Research library: Structures
2005:
December
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December
letter
The importance of sequence diversity in the aggregation and evolution of proteins
Caroline F. Wright, Sarah A. Teichmann, Jane Clarke and Christopher M. Dobson
Nature 438, 878–881
(08 December 2005); doi:10.1038/nature04195
| First Paragraph | Full Text (HTML / PDF) |
November
letter
Structures of ParB bound to DNA reveal mechanism of partition complex formation
Maria A. Schumacher and Barbara E. Funnell
Nature 438, 516–519
(24 November 2005); doi:10.1038/nature04149
| First Paragraph | Full Text (HTML / PDF) |
review article
Prion domains: sequences, structures and interactions
Eric D. Ross, Allen Minton and Reed B. Wickner
Nature Cell Biology 7, 1039–1044
(November 2005); doi:10.1038/ncb1105-1039
| Abstract | Full Text (HTML/PDF) |
letter
Negative epistasis between the malaria-protective effects of α+-thalassemia and the sickle cell trait
Thomas N Williams, Tabitha W Mwangi, Sammy Wambua, Timothy E A Peto, David J Weatherall, Sunetra Gupta, Mario Recker, Bridget S Penman, Sophie Uyoga, Alex Macharia, Jedidah K Mwacharo, Robert W Snow and Kevin Marsh
Nature Genetics 37, 1253–1257
(November 2005); doi:10.1038/ng1660
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article
Structure of the E. coli protein-conducting channel bound to a translating ribosome
Kakoli Mitra, Christiane Schaffitzel, Tanvir Shaikh, Florence Tama, Simon Jenni, Charles L. Brooks III, Nenad Ban and Joachim Frank
Nature 438, 318–324
(17 November 2005); doi:10.1038/nature04133
| Summary | Full Text (HTML / PDF) |
news and views
Cell biology: Two pores better than one?
Arnold J. M. Driessen
Nature 438, 299–300
(17 November 2005); doi:10.1038/438299a
| Full Text (HTML / PDF) |
article
A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome
Jeremiah R. Wagner, Joseph S. Brunzelle, Katrina T. Forest and Richard D. Vierstra
Nature 438, 325–331
(17 November 2005); doi:10.1038/nature04118
| Summary | Full Text (HTML / PDF) |
article
Subunit arrangement and function in NMDA receptors
Hiroyasu Furukawa, Satinder K Singh, Romina Mancusso and Eric Gouaux
Nature 438, 185–192
(10 November 2005); doi:10.1038/nature04089
| Summary | Full Text (HTML / PDF) |
letter
Principal pathway coupling agonist binding to channel gating in nicotinic receptors
Won Yong Lee and Steven M. Sine
Nature 438, 243–247
(10 November 2005); doi:10.1038/nature04156
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letter
Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel
Sarah C. R. Lummis, Darren L. Beene, Lori W. Lee, Henry A. Lester, R. William Broadhurst and Dennis A. Dougherty
Nature 438, 248–252
(10 November 2005); doi:10.1038/nature04130
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news and views
Structural biology: Proteins flex to function
Yuanpeng J. Huang and Gaetano T. Montelione
Nature 438, 36–37
(03 November 2005); doi:10.1038/438036a
| Full Text (HTML / PDF) |
October
article
Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines
Andreas Martin, Tania A. Baker and Robert T. Sauer
Nature 437, 1115–1120
(20 October 2005); doi:10.1038/nature04031
| Abstract | Full Text (HTML / PDF) |
letter
Solution structure of a protein denatured state and folding intermediate
T. L. Religa, J. S. Markson, U. Mayor, S. M. V. Freund and A. R. Fersht
Nature 437, 1053–1056
(13 October 2005); doi:10.1038/nature04054
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article
Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
Nieng Yan, Jijie Chai, Eui Seung Lee, Lichuan Gu, Qun Liu, Jiaqing He, Jia-Wei Wu, David Kokel, Huilin Li, Quan Hao, Ding Xue and Yigong Shi
Nature 437, 831–837
(06 October 2005); doi:10.1038/nature04002
| Abstract | Full Text (HTML / PDF) |
review article
The role of chromatin structure in regulating the expression of clustered genes
