Research library: Techniques
2008:
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July
article
Functional immobilization of signaling proteins enables control of stem cell fate
Kristin Alberti et al.
Nature Methods 5, 645–650
(July 2008); doi:10.1038/nmeth.1222
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brief communication
In vitro whole-organ imaging: 4D quantification of growing mouse limb buds
Marit J Boot et al.
Nature Methods 5, 609–612
(July 2008); doi:10.1038/nmeth.1219
| Summary | Full Text (HTML / PDF) |
article
Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans
Kwanghun Chung, Matthew M Crane & Hang Lu
Nature Methods 5, 637–643
(July 2008); doi:10.1038/nmeth.1227
| Summary | Full Text (HTML / PDF) |
news and views
Microfluidics: streamlining discovery in worm biology
S Elizabeth Hulme, Sergey S Shevkoplyas & Aravinthan Samuel
Nature Methods 5, 589–590
(July 2008); doi:10.1038/nmeth0708-589
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article
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer & Barbara Wold
Nature Methods 5, 621–628
(July 2008); doi:10.1038/nmeth.1226
| Summary | Full Text (HTML / PDF) |
news and views
The beginning of the end for microarrays?
Jay Shendure
Nature Methods 5, 585–587
(July 2008); doi:10.1038/nmeth0708-585
| Full Text (HTML / PDF) |
brief communication
Lifeact: a versatile marker to visualize F-actin
Julia Riedl et al.
Nature Methods 5, 605–607
(July 2008); doi:10.1038/nmeth.1220
| Summary | Full Text (HTML / PDF) |
June
letter
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
Brian G. Fuller et al.
Nature 453, 1132–1136
(19 June 2008); doi:10.1038/nature06923
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article
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
Oliver Schilling & Christopher M Overall
Nature Biotechnology 26, 685–694
(June 2008); doi:10.1038/nbt1408
| Summary | Full Text (HTML / PDF) |
news and views
Proteases' prime targets revealed
Scott L Diamond & Doron Greenbaum
Nature Biotechnology 26, 652–653
(June 2008); doi:10.1038/nbt0608-652
| Summary | Full Text (HTML / PDF) |
article
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel et al.
Nature Methods 5, 561–567
(June 2008); doi:10.1038/nmeth.1213
| Summary | Full Text (HTML / PDF) |
letter
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
Robert K. McGinty, Jaehoon Kim, Champak Chatterjee, Robert G. Roeder & Tom W. Muir
Nature 453, 812–816
(5 June 2008); doi:10.1038/nature06906
| Summary | Full Text (HTML / PDF) |
article
Real-time imaging of the intracellular glutathione redox potential
Marcus Gutscher et al.
Nature Methods 5, 553–559
(June 2008); doi:10.1038/nmeth.1212
| Summary | Full Text (HTML / PDF) |
May
letter
The impact of target site accessibility on the design of effective siRNAs
Hakim Tafer et al.
Nature Biotechnology 26, 578–583
(May 2008); doi:10.1038/nbt1404
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article
Spheroid-based engineering of a human vasculature in mice
Abdullah Alajati et al.
Nature Methods 5, 439–445
(May 2008); doi:10.1038/nmeth.1198
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article
Modeling lymphangiogenesis in a three-dimensional culture system
Françoise Bruyère et al.
Nature Methods 5, 431–437
(May 2008); doi:10.1038/nmeth.1205
| Summary | Full Text (HTML / PDF) |
news and views
Metastasis: two assays explore the two roads traveled
Diane Renee Bielenberg
Nature Methods 5, 384–385
(May 2008); doi:10.1038/nmeth0508-384
| Summary | Full Text (HTML / PDF) |
article
Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
Hari Shroff, Catherine G Galbraith, James A Galbraith & Eric Betzig
Nature Methods 5, 417–423
(May 2008); doi:10.1038/nmeth.1202
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news and views
Super-resolution light microscopy goes live
Mats G L Gustafsson
Nature Methods 5, 385–387
(May 2008); doi:10.1038/nmeth0508-385
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article
Kemp elimination catalysts by computational enzyme design
Daniela Röthlisberger et al.
Nature 453, 190–195
(8 May 2008); doi:10.1038/nature06879
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news and views
Computational biochemistry: Old enzymes, new tricks
Giovanna Ghirlanda
Nature 453, 164–166
(8 May 2008); doi:10.1038/453164a
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article
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals
Ina Poser et al.
