Research library: Techniques
2007:
December
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December
letter
Isolation of rare circulating tumour cells in cancer patients by microchip technology
Sunitha Nagrath et al.
Nature 450, 1235–1239
(20 December 2007); doi:10.1038/nature06385
| Summary | Full Text (HTML / PDF) |
letter
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes
Marta Fernández-Suárez et al.
Nature Biotechnology 25, 1483–1487
(December 2007); doi:10.1038/nbt1355
| Summary | Full Text (HTML / PDF) |
article
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state
Brian D Brown et al.
Nature Biotechnology 25, 1457–1467
(December 2007); doi:10.1038/nbt1372
| Summary | Full Text (HTML / PDF) |
article
Using expression profiling data to identify human microRNA targets
Jim C Huang et al.
Nature Methods 4, 1045–1049
(December 2007); doi:10.1038/nmeth1130
| Summary | Full Text (HTML / PDF) |
article
Genetically encoded molecules for inducibly inactivating CaV channels
Tingting Yang, Yasir Suhail, Stanislava Dalton, Timothy Kernan & Henry M Colecraft
Nature Chemical Biology 3, 795–804
(December 2007); doi:10.1038/nchembio.2007.42
| Summary | Full Text (HTML / PDF) |
news and views
Chemical genetic modification of Ca2+ channel activity
Michael Nitabach
Nature Chemical Biology 3, 754–755
(December 2007); doi:10.1038/nchembio1207-754
| Full Text (HTML / PDF) |
November
article
In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit
José Luis Royo et al.
Nature Methods 4, 937–942
(November 2007); doi:10.1038/nmeth1107
| Summary | Full Text (HTML / PDF) |
news and views
Pathogens on aspirin: promising research and therapeutic applications
Ohad Gal-Mor & B Brett Finlay
Nature Methods 4, 893–894
(November 2007); doi:10.1038/nmeth1107-893
| Summary | Full Text (HTML / PDF) |
brief communication
Semi-supervised learning for peptide identification from shotgun proteomics datasets
Lukas Käll, Jesse D Canterbury, Jason Weston, William Stafford Noble & Michael J MacCoss
Nature Methods 4, 923–925
(November 2007); doi:10.1038/nmeth1113
| Summary | Full Text (HTML / PDF) |
letter
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
Fumihiko Ishikawa et al.
Nature Biotechnology 25, 1315–1321
(November 2007); doi:10.1038/nbt1350
| Summary | Full Text (HTML / PDF) |
review
Target deconvolution strategies in drug discovery
Georg C. Terstappen, Christina Schlüpen, Roberto Raggiaschi & Giovanni Gaviraghi
Nature Reviews Drug Discovery 6, 891–903
(November 2007); doi:10.1038/nrd2410
| Summary | Full Text (HTML / PDF) |
article
Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system
Jean Livet et al.
Nature 450, 56–62
(1 November 2007); doi:10.1038/nature06293
| Summary | Full Text (HTML / PDF) |
brief communication
A monoclonal antibody for G protein-coupled receptor crystallography
Peter W Day et al.
Nature Methods 4, 927–929
(November 2007); doi:10.1038/nmeth1112
| Summary | Full Text (HTML / PDF) |
article
Comprehensive analysis of diverse ribonucleoprotein complexes
Marlene Oeffinger et al.
Nature Methods 4, 951–956
(November 2007); doi:10.1038/nmeth1101
| Summary | Full Text (HTML / PDF) |
October
letter
Computational design of antibody-affinity improvement beyond in vivo maturation
Shaun M Lippow, K Dane Wittrup, & Bruce Tidor
Nature Biotechnology 25, 1171–1176
(October 2007); doi:10.1038/nbt1336
| Summary | Full Text (HTML / PDF) |
news and views
No free energy lunch
Brian K Shoichet
Nature Biotechnology 25, 1109–1110
(October 2007); doi:10.1038/nbt1007-1109
| Full Text (HTML / PDF) |
review
Mapping protein post-translational modifications with mass spectrometry
Eric S Witze, William M Old, Katheryn A Resing & Natalie G Ahn
Nature Methods 4, 798–806
(October 2007); doi:10.1038/nmeth1100
| Summary | Full Text (HTML / PDF) |
review
Illuminating the metastatic process
Erik Sahai
Nature Reviews Cancer 7, 737–749
(October 2007); doi:10.1038/nrc2229
| Summary | Full Text (HTML / PDF) |
article
Engineering tumors with 3D scaffolds
Claudia Fischbach et al.
