt1029
| Abstract | Full Text (HTML/PDF) |

article
Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin
Beth A Sullivan and Gary H Karpen
Nature Structural and Molecular Biology 11, 1076–1083
(November 2004); doi:10.1038/nsmb845
| Abstract | Full Text (HTML/PDF) |

article
Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane
Patrick D'Silva, Qinglian Liu, William Walter and Elizabeth A Craig
Nature Structural and Molecular Biology 11, 1084–1091
(November 2004); doi:10.1038/nsmb846
| Abstract | Full Text (HTML/PDF) |

news and views
Another piece in the transcription initiation puzzle
Francisco J Asturias
Nature Structural and Molecular Biology 11, 1031–1033
(November 2004); doi:10.1038/nsmb1104-1031
| Full Text (HTML/PDF) |

article
Cell-free protein production and labeling protocol for NMR-based structural proteomics
Dmitriy A Vinarov, Betsy L Lytle, Francis C Peterson, Ejan M Tyler, Brian F Volkman and John L Markley
Nature Methods 1, 149–153
(November 2004); doi:10.1038/nmeth716
| Abstract | Full Text (HTML/PDF) |

article
Regulation of Bin1 SH3 domain binding by phosphoinositides
Chie Kojima, Ari Hashimoto, Izumi Yabuta, Mayumi Hirose, Shigeru Hashimoto, Yasunori Kanaho, Hideki Sumimoto, Takahisa Ikegami and Hisataka Sabe
The EMBO Journal 23, 4413–4422
(November 2004); doi:10.1038/sj.emboj.7600442
| Abstract | Full Text (HTML/PDF) |

article
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics
Tsan Xiao, Junichi Takagi, Barry S. Coller, Jia-Huai Wang and Timothy A. Springer
Nature 432, 59–67
(04 November 2004); doi:10.1038/nature02976
| Abstract | Full Text (HTML / PDF) |

news and views
Cell biology: Adhesion articulated
A. Paul Mould and Martin J. Humphries
Nature 432, 27–28
(04 November 2004); doi:10.1038/432027a
| Full Text (HTML / PDF) |

article
Insights into assembly from structural analysis of bacteriophage PRD1
Nicola G. A. Abrescia, Joseph J. B. Cockburn , Jonathan M. Grimes, Geoffrey C. Sutton, Jonathan M. Diprose, Sarah J. Butcher, Stephen D. Fuller, Carmen San Martín, Roger M. Burnett, David I. Stuart, Dennis H. Bamford and Jaana K. H. Bamford
Nature 432, 68–74
(04 November 2004); doi:10.1038/nature03056
| Abstract | Full Text (HTML / PDF) |

letters to nature
A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay
Nadia Amrani, Robin Ganesan, Stephanie Kervestin, David A. Mangus, Shubhendu Ghosh and Allan Jacobson
Nature 432, 112–118
(04 November 2004); doi:10.1038/nature03060
| First Paragraph | Full Text (HTML / PDF) |

review article
The LIM domain: from the cytoskeleton to the nucleus
Julie L. Kadrmas and Mary C. Beckerle
Nature Reviews Molecular Cell Biology 5, 920–931
(November 2004); doi:10.1038/nrm1499
| Abstract | Full Text (HTML / PDF) |

news and views
Opening the GAP
Michelle Montoya
Nature Structural and Molecular Biology 11, 1033
(November 2004); doi:10.1038/nsmb1104-1033
| Full Text (HTML/PDF) |

article
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC
Shao-En Ong, Gerhard Mittler and Matthias Mann
Nature Methods 1, 119–126
(November 2004); doi:10.1038/nmeth715
| Abstract | Full Text (HTML/PDF) |

October

article
Structure of the bacterial flagellar hook and implication for the molecular universal joint mechanism
Fadel A. Samatey , Hideyuki Matsunami , Katsumi Imada , Shigehiro Nagashima, Tanvir R. Shaikh, Dennis R. Thomas, James Z. Chen, David J. DeRosier, Akio Kitao and Keiichi Namba
Nature 431, 1062–1068
(28 October 2004); doi:10.1038/nature02997
| Abstract | Full Text (HTML / PDF) |

news and views
Molecular motors: Smooth coupling in Salmonella
Christopher Surridge
Nature 431, 1047
(28 October 2004); doi:10.1038/4311047b
| Full Text (HTML / PDF) |

