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Research library: Systems biology/High-throughput

2009: | December | November | October | September | August | July | June | May | April | March | February | January

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perspective
Next-generation synthetic gene networks
Timothy K Lu, Ahmad S Khalil & James J Collins
Nature Biotechnology 27, 1139–1150
(December 2009); doi:10.1038/nbt.1591
| Summary | Full Text (HTML / PDF) |

review
Synthetic biology: understanding biological design from synthetic circuits
Shankar Mukherji & Alexander van Oudenaarden
Nature Reviews Genetics 10, 859–871
(December 2009); doi:10.1038/nrg2697
| Summary | Full Text (HTML / PDF) |

letter
Cell fate decisions are specified by the dynamic ERK interactome
Alex von Kriegsheim et al.
Nature Cell Biology 11, 1458–1464
(December 2009); doi:10.1038/ncb1994
| Summary | Full Text (HTML / PDF) |

review
Evolution of biomolecular networks — lessons from metabolic and protein interactions
Takuji Yamada & Peer Bork
Nature Reviews Molecular Cell Biology 10, 791–803
(November 2009); doi:10.1038/nrm2787
| Summary | Full Text (HTML / PDF) |

review
NMR spectroscopy brings invisible protein states into focus
Andrew J Baldwin & Lewis E Kay
Nature Chemical Biology 5, 808–814
(November 2009); doi:10.1038/nchembio.238
| Summary | Full Text (HTML / PDF) |

letter
Systems-level dynamic analyses of fate change in murine embryonic stem cells
Rong Lu et al.
Nature 462, 358–362
(19 November 2009); doi:10.1038/nature08575
| Full Text (HTML / PDF) |

article
Visual proteomics of the human pathogen Leptospira interrogans
Martin Beck et al.
Nature Methods 6, 817–823
(November 2009); doi:10.1038/nmeth.1390
| Summary | Full Text (HTML / PDF) |

news and views
Adding a spatial dimension to the proteome
Kay Grünewald
Nature Methods 6, 798–800
(November 2009); doi:10.1038/nmeth1109-798
| Full Text (HTML / PDF) |

article
Emergent bistability by a growth-modulating positive feedback circuit
Cheemeng Tan, Philippe Marguet & Lingchong You
Nature Chemical Biology 5, 842–848
(November 2009); doi:10.1038/nchembio.218
| Summary | Full Text (HTML / PDF) |

review
Computer-aided design of functional protein interactions
Daniel J Mandell & Tanja Kortemme
Nature Chemical Biology 5, 797–807
(November 2009); doi:10.1038/nchembio.251
| Summary | Full Text (HTML / PDF) |

article
Predicting new molecular targets for known drugs
Michael J. Keiser et al.
Nature 462, 175–181
(12 November 2009); doi:10.1038/nature08506
| Full Text (HTML / PDF) |

news and views
Drug discovery: Predicting promiscuity
Andrew L. Hopkins
Nature 462, 167–168
(12 November 2009); doi:10.1038/462167a
| Full Text (HTML / PDF) |

article
An oestrogen-receptor-α-bound human chromatin interactome
Melissa J. Fullwood et al.
Nature 462, 58–64
(05 November 2009); doi:10.1038/nature08497
| Full Text (HTML / PDF) |

letter
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
David A. Barbie et al.
Nature 462, 108–112
(05 November 2009); doi:10.1038/nature08460
| Full Text (HTML / PDF) |

news and views
Cancer: A tumour gene's fatal flaws
Julian Downward
Nature 462, 44–45
(05 November 2009); doi:10.1038/462044a
| Full Text (HTML / PDF) |

article
'Edgetic' perturbation of a C. elegans BCL2 ortholog
Matija Dreze et al.
Nature Methods 6, 843–849
(November 2009); doi:10.1038/nmeth.1394
| Summary | Full Text (HTML / PDF) |

brief communication
A general life-death selection strategy for dissecting protein functions
Po Hien Ear & Stephen W Michnick
Nature Methods 6, 813–816
(November 2009); doi:10.1038/nmeth.1389
| Summary | Full Text (HTML / PDF) |