Nature Methods 4, 855–860
(October 2007); doi:10.1038/nmeth1085
| Summary | Full Text (HTML / PDF) |
perspective
Activity-based protein profiling for the functional annotation of enzymes
Katherine T Barglow & Benjamin F Cravatt
Nature Methods 4, 822–827
(October 2007); doi:10.1038/nmeth1092
| Summary | Full Text (HTML / PDF) |
perspective
The third dimension bridges the gap between cell culture and live tissue
Francesco Pampaloni, Emmanuel G. Reynaud & Ernst H. K. Stelzer
Nature Reviews Molecular Cell Biology 8, 839–845
(October 2007); doi:10.1038/nrm2236
| Summary | Full Text (HTML / PDF) |
article
High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe
Assen Roguev, Marianna Wiren, Jonathan S Weissman & Nevan J Krogan
Nature Methods 4, 861–866
(October 2007); doi:10.1038/nmeth1098
| Summary | Full Text (HTML / PDF) |
news and views
Fission yeast goes synthetic
Olaf Nielsen
Nature Methods 4, 777–778
(October 2007); doi:10.1038/nmeth1007-777
| Summary | Full Text (HTML / PDF) |
article
Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes
Galia Blum, Georges von Degenfeld, Milton J Merchant, Helen M Blau & Matthew Bogyo
Nature Chemical Biology 3, 668–677
(October 2007); doi:10.1038/nchembio.2007.26
| Summary | Full Text (HTML / PDF) |
September
technical report
A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist
Ian R Wilkinson, Eric Ferrandis, Peter J Artymiuk, Marc Teillot, Chantal Soulard, Caroline Touvay, Sarbendra L Pradhananga, Sue Justice, Zida Wu, Kin C Leung, Christian J Strasburger, Jon R Sayers & Richard J Ross
Nature Medicine 13, 1108–1113
(September 2007); doi:10.1038/nm1610
| Summary | Full Text (HTML / PDF) |
review
Modelling breast cancer: one size does not fit all
Tracy Vargo-Gogola & Jeffrey M. Rosen
Nature Reviews Cancer 7, 659–672
(September 2007); doi:10.1038/nrc2193
| Summary | Full Text (HTML / PDF) |
review
Beyond toothpicks: new methods for isolating mutant bacteria
A. James Link, Ki Jun Jeong & George Georgiou
Nature Reviews Microbiology 5, 680–688
(September 2007); doi:10.1038/nrmicro1715
| Summary | Full Text (HTML / PDF) |
article
An HSV vector system for selection of ligand-gated ion channel modulators
Rahul Srinivasan, Shaohua Huang, Suchita Chaudhry, Adrian Sculptoreanu, David Krisky, Michael Cascio, Peter A Friedman, William C de Groat, Darren Wolfe & Joseph C Glorioso
Nature Methods 4, 733–739
(September 2007); doi:10.1038/nmeth1077
| Summary | Full Text (HTML / PDF) |
news and views
Channeling the worm: microfluidic devices for nematode neurobiology
Shawn Lockery
Nature Methods 4, 691–692
(September 2007); doi:10.1038/nmeth0907-691
| Summary | Full Text (HTML / PDF) |
perspective
Solution NMR of supramolecular complexes: providing new insights into function
Remco Sprangers, Algirdas Velyvis & Lewis E Kay
Nature Methods 4, 697–703
(September 2007); doi:10.1038/nmeth1080
| Summary | Full Text (HTML / PDF) |
letter
Generation of functional multipotent adult stem cells from GPR125+ germline progenitors
Marco Seandel, Daylon James, Sergey V. Shmelkov, Ilaria Falciatori, Jiyeon Kim, Sai Chavala, Douglas S. Scherr, Fan Zhang, Richard Torres, Nicholas W. Gale, George D. Yancopoulos, Andrew Murphy, David M. Valenzuela, Robin M. Hobbs, Pier Paolo Pandolfi & Shahin Rafii
Nature 449, 346–350
(20 September 2007); doi:10.1038/nature06129
| Summary | Full Text (HTML / PDF) |
review
Maximizing mouse cancer models
Kristopher K. Frese & David A. Tuveson
Nature Reviews Cancer 7, 654–658
(September 2007); doi:10.1038/nrc2192
| Summary | Full Text (HTML / PDF) |
technical report
Molecular imaging of Akt kinase activity
Limin Zhang, Kuei C Lee, Mahaveer S Bhojani, Amjad P Khan, Alla Shilman, Eric C Holland, Brian D Ross & Alnawaz Rehemtulla
Nature Medicine 13, 1114–1119
(September 2007); doi:10.1038/nm1608