brief communication
Nonsteroidal anti-inflammatory drugs lower Aβ₄₂ and change presenilin 1 conformation
Alberto Lleó, Oksana Berezovska, Lauren Herl, Susan Raju, Amy Deng, Brian J Bacskai, Matthew P Frosch, Michael Irizarry and Bradley T Hyman
Nature Medicine 10, 1065–1066
(October 2004); doi:10.1038/nm1112
| First Paragraph | Full Text (HTML/PDF) |

brief communication
Regulatory evolution across the protein interaction network
Bernardo Lemos, Colin D Meiklejohn and Daniel L Hartl
Nature Genetics 36, 1059–1060
(October 2004); doi:10.1038/ng1427
| First Paragraph | Full Text (HTML/PDF) |

review article
PDZ domain proteins of synapses
Eunjoon Kim and Morgan Sheng
Nature Reviews Neuroscience 5, 771–781
(October 2004); doi:10.1038/nrn1517
| Abstract | Full Text (HTML / PDF) |

letter
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins
Ana-Maria Fernandez-Escamilla, Frederic Rousseau, Joost Schymkowitz and Luis Serrano
Nature Biotechnology 22, 1302–1306
(October 2004); doi:10.1038/nbt1012
| First Paragraph | Full Text (HTML/PDF) |

news and views
A universal TANGO?
Vijay S Pande
Nature Biotechnology 22, 1240–1241
(October 2004); doi:10.1038/nbt1004-1240
| Full Text (HTML/PDF) |

review article
Glycomics: a pathway to a class of new and improved therapeutics
Zachary Shriver, S. Raguram and Ram Sasisekharan
Nature Reviews Drug Discovery 3, 863–873
(October 2004); doi:10.1038/nrd1521
| Abstract | Full Text (HTML / PDF) |

article
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
Magnus Wolf-Watz, Vu Thai, Katherine Henzler-Wildman, Georgia Hadjipavlou, Elan Z Eisenmesser and Dorothee Kern
Nature Structural and Molecular Biology 11, 945–949
(October 2004); doi:10.1038/nsmb821
| Abstract | Full Text (HTML/PDF) |

news and views
Out of hot water
Mikael Akke
Nature Structural and Molecular Biology 11, 912–913
(October 2004); doi:10.1038/nsmb1004-912
| Full Text (HTML/PDF) |

article
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
Danny T Huang, David W Miller, Rose Mathew, Robert Cassell, James M Holton, Martine F Roussel and Brenda A Schulman
Nature Structural and Molecular Biology 11, 927–935
(October 2004); doi:10.1038/nsmb826
| Abstract | Full Text (HTML/PDF) |

news and views
Grabbing E2 by the tail
Andrew P VanDemark and Christopher P Hill
Nature Structural and Molecular Biology 11, 908–909
(October 2004); doi:10.1038/nsmb1004-908
| Full Text (HTML/PDF) |

brief communication
A rapid method for determining protein kinase phosphorylation specificity
Jessica E Hutti, Emily T Jarrell, James D Chang, Derek W Abbott, Peter Storz, Alex Toker, Lewis C Cantley and Benjamin E Turk
Nature Methods 1, 27–29
(October 2004); doi:10.1038/nmeth708
| Abstract | Full Text (HTML/PDF) |

news and views
Novel at the library
Michael B Yaffe
Nature Methods 1, 13–14
(October 2004); doi:10.1038/nmeth1004-13
| Full Text (HTML/PDF) |

article
Structure of a glutamate transporter homologue from Pyrococcus horikoshii
Dinesh Yernool, Olga Boudker, Yan Jin and Eric Gouaux
Nature 431, 811–818
(14 October 2004); doi:10.1038/nature03018
| Abstract | Full Text (HTML / PDF) |

news and views
Accessing a transporter structure
Michael P. Kavanaugh
Nature 431, 752–753
(14 October 2004); doi:10.1038/431752a
| Full Text (HTML / PDF) |

research article
The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination
Jianming Xie, Lei Wang, Ning Wu, Ansgar Brock, Glen Spraggon and Peter G Schultz
Nature Biotechnology 22, 1297–1301
(October 2004); doi:10.1038/nbt1013
| First Paragraph | Full Text (HTML/PDF) |

news and views
Phasing in iodine for structure determination
Zbigniew Dauter
Nature Biotechnology 22, 1239–1240
(October 2004); doi:10.1038/nbt1004-1239
| Full Text (HTML/PDF) |

