review How flies get their size: genetics meets physiology
Bruce A. Edgar Nature Reviews Genetics7, 907–916
(December 2006); doi:10.1038/nrg1989
| Summary | Full Text (HTML / PDF) |
article An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells
Tilmann Bürckstümmer, Keiryn L Bennett, Adrijana Preradovic, Gregor Schütze, Oliver Hantschel, Giulio Superti-Furga & Angela Bauch Nature Methods3, 1013–1019
(December 2006); doi:10.1038/nmeth968
| Summary | Full Text (HTML / PDF) |
opinion How many drug targets are there?
John P. Overington, Bissan Al-Lazikani and Andrew L. Hopkins Nature Reviews Drug Discovery5, 993–996
(December 2006); doi:10.1038/nrd2199
| Summary | Full Text (HTML / PDF) |
letter Genomic and functional evolution of the Drosophila melanogaster sperm proteome
Steve Dorus, Scott A Busby, Ursula Gerike, Jeffrey Shabanowitz, Donald F Hunt & Timothy L Karr Nature Genetics38, 1440–1445
(December 2006); doi:10.1038/ng1915
| First paragraph | Full Text (HTML / PDF) |
review Adipocyte differentiation from the inside out
Evan D. Rosen and Ormond A. MacDougald Nature Reviews Molecular Cell Biology7, 885–896
(December 2006); doi:10.1038/nrm2066
| Summary | Full Text (HTML / PDF) |
November
article Genome-wide analysis of estrogen receptor binding sites
Jason S Carroll, Clifford A Meyer, Jun Song, Wei Li, Timothy R Geistlinger, Jérôme Eeckhoute, Alexander S Brodsky, Erika Krasnickas Keeton, Kirsten C Fertuck, Giles F Hall, Qianben Wang, Stefan Bekiranov, Victor Sementchenko, Edward A Fox, Pamela A Silver, Thomas R Gingeras, X Shirley Liu & Myles Brown Nature Genetics38, 1289–1297
(November 2006); doi:10.1038/ng1901
| Summary | Full Text (HTML / PDF) |
article An efficient tandem affinity purification procedure for interaction proteomics in mammalian cells
Tilmann Bürckstümmer, Keiryn L Bennett, Adrijana Preradovic, Gregor Schütze, Oliver Hantschel, Giulio Superti-Furga & Angela Bauch Nature Methods3, 1013–1019
(November 2006); doi:10.1038/nmeth968
| Summary | Full Text (HTML / PDF) |
A protein interaction network for pluripotency of embryonic stem cells
Jianlong Wang, Sridhar Rao, Jianlin Chu, Xiaohua Shen, Dana N. Levasseur, Thorold W. Theunissen and Stuart H. Orkin Nature444, 364–368
(16 November 2006); doi:10.1038/nature05284
| First Paragraph | Full Text (HTML / PDF) |
letter A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling
Adam Friedman and Norbert Perrimon Nature444, 230–234
(09 November 2006); doi:10.1038/nature05280
| First Paragraph | Full Text (HTML / PDF) |
October
article Insights into social insects from the genome of the honeybee Apis mellifera
The Honeybee Genome Sequencing Consortium et al. Nature443, 931–949
(26 October 2006); doi:10.1038/nature05260
| Summary | Full Text (HTML / PDF) |
news and views Genomics: How to make a social insect
Edward O. Wilson Nature443, 919–920
(26 October 2006); doi:10.1038/443919a
| Full Text (HTML / PDF) |
article Analyzing proteome topology and function by automated multidimensional fluorescence microscopy
Walter Schubert, Bernd Bonnekoh, Ansgar J Pommer, Lars Philipsen, Raik Böckelmann, Yanina Malykh, Harald Gollnick, Manuela Friedenberger, Marcus Bode & Andreas W M Dress Nature Biotechnology24, 1270–1278
(2006); doi:10.1038/nbt1250
| Summary | Full Text (HTML / PDF) |
news and views Putting proteins on the map
Robert F Murphy Nature Biotechnology24, 1223–1224
(2006); doi:10.1038/nbt1006-1223
| Summary | Full Text (HTML / PDF) |
