Research library: Structures
2009:
| December
| November
| October
| September
| August
| July
| June
| May
| April
| March
| February
| January
Other Years: 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008
December
article
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Alexander I. Sobolevsky, Michael P. Rosconi & Eric Gouaux
Nature 462, 745–756
(10 December 2009); doi:10.1038/nature08624
| Full Text (HTML / PDF) |
news and views
Neuroscience: Excitatory view of a receptor
Lonnie P. Wollmuth & Stephen F. Traynelis
Nature 462, 729–731
(10 December 2009); doi:10.1038/462729a
| Full Text (HTML / PDF) |
brief communication
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain
Yogesh Kulathu, Masato Akutsu, Anja Bremm, Kay Hofmann & David Komander
Nature Structural & Molecular Biology 16, 1328–1330
(December 2009); doi:10.1038/nsmb.1731
| Summary | Full Text (HTML / PDF) |
news and views
Ubiquitin linkages make a difference
Ivan Dikic & Volker Dötsch
Nature Structural & Molecular Biology 16, 1209–1210
(December 2009); doi:10.1038/nsmb1209-1209
| Full Text (HTML / PDF) |
article
A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors
Karsten Melcher et al.
Nature 462, 602–608
(03 December 2009); doi:10.1038/nature08613
| Full Text (HTML / PDF) |
article
Structural basis of abscisic acid signalling
Ken-ichi Miyazono et al.
Nature 462, 609–614
(03 December 2009); doi:10.1038/nature08583
| Full Text (HTML / PDF) |
letter
In vitro reconstitution of an abscisic acid signalling pathway
Hiroaki Fujii et al.
Nature 462, 660–664
(03 December 2009); doi:10.1038/nature08599
| Full Text (HTML / PDF) |
letter
The abscisic acid receptor PYR1 in complex with abscisic acid
Julia Santiago et al.
Nature 462, 665–668
(03 December 2009); doi:10.1038/nature08591
| Full Text (HTML / PDF) |
news and views
Plant biology: Signal advance for abscisic acid
Laura B. Sheard & Ning Zheng
Nature 462, 575–576
(03 December 2009); doi:10.1038/462575a
| Full Text (HTML / PDF) |
article
Structural insights into the mechanism of abscisic acid signaling by PYL proteins
Ping Yin et al.
Nature Structural & Molecular Biology 16, 1230–1236
(December 2009); doi:10.1038/nsmb.1730
| Summary | Full Text (HTML / PDF) |
November
letter
Dynamic activation of an allosteric regulatory protein
Shiou-Ru Tzeng & Charalampos G. Kalodimos
Nature 462, 368–372
(19 November 2009); doi:10.1038/nature08560
| Full Text (HTML / PDF) |
article
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
Juan José Fung et al.
The EMBO Journal 28, 3315–3328
(November 2009); doi:10.1038/emboj.2009.267
| Summary | Full Text (HTML / PDF) |
October
article
Structural and kinetic determinants of protease substrates
John C Timmer et al.
Nature Structural & Molecular Biology 16, 1101–1108
(October 2009); doi:10.1038/nsmb.1668
| Summary | Full Text (HTML / PDF) |
review
The structural biology of type IV secretion systems
Rémi Fronzes, Peter J. Christie & Gabriel Waksman
Nature Reviews Microbiology 7, 703–714
(October 2009); doi:10.1038/nrmicro2218
| Summary | Full Text (HTML / PDF) |
article
Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1
Valerie Hindie et al.
Nature Chemical Biology 5, 758–764
(October 2009); doi:10.1038/nchembio.208
| Summary | Full Text (HTML / PDF) |
review
Ubiquitin-binding domains — from structures to functions
Ivan Dikic, Soichi Wakatsuki & Kylie J. Walters
Nature Reviews Molecular Cell Biology 10, 659–671
(October 2009); doi:10.1038/nrm2767
| Summary | Full Text (HTML / PDF) |
article
Interactions between lipids and voltage sensor paddles detected with tarantula toxins
Mirela Milescu et al.