article
A phenylalanine zipper mediates APS dimerization
Sirano Dhe-Paganon, Eric D Werner, Masahiro Nishi, Lone Hansen, Young-In Chi and Steven E Shoelson
Nature Structural and Molecular Biology 11, 968–974
(October 2004); doi:10.1038/nsmb829
| Abstract | Full Text (HTML/PDF) |

article
The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
Andrea Pichler, Puck Knipscheer, Hisato Saitoh, Titia K Sixma and Frauke Melchior
Nature Structural and Molecular Biology 11, 984–991
(October 2004); doi:10.1038/nsmb834
| Abstract | Full Text (HTML/PDF) |

review article
Pathways of chaperone-mediated protein folding in the cytosol
Jason C. Young, Vishwas R. Agashe, Katja Siegers and F. Ulrich Hartl
Nature Reviews Molecular Cell Biology 5, 781–791
(October 2004); doi:10.1038/nrm1492
| Abstract | Full Text (HTML / PDF) |

review article
Post-translational modification of p53 in tumorigenesis
Ann M. Bode and Zigang Dong
Nature Reviews Cancer 4, 793–805
(October 2004); doi:10.1038/nrc1455
| Abstract | Full Text (HTML / PDF) |

article
Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM
Jayati Sengupta, Jakob Nilsson, Richard Gursky, Christian M T Spahn, Poul Nissen and Joachim Frank
Nature Structural and Molecular Biology 11, 957–962
(October 2004); doi:10.1038/nsmb822
| Abstract | Full Text (HTML/PDF) |

article
Structural basis of Rab5-Rabaptin5 interaction in endocytosis
Guangyu Zhu, Peng Zhai, Jian Liu, Simon Terzyan, Guangpu Li and Xuejun C Zhang
Nature Structural and Molecular Biology 11, 975–983
(October 2004); doi:10.1038/nsmb832
| Abstract | Full Text (HTML/PDF) |

article
Control of human potassium channel inactivation by editing of a small mRNA hairpin
Tarun Bhalla, Joshua J C Rosenthal, Miguel Holmgren and Robert Reenan
Nature Structural and Molecular Biology 11, 950–956
(October 2004); doi:10.1038/nsmb825
| Abstract | Full Text (HTML/PDF) |

news and views
RNA editing of a human potassium channel modifies its inactivation
Francisco Bezanilla
Nature Structural and Molecular Biology 11, 915–916
(October 2004); doi:10.1038/nsmb1004-915
| Full Text (HTML/PDF) |

September

article
Mechanochemical coupling of two substeps in a single myosin V motor
Sotaro Uemura, Hideo Higuchi, Adrian O Olivares, Enrique M De La Cruz and Shin'ichi Ishiwata
Nature Structural and Molecular Biology 11, 877–883
(September 2004); doi:10.1038/nsmb806
| Abstract | Full Text (HTML/PDF) |

article
Myosin VI walks hand-over-hand along actin
Zeynep Ökten, L Stirling Churchman, Ronald S Rock and James A Spudich
Nature Structural and Molecular Biology 11, 884–887
(September 2004); doi:10.1038/nsmb815
| Abstract | Full Text (HTML/PDF) |

review article
From structure to disease: the evolving tale of aquaporin biology
Landon S. King, David Kozono and Peter Agre
Nature Reviews Molecular Cell Biology 5, 687–698
(September 2004); doi:10.1038/nrm1469
| Abstract | Full Text (HTML / PDF) |

article
CBFβ allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium
Jiangli Yan, Yizhou Liu, Stephen M Lukasik, Nancy A Speck and John H Bushweller
Nature Structural and Molecular Biology 11, 901–906
(September 2004); doi:10.1038/nsmb819
| Abstract | Full Text (HTML/PDF) |

letters to nature
Structure of the ESCRT-II endosomal trafficking complex
Aitor Hierro, Ji Sun, Alexander S. Rusnak, Jaewon Kim, Gali Prag, Scott D. Emr and James H. Hurley
Nature 431, 221–226
(09 September 2004); doi:10.1038/nature02914
| First Paragraph | Full Text (HTML / PDF) |

article
Structural basis for the evolutionary inactivation of Ca²⁺ binding to synaptotagmin 4
Han Dai, Ok-Ho Shin, Mischa Machius, Diana R Tomchick, Thomas C Südhof and Josep Rizo
Nature Structural and Molecular Biology 11, 844–849
(September 2004); doi:10.1038/nsmb817
| Abstract | Full Text (HTML/PDF) |

article
An unstructured initiation site is required for efficient proteasome–mediated degradation
Sumit Prakash, Lin Tian, Kevin S Ratliff, Rebecca E Lehotzky and Andreas Matouschek
Nature Structural and Molecular Biology 11, 830–837
(September 2004); doi:10.1038/nsmb814
| Abstract | Full Text (HTML/PDF) |

news and views
Signaling degradation
Jon A Kenniston and Robert T Sauer
Nature Structural and Molecular Biology 11, 800–802
(September 2004); doi:10.1038/nsmb0904–800
| Full Text (HTML/PDF) |