| Summary | Full Text (HTML / PDF) |
letter
A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Hilde Brems, Magdalena Chmara, Mourad Sahbatou, Ellen Denayer, Koji Taniguchi, Reiko Kato, Riet Somers, Ludwine Messiaen, Sofie De Schepper, Jean-Pierre Yougen Li, D Allan Drummond, Andrew M Sawayama, Christopher D Snow, Jesse D Bloom & Frances H Arnold
Nature Biotechnology 25, 1051–1056
(2007); doi:10.1038/nbt1333
| Summary | Full Text (HTML / PDF) |
article
Genome-wide prediction of matrix attachment regions that increase gene expression in mammalian cells
Pierre-Alain Girod, Duc-Quang Nguyen, David Calabrese, Stefania Puttini, Mélanie Grandjean, Danielle Martinet, Alexandre Regamey, Damien Saugy, Jacques S Beckmann, Philipp Bucher & Nicolas Mermod
Nature Methods 4, 747–753
(2007); doi:10.1038/nmeth1076
| Summary | Full Text (HTML / PDF) |
article
Structural dynamics in the gating ring of cyclic nucleotide-gated ion channels
Justin W Taraska & William N Zagotta
Nature Structural & Molecular Biology 14, 854–860
(September 2007); doi:10.1038/nsmb1281
| Summary | Full Text (HTML / PDF) |
brief communication
Highly efficient somatic-mutation identification using Escherichia coli mismatch-repair detection
Brock A Peters, Zhengyan Kan, Dragan Sebisanovic, Kanan Pujara, Zhiyong Wang, Peter Hong, Bernard Chow, Jeremy Stinson, Victoria E H Carlton, Thinh Q Pham, Howard Stern, Paul Waring, Kenneth J Hillan, David A Eberhard, Frederic de Sauvage, Jianbiao Zheng, Malek Faham & Somasekar Seshagiri
Nature Methods 4, 713–715
(September 2007); doi:10.1038/nmeth1081
| Summary | Full Text (HTML / PDF) |
perspective
Solution NMR of supramolecular complexes: providing new insights into function
Remco Sprangers, Algirdas Velyvis & Lewis E Kay
Nature Methods 4, 697–703
(September 2007); doi:10.1038/nmeth1080
| Summary | Full Text (HTML / PDF) |
August
news and views
Gene expression analysis goes digital
Victor E Velculescu & Kenneth W Kinzler
Nature Biotechnology 25, 878–880
(August 2007); doi:10.1038/nbt0807-878
| Summary | Full Text (HTML / PDF) |
brief communication
Luciferase–YFP fusion tag with enhanced emission for single-cell luminescence imaging
Hideto Hoshino, Yoshihiro Nakajima & Yoshihiro Ohmiya
Nature Methods 4, 637–639
(August 2007); doi:10.1038/nmeth1069
| Summary | Full Text (HTML / PDF) |
brief communication
Red-shifted Renilla reniformis luciferase variants for imaging in living subjects
Andreas Markus Loening, Anna M Wu & Sanjiv Sam Gambhir
Nature Methods 4, 641–643
(August 2007); doi:10.1038/nmeth1070
| Summary | Full Text (HTML / PDF) |
news and views
Bringing bioluminescence into the picture
Atsushi Miyawaki
Nature Methods 4, 616–617
(August 2007); doi:10.1038/nmeth0807-616
| Summary | Full Text (HTML / PDF) |
review
Analysis of protein complexes using mass spectrometry
Anne-Claude Gingras, Matthias Gstaiger, Brian Raught & Ruedi Aebersold
Nature Reviews Molecular Cell Biology 8, 645–654
(August 2007); doi:10.1038/nrm2208
| Summary | Full Text (HTML / PDF) |
perspective
Active-site directed probes to report enzymatic action in the ubiquitin proteasome system
Huib Ovaa
Nature Reviews Cancer 7, 613–620
(August 2007); doi:10.1038/nrc2128
| Summary | Full Text (HTML / PDF) |
news and views
Reprogramming by the numbers
Shin-ichi Nishikawa
Nature Biotechnology 25, 877–878
(August 2007); doi:10.1038/nbt0807-877
| Summary | Full Text (HTML / PDF) |
article
λN-GFP: an RNA reporter system for live-cell imaging
Nathalie Daigle & Jan Ellenberg
Nature Methods 4, 633–636
(August 2007); doi:10.1038/nmeth1065
| Summary | Full Text (HTML / PDF) |
news and views
Chemical biology: Ions illuminated
Christopher J. Chang
Nature 448, 654–660
(9 August 2007); doi:10.1038/448654a
| Full Text (HTML / PDF) |
news and views
Debugging cellular reprogramming
In-Hyun Park & George Q. Daley