Duncan Sproul, Nick Gilbert and Wendy A. Bickmore
Nature Reviews Genetics 6, 775–781
(October 2005); doi:10.1038/nrg1688
| Abstract | Full Text (HTML / PDF) |
September
letter
A non-haem iron centre in the transcription factor NorR senses nitric oxide
Benoît D'Autréaux, Nicholas P. Tucker, Ray Dixon and Stephen Spiro
Nature 437, 769–772
(29 September 2005); doi:10.1038/nature03953
| First Paragraph | Full Text (HTML / PDF) |
article
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
Richard J Brown, Julian J Adams, Rebecca A Pelekanos, Yu Wan, William J McKinstry, Kathryn Palethorpe, Ruth M Seeber, Thea A Monks, Karin A Eidne, Michael W Parker and Michael J Waters
Nature Structural and Molecular Biology 12, 814–821
(September 2005); doi:10.1038/nsmb977
| Abstract | Full Text (HTML/PDF) |
article
Structures of complement component C3 provide insights into the function and evolution of immunity
Bert J. C. Janssen, Eric G. Huizinga, Hans C. A. Raaijmakers, Anja Roos, Mohamed R. Daha, Kristina Nilsson-Ekdahl, Bo Nilsson and Piet Gros
Nature 437, 505–511
(22 September 2005); doi:10.1038/nature04005
| Abstract | Full Text (HTML / PDF) |
letter
Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA
Fernando Moreno-Herrero, Martijn de Jager, Nynke H. Dekker, Roland Kanaar, Claire Wyman and Cees Dekker
Nature 437, 440–443
(15 September 2005); doi:10.1038/nature03927
| First Paragraph | Full Text (HTML / PDF) |
letter
The most infectious prion protein particles
Jay R. Silveira, Gregory J. Raymond, Andrew G. Hughson, Richard E. Race, Valerie L. Sim, Stanley F. Hayes and Byron Caughey
Nature 437, 257–261
(08 September 2005); doi:10.1038/nature03989
| First Paragraph | Full Text (HTML / PDF) |
letter
Prion protein remodelling confers an immediate phenotypic switch
Prasanna Satpute-Krishnan and Tricia R. Serio
Nature 437, 262–265
(08 September 2005); doi:10.1038/nature03981
| First Paragraph | Full Text (HTML / PDF) |
news and views
Synthetic chemistry: Glycosylation with a twist
Sabine L. Flitsch
Nature 437, 201–202
(08 September 2005); doi:10.1038/437201a
| Full Text (HTML / PDF) |
August
letter
Atomic model of a myosin filament in the relaxed state
John L. Woodhead, Fa-Qing Zhao, Roger Craig, Edward H. Egelman, Lorenzo Alamo and Raúl Padrón
Nature 436, 1195–1199
(25 August 2005); doi:10.1038/nature03920
| First Paragraph | Full Text (HTML / PDF) |
article
Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry
René Jørgensen, A. Rod Merrill, Susan P. Yates, Victor E. Marquez, Adrian L. Schwan, Thomas Boesen and Gregers R. Andersen
Nature 436, 979–984
(18 August 2005); doi:10.1038/nature03871
| Abstract | Full Text (HTML / PDF) |
letter
Voltage-sensor activation with a tarantula toxin as cargo
L. Revell Phillips, Mirela Milescu, Yingying Li-Smerin, Joseph A. Mindell, Jae Il Kim and Kenton J. Swartz
Nature 436, 857–860
(11 August 2005); doi:10.1038/nature03873
| First Paragraph | Full Text (HTML / PDF) |
July
letter
Molecular basis of photoprotection and control of photosynthetic light-harvesting
Andrew A. Pascal, Zhenfeng Liu, Koen Broess, Bart van Oort, Herbert van Amerongen, Chao Wang, Peter Horton, Bruno Robert, Wenrui Chang and Alexander Ruban
Nature 436, 134–137
(07 July 2005); doi:10.1038/nature03795
| First Paragraph | Full Text (HTML / PDF) |
letter
X-ray structure of a tetranucleosome and its implications for the chromatin fibre
Thomas Schalch, Sylwia Duda, David F. Sargent and Timothy J. Richmond
Nature 436, 138–141
(07 July 2005); doi:10.1038/nature03686
| First Paragraph | Full Text (HTML / PDF) |
review article
AAA+ proteins: have engine, will work
Phyllis I. Hanson and Sidney W. Whiteheart
Nature Reviews Molecular Cell Biology 6, 519–529
(July 2005); doi:10.1038/nrm1684
| Summary | Full Text (HTML / PDF) |
June
research article
Intein-based biosynthetic incorporation of unlabeled protein tags into isotopically labeled proteins for NMR studies