August

letters to nature
Structural basis for glycosphingolipid transfer specificity
Lucy Malinina, Margarita L. Malakhova, Alexei Teplov, Rhoderick E. Brown and Dinshaw J. Patel
Nature 430, 1048–1053
(26 August 2004); doi:10.1038/nature02856
| First Paragraph | Full Text (HTML / PDF) |

article
Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
Julie Kniazeff, Anne-Sophie Bessis, Damien Maurel, Hervé Ansanay, Laurent Prézeau and Jean-Philippe Pin
Nature Structural and Molecular Biology 11, 706–713
(August 2004); doi:10.1038/nsmb794
| Abstract | Full Text (HTML/PDF) |

news and views
Toward understanding GPCR dimers
Charles Parnot and Brian Kobilka
Nature Structural and Molecular Biology 11, 691–692
(August 2004); doi:10.1038/nsmb0804-691
| Full Text (HTML/PDF) |

article
Allosteric inhibition of protein tyrosine phosphatase 1B
Christian Wiesmann, Kenneth J Barr, Jenny Kung, Jiang Zhu, Daniel A Erlanson, Wang Shen, Bruce J Fahr, Min Zhong, Lisa Taylor, Mike Randal, Robert S McDowell and Stig K Hansen
Nature Structural and Molecular Biology 11, 730–737
(August 2004); doi:10.1038/nsmb803
| Abstract | Full Text (HTML/PDF) |

article
PH domain of ELMO functions in trans to regulate Rac activation via Dock180
Mingjian Lu, Jason M Kinchen, Kent L Rossman, Cynthia Grimsley, Colin deBakker, Enrico Brugnera, Annie-Carole Tosello-Trampont, Lisa B Haney, Doris Klingele, John Sondek, Michael O Hengartner and Kodi S Ravichandran
Nature Structural and Molecular Biology 11, 756–762
(August 2004); doi:10.1038/nsmb800
| Abstract | Full Text (HTML/PDF) |

letters to nature
Crystal structure of a complex between anthrax toxin and its host cell receptor
Eugenio Santelli, Laurie A. Bankston, Stephen H. Leppla and Robert C. Liddington
Nature 430, 905–908
(19 August 2004); doi:10.1038/nature02763
| First Paragraph | Full Text (HTML / PDF) |

news and views
Structural biology: Anthrax hijacks host receptor
James G. Bann and Scott J. Hultgren
Nature 430, 843–844
(19 August 2004); doi:10.1038/430843a
| Full Text (HTML / PDF) |

letters to nature
Structural basis for redox regulation of Yap1 transcription factor localization
Matthew J. Wood, Gisela Storz and Nico Tjandra
Nature 430, 917–921
(19 August 2004); doi:10.1038/nature02790
| First Paragraph | Full Text (HTML / PDF) |

news and views
Recognizing a phosphate group
Evelyn Jabri
Nature Structural and Molecular Biology 11, 690
(August 2004); doi:10.1038/nsmb0804-690
| Full Text (HTML/PDF) |

letters to nature
Electron microscopic analysis of KvAP voltage-dependent K⁺ channels in an open conformation
Qiu-Xing Jiang, Da-Neng Wang and Roderick MacKinnon
Nature 430, 806–810
(12 August 2004); doi:10.1038/nature02735
| First Paragraph | Full Text (HTML / PDF) |

review article
The co-workers of actin filaments: from cell structures to signals
Céline Revenu, Rafika Athman, Sylvie Robine and Daniel Louvard
Nature Reviews Molecular Cell Biology 5, 635–646
(August 2004); doi:10.1038/nrm1437
| Summary | Full Text (HTML / PDF) |

article
DNA binding and nucleotide flipping by the human DNA repair protein AGT
Douglas S Daniels, Tammy T Woo, Kieu X Luu, David M Noll, Neil D Clarke, Anthony E Pegg and John A Tainer
Nature Structural and Molecular Biology 11, 714–720
(August 2004); doi:10.1038/nsmb791
| Abstract | Full Text (HTML/PDF) |

news and views
Reversing DNA damage with a directional bias
Thomas J Begley and Leona D Samson
Nature Structural and Molecular Biology 11, 688–690
(August 2004); doi:10.1038/nsmb0804-688
| Full Text (HTML/PDF) |