Nature Cell Biology 9, 871–873
(August 2007); doi:10.1038/ncb0807-871
| Summary | Full Text (HTML / PDF) |
article
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing
Gordon Robertson, Martin Hirst, Matthew Bainbridge, Misha Bilenky, Yongjun Zhao, Thomas Zeng, Ghia Euskirchen, Bridget Bernier, Richard Varhol, Allen Delaney, Nina Thiessen, Obi L Griffith, Ann He, Marco Marra, Michael Snyder & Steven Jones
Nature Methods 4, 651–657
(August 2007); doi:10.1038/nmeth1068
| Summary | Full Text (HTML / PDF) |
news and views
ChIP-seq: welcome to the new frontier
Elaine R Mardis
Nature Methods 4, 613–614
(August 2007); doi:10.1038/nmeth0807-613
| Summary | Full Text (HTML / PDF) |
article
Matrix and Steiner-triple-system smart pooling assays for high-performance transcription regulatory network mapping
Vanessa Vermeirssen, Bart Deplancke, M Inmaculada Barrasa, John S Reece-Hoyes, H Efsun Arda, Christian A Grove, Natalia J Martinez, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael R Brent & Albertha J M Walhout
Nature Methods 4, 659–664
(August 2007); doi:10.1038/nmeth1063
| Summary | Full Text (HTML / PDF) |
perspective
Image-based chemical screening
Anne E Carpenter
Nature Chemical Biology 3, 461–465
(August 2007); doi:10.1038/nchembio.2007.15
| Summary | Full Text (HTML / PDF) |
review
High-throughput screening assays for the identification of chemical probes
James Inglese, Ronald L Johnson, Anton Simeonov, Menghang Xia, Wei Zheng, Christopher P Austin & Douglas S Auld
Nature Chemical Biology 3, 466–479
(August 2007); doi:10.1038/nchembio.2007.17
| Summary | Full Text (HTML / PDF) |
July
article
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
Hidde L. Ploegh
Nature 448, 435–438
(26 July 2007); doi:10.1038/nature06004
| Summary | Full Text (HTML / PDF) |
article
Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator
Oded Tour, Stephen R Adams, Rex A Kerr, Rene M Meijer, Terrence J Sejnowski, Richard W Tsien & Roger Y Tsien
Nature Chemical Biology 3, 423–431
(July 2007); doi:10.1038/nchembio.2007.4
| Summary | Full Text (HTML / PDF) |
news and views
Calcium channels light up
Eric Green & Ricardo E Dolmetsch
Nature Chemical Biology 3, 369–370
(July 2007); doi:10.1038/nchembio0707-369
| Full Text (HTML / PDF) |
review
Utilizing RNA interference to enhance cancer drug discovery
Elizabeth Iorns, Christopher J. Lord, Nicholas Turner & Alan Ashworth
Nature Reviews Drug Discovery 6, 556–568
(July 2007); doi:10.1038/nrd2355
| Summary | Full Text (HTML / PDF) |
technical report
Tissue-specific and reversible RNA interference in transgenic mice
Ross A Dickins, Katherine McJunkin, Eva Hernando, Prem K Premsrirut, Valery Krizhanovsky, Darren J Burgess, Sang Yong Kim, Carlos Cordon-Cardo, Lars Zender, Gregory J Hannon & Scott W Lowe
Nature Genetics 39, 914–921
(July 2007); doi:10.1038/ng2045
| Summary | Full Text (HTML / PDF) |
technical report
Toward simpler and faster genome-wide mutagenesis in mice
Sen Wu, Guoxin Ying, Qiang Wu & Mario R Capecchi
Nature Genetics 39, 922–930
(July 2007); doi:10.1038/ng2060
| Summary | Full Text (HTML / PDF) |
review
Universal strategies in research and drug discovery based on protein-fragment complementation assays
Stephen W. Michnick, Po Hien Ear, Emily N. Manderson, Ingrid Remy & Eduard Stefan
Nature Reviews Drug Discovery 6, 569–582
(July 2007); doi:10.1038/nrd2311
| Summary | Full Text (HTML / PDF) |
article
Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly
Hiromi Ito, Akihiko Kameyama, Takashi Sato, Masako Sukegawa, Hide-Ki Ishida & Hisashi Narimatsu
Nature Methods 4, 577–582
(July 2007); doi:10.1038/nmeth1050
| Summary | Full Text (HTML / PDF) |
June
brief communication
Engineering synthetic signaling proteins with ultrasensitive input/output control
John E Dueber, Ethan A Mirsky & Wendell A Lim
