Research library: Systems biology/High-throughput
2008:
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Other Years: 2004 | 2005 | 2006 | 2007
July
article
Functional immobilization of signaling proteins enables control of stem cell fate
Kristin Alberti et al.
Nature Methods 5, 645–650
(July 2008); doi:10.1038/nmeth.1222
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article
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
Jun Zhu et al.
Nature Genetics 40, 854–861
doi:10.1038/ng.167
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article
Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans
Kwanghun Chung, Matthew M Crane & Hang Lu
Nature Methods 5, 637–643
(July 2008); doi:10.1038/nmeth.1227
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news and views
Microfluidics: streamlining discovery in worm biology
S Elizabeth Hulme, Sergey S Shevkoplyas & Aravinthan Samuel
Nature Methods 5, 589–590
(July 2008); doi:10.1038/nmeth0708-589
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article
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer & Barbara Wold
Nature Methods 5, 621–628
(July 2008); doi:10.1038/nmeth.1226
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news and views
The beginning of the end for microarrays?
Jay Shendure
Nature Methods 5, 585–587
(July 2008); doi:10.1038/nmeth0708-585
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June
letter
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
Helene R. McMurray et al.
Nature 453, 1112–1116
(19 June 2008); doi:10.1038/nature06973
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news and views
Cancer: Deconstructing oncogenesis
Ji Luo & Stephen J. Elledge
Nature 453, 995–996
(19 June 2008); doi:10.1038/453995a
| Full Text (HTML / PDF) |
perspective
The Mouse Tumor Biology database
Debra M. Krupke, Dale A. Begley, John P. Sundberg, Carol J. Bult & Janan T. Eppig
Nature Reviews Cancer 8, 459–465
(June 2008); doi:10.1038/nrc2390
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article
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
Nobutaka Kato et al.
Nature Chemical Biology 4, 347–356
(June 2008); doi:10.1038/nchembio.87
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news and views
Stopping malaria parasites dead in their tracks
Christian D Doerig
Nature Chemical Biology 4, 334–335
(June 2008); doi:10.1038/nchembio0608-3340
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letter
Global control of cell-cycle transcription by coupled CDK and network oscillators
David A. Orlando et al.
Nature 453, 944–947
(12 June 2008); doi:10.1038/nature06955
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article
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
Oliver Schilling & Christopher M Overall
Nature Biotechnology 26, 685–694
(June 2008); doi:10.1038/nbt1408
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news and views
Proteases' prime targets revealed
Scott L Diamond & Doron Greenbaum
Nature Biotechnology 26, 652–653
(June 2008); doi:10.1038/nbt0608-652
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May
letter
Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
Yi Guo et al.
Nature 453, 657–661
(29 May 2008); doi:10.1038/nature06928
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article
Stromal gene expression predicts clinical outcome in breast cancer
Greg Finak et al.
Nature Medicine 14, 518–527
(May 2008); doi:10.1038/nm1764
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perpective
High-throughput kinase profiling as a platform for drug discovery
David M. Goldstein, Nathanael S. Gray & Patrick P. Zarrinkar
Nature Reviews Drug Discovery 7, 391–397
(May 2008); doi:10.1038/nrd2541
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article
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
Andrea Williams et al.
Nature Chemical Biology 5, 295–305
(May 2008); doi:10.1038/nchembio.79
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letter
Hierarchical structure and the prediction of missing links in networks
Aaron Clauset, Cristopher Moore & M. E. J. Newman
Nature 453, 98–101
(1 May 2008); doi:10.1038/nature06830
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news and views
Networks: Teasing out the missing links
Sid Redner
Nature 453, 47–47
(1 May 2008); doi:10.1038/453047a
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letter
Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions
Stavroula Mili, Konstadinos Moissoglu & Ian G. Macara
Nature 453, 115–114
(1 May 2008); doi:10.1038/nature06888
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analysis
An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
Ittai Ben-Porath et al.
Nature Genetics 40, 499–507
(May 2008); doi:10.1038/ng.127
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article
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals
Ina Poser et al.