Sara Züger and Hideo Iwai
Nature Biotechnology 23, 736–740
(June 2005); doi:10.1038/nbt1097
| First Paragraph | Full Text (HTML/PDF) |
article
Signaling conformations of the tall cytokine receptor gp130 when in complex with IL-6 and IL-6 receptor
Georgios Skiniotis, Martin J Boulanger, K Christopher Garcia and Thomas Walz
Nature Structural and Molecular Biology 12, 545–551
(June 2005); doi:10.1038/nsmb941
| Abstract | Full Text (HTML/PDF) |
news and views
Bow to your partner for signaling
Heike M Hermanns, Gerhard Müller-Newen, Peter C Heinrich and Serge Haan
Nature Structural and Molecular Biology 12, 476–478
(June 2005); doi:10.1038/nsmb0605-476
| Full Text (HTML/PDF) |
review article
Glycans in cancer and inflammation — potential for therapeutics and diagnostics
Danielle H. Dube and Carolyn R. Bertozzi
Nature Reviews Drug Discovery 4, 477–488
(June 2005); doi:10.1038/nrd1751
| Summary | Full Text (HTML / PDF) |
article
The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1
Peggy Huang, Matthias Gautschi, William Walter, Sabine Rospert and Elizabeth A Craig
Nature Structural and Molecular Biology 12, 497–504
(June 2005); doi:10.1038/nsmb942
| Abstract | Full Text (HTML/PDF) |
news and views
Ribosomes catch Hsp70s
Bernd Bukau
Nature Structural and Molecular Biology 12, 472–473
(June 2005); doi:10.1038/nsmb0605-472
| Full Text (HTML/PDF) |
article
Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75
Peter Cherepanov, Zhen-Yu J Sun, Shaila Rahman, Goedele Maertens, Gerhard Wagner and Alan Engelman
Nature Structural and Molecular Biology 12, 526–532
(June 2005); doi:10.1038/nsmb937
| Abstract | Full Text (HTML/PDF) |
letter
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex
David Reverter and Christopher D. Lima
Nature 435, 687–692
(02 June 2005); doi:10.1038/nature03588
| First Paragraph | Full Text (HTML / PDF) |
article
RNA editing produces glycine receptor α3P185L, resulting in high agonist potency
Jochen C Meier, Christian Henneberger, Igor Melnick, Claudia Racca, Robert J Harvey, Uwe Heinemann, Volker Schmieden and Rosemarie Grantyn
Nature Neuroscience 8, 736–744
(June 2005); doi:10.1038/nn1467
| Abstract | Full Text (HTML/PDF) |
article
The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage
A D J Scadden
Nature Structural and Molecular Biology 12, 489–496
(June 2005); doi:10.1038/nsmb936
| Abstract | Full Text (HTML/PDF) |
brief communication
Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension
Jérôme Fagart, Jessica Huyet, Grégory M Pinon, Marina Rochel, Claudine Mayer and Marie-Edith Rafestin-Oblin
Nature Structural and Molecular Biology 12, 554–555
(June 2005); doi:10.1038/nsmb939
| First Paragraph | Full Text (HTML/PDF) |
May
letter to nature
Allosteric modulation of the presynaptic Ca2+ sensor for vesicle fusion
Xuelin Lou, Volker Scheuss and Ralf Schneggenburger
Nature 435, 497–501
(26 May 2005); doi:10.1038/nature03568
| First Paragraph | Full Text (HTML / PDF) |
letter to nature
Structural and mechanistic insights into the interaction between Rho and mammalian Dia
R. Rose, M. Weyand, M. Lammers, T. Ishizaki, M. R. Ahmadian and A. Wittinghofer
Nature 435, 513–518
(26 May 2005); doi:10.1038/nature03604
| First Paragraph | Full Text (HTML / PDF) |
letter to nature
Insights into microtubule nucleation from the crystal structure of human γ-tubulin
Hector Aldaz , Luke M. Rice, Tim Stearns and David A. Agard
Nature 435, 523–527
(26 May 2005); doi:10.1038/nature03586
| First Paragraph | Full Text (HTML / PDF) |
article
The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination
Galina V Petukhova, Roberto J Pezza, Filip Vanevski, Mickael Ploquin, Jean-Yves Masson and R Daniel Camerini-Otero
Nature Structural and Molecular Biology 12, 449–453
(May 2005); doi:10.1038/nsmb923
| Abstract | Full Text (HTML/PDF) |
perspectives
Phosphorylation-specific prolyl isomerization: is there an underlying theme?