Nature Biotechnology 25, 660–662
(June 2007); doi:10.1038/nbt1308
| Summary | Full Text (HTML / PDF) |
news and views
Membrane proteins up for grabs
Gunnar von Heijne
Nature Biotechnology 25, 646–647
(June 2007); doi:10.1038/nbt0607-646
| Summary | Full Text (HTML / PDF) |
letter
Decoding global gene expression programs in liver cancer by noninvasive imaging
Eran Segal, Claude B Sirlin, Clara Ooi, Adam S Adler, Jeremy Gollub, Xin Chen, Bryan K Chan, George R Matcuk, Christopher T Barry, Howard Y Chang & Michael D Kuo
Nature Biotechnology 25, 675–680
(June 2007); doi:10.1038/nbt1306
| Summary | Full Text (HTML / PDF) |
letter
A ROCK inhibitor permits survival of dissociated human embryonic stem cells
Kiichi Watanabe, Morio Ueno, Daisuke Kamiya, Ayaka Nishiyama, Michiru Matsumura, Takafumi Wataya, Jun B Takahashi, Satomi Nishikawa, Shin-ichi Nishikawa, Keiko Muguruma & Yoshiki Sasai
Nature Biotechnology 25, 681–686
(June 2007); doi:10.1038/nbt1310
| Summary | Full Text (HTML / PDF) |
letter
Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
Brian J. Yeh, Robert J. Rutigliano, Anrica Deb, Dafna Bar-Sagi & Wendell A. Lim
Nature 447, 596–600
(31 May 2007); doi:10.1038/nature05851
| Summary | Full Text (HTML / PDF) |
review
Unravelling developmental dynamics: transient intervention and live imaging in plants
G. Venugopala Reddy, Sean P. Gordon & Elliot M. Meyerowitz
Nature Reviews Molecular Cell Biology 8, 491–501
(June 2007); doi:10.1038/nrm2188
| Summary | Full Text (HTML / PDF) |
article
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics
Nelly Khidekel, Scott B Ficarro, Peter M Clark, Marian C Bryan, Danielle L Swaney, Jessica E Rexach, Yi E Sun, Joshua J Coon, Eric C Peters & Linda C Hsieh-Wilson
Nature Chemical Biology 3, 339–348
(June 2007); doi:10.1038/nchembio881
| Summary | Full Text (HTML / PDF) |
news and views
A QUICk look at O-GlcNAc dynamics
Lance Wells
Nature Chemical Biology 3, 303–304
(June 2007); doi:10.1038/nchembio0607-303
| Summary | Full Text (HTML / PDF) |
May
perspective
Towards zoomable multidimensional maps of the cell
Zhenjun Hu, Joe Mellor, Jie Wu, Minoru Kanehisa, Joshua M Stuart & Charles DeLisi
Nature Biotechnology 25, 547–554
(May 2007); doi:10.1038/nbt1304
| Summary | Full Text (HTML / PDF) |
article
Chemoselective probes for metabolite enrichment and profiling
Erin E Carlson & Benjamin F Cravatt
Nature Methods 4, 429–435
(May 2007); doi:10.1038/nmeth1038
| Summary | Full Text (HTML / PDF) |
news and views
High-throughput screening flows along
Hicham Fenniri & Ramon Alvarez-Puebla
Nature Chemical Biology 3, 247–249
(May 2007); doi:10.1038/nchembio0507-247
| Summary | Full Text (HTML / PDF) |
article
Image-based multivariate profiling of drug responses from single cells
Lit-Hsin Loo, Lani F Wu & Steven J Altschuler
Nature Methods 4, 445–453
(May 2007); doi:10.1038/nmeth1032
| Summary | Full Text (HTML / PDF) |
brief communication
Ligand interaction scan: a general method for engineering ligand-sensitive protein alleles
Oran Erster, Miriam Eisenstein & Mordechai Liscovitch
Nature Methods 4, 393–395
(May 2007); doi:10.1038/nmeth1046
| Summary | Full Text (HTML / PDF) |
letter
Molecular imaging of hydrogen peroxide produced for cell signaling
Evan W Miller, Orapim Tulyathan, Ehud Y Isacoff & Christopher J Chang
Nature Chemical Biology 3, 263–267
(May 2007); doi:10.1038/nchembio871
| Summary | Full Text (HTML / PDF) |
news and views
Measuring H2O2 produced in response to cell surface receptor activation
Sue Goo Rhee
Nature Chemical Biology 3, 244–246
(May 2007); doi:10.1038/nchembio0507-244
| Summary | Full Text (HTML / PDF) |
brief communication
A yeast two-hybrid smart-pool-array system for protein-interaction mapping
Fulai Jin, Larisa Avramova, Jing Huang & Tony Hazbun
Nature Methods 4, 405–407
(May 2007); doi:10.1038/nmeth1042
