Research library: Techniques
2010:
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August
technical report
A molecularly engineered split reporter for imaging protein-protein interactions with positron emission tomography
Tarik F Massoud, Ramasamy Paulmurugan & Sanjiv S Gambhir
Nature Medicine 16, 921–926
(August 2010); doi:10.1038/nm.2185
| Summary | Full Text (HTML / PDF) |
letter
Microbial metalloproteomes are largely uncharacterized
Aleksandar Cvetkovic et al.
Nature 466, 779–782
(05 August 2010); doi:10.1038/nature09265
| Full Text (HTML / PDF) |
July
technical report
Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos
Slobodan Beronja, Geulah Livshits, Scott Williams & Elaine Fuchs
Nature Medicine 16, 821–827
(July 2010); doi:10.1038/nm.2167
| Summary | Full Text (HTML / PDF) |
article
A paired-end sequencing strategy to map the complex landscape of transcription initiation
Ting Ni et al.
Nature Methods 7, 521–527
(July 2010); doi:10.1038/nmeth.1464
| Summary | Full Text (HTML / PDF) |
news and views
Illuminating eukaryotic transcription start sites
John A Stamatoyannopoulos
Nature Methods 7, 501–503
(July 2010); doi:10.1038/nmeth0710-501
| Full Text (HTML / PDF) |
article
Enhanced neuronal RNAi in C. elegans using SID-1
Andrea Calixto, Dattananda Chelur, Irini Topalidou, Xiaoyin Chen & Martin Chalfie
Nature Methods 7, 554–559
(July 2010); doi:10.1038/nmeth.1463
| Summary | Full Text (HTML / PDF) |
article
Membrane targeting mechanism of Rab GTPases elucidated by semisynthetic protein probes
Yao-Wen Wu et al.
Nature Chemical Biology 6, 534–540
(July 2010); doi:10.1038/nchembio.386
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article
Imaging the nanoscale organization of peptidoglycan in living Lactococcus lactis cells
Guillaume Andre et al.
Nature Communications 1, 1–8
(June 2010); doi:10.1038/ncomms1027
| Summary | Full Text (HTML / PDF) |
letter
Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics
Carsten Grashoff et al.
Nature 466, 263–266
(08 July 2010); doi:10.1038/nature09198
| Summary | Full Text (HTML / PDF) |
news and views
Cell biology: Sensing tension
Andrew D. Doyle & Kenneth M. Yamada
Nature 466, 192–193
(08 July 2010); doi:10.1038/466192a
| Full Text (HTML / PDF) |
letter
Single-cell NF-κB dynamics reveal digital activation and analogue information processing
Savaş Tay et al.
Nature 466, 267–271
(08 July 2010); doi:10.1038/nature09145
| Summary | Full Text (HTML / PDF) |
research
Rationalizing the development of live attenuated virus vaccines
Adam S Lauring, Jeremy O Jones & Raul Andino
Nature Biotechnology 28, 573–579
(June 2010); doi:10.1038/nbt.1635
| Summary | Full Text (HTML / PDF) |
brief communication
Proteome-wide analysis of protein carboxy termini: C terminomics
Oliver Schilling, Olivier Barré, Pitter F Huesgen & Christopher M Overall
Nature Methods 7, 508–511
(July 2010); doi:10.1038/nmeth.1467
| Summary | Full Text (HTML / PDF) |
brief communication
Complementary positional proteomics for screening substrates of endo- and exoproteases
Petra Van Damme et al.
Nature Methods 7, 512–515
(July 2010); doi:10.1038/nmeth.1469
| Summary | Full Text (HTML / PDF) |
June
review
Decoding signalling networks by mass spectrometry-based proteomics
Chunaram Choudhary & Matthias Mann
Nature Reviews Molecular Cell Biology 11, 427–439
(June 2010); doi:10.1038/nrm2900
| Summary | Full Text (HTML / PDF) |
review
Spatial organization of intracellular communication: insights from imaging
Leif Dehmelt & Philippe I. H. Bastiaens
Nature Reviews Molecular Cell Biology 11, 440–452
(June 2010); doi:10.1038/nrm2903
| Summary | Full Text (HTML / PDF) |
brief communication
Targeted gene deletions in C. elegans using transposon excision
Christian Frøkjær-Jensen et al.
Nature Methods 7, 451–453
(June 2010); doi:10.1038/nmeth.1454
| Summary | Full Text (HTML / PDF) |
news and views
Knock it down, switch it on
Jean-Louis Bessereau
Nature Methods 7, 439–441
(June 2010); doi:10.1038/nmeth0610-439
| Full Text (HTML / PDF) |
article
Fluidic supramolecular nano- and microfibres as molecular rails for regulated movement of nanosubstances
Shun-ichi Tamaru et al.