July

article
Crystal structure of the calcium pump with a bound ATP analogue
Chikashi Toyoshima and Tatsuaki Mizutani
Nature 430, 529–535
(29 July 2004); doi:10.1038/nature02680
| Abstract | Full Text (HTML / PDF) |

letters to nature
Structural basis for vinculin activation at sites of cell adhesion
Constantina Bakolitsa, Daniel M. Cohen, Laurie A. Bankston, Andrey A. Bobkov, Gregory W. Cadwell, Lisa Jennings, David R. Critchley, Susan W. Craig and Robert C. Liddington
Nature 430, 583–586
(29 July 2004); doi:10.1038/nature02610
| First Paragraph | Full Text (HTML / PDF) |

news and views
Cell biology: How to build a cell junction
William I. Weis
Nature 430, 513–515
(29 July 2004); doi:10.1038/430513a
| Full Text (HTML / PDF) |

letters to nature
Low-populated folding intermediates of Fyn SH3 characterized by relaxation dispersion NMR
Dmitry M. Korzhnev , Xavier Salvatella, Michele Vendruscolo, Ariel A. Di Nardo, Alan R. Davidson, Christopher M. Dobson and Lewis E. Kay
Nature 430, 586–590
(29 July 2004); doi:10.1038/nature02655
| First Paragraph | Full Text (HTML / PDF) |

article
Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR
Yuan Guo, Hadar Feinberg, Edward Conroy, Daniel A Mitchell, Richard Alvarez, Ola Blixt, Maureen E Taylor, William I Weis and Kurt Drickamer
Nature Structural and Molecular Biology 11, 591–598
(July 2004); doi:10.1038/nsmb784
| Abstract | Full Text (HTML/PDF) |

article
Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1α
Michihiro Tateyama, Hideki Abe, Hiroyasu Nakata, Osamu Saito and Yoshihiro Kubo
Nature Structural and Molecular Biology 11, 637–642
(July 2004); doi:10.1038/nsmb770
| Abstract | Full Text (HTML/PDF) |

article
Distinct conformational states of nuclear receptor-bound CRSP-Med complexes
Dylan J Taatjes, Tilman Schneider-Poetsch and Robert Tjian
Nature Structural and Molecular Biology 11, 664–671
(July 2004); doi:10.1038/nsmb789
| Abstract | Full Text (HTML/PDF) |

article
TFIIH contains a PH domain involved in DNA nucleotide excision repair
Virginie Gervais, Valérie Lamour, Anass Jawhari, Florent Frindel, Emeric Wasielewski, Sandy Dubaele, Jean-Marc Egly, Jean-Claude Thierry, Bruno Kieffer and Arnaud Poterszman
Nature Structural and Molecular Biology 11, 616–622
(July 2004); doi:10.1038/nsmb782
| Abstract | Full Text (HTML/PDF) |

news and views
Transcription meets DNA repair at a PH domain
Kon Yew Kwek, William O'Gorman and Alexandre Akoulitchev
Nature Structural and Molecular Biology 11, 588–589
(July 2004); doi:10.1038/nsmb0704-588
| Full Text (HTML/PDF) |

letters to nature
Context-dependent contributions of backbone hydrogen bonding to -sheet folding energetics
Songpon Deechongkit, Houbi Nguyen, Evan T. Powers, Philip E. Dawson, Martin Gruebele & Jeffery W. Kelly
Nature 430, 101–105
(01 July 2004); doi:10.1038/nature02611
| Abstract | Full Text (HTML / PDF) |