Nature Methods 5, 409–415
(May 2008); doi:10.1038/nmeth.1199
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article
BAC to the future: functional genomics in mammals
Assen Roguev & Nevan J Krogan
Nature Methods 5, 383–384
(May 2008); doi:10.1038/nmeth0508-383
| Summary | Full Text (HTML / PDF) |
April
article
MicroRNAs accurately identify cancer tissue origin
Nitzan Rosenfeld et al.
Nature Biotechnology 26, 462–469
(April 2008); doi:10.1038/nbt1392
| Summary | Full Text (HTML / PDF) |
news and views
Cancer biomarker profiling with microRNAs
Stefanie S Jeffrey
Nature Biotechnology 26, 400–401
(April 2008); doi:10.1038/nbt0408-400
| Summary | Full Text (HTML / PDF) |
brief communication
Genetic control of neuronal activity in mice conditionally expressing TRPV1
Benjamin R Arenkiel, Marguerita E Klein, Ian G Davison, Lawrence C Katz & Michael D Ehlers
Nature Methods 5, 299–302
(April 2008); doi:10.1038/nmeth.1190
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news and views
Expanding the toolbox for remote control of neuronal circuits
Thomas Knöpfel
Nature Methods 5, 293–295
(April 2008); doi:10.1038/nmeth0408-293
| Summary | Full Text (HTML / PDF) |
letter
LNA-mediated microRNA silencing in non-human primates
Joacim Elmén et al.
Nature 452, 896–899
(17 April 2008); doi:10.1038/nature06783
| Summary | Full Text (HTML / PDF) |
article
Photochemical control of endogenous ion channels and cellular excitability
Doris L Fortin et al.
Nature Methods 5, 331–338
(April 2008); doi:10.1038/nmeth.1187
| Summary | Full Text (HTML / PDF) |
brief communication
A quantitative analysis software tool for mass spectrometry-based proteomics
Sung Kyu Park, John D Venable, Tao Xu & John R Yates III
Nature Methods 5, 319–322
(April 2008); doi:10.1038/nmeth.1195
| Summary | Full Text (HTML / PDF) |
review
Imaging in the era of molecular oncology
Ralph Weissleder & Mikael J. Pittet
Nature 452, 580–589
(3 April 2008); doi:10.1038/nature06917
| Summary | Full Text (HTML / PDF) |
article
Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer
Gisela D Cymes & Claudio Grosman
Nature Structural & Molecular Biology 15, 389–396
(April 2008); doi:10.1038/nsmb.1407
| Summary | Full Text (HTML / PDF) |
article
Direct measurement of protein dynamics inside cells using a rationally designed photoconvertible protein
Tomoki Matsuda, Atsushi Miyawaki & Takeharu Nagai
Nature Methods 5, 339–345
(April 2008); doi:10.1038/nmeth.1193
| Summary | Full Text (HTML / PDF) |
March
article
Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors
Sergei Romanov et al.
Nature Methods 5, 253–260
(March 2008); doi:10.1038/nmeth.1186
| Summary | Full Text (HTML / PDF) |
review
Synthetic fluorescent sensors for studying the cell biology of metals
Dylan W Domaille, Emily L Que & Christopher J Chang
Nature Chemical Biology 4, 168–175
(March 2008); doi:10.1038/nchembio.69
| Summary | Full Text (HTML / PDF) |
resources
Large-scale chemical dissection of mitochondrial function
Bridget K Wagner et al.
Nature Biotechnology 26, 343–351
(March 2008); doi:10.1038/nbt1387
| Summary | Full Text (HTML / PDF) |
news and views
A toolkit for the cell's powerhouse
Eric A Schon
Nature Biotechnology 26, 294–296
(March 2008); doi:10.1038/nbt0308-294
| Summary | Full Text (HTML / PDF) |
review
Synthetic fluorescent sensors for studying the cell biology of metals
Dylan W Domaille, Emily L Que & Christopher J Chang
Nature Chemical Biology 4, 168–175
(March 2008); doi:10.1038/nchembio.69
| Summary | Full Text (HTML / PDF) |
brief communication
Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene
Aytekin Akyol, Takao Hinoi, Ying Feng, Guido T Bommer, Thomas M Glaser & Eric R Fearon
Nature Methods 5, 231–233
(March 2008); doi:10.1038/nmeth.1182
| Summary | Full Text (HTML / PDF) |
news and views
Harnessing mismatch repair to model sporadic cancers
Richard Fishel & Joanna Groden
Nature Methods 5, 225–226
(March 2008); doi:10.1038/nmeth0308-225
| Summary | Full Text (HTML / PDF) |
February
brief communication
A secreted luciferase for ex vivo monitoring of in vivo processes
Thomas Wurdinger et al.