commentary Minimizing the risk of reporting false positives in large-scale RNAi screens
Christophe J Echeverri, Philip A Beachy, Buzz Baum, Michael Boutros, Frank Buchholz, Sumit K Chanda, Julian Downward, Jan Ellenberg, Andrew G Fraser, Nir Hacohen, William C Hahn, Aimee L Jackson, Amy Kiger, Peter S Linsley, Lawrence Lum, Yong Ma, Bernard Mathey-Prévôt, David E Root, David M Sabatini, Jussi Taipale, Norbert Perrimon & René Bernards Nature Methods3, 777–779
(2006); doi:10.1038/nmeth1006-777
| Summary | Full Text (HTML / PDF) |
article Genome-wide genetic analysis of polyploidy in yeast
Zuzana Storchová, Amanda Breneman, Jessica Cande, Joshua Dunn, Kendra Burbank, Eileen O'Toole and David Pellman Nature443, 541–547
(05 October 2006); doi:10.1038/nature05178
| Summary | Full Text (HTML / PDF) |
September
perspective High-throughput fluorescence microscopy for systems biology
Rainer Pepperkok and Jan Ellenberg Nature Reviews Molecular Cell Biology7, 690–696
(September 2006); doi:10.1038/nrm1979
| Summary | Full Text (HTML / PDF) |
letter Prevalence of off-target effects in Drosophila RNA interference screens
Yong Ma, Adrian Creanga, Lawrence Lum and Philip A. Beachy Nature443, 359–363
(21 September 2006); doi:10.1038/nature05179
| Summary | Full Text (HTML / PDF) |
August
perspective Proteome chips for whole-organism assays
Li A. Kung and Michael Snyder Nature Reviews Molecular Cell Biology7, 617–622
(August 2006); doi:10.1038/nrm1941
| Summary | Full Text (HTML / PDF) |
article Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice
Pengyuan Liu, Yian Wang, Haris Vikis, Anna Maciag, Daolong Wang, Yan Lu, Yan Liu & Ming You Nature Genetics38, 888–895
(10 August 2006); doi:10.1038/ng1849
| Summary | Full Text (HTML / PDF) |
article Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
Ben Lehner, Catriona Crombie, Julia Tischler, Angelo Fortunato & Andrew G Fraser Nature Genetics38, 896–903
(August 2006); doi:10.1038/ng1844
| Summary | Full Text (HTML / PDF) |
news and views From worm genetic networks to complex human diseases
Howard Bussey, Brenda Andrews & Charles Boone Nature Genetics38, 862–863
(August 2006); doi:10.1038/ng0806-862
| Summary | Full Text (HTML / PDF) |
reviews Standards for systems biology
Alvis Brazma, Maria Krestyaninova and Ugis Sarkans Nature Review Genetics7, 593–605
(August 2006); doi:10.1038/nrg1922
| Summary | Full Text (HTML / PDF) |
article Genome-wide genetic association of complex traits in heterogeneous stock mice
William Valdar, Leah C Solberg, Dominique Gauguier, Stephanie Burnett, Paul Klenerman, William O Cookson, Martin S Taylor, J Nicholas P Rawlins, Richard Mott & Jonathan Flint Nature Genetics38, 879–887
(August 2006); doi:10.1038/ng1840
| Summary | Full Text (HTML / PDF) |
article High-throughput screening methodology for the directed evolution of glycosyltransferases
Amir Aharoni, Karena Thieme, Cecilia P C Chiu, Sabrina Buchini, Luke L Lairson, Hongming Chen, Natalie C J Strynadka, Warren W Wakarchuk & Stephen G Withers Nature Methods3, 609–614
(August 2006); doi:10.1038/nmeth899
| Summary | Full Text (HTML / PDF) |
July
review EGF-ERBB signalling: towards the systems level
Ami Citri and Yosef Yarden Nature Reviews Molecular Cell Biology7, 505–516
(July 2006); doi:10.1038/nrm1962
| Summary | Full Text (HTML / PDF) |
article The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
