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Research library: Structures

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article
Type IIA topoisomerase inhibition by a new class of antibacterial agents
Benjamin D. Bax et al.
Nature 466, 935–940
(19 August 2010); doi:10.1038/nature09197
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letter
Crystal structure of the α6β6 holoenzyme of propionyl-coenzyme A carboxylase
Christine S. Huang et al.
Nature 466, 1001–1005
(19 August 2010); doi:10.1038/nature09302
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brief communication
Acute D2 receptor blockade induces rapid, reversible remodeling in human cortical-striatal circuits
Heike Tost et al.
Nature Neuroscience 13, 920–922
(August 2010); doi:10.1038/nn.2572
| Summary | Full Text (HTML / PDF) |

review
ABC proteins in antigen translocation and viral inhibition
David Parcej & Robert Tampé
Nature Chemical Biology 6, 572–580
(August 2010); doi:10.1038/nchembio.410
| Summary | Full Text (HTML / PDF) |

article
An ATP-independent strategy for amide bond formation in antibiotic biosynthesis
Masanori Funabashi et al.
Nature Chemical Biology 6, 581–586
(August 2010); doi:10.1038/nchembio.393
| Summary | Full Text (HTML / PDF) |

perspective
Structure–function relationships of HIV-1 envelope sequence-variable regions refocus vaccine design
Susan Zolla-Pazner & Timothy Cardozo
Nature Reviews Immunology 10, 527–535
(July 2010); doi:10.1038/nri2801
| Summary | Full Text (HTML / PDF) |

article
Determinants of structural and functional plasticity of a widely conserved protease chaperone complex
Melisa Merdanovic et al.
Nature Structural & Molecular Biology 17, 837–843
(July 2010); doi:10.1038/nsmb.1839
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article
Role for the MOV10 RNA helicase in Polycomb-mediated repression of the INK4a tumor suppressor
Selma El Messaoudi-Aubert et al.
Nature Structural & Molecular Biology 17, 862–868
(July 2010); doi:10.1038/nsmb.1824
| Summary | Full Text (HTML / PDF) |

article
An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1
I Scott Ramsey et al.
Nature Structural & Molecular Biology 17, 869–875
(July 2010); doi:10.1038/nsmb.1826
| Summary | Full Text (HTML / PDF) |

article
Dynamic structure of membrane-anchored Arf•GTP
Yizhou Liu, Richard A Kahn & James H Prestegard
Nature Structural & Molecular Biology 17, 876–881
(July 2010); doi:10.1038/nsmb.1853
| Summary | Full Text (HTML / PDF) |

review
Structure-based discovery of antibacterial drugs
Katie J. Simmons, Ian Chopra & Colin W. G. Fishwick
Nature Reviews Microbiology 8, 501–510
(July 2010); doi:10.1038/nrmicro2349
| Summary | Full Text (HTML / PDF) |

article
Structural basis of G protein–coupled receptor–G protein interactions
Jianxin Hu et al.
Nature Chemical Biology 6, 541–548
(July 2010); doi:10.1038/nchembio.385
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article
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans
Andrew R Burns et al.
Nature Chemical Biology 6, 549–557
(July 2010); doi:10.1038/nchembio.380
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article
Structural mechanism of C-type inactivation in K+ channels
Luis G. Cuello, Vishwanath Jogini, D. Marien Cortes & Eduardo Perozo
Nature 466, 203–208
(08 July 2010); doi:10.1038/nature09153
| Summary | Full Text (HTML / PDF) |

letter
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b
Lei Zeng et al.
Nature 466, 258–262
(08 July 2010); doi:10.1038/nature09139
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article
Protein refolding is required for assembly of the type three secretion needle
Ömer Poyraz et al.
Nature Structural & Molecular Biology 17, 788–792
(July 2010); doi:10.1038/nsmb.1822
| Summary | Full Text (HTML / PDF) |

article
Following the intersubunit conformation of the ribosome during translation in real time
Colin Echeverría Aitken & Joseph D Puglisi
Nature Structural & Molecular Biology 17, 793–800
(July 2010); doi:10.1038/nsmb.1828
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article
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor
Albane le Maire et al.
Nature Structural & Molecular Biology 17, 801–807
(July 2010); doi:10.1038/nsmb.1855
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article
Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction
Caroline A Phelan et al.
Nature Structural & Molecular Biology 17, 808–814
(July 2010); doi:10.1038/nsmb.1860
| Summary | Full Text (HTML / PDF) |

article
RNA-mediated displacement of an inhibitory snRNP complex activates transcription elongation
Iván D'Orso & Alan D Frankel
Nature Structural & Molecular Biology 17, 815–821
(July 2010); doi:10.1038/nsmb.1827
| Summary | Full Text (HTML / PDF) |

article
Branched intermediate formation stimulates peptide bond cleavage in protein splicing
Silvia Frutos, Michael Goger, Baldissera Giovani, David Cowburn & Tom W Muir
Nature Chemical Biology 6, 527–533
(July 2010); doi:10.1038/nchembio.371
| Summary | Full Text (HTML / PDF) |