| Summary | Full Text (HTML / PDF) |
article
Imaging dynamics of endogenous mitochondrial RNA in single living cells
Takeaki Ozawa, Yutaka Natori, Moritoshi Sato & Yoshio Umezawa
Nature Methods 4, 413–419
(May 2007); doi:10.1038/nmeth1030
| Summary | Full Text (HTML / PDF) |
article
RNA visualization in live bacterial cells using fluorescent protein complementation
Maria Valencia-Burton, Ron M McCullough, Charles R Cantor & Natalia E Broude
Nature Methods 4, 421–427
(May 2007); doi:10.1038/nmeth1023
| Summary | Full Text (HTML / PDF) |
brief communication
A genomic integration method to visualize localization of endogenous mRNAs in living yeast
Liora Haim, Gadi Zipor, Stella Aronov & Jeffrey E Gerst
Nature Methods 4, 409–412
(May 2007); doi:10.1038/nmeth1040
| Summary | Full Text (HTML / PDF) |
news and views
Splitting or stacking fluorescent proteins to visualize mRNA in living cells
Sanjay Tyagi
Nature Methods 4, 391–392
(May 2007); doi:10.1038/nmeth0507-391
| Summary | Full Text (HTML / PDF) |
April
article
Sequence-specific dynamics modulate recognition specificity in WW domains
Tao Peng, John S Zintsmaster, Andrew T Namanja & Jeffrey W Peng
Nature Structural & Molecular Biology 14, 325–331
(April 2007); doi:10.1038/nsmb1207
| Summary | Full Text (HTML / PDF) |
article
Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies
Ralf Kittler, Vineeth Surendranath, Anne-Kristin Heninger, Mikolaj Slabicki, Mirko Theis, Gabriele Putz, Kristin Franke, Antonio Caldarelli, Hannes Grabner, Karol Kozak, Jan Wagner, Effi Rees, Bernd Korn, Corina Frenzel, Christoph Sachse, Birte Sönnichsen, Jie Guo, Janell Schelter, Julja Burchard, Peter S Linsley, Aimee L Jackson, Bianca Habermann & Frank Buchholz
Nature Methods 4, 337–344
(April 2007); doi:10.1038/nmeth1025
| Summary | Full Text (HTML / PDF) |
brief communication
Multiplexed protein detection by proximity ligation for cancer biomarker validation
Simon Fredriksson, William Dixon, Hanlee Ji, Albert C Koong, Michael Mindrinos & Ronald W Davis
Nature Methods 4, 327–329
(April 2007); doi:10.1038/nmeth1020
| Summary | Full Text (HTML / PDF) |
technical report
MRI detection of transcriptional regulation of gene expression in transgenic mice
Batya Cohen, Keren Ziv, Vicki Plaks, Tomer Israely, Vyacheslav Kalchenko, Alon Harmelin, Laura E Benjamin & Michal Neeman
Nature Medicine 13, 498–503
(April 2007); doi:10.1038/nm1497
| Summary | Full Text (HTML / PDF) |
technical report
Molecular imaging of VEGF receptors in angiogenic vasculature with single-chain VEGF-based probes
Marina V Backer, Zoya Levashova, Vimalkumar Patel, Brian T Jehning, Kevin Claffey, Francis G Blankenberg & Joseph M Backer
Nature Medicine 13, 504–509
(April 2007); doi:10.1038/nm1522
| Summary | Full Text (HTML / PDF) |
review
Reporter proteins for in vivo fluorescence without oxygen
Thomas Drepper, Thorsten Eggert, Franco Circolone, Achim Heck, Ulrich Krauß, Jan-Karl Guterl, Marion Wendorff, Aba Losi, Wolfgang Gärtner & Karl-Erich Jaeger
Nature Biotechnology 25, 443–445
(April 2007); doi:10.1038/nbt1293
| Summary | Full Text (HTML / PDF) |
brief communication
Subunit counting in membrane-bound proteins
Maximilian H Ulbrich & Ehud Y Isacoff
Nature Methods 4, 319–321
(April 2007); doi:10.1038/nmeth1024
| Summary | Full Text (HTML / PDF) |
brief communication
Single-molecule analysis of DNA-protein complexes using nanopores
Breton Hornblower, Amy Coombs, Richard D Whitaker, Anatoly Kolomeisky, Stephen J Picone, Amit Meller & Mark Akeson
Nature Methods 4, 315–317
(April 2007); doi:10.1038/nmeth1021
| Summary | Full Text (HTML / PDF) |
article
Unitary permeability of gap junction channels to second messengers measured by FRET microscopy
Victor H Hernandez, Mario Bortolozzi, Vanessa Pertegato, Martina Beltramello, Michele Giarin, Manuela Zaccolo, Sergio Pantano & Fabio Mammano