Nature Structural & Molecular Biology 16, 1080–1085
(October 2009); doi:10.1038/nsmb.1679
| Summary | Full Text (HTML / PDF) |
September
letter
A dimerization-dependent mechanism drives RAF catalytic activation
Thanashan Rajakulendran, Malha Sahmi, Martin Lefrançois, Frank Sicheri & Marc Therrien
Nature 461, 542–545
(24 September 2009); doi:10.1038/nature08314
| Full Text (HTML / PDF) |
review
Tickets to ride: selecting cargo for clathrin-regulated internalization
Linton M. Traub
Nature Reviews Molecular Cell Biology 10, 583–596
(September 2009); doi:10.1038/nrm2751
| Summary | Full Text (HTML / PDF) |
article
The structural basis of tail-anchored membrane protein recognition by Get3
Agnieszka Mateja et al.
Nature 461, 361–366
(17 September 2009); doi:10.1038/nature08319
| Full Text (HTML / PDF) |
article
Synthetic partial agonists reveal key steps in IP3 receptor activation
Ana M Rossi et al.
Nature Chemical Biology 5, 631–639
(September 2009); doi:10.1038/nchembio.195
| Summary | Full Text (HTML / PDF) |
article
A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9
Firaz Mohideen et al.
Nature Structural & Molecular Biology 16, 945–952
(September 2009); doi:10.1038/nsmb.1648
| Summary | Full Text (HTML / PDF) |
article
Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation
Yang Han, Irina S Moreira, Eneko Urizar, Harel Weinstein & Jonathan A Javitch
Nature Chemical Biology 5, 688–695
(September 2009); doi:10.1038/nchembio.199
| Summary | Full Text (HTML / PDF) |
news and views
A division of labor: asymmetric roles for GPCR subunits in receptor dimers
Peter Zylbergold & Terence E Hébert
Nature Chemical Biology 5, 608–609
(September 2009); doi:10.1038/nchembio0909-608
| Full Text (HTML / PDF) |
letter
Direct observation of the binding state of the kinesin head to the microtubule
Nicholas R. Guydosh & Steven M. Block
Nature 461, 125–128
(03 September 2009); doi:10.1038/nature08259
| Full Text (HTML / PDF) |
August
review
Breaking the chains: structure and function of the deubiquitinases
David Komander, Michael J. Clague & Sylvie Urbé
Nature Reviews Molecular Cell Biology 10, 550–563
(August 2009); doi:10.1038/nrm2731
| Summary | Full Text (HTML / PDF) |
article
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
Sang-Moon Yun et al.
Nature Structural & Molecular Biology 16,
doi:10.1038/nsmb.1628
| Summary | Full Text (HTML / PDF) |
article
Avid interactions underlie the Lys63-linked polyubiquitin binding specificities observed for UBA domains
Joshua J Sims, Aydin Haririnia, Bryan C Dickinson, David Fushman & Robert E Cohen
Nature Structural & Molecular Biology 16,
doi:10.1038/nsmb.1637
| Summary | Full Text (HTML / PDF) |
article
Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
Rafael S Depetris, Jinhua Wu & Stevan R Hubbard
Nature Structural & Molecular Biology 16, 833–839
(August 2009); doi:10.1038/nsmb.1642
| Summary | Full Text (HTML / PDF) |
news and views
Grb-ing hold of insulin signaling
Derek F J Ceccarelli & Frank Sicheri
Nature Structural & Molecular Biology 16, 803–804
(August 2009); doi:10.1038/nsmb0809-803
| Full Text (HTML / PDF) |
article
Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics
Zhiwei Huang et al.
Nature Structural & Molecular Biology 16, 853–860
(August 2009); doi:10.1038/nsmb.1647
| Summary | Full Text (HTML / PDF) |
article
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)
Greg L Hura et al.