Mohammed Sebaihia, Brendan W Wren, Peter Mullany, Neil F Fairweather, Nigel Minton, Richard Stabler, Nicholas R Thomson, Adam P Roberts, Ana M Cerdeño-Tárraga, Hongmei Wang, Matthew TG Holden, Anne Wright, Carol Churcher, Michael A Quail, Stephen Baker, Nathalie Bason, Karen Brooks, Tracey Chillingworth, Ann Cronin, Paul Davis, Linda Dowd, Audrey Fraser, Theresa Feltwell, Zahra Hance, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Mark Simmonds, Kim Stevens, Louise Unwin, Sally Whithead, Bruno Dupuy, Gordon Dougan, Bart Barrell & Julian Parkhill Nature Genetics38, 779–786
(25 June 2006); doi:10.1038/ng1830
| First Paragraph | Full Text (HTML / PDF) |
review article Reading protein modifications with interaction domains
Bruce T. Seet, Ivan Dikic, Ming-Ming Zhou and Tony Pawson Nature Reviews Molecular Cell Biology7, 473–483
(July 2006); doi:10.1038/nrm1960
| Summary | Full Text (HTML / PDF) |
review article Genetic defects in the human glycome
Hudson H. Freeze Nature Reviews Genetics7, 537–551
(July 2006); doi:10.1038/nrg1894
| Summary | Full Text (HTML / PDF) |
June
article Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
John R. S. Newman, Sina Ghaemmaghami , Jan Ihmels, David K. Breslow, Matthew Noble, Joseph L. DeRisi and Jonathan S. Weissman Nature441, 840–846
(15 June 2006); doi:10.1038/nature04785
| Summary | Full Text (HTML / PDF) |
article Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics
Neetu Gupta, Bernd Wollscheid, Julian D Watts, Barbara Scheer, Ruedi Aebersold & Anthony L DeFranco Nature Immunology7, 625–633
(June 2006); doi:10.1038/ni1337
| First Paragraph | Full Text (HTML / PDF) |
review article Addressing the problems with life-science databases for traditional uses and systems biology
Stephan Philippi and Jacob Köhler Nature Reviews Genetics7, 482–488
(June 2006); doi:10.1038/nrg1872
| Summary | Full Text (HTML / PDF) |
May
review High–throughput RNAi screening in cultured cells: a user's guide
Christophe J. Echeverri and Norbert Perrimon Nature Reviews Genetics7, 373–384
(May 2006); doi:10.1038/nrg1836
| Summary | Full Text (HTML / PDF) |
article Fluorescent cell barcoding in flow cytometry allows high–throughput drug screening and signaling profiling
Peter O Krutzik, Garry P Nolan Nature Methods3, 361–368
(May 2006); doi:10.1038/nmeth872
| Summary | Full Text (HTML / PDF) |
article Systems biology approaches identify ATF3 as a negative regulator of Toll–like receptor 4
Mark Gilchrist, Vesteinn Thorsson, Bin Li, Alistair G. Rust, Martin Korb, Kathleen Kennedy, Tsonwin Hai, Hamid Bolouri and Alan Aderem Nature441, 173–178
(11 May 2006); doi:10.1038/nature04768
| Summary | Full Text (HTML / PDF) |
review article Mesoderm induction: from caps to chips
David Kimelman Nature Reviews Genetics7, 360–372
(May 2006); doi:10.1038/nrg1837
| Summary | Full Text (HTML / PDF) |
April
review article Multiplexed protein measurement: technologies and applications of protein and antibody arrays
Stephen F. Kingsmore Nature Reviews Drug Discovery5, 310–321
(April 2006); doi:10.1038/nrd2006 Nature Reviews Drug Discovery published online
| Summary | Full Text (HTML / PDF) |
March
letter Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
Nevan J. Krogan, Gerard Cagney, Haiyuan Yu, Gouqing Zhong, Xinghua Guo, Alexandr Ignatchenko, Joyce Li, Shuye Pu, Nira Datta, Aaron P. Tikuisis, Thanuja Punna, José M. Peregrín-Alvarez, Michael Shales, Xin Zhang, Michael Davey, Mark D. Robinson, Alberto Paccanaro, James E. Bray, Anthony Sheung, Bryan Beattie, Dawn P. Richards, Veronica Canadien, Atanas Lalev, Frank Mena, Peter Wong, Andrei Starostine, Myra M. Canete, James Vlasblom, Samuel Wu, Chris Orsi, Sean R. Collins, Shamanta Chandran, Robin Haw, Jennifer J. Rilstone, Kiran Gandi, Natalie J. Thompson, Gabe Musso, Peter St Onge, Shaun Ghanny, Mandy H. Y. Lam, Gareth Butland, Amin M. Altaf-Ul, Shigehiko Kanaya, Ali Shilatifard, Erin O'Shea, Jonathan S. Weissman, C. James Ingles, Timothy R. Hughes, John Parkinson, Mark Gerstein, Shoshana J. Wodak, Andrew Emili and Jack F. Greenblatt Nature440, 637–643