June

article
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
R Scott Williams, Megan S Lee, D Duong Hau and J N Mark Glover
Nature Structural and Molecular Biology 11, 519–525
(June 2004); doi:10.1038/nsmb776
| Abstract | Full Text (HTML/PDF) |

news and views
Opening the gate in potassium channels
Kenton J Swartz
Nature Structural and Molecular Biology 11, 499–501
(June 2004); doi:10.1038/nsmb0604-499
| Full Text (HTML/PDF) |

letters to nature
Structural basis of protein phosphatase 1 regulation
Mohammed Terrak, Frederic Kerff, Knut Langsetmo, Terence Tao and Roberto Dominguez
Nature 429, 780–784
(17 June 2004); doi:10.1038/nature02582
| First Paragraph | Full Text (HTML / PDF) |

article
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer
Julie A Clapperton, Isaac A Manke, Drew M Lowery, Timmy Ho, Lesley F Haire, Michael B Yaffe and Stephen J Smerdon
Nature Structural and Molecular Biology 11, 512–518
(June 2004); doi:10.1038/nsmb775
| Abstract | Full Text (HTML/PDF) |

article
Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
R Scott Williams, Megan S Lee, D Duong Hau & J N Mark Glover
Nature Structural and Molecular Biology 11, 519–525
(June 2004); doi:10.1038/nsmb776
| Abstract | Full Text (HTML/PDF) |

letters to nature
Structure of a complex between a voltage-gated calcium channel β-subunit and an α-subunit domain
Filip Van Petegem, Kimberly A. Clark, Franck C. Chatelain and Daniel L. Minor Jr
Nature 429, 671–675
(10 June 2004); doi:10.1038/nature02588
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
Structural basis of the α₁-β subunit interaction of voltage-gated Ca²⁺ channels
Yu-hang Chen, Ming-hui Li, Yun Zhang, Lin-ling He, Yoichi Yamada, Aileen Fitzmaurice, Yang Shen, Hailong Zhang, Liang Tong and Jian Yang
Nature 429, 675–680
(10 June 2004); doi:10.1038/nature02641
| First Paragraph | Full Text (HTML / PDF) |

May

letters to nature
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
Jin-Biao Ma, Keqiong Ye and Dinshaw J. Patel
Nature 429, 318–322
(20 May 2004); doi:10.1038/nature02519
| First Paragraph | Full Text (HTML / PDF) |

letters to nature
The GTPase-activating protein Rap1GAP uses a catalytic asparagine
Oliver Daumke, Michael Weyand, Partha P. Chakrabarti, Ingrid R. Vetter and Alfred Wittinghofer
Nature 429, 197–201
(13 May 2004); doi:10.1038/nature02505
| First Paragraph | Full Text (HTML / PDF) |

news and views
Signal transduction: Thumbs up for inactivation
Holger Rehmann and Johannes L. Bos
Nature 429, 138–139
(13 May 2004); doi:10.1038/429138a
| Full Text (HTML / PDF) |

article
Communication between ClpX and ClpP during substrate processing and degradation
Shilpa A Joshi, Greg L Hersch, Tania A Baker and Robert T Sauer
Nature Structural and Molecular Biology 11, 404–411
(May 2004); doi:10.1038/nsmb752
| Abstract | Full Text (HTML/PDF) |

review article
Type IV pilus structure and bacterial pathogenicity
Lisa Craig, Michael E. Pique and John A. Tainer
Nature Reviews Microbiology 2, 363–378
(May 2004); doi:10.1038/nrmicro885
| Abstract | Full Text (HTML / PDF) |

article
Molecular recognition of BMP-2 and BMP receptor IA
Sascha Keller, Joachim Nickel, Jin-Li Zhang, Walter Sebald and Thomas D Mueller
Nature Structural and Molecular Biology 11, 481–488
(May 2004); doi:10.1038/nsmb756
| Abstract | Full Text (HTML/PDF) |

April

research article
Reversible site-selective labeling of membrane proteins in live cells
Emmanuel G Guignet, Ruud Hovius and Horst Vogel
Nature Biotechnology 22, 440–444
(April 2004); doi:10.1038/nbt954
| First Paragraph | Full Text (HTML/PDF) |

news and views
Finding needles in haystacks
Jonathan A Javitch
Nature Biotechnology 22, 394–396
(April 2004); doi:10.1038/nbt0404-394
| Full Text (HTML/PDF) |

article
Structural basis of sugar-recognizing ubiquitin ligase
Tsunehiro Mizushima, Takeshi Hirao, Yukiko Yoshida, Soo Jae Lee, Tomoki Chiba, Kazuhiro Iwai, Yoshiki Yamaguchi, Koichi Kato, Tomitake Tsukihara and Keiji Tanaka
Nature Structural and Molecular Biology 11, 365–370
(April 2004); doi:10.1038/nsmb732
| Abstract | Full Text (HTML/PDF) |