Gerburg Wulf, Greg Finn, Futoshi Suizu and Kun Ping Lu
Nature Cell Biology 7, 435–441
(May 2005); doi:10.1038/ncb0505-435
| Abstract | Full Text (HTML/PDF) |
article
Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines
Revital Shamri, Valentin Grabovsky, Jean–Marc Gauguet, Sara Feigelson, Eugenia Manevich, Waldemar Kolanus, Martyn K Robinson, Donald E Staunton, Ulrich H von Andrian and Ronen Alon
Nature Immunology 6, 497–506
(May 2005); doi:10.1038/ni1194
| Abstract | Full Text (HTML/PDF) |
news and views
Integrin activation under flow: a local affair
Carlo Laudanna
Nature Immunology 6, 429–430
(May 2005); doi:10.1038/ni0505-429
| Full Text (HTML/PDF) |
review article
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
Prakash Jagtap and Csaba Szabó
Nature Reviews Drug Discovery 4, 421–440
(May 2005); doi:10.1038/nrd1718
| Summary | Full Text (HTML / PDF) |
article
Hemifusion in SNARE-mediated membrane fusion
Yibin Xu, Fan Zhang, Zengliu Su, James A McNew and Yeon-Kyun Shin
Nature Structural and Molecular Biology 12, 417–422
(May 2005); doi:10.1038/nsmb921
| Abstract | Full Text (HTML/PDF) |
news and views
Searching for the silver lining
Judith M White and J David Castle
Nature Structural and Molecular Biology 12, 382–384
(May 2005); doi:10.1038/nsmb0505-382
| Full Text (HTML/PDF) |
article
Monitoring macromolecular complexes involved in the chaperonin-assisted protein folding cycle by mass spectrometry
Esther van Duijn, Patrick J Bakkes, Ron M A Heeren, Robert H H van den Heuvel, Harm van Heerikhuizen, Saskia M van der Vies and Albert J R Heck
Nature Methods 2, 371–376
(May 2005); doi:10.1038/nmeth753
| Abstract | Full Text (HTML/PDF) |
news and views
Watching and weighting—chaperone complexes in action
Carol V Robinson
Nature Methods 2, 331–332
(May 2005); doi:10.1038/nmeth0505-331
| Abstract | Full Text (HTML/PDF) |
article
The Rad50 hook domain is a critical determinant of Mre11 complex functions
Jed J W Wiltzius, Marcel Hohl, James C Fleming and John H J Petrini
Nature Structural and Molecular Biology 12, 403–407
(May 2005); doi:10.1038/nsmb928
| Abstract | Full Text (HTML/PDF) |
news and views
Rad50 connects by hook or by crook
Michael Lichten
Nature Structural and Molecular Biology 12, 392–393
(May 2005); doi:10.1038/nsmb0505-392
| Full Text (HTML/PDF) |
April
letters to nature
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
Toby Lawrence , Magali Bebien, George Y. Liu, Victor Nizet and Michael Karin
Nature 434, 1138–1143
(28 April 2005); doi:10.1038/nature03491
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Clathrin is required for the function of the mitotic spindle
Stephen J. Royle, Nicholas A. Bright and Leon Lagnado
Nature 434, 1152–1157
(28 April 2005); doi:10.1038/nature03502
| First Paragraph | Full Text (HTML / PDF) |
letter
Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors
Xinhua Wang, Weizhong Zeng, Abigail A. Soyombo, Wei Tang, Elliott M. Ross, Anthony P. Barnes, Sharon L. Milgram, Josef M. Penninger, Patrick B. Allen, Paul Greengard and Shmuel Muallem
Nature Cell Biology 7, 405–411
(April 2005); doi:10.1038/ncb1237
| First Paragraph | Full Text (HTML/PDF) |
article
Essential role for the second extracellular loop in C5a receptor activation
Jeffery M Klco, Christina B Wiegand, Kirk Narzinski and Thomas J Baranski
Nature Structural and Molecular Biology 12, 320–326
(April 2005); doi:10.1038/nsmb913
| Abstract | Full Text (HTML/PDF) |
news and views
The second extracellular loop: a damper for G protein-coupled receptors?