Nature Methods 5, 171–173
(February 2008); doi:10.1038/nmeth.1177
| Summary | Full Text (HTML / PDF) |
letter
Fluorogen-activating single-chain antibodies for imaging cell surface proteins
Christopher Szent-Gyorgyi et al.
Nature Biotechnology 26, 235–240
(February 2008); doi:10.1038/nbt1368
| Summary | Full Text (HTML / PDF) |
brief communication
Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies
Xiaodong Zhang et al.
Nature Methods 5, 163–165
(February 2008); doi:10.1038/nmeth1170
| Summary | Full Text (HTML / PDF) |
review
New approaches for imaging tumour responses to treatment
Kevin Brindle
Nature Reviews Cancer 8, 94–107
(February 2008); doi:10.1038/nrc2289
| Summary | Full Text (HTML / PDF) |
review
Protein production and purification
Structural Genomics Consortium et al.
Nature Methods 5, 135–146
(February 2008); doi:10.1038/nmeth.f.202
| Summary | Full Text (HTML / PDF) |
brief communication
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
Masayuki Kai et al.
Nature Biotechnology 26, 209–211
(February 2008); doi:10.1038/nbt1376
| Summary | Full Text (HTML / PDF) |
article
High-content single-cell drug screening with phosphospecific flow cytometry
Peter O Krutzik, Janelle M Crane, Matthew R Clutter & Garry P Nolan
Nature Chemical Biology 4, 132–142
(February 2008); doi:10.1038/nchembio.2007.59
| Summary | Full Text (HTML / PDF) |
brief communication
High-density mapping of single-molecule trajectories with photoactivated localization microscopy
Suliana Manley et al.
Nature Methods 5, 155–157
(February 2008); doi:10.1038/nmeth.1176
| Summary | Full Text (HTML / PDF) |
brief communication
Highly inclined thin illumination enables clear single-molecule imaging in cells
Makio Tokunaga, Naoko Imamoto & Kumiko Sakata-Sogawa
Nature Methods 5, 159–161
(February 2008); doi:10.1038/nmeth1171
| Summary | Full Text (HTML / PDF) |
news and views
How the sum of its parts gets greater than the whole
Mario Brameshuber & Gerhard J Schütz
Nature Methods 5, 133–134
(February 2008); doi:10.1038/nmeth0208-133
| Summary | Full Text (HTML / PDF) |
January
letter
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Masato Nakagawa et al.
Nature Biotechnology 26, 101–106
(January 2008); doi:10.1038/nbt1374
| Summary | Full Text (HTML / PDF) |
news and views
Simpler and safer cell reprogramming
Martin F Pera & Kouichi Hasegawa
Nature Biotechnology 26, 59–60
(January 2008); doi:10.1038/nbt0108-59
| Summary | Full Text (HTML / PDF) |
article
Tracking transmitter-gated P2X cation channel activation in vitro and in vivo
Esther Richler et al.
Nature Methods 5, 87–93
(January 2008); doi:10.1038/nmeth1144
| Summary | Full Text (HTML / PDF) |
article
CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand
David Depoil et al.
Nature Immunology 9, 63–72
(January 2008); doi:10.1038/ni1547
| Summary | Full Text (HTML / PDF) |
review
Live-cell imaging of cAMP dynamics
Debbie Willoughby & Dermot M F Cooper
Nature Methods 5, 29–36
(January 2008); doi:10.1038/nmeth1135
| Summary | Full Text (HTML / PDF) |
article
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B Yu et al.
Nature Chemical Biology 4, 33–41
(January 2008); doi:10.1038/nchembio.2007.54
| Summary | Full Text (HTML / PDF) |
news and views
Small-molecule dissection of BMP signaling
Gregory J Anderson & Deepak Darshan
Nature Chemical Biology 4, 15–16
(January 2008); doi:10.1038/nchembio0108-15
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