Nature Methods 6, 606–612
(August 2009); doi:10.1038/nmeth.1353
| Summary | Full Text (HTML / PDF) |
July
article
Crystal structure of the ATP-gated P2X4 ion channel in the closed state
Toshimitsu Kawate, Jennifer Carlisle Michel, William T. Birdsong & Eric Gouaux
Nature 460, 592–598
(30 July 2009); doi:10.1038/nature08198
| Full Text (HTML / PDF) |
article
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
Eric B. Gonzales, Toshimitsu Kawate & Eric Gouaux
Nature 460, 599–604
(30 July 2009); doi:10.1038/nature08218
| Full Text (HTML / PDF) |
news and views
Structural biology: Trimeric ion-channel design
Shai D. Silberberg & Kenton J. Swartz
Nature 460, 580–581
(July 2009); doi:10.1038/460580a
| Full Text (HTML / PDF) |
article
The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
Ivan Bosanac et al.
Nature Structural & Molecular Biology 16, 691–697
(July 2009); doi:10.1038/nsmb.1632
| Summary | Full Text (HTML / PDF) |
article
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP
Benjamin Bishop et al.
Nature Structural & Molecular Biology 16, 698–703
(July 2009); doi:10.1038/nsmb.1607
| Summary | Full Text (HTML / PDF) |
article
The active form of DNA polymerase V is UmuD'2C–RecA–ATP
Qingfei Jiang, Kiyonobu Karata, Roger Woodgate, Michael M. Cox & Myron F. Goodman
Nature 460, 359–363
(16 July 2009); doi:10.1038/nature08178
| Full Text (HTML / PDF) |
article
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
Suzan H M Rooijakkers et al.
Nature Immunology 10, 721–727
(July 2009); doi:10.1038/ni.1756
| Summary | Full Text (HTML / PDF) |
article
Structure of complement fragment C3b–factor H and implications for host protection by complement regulators
Jin Wu et al.
Nature Immunology 10, 728–733
(July 2009); doi:10.1038/ni.1755
| Summary | Full Text (HTML / PDF) |
June
letter
Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
Lei Chen et al.
Nature 459, 1146–1149
(25 June 2009); doi:10.1038/nature08075
| Full Text (HTML / PDF) |
perspective
It takes two to tango: regulation of G proteins by dimerization
Raphael Gasper, Simon Meyer, Katja Gotthardt, Minhajuddin Sirajuddin & Alfred Wittinghofer
Nature Reviews Molecular Cell Biology 10, 423–429
(June 2009); doi:10.1038/nrm2689
| Summary | Full Text (HTML / PDF) |
brief communication
FTIR analysis of GPCR activation using azido probes
Shixin Ye, Thomas Huber, Reiner Vogel & Thomas P Sakmar
Nature Chemical Biology 5, 397–399
(June 2009); doi:10.1038/nchembio.167
| Summary | Full Text (HTML / PDF) |
letter
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase
Thomas R. M. Barends et al.
Nature 459, 1015–1018
(18 June 2009); doi:10.1038/nature07966
| Full Text (HTML / PDF) |
article
PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity
Angus J M Cameron, Cristina Escribano, Adrian T Saurin, Brenda Kostelecky & Peter J Parker
Nature Structural & Molecular Biology 16, 624–630
(June 2009); doi:10.1038/nsmb.1606
| Summary | Full Text (HTML / PDF) |
letter
Chaperone-mediated pathway of proteasome regulatory particle assembly
Jeroen Roelofs et al.
Nature 459, 861–865
(11 June 2009); doi:10.1038/nature08063
| Full Text (HTML / PDF) |
letter
Hexameric assembly of the proteasomal ATPases is templated through their C termini
Soyeon Park et al.
Nature 459, 866–870
(11 June 2009); doi:10.1038/nature08065
| Full Text (HTML / PDF) |
news and views
Cell biology: The proteasome assembly line
Kiran Madura
Nature 459, 787–788
(11 June 2009); doi:10.1038/459787a
| Full Text (HTML / PDF) |
article
The N-terminal domain of GluR6-subtype glutamate receptor ion channels
Janesh Kumar, Peter Schuck, Rongsheng Jin & Mark L Mayer
Nature Structural & Molecular Biology 16, 631–638
(June 2009); doi:10.1038/nsmb.1613
| Summary | Full Text (HTML / PDF) |
letter
Mechanism of differential control of NMDA receptor activity by NR2 subunits
Marc Gielen, Beth Siegler Retchless, Laetitia Mony, Jon W. Johnson & Pierre Paoletti
Nature 459, 703–707
(04 June 2009); doi:10.1038/nature07993
| Full Text (HTML / PDF) |
analysis
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008
Mayako Michino et al.