news and views
You too can play with an edge
Michael Costanzo, Anastasia Baryshnikova, Corey Nislow, Brenda Andrews & Charles Boone
Nature Methods 6, 797–798
(November 2009); doi:10.1038/nmeth1109-797
| Full Text (HTML / PDF) |

perspective
The role of dynamic conformational ensembles in biomolecular recognition
David D Boehr, Ruth Nussinov & Peter E Wright
Nature Chemical Biology 5, 789–796
doi:10.1038/nchembio.232
| Summary | Full Text (HTML / PDF) |

letter
A proteomics approach to discovering natural products and their biosynthetic pathways
Stefanie B Bumpus, Bradley S Evans, Paul M Thomas, Ioanna Ntai & Neil L Kelleher
Nature Biotechnology 27, 951–956
(October 2009); doi:10.1038/nbt.1565
| Summary | Full Text (HTML / PDF) |

article
Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms
Tim van Opijnen, Kip L Bodi & Andrew Camilli
Nature Methods 6, 767–772
(October 2009); doi:10.1038/nmeth.1377
| Summary | Full Text (HTML / PDF) |

article
Sensitive multiplexed analysis of kinase activities and activity-based kinase identification
Kazuishi Kubota et al.
Nature Biotechnology 27, 933–940
(October 2009); doi:10.1038/nbt.1566
| Summary | Full Text (HTML / PDF) |

news and views
Snapshots of kinase activities
Javier Muñoz & Albert J R Heck
Nature Biotechnology 27, 912–913
(October 2009); doi:10.1038/nbt1009-912
| Full Text (HTML / PDF) |

article
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
Hidetaka Kosako et al.
Nature Structural & Molecular Biology 16, 1026–1035
(October 2009); doi:10.1038/nsmb.1656
| Summary | Full Text (HTML / PDF) |

news and views
PORE-ing over ERK substrates
Natalie G Ahn
Nature Structural & Molecular Biology 16, 1004–1005
(October 2009); doi:10.1038/nsmb1009-1004
| Full Text (HTML / PDF) |

brief communication
Proteomics strategy for quantitative protein interaction profiling in cell extracts
Kirti Sharma et al.
Nature Methods 6, 741–744
(October 2009); doi:10.1038/nmeth.1373
| Summary | Full Text (HTML / PDF) |

letter
In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression
Corbin E Meacham, Emily E Ho, Esther Dubrovsky, Frank B Gertler & Michael T Hemann
Nature Genetics 41, 1133–1137
(October 2009); doi:10.1038/ng.451
| Summary | Full Text (HTML / PDF) |

primer
How to visually interpret biological data using networks
Daniele Merico, David Gfeller & Gary D Bader
Nature Biotechnology 27, 921–924
(October 2009); doi:10.1038/nbt.1567
| Summary | Full Text (HTML / PDF) |

review
Systems biology of stem cell fate and cellular reprogramming
Ben D. MacArthur, Avi Ma'ayan & Ihor R. Lemischka
Nature Reviews Molecular Cell Biology 10, 672–681
(October 2009); doi:10.1038/nrm2766
| Summary | Full Text (HTML / PDF) |

letter
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Todd D Prickett et al.
Nature Genetics 41, 1127–1132
(October 2009); doi:10.1038/ng.438
| Summary | Full Text (HTML / PDF) |

article
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression
Marlon Stoeckius et al.
Nature Methods 6, 745–751
(October 2009); doi:10.1038/nmeth.1370
| Summary | Full Text (HTML / PDF) |

brief communication
Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis
Jan L Vinkenborg et al.
Nature Methods 6, 737–740
(October 2009); doi:10.1038/nmeth.1368
| Summary | Full Text (HTML / PDF) |

review
Applying mass spectrometry-based proteomics to genetics, genomics and network biology
Matthias Gstaiger & Ruedi Aebersold
Nature Reviews Genetics 10, 617–627
(September 2009); doi:10.1038/nrg2633
| Summary | Full Text (HTML / PDF) |

review
Neuroproteomics: understanding the molecular organization and complexity of the brain
Alex Bayés & Seth G. N. Grant
Nature Reviews Neuroscience 10, 635–646
(September 2009); doi:10.1038/nrn2701
| Summary | Full Text (HTML / PDF) |