(30 March 2006); doi:10.1038/nature04670
| First Paragraph | Full Text (HTML / PDF) |
review article A visual approach to proteomics
Stephan Nickell, Christine Kofler, Andrew P. Leis and Wolfgang Baumeister Nature Reviews Molecular Cell Biology7, 225–230
(30 March 2006); doi:10.1038/nrm1861
| First Paragraph | Full Text (HTML / PDF) |
article Challenges in deriving high-confidence protein identifications from data gathered by a HUPO plasma proteome collaborative study
David J States, Gilbert S Omenn, Thomas W Blackwell, Damian Fermin, Jimmy Eng, David W Speicher & Samir M Hanash Nature Biotechnology24, 333–338
(March 2006); doi:10.1038/nbt1183
| Summary | Full Text (HTML / PDF) |
letter Human chromosome 11 DNA sequence and analysis including novel gene identification
Todd D. Taylor, Hideki Noguchi, Yasushi Totoki, Atsushi Toyoda, Yoko Kuroki, Ken Dewar, Christine Lloyd, Takehiko Itoh, Tadayuki Takeda, Dae-Won Kim, Xinwei She, Karen F. Barlow, Toby Bloom, Elspeth Bruford, Jean L. Chang, Christina A. Cuomo, Evan Eichler, Michael G. FitzGerald, David B. Jaffe, Kurt LaButti, Robert Nicol, Hong-Seog Park, Christopher Seaman, Carrie Sougnez, Xiaoping Yang, Andrew R. Zimmer, Michael C. Zody, Bruce W. Birren, Chad Nusbaum, Asao Fujiyama, Masahira Hattori, Jane Rogers, Eric S. Lander and Yoshiyuki Sakaki Nature440, 497–500
(23 March 2006); doi:10.1038/nature04632
| Summary | Full Text (HTML / PDF) |
review article Building mammalian signalling pathways with RNAi screens
Jason Moffat and David M. Sabatini Nature Reviews Molecular Cell Biology7, 177–187
(March 2006); doi:10.1038/nrm1860
| Summary | Full Text (HTML / PDF) |
review article Microarray technology: beyond transcript profiling and genotype analysis
Jörg D. Hoheisel Nature Reviews Genetics7, 200–210
(March 2006); doi:10.1038/nrg1809
| Summary | Full Text (HTML / PDF) |
review article Structural systems biology: modelling protein interactions
Patrick Aloy and Robert B. Russell Nature Reviews Molecular Cell Biology7, 188–197
(March 2006); doi:10.1038/nrm1859
| Summary | Full Text (HTML / PDF) |
news and views Pooling in systems biology becomes smart
Nicolas Thierry-Mieg Nature Methods3, 161–162
(March 2006); doi:10.1038/nmeth0306-161
| Full Text (HTML/PDF) |
article A pooling-deconvolution strategy for biological network elucidation
Fulai Jin, Tony Hazbun, Gregory A Michaud, Michael Salcius, Paul F Predki, Stanley Fields and Jing Huang Nature Methods3, 183–189
(March 2006); doi:10.1038/nmeth859
| Abstract | Full Text (HTML/PDF) |
review article The model organism as a system: integrating 'omics' data sets
Andrew R. Joyce and Bernhard Ø. Palsson Nature Reviews Molecular Cell Biology7, 198–210
(March 2006); doi:10.1038/nrm1857
| Summary | Full Text (HTML / PDF) |
review article Genetic susceptibility to coronary artery disease: from promise to progress
Hugh Watkins and Martin Farrall Nature Reviews Genetics7, 163–173
(March 2006); doi:10.1038/nrg1805
| Summary | Full Text (HTML / PDF) |
February
review article Mapping normal and cancer cell signalling networks: towards single-cell proteomics