Nature Communications 1, 1–7
(May 2010); doi:10.1038/ncomms1018
| Summary | Full Text (HTML / PDF) |
review
Designing customized cell signalling circuits
Wendell A. Lim
Nature Reviews Molecular Cell Biology 11, 393–403
(June 2010); doi:10.1038/nrm2904
| Summary | Full Text (HTML / PDF) |
article
Direct detection of DNA methylation during single-molecule, real-time sequencing
Benjamin A Flusberg et al.
Nature Methods 7, 461–465
(June 2010); doi:10.1038/nmeth.1459
| Summary | Full Text (HTML / PDF) |
article
In situ analysis of tyrosine phosphorylation networks by FLIM on cell arrays
Hernán E Grecco et al.
Nature Methods 7, 467–472
(June 2010); doi:10.1038/nmeth.1458
| Summary | Full Text (HTML / PDF) |
article
Metabolic oxidation regulates embryonic stem cell differentiation
Oscar Yanes et al.
Nature Chemical Biology 6, 411–417
(June 2010); doi:10.1038/nchembio.364
| Summary | Full Text (HTML / PDF) |
May
letter
A proximity-based programmable DNA nanoscale assembly line
Hongzhou Gu, Jie Chao, Shou-Jun Xiao & Nadrian C. Seeman
Nature 465, 202–205
(13 May 2010); doi:10.1038/nature09026
| Full Text (HTML / PDF) |
letter
Molecular robots guided by prescriptive landscapes
Kyle Lund et al.
Nature 465, 206–210
(13 May 2010); doi:10.1038/nature09012
| Full Text (HTML / PDF) |
news and views
Nanotechnology: Molecular robots on the move
Lloyd M. Smith
Nature 465, 167–168
(13 May 2010); doi:10.1038/465167a
| Full Text (HTML / PDF) |
review
Spatial organization and signal transduction at intercellular junctions
Boryana N. Manz & Jay T. Groves
Nature Reviews Molecular Cell Biology 11, 342–352
(May 2010); doi:10.1038/nrm2883
| Summary | Full Text (HTML / PDF) |
article
Electron tomography reveals unbranched networks of actin filaments in lamellipodia
Edit Urban, Sonja Jacob, Maria Nemethova, Guenter P. Resch & J. Victor Small
Nature Cell Biology 12, 429–435
(May 2010); doi:10.1038/ncb2044
| Summary | Full Text (HTML / PDF) |
February
article
Systems analysis of EGF receptor signaling dynamics with microwestern arrays
Mark F Ciaccio, Joel P Wagner, Chih-Pin Chuu, Douglas A Lauffenburger & Richard B Jones
Nature Methods 7, 148–155
(February 2010); doi:10.1038/nmeth.1418
| Summary | Full Text (HTML / PDF) |
brief communication
FRT-seq: amplification-free, strand-specific transcriptome sequencing
Lira Mamanova et al.
Nature Methods 7, 130–132
(February 2010); doi:10.1038/nmeth.1417
| Summary | Full Text (HTML / PDF) |
review
Target-enrichment strategies for next-generation sequencing
Lira Mamanova et al.
Nature Methods 7, 111–118
(February 2010); doi:10.1038/nmeth.1419
| Summary | Full Text (HTML / PDF) |
brief communication
Two-color, two-photon uncaging of glutamate and GABA
Srinivas Kantevari, Masanori Matsuzaki, Yuya Kanemoto, Haruo Kasai & Graham C R Ellis-Davies
Nature Methods 7, 123–125
(February 2010); doi:10.1038/nmeth.1413
| Summary | Full Text (HTML / PDF) |
January
article
Integrated analysis of receptor activation and downstream signaling with EXTassays
Anna Botvinnik, Sven P Wichert, Tobias M Fischer & Moritz J Rossner
Nature Methods 7, 74–80
(January 2010); doi:10.1038/nmeth.1407
| Summary | Full Text (HTML / PDF) |
article
Automatic policing of biochemical annotations using genomic correlations
Tzu-Lin Hsiao, Olga Revelles, Lifeng Chen, Uwe Sauer & Dennis Vitkup
Nature Chemical Biology 6, 34–40
(January 2010); doi:10.1038/nchembio.266
| Summary | Full Text (HTML / PDF) |
news and views
Biochemical networks: The evolution of gene annotation
Simon Kasif & Martin Steffen
Nature Chemical Biology 6, 4–5
(January 2010); doi:10.1038/nchembio.288
| Full Text (HTML / PDF) |
article
Engineering a polarity-sensitive biosensor for time-lapse imaging of apoptotic processes and degeneration
Yujin E Kim, Jeannie Chen, Jonah R Chan & Ralf Langen
Nature Methods 7, 67–73
(January 2010); doi:10.1038/nmeth.1405
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