analysis
Genome-wide identification of post-translational modulators of transcription factor activity in human B cells
Kai Wang et al.
Nature Biotechnology 27, 829–837
(September 2009); doi:10.1038/nbt.1563
| Summary | Full Text (HTML / PDF) |

review
Genetics of human gene expression: mapping DNA variants that influence gene expression
Vivian G. Cheung & Richard S. Spielman
Nature Reviews Genetics 10, 595–604
(September 2009); doi:10.1038/nrg2630
| Summary | Full Text (HTML / PDF) |

review
Insights from genomic profiling of transcription factors
Peggy J. Farnham
Nature Reviews Genetics 10, 605–616
(September 2009); doi:10.1038/nrg2636
| Summary | Full Text (HTML / PDF) |

article
Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages
Gabriela Molina et al.
Nature Chemical Biology 5, 680–687
(September 2009); doi:10.1038/nchembio.190
| Summary | Full Text (HTML / PDF) |

perspective
Biology under construction: in vitro reconstitution of cellular function
Allen P. Liu & Daniel A. Fletcher
Nature Reviews Molecular Cell Biology 10, 644–650
(September 2009); doi:10.1038/nrm2746
| Summary | Full Text (HTML / PDF) |

review
Microfluidic devices for measuring gene network dynamics in single cells
Matthew R. Bennett & Jeff Hasty
Nature Reviews Genetics 10, 628–638
(September 2009); doi:10.1038/nrg2625
| Summary | Full Text (HTML / PDF) |

perspective
Systems genetics analysis of cancer susceptibility: from mouse models to humans
David Quigley & Allan Balmain
Nature Reviews Genetics 10, 651–657
(September 2009); doi:10.1038/nrg2617
| Summary | Full Text (HTML / PDF) |

article
A 3D digital atlas of C. elegans and its application to single-cell analyses
Fuhui Long, Hanchuan Peng, Xiao Liu, Stuart K Kim & Eugene Myers
Nature Methods 6, 667–672
(September 2009); doi:10.1038/nmeth.1366
| Summary | Full Text (HTML / PDF) |

news and views
Google 'EarthWorm'
William A Mohler
Nature Methods 6, 635–636
(September 2009); doi:10.1038/nmeth0909-635
| Full Text (HTML / PDF) |

perspective
The Systems Biology Graphical Notation
Nicolas Le Novère et al.
Nature Biotechnology 27, 735–741
(August 2009); doi:10.1038/nbt.1558
| Summary | Full Text (HTML / PDF) |

brief communication
Metabolic network analysis integrated with transcript verification for sequenced genomes
Ani Manichaikul et al.
Nature Methods 6, 589–592
(August 2009); doi:10.1038/nmeth.1348
| Summary | Full Text (HTML / PDF) |

research
Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma
Terri A Addona et al.
Nature Biotechnology 27, 633–641
(July 2009); doi:10.1038/nbt.1546
| Summary | Full Text (HTML / PDF) |

news and views
Biomarker validation by targeted mass spectrometry
Martin McIntosh & Matthew Fitzgibbon
Nature Biotechnology 27, 622–623
(July 2009); doi:10.1038/nbt0709-622
| Full Text (HTML / PDF) |

article
Quantifying biogenic bias in screening libraries
Jérôme Hert, John J Irwin, Christian Laggner, Michael J Keiser & Brian K Shoichet
Nature Chemical Biology 5, 479–483
(July 2009); doi:10.1038/nchembio.180
| Summary | Full Text (HTML / PDF) |

article
Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Sung Wook Chi, Julie B. Zang, Aldo Mele & Robert B. Darnell
Nature 460, 479–486
(23 July 2009); doi:10.1038/nature08170
| Full Text (HTML / PDF) |

article
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Philip L De Jager et al.
Nature Genetics 41, 776–782
(July 2009); doi:10.1038/ng.401
| Summary | Full Text (HTML / PDF) |

research
Quantification of the yeast transcriptome by single-molecule sequencing
Doron Lipson et al.
Nature Biotechnology 27, 652–658
(July 2009); doi:10.1038/nbt.1551
| Summary | Full Text (HTML / PDF) |