Nature Methods 4, 353–358
(April 2007); doi:10.1038/nmeth1031
| Summary | Full Text (HTML / PDF) |
March
article
Live dynamic imaging of caveolae pumping targeted antibody rapidly and specifically across endothelium in the lung
Phil Oh, Per Borgström, Halina Witkiewicz, Yan Li, Bengt J Borgström, Adrian Chrastina, Koji Iwata, Kurt R Zinn, Richard Baldwin, Jacqueline E Testa & Jan E Schnitzer
Nature Biotechnology 25, 327–337
(March 2007); doi:10.1038/nbt1292
| Summary | Full Text (HTML / PDF) |
article
Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation
Astrid Jakobs, Jesko Koehnke, Fabian Himstedt, Martin Funk, Bernhard Korn, Matthias Gaestel & Rainer Niedenthal
Nature Methods 4, 245–250
(March 2007); doi:10.1038/nmeth1006
| Summary | Full Text (HTML / PDF) |
review
In search of partners: linking extracellular proteases to substrates
Christopher M. Overall and Carl P. Blobel
Nature Reviews Molecular Cell Biology 8, 245–257
(March 2007); doi:10.1038/nrm2120
| Summary | Full Text (HTML / PDF) |
review
Virus trafficking — learning from single-virus tracking
Boerries Brandenburg and Xiaowei Zhuang
Nature Reviews Microbiology 5, 197–208
(March 2007); doi:10.1038/nrmicro1615
| Summary | Full Text (HTML / PDF) |
letter
High-throughput oncogene mutation profiling in human cancer
Roman K Thomas et al.
Nature Genetics 39, 347 - 351
(March 2007); doi:10.1038/ng1975
| Summary | Full Text (HTML / PDF) |
news and views
The devil is in the DNA
Stephen J Chanock & Gilles Thomas
Nature Genetics 39, 283 - 284
(March 2007); doi:10.1038/ng0307-283
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article
An integrated mass spectrometric and computational framework for the analysis of protein interaction networks
Oliver Rinner, Lukas N. Mueller, Martin Hubálek, Markus Müller, Matthias Gstaiger & Ruedi Aebersold
Nature Biotechnology 25, 345 - 352
(March 2007); doi:10.1038/nbt1289
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brief communication
Small-molecule regulation of zebrafish gene expression
Hanife Esengil, Vicky Chang, John K Mich and James K Chen
Nature Chemical Biology 3, 154 - 155
(March 2007); doi:10.1038/nchembio858
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news and views
Small-molecule switch for zebrafish gene expression
Young-Tae Chang
Nature Chemical Biology 3, 135 - 136
(March 2007); doi:10.1038/nchembio0307-135
| Full Text (HTML / PDF) |
article
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast
Saurabh Paliwal, Pablo A. Iglesias, Kyle Campbell, Zoe Hilioti, Alex Groisman and Andre Levchenko
Nature 446, 46–51
(1 March 2007); doi:10.1038/nature05561
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letter
Chemical rescue of cleft palate and midline defects in conditional GSK-3β mice
Karen J. Liu, Joseph R. Arron, Kryn Stankunas, Gerald R. Crabtree and Michael T. Longaker
Nature 446, 79–82
(1 March 2007); doi:10.1038/nature05557
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February
article
Rapid identification of functionally critical amino acids in a G protein-coupled receptor
Bo Li, Marco Scarselli, Christopher D Knudsen, Soo-Kyung Kim, Kenneth A Jacobson, Sara M McMillin & Jürgen Wess
Nature Methods 4, 169–174
(February 2007); doi:10.1038/nmeth990
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review
Imaging single events at the cell membrane
Jyoti K Jaiswal and Sanford M Simon
Nature Chemical Biology 3, 92–98
(February 2007); doi:10.1038/nchembio855
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January
letter
'Infotaxis' as a strategy for searching without gradients
Massimo Vergassola, Emmanuel Villermaux and Boris I. Shraiman
Nature 445, 406–409
(25 January 2007); doi:10.1038/nature05464
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perspective