Nature Reviews Drug Discovery 8, 455–463
(June 2009); doi:10.1038/nrd2877
| Summary | Full Text (HTML / PDF) |
May
article
Direct measurement of the ionization state of an essential guanine in the hairpin ribozyme
Lu Liu, Joseph W Cottrell, Lincoln G Scott & Martha J Fedor
Nature Chemical Biology 5, 351–357
(May 2009); doi:10.1038/nchembio.156
| Summary | Full Text (HTML / PDF) |
review
Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways
Brenda A. Schulman & J. Wade Harper
Nature Reviews Molecular Cell Biology 10, 319–331
(May 2009); doi:10.1038/nrm2673
| Summary | Full Text (HTML / PDF) |
brief communication
Structural basis for assembly and disassembly of the CRM1 nuclear export complex
Xiuhua Dong, Anindita Biswas & Yuh Min Chook
Nature Structural & Molecular Biology 16, 558–560
(May 2009); doi:10.1038/nsmb.1586
| Summary | Full Text (HTML / PDF) |
news and views
Nuclear transport comes full circle
Erik W Debler, Günter Blobel & André Hoelz
Nature Structural & Molecular Biology 16, 457–459
(May 2009); doi:10.1038/nsmb0509-457
| Full Text (HTML / PDF) |
review
Ion channels versus ion pumps: the principal difference, in principle
David C. Gadsby
Nature Reviews Molecular Cell Biology 10, 344–352
(May 2009); doi:10.1038/nrm2668
| Summary | Full Text (HTML / PDF) |
article
Molecular mimicry of SUMO promotes DNA repair
John Prudden, J Jefferson P Perry, Andrew S Arvai, John A Tainer & Michael N Boddy
Nature Structural & Molecular Biology 16, 509–516
(May 2009); doi:10.1038/nsmb.1582
| Summary | Full Text (HTML / PDF) |
letter
The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex
Beom Seok Park et al.
Nature 458, 1191–1195
(30 April 2009); doi:10.1038/nature07830
| Summary | Full Text (HTML / PDF) |
April
brief communication
Inhibition of Wnt signaling by Dishevelled PDZ peptides
Yingnan Zhang et al.
Nature Chemical Biology 5, 217–219
(April 2009); doi:10.1038/nchembio.152
| Summary | Full Text (HTML / PDF) |
scientific report
NF-κB p52:RelB heterodimer recognizes two classes of κB sites with two distinct modes
Amanda J Fusco et al.
EMBO Reports 10, 152–159
(April 2009); doi:10.1038/embor2008227
| Summary | Full Text (HTML / PDF) |
March
review
ABC transporters: the power to change
Douglas C. Rees, Eric Johnson & Oded Lewinson
Nature Reviews Molecular Cell Biology 10, 218–227
(March 2009); doi:10.1038/nrm2646
| Summary | Full Text (HTML / PDF) |
article
The large conformational changes of Hsp90 are only weakly coupled to ATP hydrolysis
Moritz Mickler, Martin Hessling, Christoph Ratzke, Johannes Buchner & Thorsten Hugel
Nature Structural & Molecular Biology 16, 281–286
(March 2009); doi:10.1038/nsmb.1557
| Summary | Full Text (HTML / PDF) |
article
Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90
Martin Hessling, Klaus Richter & Johannes Buchner
Nature Structural & Molecular Biology 16, 287–293
(March 2009); doi:10.1038/nsmb.1565
| Summary | Full Text (HTML / PDF) |
news and views
Visualizing the twists and turns of a molecular chaperone
Len Neckers, Shinji Tsutsumi & Mehdi Mollapour
Nature Structural & Molecular Biology 16, 235–236
(March 2009); doi:10.1038/nsmb0309-235
| Full Text (HTML / PDF) |
letter
SOAR and the polybasic STIM1 domains gate and regulate Orai channels
Joseph P. Yuan et al.