review
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
Yan Feng, Timothy J. Mitchison, Andreas Bender, Daniel W. Young & John A. Tallarico
Nature Reviews Drug Discovery 8, 567–578
(July 2009); doi:10.1038/nrd2876
| Summary | Full Text (HTML / PDF) |

letter
Unlimited multistability in multisite phosphorylation systems
Matthew Thomson & Jeremy Gunawardena
Nature 460, 274–277
(09 July 2009); doi:10.1038/nature08102
| Full Text (HTML / PDF) |

article
Phage-encoded combinatorial chemical libraries based on bicyclic peptides
Christian Heinis, Trevor Rutherford, Stephan Freund & Greg Winter
Nature Chemical Biology 5, 502–507
(July 2009); doi:10.1038/nchembio.184
| Summary | Full Text (HTML / PDF) |

news and views
Encoding chemistry
Dario Neri & André W Brändli
Nature Chemical Biology 5, 452–453
(July 2009); doi:10.1038/nchembio0709-452
| Full Text (HTML / PDF) |

brief communication
Protein interaction platforms: visualization of interacting proteins in yeast
Alexa M Schmitz, Monica F Morrison, Akochi O Agunwamba, Max L Nibert & Cammie F Lesser
Nature Methods 6, 500–502
(July 2009); doi:10.1038/nmeth.1337
| Summary | Full Text (HTML / PDF) |

article
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes
Takeshi Ohya et al.
Nature 459, 1091–1097
(25 June 2009); doi:10.1038/nature08107
| Full Text (HTML / PDF) |

news and views
Cell biology: A score for membrane fusion
Ruth N. Collins & Joshua Zimmerberg
Nature 459, 1065–1066
(June 2009); doi:10.1038/4591065a
| Full Text (HTML / PDF) |

letter
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
Gabriele Siegel et al.
Nature Cell Biology 11, 705–716
(June 2009); doi:10.1038/ncb1876
| Summary | Full Text (HTML / PDF) |

news and views
MicroRNA-mediated regulation of synaptic palmitoylation: shrinking fat spines
Damien Carrel & Bonnie L. Firestein
Nature Cell Biology 11, 681–682
(June 2009); doi:10.1038/ncb0609-681
| Full Text (HTML / PDF) |

progress
New insights into the aetiology of colorectal cancer from genome-wide association studies
Albert Tenesa & Malcolm G. Dunlop
Nature Reviews Genetics 10, 353–358
(June 2009); doi:10.1038/nrg2574
| Summary | Full Text (HTML / PDF) |

brief communication
Proteomic analysis of S-nitrosylation and denitrosylation by resin-assisted capture
Michael T Forrester et al.
Nature Biotechnology 27, 557–559
(June 2009); doi:10.1038/nbt.1545
| Summary | Full Text (HTML / PDF) |

review
The second wave of synthetic biology: from modules to systems
Priscilla E. M. Purnick & Ron Weiss
Nature Reviews Molecular Cell Biology 10, 410–422
(June 2009); doi:10.1038/nrm2698
| Summary | Full Text (HTML / PDF) |

review
Detecting gene–gene interactions that underlie human diseases
Heather J Cordell
Nature Reviews Genetics 10, 392–404
(June 2009); doi:10.1038/nrg2579
| Summary | Full Text (HTML / PDF) |

review
High-throughput insertional mutagenesis screens in mice to identify oncogenic networks
Jaap Kool & Anton Berns
Nature Reviews Cancer 9, 389–399
(June 2009); doi:10.1038/nrc2647
| Summary | Full Text (HTML / PDF) |

brief communication
A new screening assay for allosteric inhibitors of cSrc
Jeffrey R Simard et al.
Nature Chemical Biology 5, 394–396
(June 2009); doi:10.1038/nchembio.162
| Summary | Full Text (HTML / PDF) |

letter
Irreversibility of mitotic exit is the consequence of systems-level feedback
Sandra López-Avilés, Orsolya Kapuy, Béla Novák & Frank Uhlmann
Nature 459, 592–595
(28 May 2009); doi:10.1038/nature07984
| Full Text (HTML / PDF) |