article
Regulation of the p300 HAT domain via a novel activation loop
Paul R Thompson, Dongxia Wang, Ling Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert G Roeder, Jiemin Wong, Massimo Levrero, Vittorio Sartorelli, Robert J Cotter and Philip A Cole
Nature Structural and Molecular Biology 11, 308–315
(April 2004); doi:10.1038/nsmb740
| Abstract | Full Text (HTML/PDF) |

news and views
Is acetylation the key to opening locked gates?
B Franklin Pugh
Nature Structural and Molecular Biology 11, 298–300
(April 2004); doi:10.1038/nsmb0404-298
| Full Text (HTML/PDF) |

article
The Mad2 spindle checkpoint protein has two distinct natively folded states
Xuelian Luo, Zhanyun Tang, Guohong Xia, Katja Wassmann, Tomohiro Matsumoto, Josep Rizo and Hongtao Yu
Nature Structural and Molecular Biology 11, 338–345
(April 2004); doi:10.1038/nsmb748
| Abstract | Full Text (HTML/PDF) |

article
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding
Eilyn R Lacy, Igor Filippov, William S Lewis, Steve Otieno, Limin Xiao, Sonja Weiss, Ludger Hengst and Richard W Kriwacki
Nature Structural and Molecular Biology 11, 358–364
(April 2004); doi:10.1038/nsmb746
| Abstract | Full Text (HTML/PDF) |

March

article
Counterion displacement in the molecular evolution of the rhodopsin family
Akihisa Terakita, Mitsumasa Koyanagi, Hisao Tsukamoto, Takahiro Yamashita, Takashi Miyata and Yoshinori Shichida
Nature Structural and Molecular Biology 11, 284–289
(March 2004); doi:10.1038/nsmb731
| Abstract | Full Text (HTML/PDF) |

letters to nature
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
Raimond B.G. Ravelli, Benoît Gigant, Patrick A. Curmi, Isabelle Jourdain, Sylvie Lachkar, André Sobel and Marcel Knossow
Nature 428, 198–202
(11 March 2004); doi:10.1038/nature02393
| First Paragraph | Full Text (HTML / PDF) |

article
Two distinct interaction motifs in amphiphysin bind two independent sites on the clathrin terminal domain β-propeller
Adriana E Miele, Peter J Watson, Philip R Evans, Linton M Traub and David J Owen
Nature Structural and Molecular Biology 11, 242–248
(March 2004); doi:10.1038/nsmb736
| Abstract | Full Text (HTML/PDF) |

news and views
Turning on FLT3
Elizabeth Grzymski
Nature Structural and Molecular Biology 11, 212
(March 2004); doi:10.1038/nsmb0304-212
| Full Text (HTML/PDF) |

article
An EF-hand in the sodium channel couples intracellular calcium to cardiac excitability
Tammy L Wingo, Vikas N Shah, Mark E Anderson, Terry P Lybrand, Walter J Chazin and Jeffrey R Balser
Nature Structural and Molecular Biology 11, 219–225
(March 2004); doi:10.1038/nsmb737
| Abstract | Full Text (HTML/PDF) |

February

article
Secondary active transport mediated by a prokaryotic homologue of ClC Cl^- channels
Alessio Accardi and Christopher Miller
Nature 427, 803–807
(26 February 2004); doi:10.1038/nature02314
| Abstract | Full Text (HTML / PDF) |

news and views
Ion transport: Spot the difference
David C. Gadsby
Nature 427, 795–797
(26 February 2004); doi:10.1038/427795a
| Full Text (HTML / PDF) |

review article
Human antibody-Fc receptor interactions illuminated by crystal structures
Jenny M. Woof and Dennis R. Burton
Nature Reviews Immunology 4, 89–99
(February 2004); doi:10.1038/nri1266
| Abstract | Full Text (HTML / PDF) |

article
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Yoshiaki Kise, Sang Won Lee, Sang Gyu Park, Shuya Fukai, Toru Sengoku, Ryohei Ishii, Shigeyuki Yokoyama, Sunghoon Kim and Osamu Nureki
Nature Structural and Molecular Biology 11, 149–156
(February 2004); doi:10.1038/nsmb722
| Abstract | Full Text (HTML/PDF) |

article
Crystal structure of MO25α in complex with the C terminus of the pseudo kinase STE20-related adaptor
Christine C Milburn, Jérôme Boudeau, Maria Deak, Dario R Alessi and Daan M F van Aalten
Nature Structural and Molecular Biology 11, 193–200
(February 2004); doi:10.1038/nsmb716
| Abstract | Full Text (HTML/PDF) |