article
Structural basis for the suppression of skin cancers by DNA polymerase η
Timothy D. Silverstein et al.
Nature 465, 1039–1043
(24 June 2010); doi:10.1038/nature09104
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article
Structure and mechanism of human DNA polymerase η
Christian Biertümpfel et al.
Nature 465, 1044–1048
(24 June 2010); doi:10.1038/nature09196
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news and views
DNA repair: How to accurately bypass damage
Suse Broyde & Dinshaw J. Patel
Nature 465, 1023–1024
(24 June 2010); doi:10.1038/4651023a
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review
Signal integration through blending, bolstering and bifurcating of intracellular information
Catherine T Pawson & John D Scott
Nature Structural & Molecular Biology 17, 653–658
(June 2010); doi:10.1038/nsmb.1843
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review
Molecular mechanisms in signal transduction at the membrane
Jay T Groves & John Kuriyan
Nature Structural & Molecular Biology 17, 659–665
(June 2010); doi:10.1038/nsmb.1844
| Summary | Full Text (HTML / PDF) |

review
Post-translational modifications in signal integration
Yonathan Lissanu Deribe, Tony Pawson & Ivan Dikic
Nature Structural & Molecular Biology 17, 666–672
(June 2010); doi:10.1038/nsmb.1842
| Summary | Full Text (HTML / PDF) |

article
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa
Urszula Brykczynska et al.
Nature Structural & Molecular Biology 17, 679–687
(June 2010); doi:10.1038/nsmb.1821
| Summary | Full Text (HTML / PDF) |

letter
The folding cooperativity of a protein is controlled by its chain topology
Elizabeth A. Shank, Ciro Cecconi, Jesse W. Dill, Susan Marqusee & Carlos Bustamante
Nature 465, 637–640
(03 June 2010); doi:10.1038/nature09021
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letter
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases
Bryan H. Schmidt, Alex B. Burgin, Joseph E. Deweese, Neil Osheroff & James M. Berger
Nature 465, 641–644
(03 June 2010); doi:10.1038/nature08974
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news and views
Cell biology: Manipulating proteostasis
Richard N Sifers
Nature Chemical Biology 6, 400–401
(June 2010); doi:10.1038/nchembio.374
| Full Text (HTML / PDF) |

article
G domain dimerization controls dynamin's assembly-stimulated GTPase activity
Joshua S. Chappie, Sharmistha Acharya, Marilyn Leonard, Sandra L. Schmid & Fred Dyda
Nature 465, 435–440
(27 May 2010); doi:10.1038/nature09032
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article
The architecture of respiratory complex I
Rouslan G. Efremov, Rozbeh Baradaran & Leonid A. Sazanov
Nature 465, 441–445
(27 May 2010); doi:10.1038/nature09066
| Full Text (HTML / PDF) |

news and views
Structural biology: Piston drives a proton pump
Tomoko Ohnishi
Nature 465, 428–429
(27 May 2010); doi:10.1038/465428a
| Full Text (HTML / PDF) |

letter
Recognition of a signal peptide by the signal recognition particle
Claudia Y. Janda et al.
Nature 465, 507–510
(27 May 2010); doi:10.1038/nature08870
| Full Text (HTML / PDF) |

brief communication
Structural and mechanistic basis for a new mode of glycosyltransferase inhibition
Thomas Pesnot, Rene Jørgensen, Monica M Palcic & Gerd K Wagner
Nature Chemical Biology 6, 321–323
(May 2010); doi:10.1038/nchembio.343
| Summary | Full Text (HTML / PDF) |

letter
Tracking G-protein-coupled receptor activation using genetically encoded infrared probes
Shixin Ye et al.
Nature 464, 1386–1389
(29 April 2010); doi:10.1038/nature08948
| Full Text (HTML / PDF) |

article
Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex
Ucheor B Choi et al.
Nature Structural & Molecular Biology 17, 318–324
(March 2010); doi:10.1038/nsmb.1763
| Summary | Full Text (HTML / PDF) |

article
Molecular mechanism of the synaptotagmin–SNARE interaction in Ca2+-triggered vesicle fusion
Marija Vrljic et al.
Nature Structural & Molecular Biology 17, 325–331
(March 2010); doi:10.1038/nsmb.1764
| Summary | Full Text (HTML / PDF) |

news and views
Synaptotagmin-SNARE coupling enlightened
Josep Rizo
Nature Structural & Molecular Biology 17, 260–262
(March 2010); doi:10.1038/nsmb0310-260
| Full Text (HTML / PDF) |

article
The PTB domain of ShcA couples receptor activation to the cytoskeletal regulator IQGAP1
Matthew J Smith et al.
The EMBO Journal 29, 884–896
(March 2010); doi:10.1038/emboj.2009.399
| Summary | Full Text (HTML / PDF) |

article
An in vitro translation, selection and amplification system for peptide nucleic acids
Yevgeny Brudno, Michael E Birnbaum, Ralph E Kleiner & David R Liu
Nature Chemical Biology 6, 148–155
(February 2010); doi:10.1038/nchembio.280
| Summary | Full Text (HTML / PDF) |

news and views
Directed evolution: Overcoming biology's limitations
Daniel H Appella
Nature Chemical Biology 6, 87–88
(February 2010); doi:10.1038/nchembio.300
| Full Text (HTML / PDF) |

review
The nuts and bolts of AGC protein kinases
Laura R. Pearce, David Komander & Dario R. Alessi
Nature Reviews Molecular Cell Biology 11, 9–22
(January 2010); doi:10.1038/nrm2822
| Summary | Full Text (HTML / PDF) |

letter
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
Michael P. Bokoch et al.
Nature 463, 108–112
(07 January 2010); doi:10.1038/nature08650
| Full Text (HTML / PDF) |

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Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
Bancinyane L. Sibanda, Dimitri Y. Chirgadze & Tom L. Blundell
Nature 463, 118–121
(07 January 2010); doi:10.1038/nature08648
| Full Text (HTML / PDF) |

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