Nature Cell Biology 11, 337–343
(March 2009); doi:10.1038/ncb1842
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding
Irene Díaz-Moreno et al.
Nature Structural & Molecular Biology 16, 238–246
(March 2009); doi:10.1038/nsmb.1558
| Summary | Full Text (HTML / PDF) |
review
Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
Timothy J. Knowles, Anthony Scott-Tucker, Michael Overduin & Ian R. Henderson
Nature Reviews Microbiology 7, 206–214
(March 2009); doi:10.1038/nrmicro2069
| Summary | Full Text (HTML / PDF) |
February
review
Molecular mechanisms of proteasome assembly
Shigeo Murata, Hideki Yashiroda & Keiji Tanaka
Nature Reviews Molecular Cell Biology 10, 104–115
(February 2009); doi:10.1038/nrm2630
| Summary | Full Text (HTML / PDF) |
letter
The Fas-FADD death domain complex structure unravels signalling by receptor clustering
Fiona L. Scott et al.
Nature 457, 1019–1022
(19 February 2009); doi:10.1038/nature07606
| Summary | Full Text (HTML / PDF) |
review
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Wei Feng & Mingjie Zhang
Nature Reviews Neuroscience 10, 87–99
(February 2009); doi:10.1038/nrn2540
| Summary | Full Text (HTML / PDF) |
January
article
The nature of the globular- to fibrous-actin transition
Toshiro Oda, Mitsusada Iwasa, Tomoki Aihara, Yuichiro Maéda & Akihiro Narita
Nature 457, 441–445
(22 January 2009); doi:10.1038/nature07685
| Summary | Full Text (HTML / PDF) |
news and views
Structural biology: Actin in a twist
Kenneth C. Holmes
Nature 457, 389–390
(22 January 2009); doi:10.1038/457389a
| Full Text (HTML / PDF) |
article
Intersubunit coordination in a homomeric ring ATPase
Jeffrey R. Moffitt, Yann R. Chemla, K. Aathavan, Shelley Grimes, Paul J. Jardine, Dwight L. Anderson & Carlos Bustamante
Nature 457, 446–450
(22 January 2009); doi:10.1038/nature07637
| Summary | Full Text (HTML / PDF) |
news and views
Molecular biology: Concealed enzyme coordination
Elio A. Abbondanzieri & Xiaowei Zhuang
Nature 457, 392–393
(22 January 2009); doi:10.1038/457392a
| Full Text (HTML / PDF) |
review
A three-dimensional view of the molecular machinery of RNA interference
Martin Jinek & Jennifer A. Doudna
Nature 457, 405–412
(22 January 2009); doi:10.1038/nature07755
| Summary | Full Text (HTML / PDF) |
article
The mechanism of pentabromopseudilin inhibition of myosin motor activity
Roman Fedorov et al.
Nature Structural & Molecular Biology 16, 80–88
(January 2009); doi:10.1038/nsmb.1542
| Summary | Full Text (HTML / PDF) |
article
Substrate selection by the proteasome during degradation of protein complexes
Sumit Prakash, Tomonao Inobe, Ace Joseph Hatch & Andreas Matouschek
Nature Chemical Biology 5, 29–36
(January 2009); doi:10.1038/nchembio.130
| Summary | Full Text (HTML / PDF) |
news and views
The proteasome makes sense of mixed signals
Thomas J Wandless
Nature Chemical Biology 5, 3–4
(January 2009); doi:10.1038/nchembio0109-3
| Full Text (HTML / PDF) |
letter
Structural basis for androgen specificity and oestrogen synthesis in human aromatase
Debashis Ghosh, Jennifer Griswold, Mary Erman & Walter Pangborn
Nature 457, 219–223
(08 January 2009); doi:10.1038/nature07614
| Summary | Full Text (HTML / PDF) |
news and views
Structural biology: Anticancer drug target pictured
Michael R. Waterman
Nature 457, 159–160
(08 January 2009); doi:10.1038/457159a
| Full Text (HTML / PDF) |
|