article
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line
The FANTOM Consortium & Riken Omics Science Center
Nature Genetics 41, 553–562
(May 2009); doi:10.1038/ng.375
| Summary | Full Text (HTML / PDF) |

article
Diversity-based, model-guided construction of synthetic gene networks with predicted functions
Tom Ellis, Xiao Wang & James J Collins
Nature Biotechnology 27, 465–471
(May 2009); doi:10.1038/nbt.1536
| Summary | Full Text (HTML / PDF) |

news and views
Overpowering the component problem
Matthew R Bennett & Jeff Hasty
Nature Biotechnology 27, 450–451
(May 2009); doi:10.1038/nbt0509-450
| Full Text (HTML / PDF) |

article
Molecular docking and ligand specificity in fragment-based inhibitor discovery
Yu Chen & Brian K Shoichet
Nature Chemical Biology 5, 358–364
(May 2009); doi:10.1038/nchembio.155
| Summary | Full Text (HTML / PDF) |

news and views
Fragment-based drug discovery takes a virtual turn
Maurizio Pellecchia
Nature Chemical Biology 5, 274–275
(May 2009); doi:10.1038/nchembio0509-274
| Full Text (HTML / PDF) |

letter
Modularity of MAP kinases allows deformation of their signalling pathways
Areez Mody, Joan Weiner & Sharad Ramanathan
Nature Cell Biology 11, 484–491
(April 2009); doi:10.1038/ncb1856
| Summary | Full Text (HTML / PDF) |

article
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
Madeleine P Ball et al.
Nature Biotechnology 27, 361–368
(April 2009); doi:10.1038/nbt.1533
| Summary | Full Text (HTML / PDF) |

news and views
Locking in on the human methylome
Benjamin P Berman, Daniel J Weisenberger & Peter W Laird
Nature Biotechnology 27, 341–342
(April 2009); doi:10.1038/nbt0409-341
| Full Text (HTML / PDF) |

perspective
A network view of disease and compound screening
Eric E. Schadt, Stephen H. Friend & David A. Shaywitz
Nature Reviews Drug Discovery 8, 286–295
(April 2009); doi:10.1038/nrd2826
| Summary | Full Text (HTML / PDF) |

article
Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals
Vladimir Litvak et al.
Nature Immunology 10, 437–443
(April 2009); doi:10.1038/ni.1721
| Summary | Full Text (HTML / PDF) |

article
Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation
Jing-Ruey J Yeh et al.
Nature Chemical Biology 5, 236–243
(April 2009); doi:10.1038/nchembio.147
| Summary | Full Text (HTML / PDF) |

research
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma
Vincent W Keng et al.
Nature Biotechnology 27, 264–274
(March 2009); doi:10.1038/nbt.1526
| Summary | Full Text (HTML / PDF) |

news and views
Jump-starting cancer gene discovery
Anthony Uren & Anton Berns
Nature Biotechnology 27, 251–252
(March 2009); doi:10.1038/nbt0309-251
| Full Text (HTML / PDF) |

review
Mapping complex disease traits with global gene expression
William Cookson, Liming Liang, Gonçalo Abecasis, Miriam Moffatt & Mark Lathrop
Nature Reviews Genetics 10, 184–194
(March 2009); doi:10.1038/nrg2537
| Summary | Full Text (HTML / PDF) |

letter
Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival
Nicolas Bidère et al.
Nature 458, 92–96
(March 2009); doi:10.1038/nature07613
| Summary | Full Text (HTML / PDF) |

letter
Transcriptome sequencing to detect gene fusions in cancer
Christopher A. Maher et al.
Nature 458, 97–101
(March 2009); doi:10.1038/nature07638
| Summary | Full Text (HTML / PDF) |

article
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity
Esti Yeger-Lotem et al.
Nature Genetics 41, 316–323
(March 2009); doi:10.1038/ng.337
| Summary | Full Text (HTML / PDF) |

brief communication
Quantitative interaction proteomics using mass spectrometry
Alexander Wepf, Timo Glatter, Alexander Schmidt, Ruedi Aebersold & Matthias Gstaiger
Nature Methods 6, 203–205
(March 2009); doi:10.1038/nmeth.1302
| Summary | Full Text (HTML / PDF) |