The Connectivity Map: a new tool for biomedical research
Justin Lamb
Nature Reviews Cancer 7, 54–60
(January 2007); doi:10.1038/nrc2044
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article
PDGF signaling specificity is mediated through multiple immediate early genes
Jennifer Schmahl, Christopher S Raymond & Philippe Soriano
Nature Genetics 39, 52–60
(January 2007); doi:10.1038/ng1922
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article
Isolation of amniotic stem cell lines with potential for therapy
Paolo De Coppi, Georg Bartsch Jr, M Minhaj Siddiqui, Tao Xu, Cesar C Santos, Laura Perin, Gustavo Mostoslavsky, Angéline C Serre, Evan Y Snyder, James J Yoo, Mark E Furth, Shay Soker & Anthony Atala
Nature Biotechnology 25, 100–106
(January 2007); doi:10.1038/nbt1274
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brief communication
Fast manipulation of cellular cAMP level by light in vivo
Saskia Schröder-Lang, Martin Schwärzel, Reinhard Seifert, Timo Strünker, Suneel Kateriya, Jens Looser, Masakatsu Watanabe, U Benjamin Kaupp, Peter Hegemann & Georg Nagel
Nature Methods 4, 39–42
(January 2007); doi:10.1038/nmeth975
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article
Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation
Peng Lu, Christine Vogel, Rong Wang, Xin Yao & Edward M Marcotte
Nature Biotechnology 25, 117–124
(January 2007); doi:10.1038/nbt1270
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letter
Computational prediction of proteotypic peptides for quantitative proteomics
Parag Mallick, Markus Schirle, Sharon S Chen, Mark R Flory, Hookeun Lee, Daniel Martin, Jeffrey Ranish, Brian Raught, Robert Schmitt, Thilo Werner, Bernhard Kuster & Ruedi Aebersold
Nature Biotechnology 25, 125–131
(January 2007); doi:10.1038/nbt1275
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news and views
Peptides you can count on
John JM Bergeron & Michael Hallett
Nature Biotechnology 25, 61–62
(January 2007); doi:10.1038/nbt0107-61
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article
Imaging cellular network dynamics in three dimensions using fast 3D laser scanning
Werner Göbel, Björn M Kampa & Fritjof Helmchen
Nature Methods 4, 73–79
(January 2007); doi:10.1038/nmeth989
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letter
Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
Jaeki Min, Yun Kyung Kim, Patricia G Cipriani, Mira Kang, Sonya M Khersonsky, Daniel P Walsh, Ji-Young Lee, Sherry Niessen, John R Yates, III, Kristin Gunsalus, Fabio Piano and Young-Tae Chang
Nature Chemical Biology 3, 55–59
(January 2007); doi:10.1038/nchembio833
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letter
Post-translational enzyme activation in an animal via optimized conditional protein splicing
Edmund C Schwartz, Lino Saez, Michael W Young and Tom W Muir
Nature Chemical Biology 3, 50–54
(January 2007); doi:10.1038/nchembio832
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news and views
Shining a light on protein expression in living organisms
Francine B Perler
Nature Chemical Biology 3, 17–18
(January 2007); doi:10.1038/nchembio0107-17
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review
The mouse as a model for human biology: a resource guide for complex trait analysis
Luanne L. Peters, Raymond F. Robledo, Carol J. Bult, Gary A. Churchill, Beverly J. Paigen and Karen L. Svenso
Nature Reviews Genetics 8, 58–69
(January 2007); doi:10.1038/nrg2025
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brief communication
Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization
Sjors H W Scheres, Haixiao Gao, Mikel Valle, Gabor T Herman, Paul P B Eggermont, Joachim Frank & Jose-Maria Carazo
Nature Methods 4, 27–29
(January 2007); doi:10.1038/nmeth992
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