Dominique Massotte and Brigitte L Kieffer
Nature Structural and Molecular Biology 12, 287–288
(April 2005); doi:10.1038/nsmb0405-287
| Full Text (HTML/PDF) |
article
The HEAT repeat protein Blm10 regulates the yeast proteasome by capping the core particle
Marion Schmidt, Wilhelm Haas, Bernat Crosas, Patricia G Santamaria, Steven P Gygi, Thomas Walz and Daniel Finley
Nature Structural and Molecular Biology 12, 294–303
(April 2005); doi:10.1038/nsmb914
| Abstract | Full Text (HTML/PDF) |
letters to nature
Structure of the apoptotic protease-activating factor 1 bound to ADP
Stefan J. Riedl, Wenyu Li, Yang Chao, Robert Schwarzenbacher and Yigong Shi
Nature 434, 926–933
(14 April 2005); doi:10.1038/nature03465
| First Paragraph | Full Text (HTML / PDF) |
article
β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
Danette L Daniels and William I Weis
Nature Structural and Molecular Biology 12, 364–371
(April 2005); doi:10.1038/nsmb912
| Abstract | Full Text (HTML/PDF) |
article
Essential Cavβ modulatory properties are AID-independent
Janet M Maltez, Deborah A Nunziato, James Kim and Geoffrey S Pitt
Nature Structural and Molecular Biology 12, 372–377
(April 2005); doi:10.1038/nsmb909
| Abstract | Full Text (HTML/PDF) |
article
Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects
Hisanori Takagi, Yoshimitsu Kakuta, Takahiro Okada, Min Yao, Isao Tanaka and Makoto Kimura
Nature Structural and Molecular Biology 12, 327–331
(April 2005); doi:10.1038/nsmb911
| Abstract | Full Text (HTML/PDF) |
news and views
RelBE or not to be
Daniel N Wilson and Knud H Nierhaus
Nature Structural and Molecular Biology 12, 282–284
(April 2005); doi:10.1038/nsmb0405-282
| Full Text (HTML/PDF) |
article
Purified Argonaute2 and an siRNA form recombinant human RISC
Fabiola V Rivas, Niraj H Tolia, Ji-Joon Song, Juan P Aragon, Jidong Liu, Gregory J Hannon and Leemor Joshua-Tor
Nature Structural and Molecular Biology 12, 340–349
(April 2005); doi:10.1038/nsmb918
| Abstract | Full Text (HTML/PDF) |
article
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
Jacob Falck, Julia Coates and Stephen P. Jackson
Nature 434, 605–611
(31 March 2005); doi:10.1038/nature03442
| Summary | Full Text (HTML / PDF) |
letters to nature
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex
James S. Parker, S. Mark Roe and David Barford
Nature 434, 663–666
(31 March 2005); doi:10.1038/nature03462
| First Paragraph | Full Text (HTML / PDF) |
letters to nature
Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
Jin-Biao Ma, Yu-Ren Yuan, Gunter Meister, Yi Pei, Thomas Tuschl and Dinshaw J. Patel
Nature 434, 666–670
(31 March 2005); doi:10.1038/nature03514
| First Paragraph | Full Text (HTML / PDF) |
review article
Thinking quantitatively about transcriptional regulation
Sandra J. Greive and Peter H. von Hippel
Nature Reviews Molecular Cell Biology 6, 221–232
(March 2005); doi:10.1038/nrm1588
| Summary | Full Text (HTML / PDF) |
news and views
RecA kicks Pol V into gear
Joann B Sweasy
Nature Structural and Molecular Biology 12, 215–216
(March 2005); doi:10.1038/nsmb0305-215
| Full Text (HTML/PDF) |
March
article
Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase
Vito Mennella, Gregory C. Rogers, Stephen L. Rogers, Daniel W. Buster, Ronald D. Vale and David J. Sharp
Nature Cell Biology 7, 235–245
(March 2005); doi:10.1038/ncb1222
| Abstract | Full Text (HTML/PDF) |
review article
The mitochondrial uncoupling-protein homologues
Stefan Krauss , Chen-Yu Zhang and Bradford B. Lowell
Nature Reviews Molecular Cell Biology 6, 248–261
(March 2005); doi:10.1038/nrm1592
| Summary | Full Text (HTML / PDF) |
news and views
Some assembly required
Mark L Mayer
Nature Structural and Molecular Biology 12, 208–209
(March 2005); doi:10.1038/nsmb0305-208
| Full Text (HTML/PDF) |
news and views
Rings around kinetochore microtubules in yeast
J Richard McIntosh
Nature Structural and Molecular Biology 12, 210–212
(March 2005); doi:10.1038/nsmb0305-210
| Full Text (HTML/PDF) |
article
Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression
Alexandre Méjat, Francis Ramond, Rhonda Bassel-Duby, Saadi Khochbin, Eric N Olson and Laurent Schaeffer
Nature Neuroscience 8, 313–321
(March 2005); doi:10.1038/nn1408
| Abstract | Full Text (HTML/PDF) |
article
SUMO modification of the ubiquitin-conjugating enzyme E2-25K
Andrea Pichler, Puck Knipscheer, Edith Oberhofer, Willem J van Dijk, Roman Körner, Jesper Velgaard Olsen, Stefan Jentsch, Frauke Melchior and Titia K Sixma
Nature Structural and Molecular Biology 12, 264–269