Nature Methods 5, 409–415
(May 2008); doi:10.1038/nmeth.1199
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article
BAC to the future: functional genomics in mammals
Assen Roguev & Nevan J Krogan
Nature Methods 5, 383–384
(May 2008); doi:10.1038/nmeth0508-383
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April
letter
A deadenylation negative feedback mechanism governs meiotic metaphase arrest
Eulàlia Belloc & Raúl Méndez
Nature 452, 1017–1021
(24 April 2008); doi:10.1038/nature06809
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article
MicroRNAs accurately identify cancer tissue origin
Nitzan Rosenfeld et al.
Nature Biotechnology 26, 462–469
(April 2008); doi:10.1038/nbt1392
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news and views
Cancer biomarker profiling with microRNAs
Stefanie S Jeffrey
Nature Biotechnology 26, 400–401
(April 2008); doi:10.1038/nbt0408-400
| Summary | Full Text (HTML / PDF) |
review
High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology
John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev & Robert Arias
Nature Reviews Drug Discovery 7, 358–368
(April 2008); doi:10.1038/nrd2552
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brief communication
A quantitative analysis software tool for mass spectrometry-based proteomics
Sung Kyu Park, John D Venable, Tao Xu & John R Yates III
Nature Methods 5, 319–322
(April 2008); doi:10.1038/nmeth.1195
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review
Mining the plasma proteome for cancer biomarkers
Samir M. Hanash, Sharon J. Pitteri & Vitor M. Faca
Nature 452, 571–579
(3 April 2008); doi:10.1038/nature06916
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brief communication
Evolutionary plasticity of genetic interaction networks
Julia Tischler, Ben Lehner & Andrew G Fraser
Nature Genetics 40, 390–391
(April 2008); doi:10.1038/ng.114
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article
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
Shuang Chang, Steven M Bray, Zigang Li, Daniela C Zarnescu, Chuan He, Peng Jin & Stephen T Warren
Nature Chemical Biology 4, 256–263
(April 2008); doi:10.1038/nchembio.78
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March
article
Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors
Sergei Romanov et al.
Nature Methods 5, 253–260
(March 2008); doi:10.1038/nmeth.1186
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resources
Large-scale chemical dissection of mitochondrial function
Bridget K Wagner et al.
Nature Biotechnology 26, 343–351
(March 2008); doi:10.1038/nbt1387
| Summary | Full Text (HTML / PDF) |
news and views
A toolkit for the cell's powerhouse
Eric A Schon
Nature Biotechnology 26, 294–296
(March 2008); doi:10.1038/nbt0308-294
| Summary | Full Text (HTML / PDF) |
February
article
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
May H. Han et al.
Nature 451, 1076–1081
(28 February 2008); doi:10.1038/nature06559
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article
A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex
Aude Dupré et al.
Nature Chemical Biology 4, 119–125
(February 2008); doi:10.1038/nchembio.63
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news and views
Small molecule versus DNA repair nanomachine
James T Stivers
Nature Chemical Biology 4, 86–88
(February 2008); doi:10.1038/nchembio0208-86
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article
High-content single-cell drug screening with phosphospecific flow cytometry
Peter O Krutzik, Janelle M Crane, Matthew R Clutter & Garry P Nolan
Nature Chemical Biology 4, 132–142
(February 2008); doi:10.1038/nchembio.2007.59
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scientific report
CARM1 promotes adipocyte differentiation by coactivating PPARγ
Neelu Yadav et al.
EMBO Reports 9, 193–198
(February 2008); doi:10.1038/sj.embor.7401151
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perspective
New surveyor tools for charting microbial metabolic maps
Rainer Breitling, Dennis Vitkup & Michael P. Barrett
Nature Reviews Microbiology 6, 156–161
(February 2008); doi:10.1038/nrmicro1797
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January
letter
A quantitative analysis of kinase inhibitor selectivity
Mazen W Karaman et al.
Nature Biotechnology 26, 127–132
(January 2008); doi:10.1038/nbt1358
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review
Coupling and coordination in gene expression processes: a systems biology view
Suzanne Komili & Pamela A. Silver
Nature Reviews Genetics 9, 38–48
(January 2008); doi:10.1038/nrg2223
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article
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B Yu et al.
Nature Chemical Biology 4, 33–41
(January 2008); doi:10.1038/nchembio.2007.54
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news and views
Small-molecule dissection of BMP signaling
Gregory J Anderson & Deepak Darshan
Nature Chemical Biology 4, 15–16
(January 2008); doi:10.1038/nchembio0108-15
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