review
Stochastic modelling for quantitative description of heterogeneous biological systems
Darren J. Wilkinson
Nature Reviews Genetics 10, 122–133
(February 2009); doi:10.1038/nrg2509
| Summary | Full Text (HTML / PDF) |

review
Protein promiscuity and its implications for biotechnology
Irene Nobeli, Angelo D Favia & Janet M Thornton
Nature Biotechnology 27, 157–167
(February 2009); doi:10.1038/nbt1519
| Summary | Full Text (HTML / PDF) |

analysis
Mechanisms of drug combinations: interaction and network perspectives
Jia Jia et al.
Nature Reviews Drug Discovery 8, 111–128
(February 2009); doi:10.1038/nrd2683
| Summary | Full Text (HTML / PDF) |

letter
Dynamic modularity in protein interaction networks predicts breast cancer outcome
Ian W Taylor et al.
Nature Biotechnology 27, 199–204
(February 2009); doi:10.1038/nbt.1522
| Summary | Full Text (HTML / PDF) |

review
Reconstruction of biochemical networks in microorganisms
Adam M. Feist, Markus J. Herrgård, Ines Thiele, Jennie L. Reed & Bernhard Ø. Palsson
Nature Reviews Microbiology 7, 129–143
(February 2009); doi:10.1038/nrmicro1949
| Summary | Full Text (HTML / PDF) |

brief communication
An in vitro microfluidic approach to generating protein-interaction networks
Doron Gerber, Sebastian J Maerkl & Stephen R Quake
Nature Methods 6, 71–74
(January 2009); doi:10.1038/nmeth.1289
| Summary | Full Text (HTML / PDF) |

perspective
Literature-curated protein interaction datasets
Michael E Cusick et al.
Nature Methods 6, 39–46
(January 2009); doi:10.1038/nmeth.1284
| Summary | Full Text (HTML / PDF) |

brief communication
Peptidase substrates via global peptide profiling
Debarati M Tagore et al.
Nature Chemical Biology 5, 23–25
(January 2009); doi:10.1038/nchembio.126
| Summary | Full Text (HTML / PDF) |

news and views
Metabolomics cuts to the chase to chase the cuts
Matthew Bogyo
Nature Chemical Biology 5, 5–6
(January 2009); doi:10.1038/nchembio0109-5
| Full Text (HTML / PDF) |

letter
Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs
Joseph M Ziegelbauer, Christopher S Sullivan & Don Ganem
Nature Genetics 41, 130–134
(January 2009); doi:10.1038/ng.266
| Summary | Full Text (HTML / PDF) |

news and views
Searching for targets of viral microRNAs
Denise Whitby
Nature Genetics 41, 7–8
(January 2009); doi:10.1038/ng0109-7
| Full Text (HTML / PDF) |

article
High-resolution mapping of copy-number alterations with massively parallel sequencing
Derek Y Chiang et al.
Nature Methods 6, 99–103
(January 2009); doi:10.1038/nmeth.1276
| Summary | Full Text (HTML / PDF) |

letter
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
Jinyan Du et al.
Nature Biotechnology 27, 77–83
(January 2009); doi:10.1038/nbt.1513
| Summary | Full Text (HTML / PDF) |

brief communication
Integrated network analysis platform for protein-protein interactions
Jianmin Wu et al.
Nature Methods 6, 75–77
(January 2009); doi:10.1038/nmeth.1282
| Summary | Full Text (HTML / PDF) |

article
An empirical framework for binary interactome mapping
Kavitha Venkatesan et al.
Nature Methods 6, 83–90
(January 2009); doi:10.1038/nmeth.1280
| Summary | Full Text (HTML / PDF) |

article
An experimentally derived confidence score for binary protein-protein interactions
Pascal Braun et al.
Nature Methods 6, 91–97
(January 2009); doi:10.1038/nmeth.1281
| Summary | Full Text (HTML / PDF) |

resource
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network
Nicolas Simonis et al.
Nature Methods 6, 47–54
(January 2009); doi:10.1038/nmeth.1279
| Summary | Full Text (HTML / PDF) |

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