(March 2005); doi:10.1038/nsmb903
| Abstract | Full Text (HTML/PDF) |
news and views
Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3
Óscar Llorca, Ernesto Arias-Palomo, José L Zugaza and Xosé R Bustelo
EMBO Journal AOP,
(10 March 2005); doi:10.1038/sj.emboj.7600617
| Abstract | Full Text (HTML/PDF) |
letter
Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin
Edgar A Otto, Bart Loeys, Hemant Khanna, Jan Hellemans, Ralf Sudbrak, Shuling Fan, Ulla Muerb, John F O'Toole, Juliana Helou, Massimo Attanasio, Boris Utsch, John A Sayer, Concepcion Lillo, David Jimeno, Paul Coucke, Anne De Paepe, Richard Reinhardt, Sven Klages, Motoyuki Tsuda, Isao Kawakami, Takehiro Kusakabe, Heymut Omran, Anita Imm, Melissa Tippens, Pamela A Raymond, Jo Hill, Phil Beales, Shirley He, Andreas Kispert, Benjamin Margolis, David S Williams, Anand Swaroop and Friedhelm Hildebrandt
Nature Genetics 37, 282–288
(March 2005); doi:10.1038/ng1520
| First Paragraph | Full Text (HTML/PDF) |
article
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification
Scott Pegan, Christine Arrabit, Wei Zhou, Witek Kwiatkowski, Anthony Collins, Paul A Slesinger and Senyon Choe
Nature Neuroscience 8, 279–287
(March 2005); doi:10.1038/nn1411
| Abstract | Full Text (HTML/PDF) |
article
Nucleotide-dependent substrate recognition by the AAA+ HslUV protease
Randall E Burton, Tania A Baker and Robert T Sauer
Nature Structural and Molecular Biology 12, 245–251
(March 2005); doi:10.1038/nsmb898
| Abstract | Full Text (HTML/PDF) |
letters to nature
Phospholipase Cγ1 controls surface expression of TRPC3 through an intermolecular PH domain
Damian B. van Rossum, Randen L. Patterson, Sumit Sharma, Roxanne K. Barrow, Michael Kornberg, Donald L. Gill and Solomon H. Snyder
Nature 434, 99–104
(03 March 2005); doi:10.1038/nature03340
| First Paragraph | Full Text (HTML / PDF) |
news and views
Cdc48-Ufd2-Rad23: the road less ubiquitinated?
Omar A. Bazirgan and Randolph Y. Hampton
Nature Cell Biology 7, 207–209
(March 2005); doi:10.1038/ncb0305-207
| Full Text (HTML/PDF) |
review article
Intrinsically unstructured proteins and their functions
H. Jane Dyson and Peter E. Wright
Nature Reviews Molecular Cell Biology 6, 197–208
(March 2005); doi:10.1038/nrm1589
| Summary | Full Text (HTML / PDF) |
article
Actin and hnRNP U cooperate for productive transcription by RNA polymerase II
Alexander Kukalev, Ylva Nord, Carina Palmberg, Tomas Bergman and Piergiorgio Percipalle
Nature Structural and Molecular Biology 12, 238–244
(March 2005); doi:10.1038/nsmb904
| Abstract | Full Text (HTML/PDF) |
February
letters to nature
CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains
Paola Vergani, Steve W. Lockless, Angus C. Nairn and David C. Gadsby
Nature 433, 876–880
(24 February 2005); doi:10.1038/nature03313
| First Paragraph | Full Text (HTML / PDF) |
letter
Synthetic shRNAs as potent RNAi triggers
Despina Siolas, Cara Lerner, Julja Burchard, Wei Ge, Peter S Linsley, Patrick J Paddison, Gregory J Hannon and Michele A Cleary
Nature Biotechnology 23, 227–231
(February 2005); doi:10.1038/nbt1052
| First Paragraph | Full Text (HTML/PDF) |
news and views
Human immunodeficiency virus: Refolding the envelope
Peter D. Kwong
Nature 433, 815–816
(24 February 2005); doi:10.1038/433815a
| Full Text (HTML / PDF) |
letter
Basic mechanism of three-dimensional collagen fibre transport by fibroblasts
Adam S. Meshel, Qize Wei, Robert S. Adelstein and Michael P. Sheetz
Nature Cell Biology 7, 157–164
(February 2005); doi:10.1038/ncb1216
| First Paragraph | Full Text (HTML/PDF) |
review article
Assembly and function of RNA silencing complexes
Erik J. Sontheimer
Nature Reviews Molecular Cell Biology AOP published online 14 January 2005; doi:10.1038/nrm1568
| Summary | Full Text (HTML / PDF) |
letter
Polyglutamine expansion of huntingtin impairs its nuclear export
Jonathan Cornett, Fengli Cao, Chuan-En Wang, Christopher A Ross, Gillian P Bates, Shi-Hua Li and Xiao-Jiang Li
Nature Genetics 37, 198–204
(February 2005); doi:10.1038/ng1503
| First Paragraph | Full Text (HTML/PDF) |
research article
Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy
Dong-Ho Kim, Mark A Behlke, Scott D Rose, Mi-Sook Chang, Sangdun Choi and John J Rossi
Nature Biotechnology 23, 222–226
(February 2005); doi:10.1038/nbt1051
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Dicing with siRNA
Bryan R.G. Williams
Nature Biotechnology 23, 181–182
(February 2005); doi:10.1038/nbt0205-181
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article