Jonathan M. Irish, Nikesh Kotecha and Garry P. Nolan
Flow cytometry can be used to map signalling networks in individual cancer cells. This form of 'single-cell proteomics' can reveal important new information about the pathways that are activated in therapy-resistant cells and provide biomarkers for use in diagnosis and determining prognosis. Nature Reviews Cancer6, 146–155
(February 2006); doi:10.1038/nrc1804
| Summary | Full Text (HTML / PDF) |
article Proteome survey reveals modularity of the yeast cell machinery
Anne-Claude Gavin, Patrick Aloy, Paola Grandi, Roland Krause, Markus Boesche, Martina Marzioch, Christina Rau1, Lars Juhl Jensen, Sonja Bastuck, Birgit Dümpelfeld, Angela Edelmann, Marie-Anne Heurtier, Verena Hoffman, Christian Hoefert, Karin Klein, Manuela Hudak, Anne-Marie Michon, Malgorzata Schelder, Markus Schirle, Marita Remor, Tatjana Rudi, Sean Hooper, Andreas Bauer, Tewis Bouwmeester, Georg Casari, Gerard Drewes, Gitte Neubauer, Jens M. Rick, Bernhard Kuster, Peer Bork, Robert B. Russell and Giulio Superti-Furga NatureAdvance online publication
(22 January 2006); doi:10.1038/nature04561
| First Paragraph | Full Text (HTML / PDF) |
protocol Protein-protein interaction assays: eliminating false positive interactions
Tuan N Nguyen and James A Goodrich Nature Methods3, 135–139
(February 2006); doi:10.1038/nmeth0206-135
| Full Text (HTML/PDF) |
letter Functional genomics reveals genes involved in protein secretion and Golgi organization
Frederic Bard, Laetitia Casano, Arrate Mallabiabarrena, Erin Wallace, Kota Saito, Hitoshi Kitayama, Gianni Guizzunti, Yue Hu, Franz Wendler, Ramanuj DasGupta, Norbert Perrimon and Vivek Malhotra Nature439, 604–607
(02 February 2006); doi:10.1038/nature04377
| First Paragraph | Full Text (HTML / PDF) |
review article Literature mining for the biologist: from information retrieval to biological discovery
Lars Juhl Jensen, Jasmin Saric and Peer Bork Nature Reviews Genetics7, 119–129
(February 2006); doi:10.1038/nrg1768
| Summary | Full Text (HTML / PDF) |
January
letter Oncogenic pathway signatures in human cancers as a guide to targeted therapies
Andrea H. Bild, Guang Yao, Jeffrey T. Chang, Quanli Wang, Anil Potti, Dawn Chasse, Mary-Beth Joshi, David Harpole, Johnathan M. Lancaster, Andrew Berchuck, John A. Olson Jr, Jeffrey R. Marks, Holly K. Dressman, Mike West and Joseph R. Nevins Nature439, 353–357
(February 2006); doi:10.1038/nature04296
| First Paragraph | Full Text (HTML / PDF) |
review article Microarray data analysis: from disarray to consolidation and consensus
David B. Allison , Xiangqin Cui, Grier P. Page and Mahyar Sabripour Nature Reviews Genetics7, 55–65
(January 2006); doi:10.1038/nrg1749
| Summary | Full Text (HTML / PDF) |
technical report Lipid microarrays identify key mediators of autoimmune brain inflammation
Jennifer L Kanter, Sirisha Narayana, Peggy P Ho, Ingrid Catz, Kenneth G Warren, Raymond A Sobel, Lawrence Steinman and William H Robinson Nature Medicine12, 138–143
(January 2006); doi:10.1038/nm1344
| Abstract | Full Text (HTML/PDF) |
brief communication Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression
Siew Hong Lam, Yi Lian Wu, Vinsensius B Vega, Lance D Miller, Jan Spitsbergen, Yan Tong, Huiqing Zhan, Kunde R Govindarajan, Serene Lee, Sinnakarupan Mathavan, Karuturi R Krishna Murthy, Donald R Buhler, Edison T Liu and Zhiyuan Gong Nature Biotechnology24, 73–75
(January 2006); doi:10.1038/nbt1169
| First Paragraph | Full Text (HTML/PDF) |