news and views
Barreling through the membrane
Arthur E Johnson and Robert E Jensen
Nature Structural and Molecular Biology 11, 113–114
(February 2004); doi:10.1038/nsmb0204-113
| Full Text (HTML/PDF) |

news and views
GTPase twins in the SRP family
Elisabet C Mandon and Reid Gilmore
Nature Structural and Molecular Biology 11, 115–116
(February 2004); doi:10.1038/nsmb0204-115
| Full Text (HTML/PDF) |

January

perspectives
Controlling Abl: auto-inhibition and co-inhibition?
Jean Y. J. Wang
Nature Cell Biology 6, 3–7
(January 2004); doi:10.1038/ncb0104-3
| Abstract | Full Text (HTML/PDF) |

article
A conformational switch in the Piccolo C₂A domain regulated by alternative splicing
Jesus Garcia, Stefan H Gerber, Shuzo Sugita, Thomas C Südhof and Josep Rizo
Nature Structural and Molecular Biology 11, 45–53
(January 2004); doi:10.1038/nsmb707
| Abstract | Full Text (HTML/PDF) |

news and views
Sculpting a domain by splicing
Bazbek Davletov and José L Jiménez
Nature Structural and Molecular Biology 11, 4–5
(January 2004); doi:10.1038/nsmb0104-4
| Full Text (HTML/PDF) |

article
Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1
Mousheng Wu, Lei Lu, Wanjin Hong and Haiwei Song
Nature Structural and Molecular Biology 11, 86–94
(January 2004); doi:10.1038/nsmb714
| Abstract | Full Text (HTML/PDF) |

article
Structure of the dengue virus envelope protein after membrane fusion
Yorgo Modis, Steven Ogata, David Clements and Stephen C. Harrison
Nature 427, 313–319
(22 January 2004); doi:10.1038/nature02165
| Summary | Full Text (HTML / PDF) |

article
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus
Don L. Gibbons, Marie-Christine Vaney, Alain Roussel, Armelle Vigouroux, Brigid Reilly, Jean Lepault, Margaret Kielian and Félix A. Rey
Nature 427, 320–325
(22 January 2004); doi:10.1038/nature02239
| Summary | Full Text (HTML / PDF) |

news and views
Virology: A class act
Theodore S. Jardetzky and Robert A. Lamb
Nature 427, 307–308
(22 January 2004); doi:10.1038/427307a
| Full Text (HTML / PDF) |

article
Substrate twinning activates the signal recognition particle and its receptor
Pascal F. Egea, Shu-ou Shan, Johanna Napetschnig, David F. Savage, Peter Walter and Robert M. Stroud
Nature 427, 215–221
(15 January 2004); doi:10.1038/nature02250
| Abstract | Full Text (HTML / PDF) |

article
A mechanical unfolding intermediate in an actin-crosslinking protein
Ingo Schwaiger, Angelika Kardinal, Michael Schleicher, Angelika A Noegel & Matthias Rief
Nature Structural and Molecular Biology 11, 81–85
(29 December 2003); doi:10.1038/nsmb705
| Abstract | | Full Text (HTML/PDF) |

article
X-ray structure of a protein-conducting channel
Bert van den Berg, William M. Clemons Jr, Ian Collinson, Yorgo Modis, Enno Hartmann, Stephen C. Harrison and Tom A. Rapoport
Nature 427, 36–44
(01 January 2004); doi:10.1038/nature02218
| Abstract | Full Text (HTML / PDF) |

news and views
Cell biology: Shape-shifting protein channel
Jordi Benach and John F. Hunt
Nature 427, 24–26
(01 January 2004); doi:10.1038/427024a
| Full Text (HTML / PDF) |

letters to nature
Vinculin activation by talin through helical bundle conversion
Tina Izard, Gwyndaf Evans, Robert A. Borgon, Christina L. Rush, Gerard Bricogne and Philippe R. J. Bois
Nature 427, 171–175
(08 January 2004); doi:10.1038/nature02281
| First Paragraph | Full Text (HTML / PDF) |

HOME | SIGNALING UPDATE | MOLECULE PAGES | DATA CENTER | ABOUT US
registration | e-alert | help | contact us | site guide | search

© 2002-2008 Nature Publishing Group

Privacy Policy