Structure of the p115RhoGEF rgRGS domain-Gα13/i1 chimera complex suggests convergent evolution of a GTPase activator
Zhe Chen, William D Singer, Paul C Sternweis and Stephen R Sprang
Nature Structural and Molecular Biology 12, 191–197
(February 2005); doi:10.1038/nsmb888
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ACEing GPI release
Satyajit Mayor
Nature Structural and Molecular Biology 12, 107–108
(February 2005); doi:10.1038/nsmb0205-107
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SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells
Sebastian Leidel, Marie Delattre, Lorenzo Cerutti, Karine Baumer and Pierre Gönczy
Nature Cell Biology 7, 115–125
(February 2005); doi:10.1038/ncb1220
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Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage
Paul S Bradshaw, Dimitrios J Stavropoulos and M Stephen Meyn
Nature Genetics 37, 193–197
(February 2005); doi:10.1038/ng1506
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Telomere-binding factors and general DNA repair
Woodring E Wright and Jerry W Shay
Nature Genetics 37, 116–118
(February 2005); doi:10.1038/ng0205-116
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article
The yeast DASH complex forms closed rings on microtubules
JJ L Miranda, Peter De Wulf, Peter K Sorger and Stephen C Harrison
Nature Structural and Molecular Biology 12, 138–143
(February 2005); doi:10.1038/nsmb896
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article
Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis
Ken Sato and Akihiko Nakano
Nature Structural and Molecular Biology 12, 167–174
(February 2005); doi:10.1038/nsmb893
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Illuminating COPII coat dynamics
Wei Liu and Jennifer Lippincott-Schwartz
Nature Structural and Molecular Biology 12, 106–107
(February 2005); doi:10.1038/nsmb0205-106
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review article
DNA supercoiling — a global transcriptional regulator for enterobacterial growth?
Andrew Travers and Georgi Muskhelishvili
Nature Reviews Microbiology 3, 157–169
(February 2005); doi:10.1038/nrmicro1088
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letters to nature
Structural basis for substrate binding, cleavage and allostery in the tRNA maturase RNase Z
Inés Li De La Sierra-Gallay, Olivier Pellegrini and Ciarán Condon
Nature 433, 657–661
(10 February 2005); doi:10.1038/nature03284
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review article
Histone variants meet their match
Kavitha Sarma and Danny Reinberg
Nature Reviews Molecular Cell Biology 6, 139–149
(February 2005); doi:10.1038/nrm1567
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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Kent L. Rossman , Channing J. Der and John Sondek
Nature Reviews Molecular Cell Biology 6, 167–180
(February 2005); doi:10.1038/nrm1587
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article
Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo
Brent A Hanks, Jianghong Jiang, Rana A K Singh, Weitao Song, Michael Barry, Mary H Huls, Kevin M Slawin and David M Spencer
Nature Medicine 11, 130–137
(February 2005); doi:10.1038/nm1183
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Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
Gen Kondoh, Hiromasa Tojo, Yuka Nakatani, Nobuyasu Komazawa, Chie Murata, Kazuo Yamagata, Yusuke Maeda, Taroh Kinoshita, Masaru Okabe, Ryo Taguchi and Junji Takeda
Nature Medicine 11, 160–166
(February 2005); doi:10.1038/nm1179
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ACE sets up fertilization
Pierre Corvol
Nature Medicine 11, 118–119
(February 2005); doi:10.1038/nm0205-118
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Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain
Takanori Otomo, Diana R. Tomchick, Chinatsu Otomo, Sanjay C. Panchal, Mischa Machius and Michael K. Rosen
Nature 433, 488–494
(03 February 2005); doi:10.1038/nature03251
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Structure and different conformational states of native AMPA receptor complexes
Terunaga Nakagawa, Yifan Cheng, Elizabeth Ramm, Morgan Sheng and Thomas Walz
Nature 433, 545–549
(03 February 2005); doi:10.1038/nature03328
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Protein S-nitrosylation: purview and parameters
Douglas T. Hess, Akio Matsumoto, Sung-Oog Kim, Harvey E. Marshall and Jonathan S. Stamler
Nature Reviews Molecular Cell Biology 6, 150–166
(February 2005); doi:10.1038/nrm1569
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A leucine zipper in the N terminus confers membrane association to SLP-65
Fabian Köhler, Bettina Storch, Yogesh Kulathu, Sebastian Herzog, Stephan Kuppig, Michael Reth and Hassan Jumaa
Nature Immunology 6, 204–210
(February 2005); doi:10.1038/ni1163
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Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex
Wanping Xu, Xitong Yuan, Zhexin Xiang, Edward Mimnaugh, Monica Marcu and Len Neckers
Nature Structural and Molecular Biology 12, 120–126
(February 2005); doi:10.1038/nsmb885
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January
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Drosophila Spire is an actin nucleation factor
Margot E. Quinlan, John E. Heuser, Eugen Kerkhoff and R. Dyche Mullins
Nature 433, 382–388
(27 January 2005); doi:10.1038/nature03241
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research article
Protein tagging and detection with engineered self-assembling fragments of green fluorescent protein
Stéphanie Cabantous, Thomas C Terwilliger and Geoffrey S Waldo
Nature Biotechnology 23, 102–107
(January 2005); doi:10.1038/nbt1044
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Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
Michael H Tatham, Suhkmann Kim, Ellis Jaffray, Jing Song, Yuan Chen and Ronald T Hay
Nature Structural and Molecular Biology 12, 67–74
(January 2005); doi:10.1038/nsmb878
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Structural characterization of a type III secretion system filament protein in complex with its chaperone
Calvin K Yip, B Brett Finlay and Natalie C J Strynadka
Nature Structural and Molecular Biology 12, 75–81
(January 2005); doi:10.1038/nsmb879
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Immunoregulatory functions of surfactant proteins
Jo Rae Wright
Nature Reviews Immunology 5, 58–68
(January 2005); doi:10.1038/nri1528
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Conformational changes in the Arp2/3 complex leading to actin nucleation
Avital A Rodal, Olga Sokolova, Deborah B Robins, Karen M Daugherty, Simon Hippenmeyer, Howard Riezman, Nikolaus Grigorieff and Bruce L Goode
Nature Structural and Molecular Biology 12, 26–31
(January 2005); doi:10.1038/nsmb870
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Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
Clemens Steegborn, Tatiana N Litvin, Lonny R Levin, Jochen Buck and Hao Wu
Nature Structural and Molecular Biology 12, 32–37
(January 2005); doi:10.1038/nsmb880
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A seminal study of soluble adenylyl cyclase
John J G Tesmer
Nature Structural and Molecular Biology 12, 7–8
(January 2005); doi:10.1038/nsmb0105-7
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Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP
Yeon-Gil Kim, Eun Ju Sohn, Jawon Seo, Kong-Joo Lee, Heung-Soo Lee, Inhwan Hwang, Malcolm Whiteway, Michael Sacher and Byung-Ha Oh
Nature Structural and Molecular Biology 12, 38–45
(January 2005); doi:10.1038/nsmb871
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Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1
Toshinori Kinoshita , Ana Caño-Delgado, Hideharu Seto, Sayoko Hiranuma, Shozo Fujioka, Shigeo Yoshida and Joanne Chory
Nature 433, 167–171
(13 January 2005); doi:10.1038/nature03227
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IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
Tencho Tenev, Anna Zachariou, Rebecca Wilson, Mark Ditzel and Pascal Meier
Nature Cell Biology 7, 70–77
(January 2005); doi:10.1038/ncb1204
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Nuclear pore complexes: Round the bend?
Wolfram Antonin and Iain W. Mattaj
Nature Cell Biology 7, 10–12
(January 2005); doi:10.1038/ncb0105-10
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review article
Function and regulation of cullin-RING ubiquitin ligases
Matthew D. Petroski and Raymond J. Deshaies
Nature Reviews Molecular Cell Biology 6, 9–20
(January 2005); doi:10.1038/nrm1547
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Using protein-DNA chimeras to detect and count small numbers of molecules
Ian Burbulis, Kumiko Yamaguchi, Andrew Gordon, Robert Carlson and Roger Brent
Nature Methods 2, 31–37
(January 2005); doi:10.1038/nmeth729
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Tadpoles by the tail
Garry P Nolan
Nature Methods 2, 11–12
(January 2005); doi:10.1038/nmeth0105-11
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