article Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3
Stephen B Ting, Tomasz Wilanowski, Alana Auden, Mark Hall, Anne K Voss, Tim Thomas, Vishwas Parekh, John M Cunningham and Stephen M Jane Nature Medicine9, 1513–1519
(December 2003); doi:10.1038/nm961
| Abstract | Full Text (HTML/PDF) |
article Deletion of β-catenin impairs T cell development
Youyuan Xu, Daliya Banerjee, Joerg Huelsken, Walter Birchmeier and Jyoti Misra Sen Nature Immunology4, 1177–1182
(December 2003); doi:10.1038/ni1008
| Abstract | Full Text (HTML/PDF) |
article Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells
Karen W Makar, Mercedes Pérez-Melgosa, Maria Shnyreva, William M Weaver, David R Fitzpatrick and Christopher B Wilson Nature Immunology4, 1183–1190
(December 2003); doi:10.1038/ni1004
| Abstract | Full Text (HTML/PDF) |
article Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development
Akihiro Nishida, Akiko Furukawa, Chieko Koike, Yasuo Tano, Shinichi Aizawa, Isao Matsuo and Takahisa Furukawa Nature Neuroscience6, 1255–1263
(December 2003); doi:10.1038/nn1155
| Abstract | Full Text (HTML/PDF) |
November
letters to nature An ancient role for nuclear β-catenin in the evolution of axial polarity and germ layer segregation
Athula H. Wikramanayake, Melanie Hong, Patricia N. Lee, Kevin Pang, Christine A. Byrum, Joanna M. Bince, Ronghui Xu and Mark Q. Martindale Nature426, 446–450
(27 November 2003); doi:10.1038/nature02113
| First Paragraph | Full Text (HTML / PDF) |
review article AP-1: a double-edged sword in tumorigenesis
Robert Eferl and Erwin F. Wagner Nature Reviews Cancer3, 859–868
(November 2003); doi:10.1038/nrc1209
| Abstract | Full Text (HTML / PDF) |
review article The genetic and molecular basis of congenital eye defects
Jochen Graw Nature Reviews Genetics4, 876–888
(November 2003); doi:10.1038/nrg1202
| Abstract | Full Text (HTML / PDF) |
article Vertebrate neurogenesis is counteracted by Sox1-3 activity
Magdalena Bylund, Elisabeth Andersson, Bennett G Novitch and Jonas Muhr Nature Neuroscience6, 1162–1168
(November 2003); doi:10.1038/nn1131
| Abstract | Full Text (HTML/PDF) |
news and views Pulling the Soxs off proliferation
Kalyani Narasimhan Nature Neuroscience6, 1125
(November 2003); doi:10.1038/nn1103-1125
| Full Text (HTML/PDF) |
article β-catenin is critical for dendritic morphogenesis
Xiang Yu and Robert C Malenka Nature Neuroscience6, 1169–1177
(November 2003); doi:10.1038/nn1132
| Abstract | Full Text (HTML/PDF) |
article Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis
Xue Li, Kenneth A. Oghi, Jie Zhang, Anna Krones, Kevin T. Bush, Christopher K. Glass, Sanjay K. Nigam, Aneel K. Aggarwal, Richard Maas, David W. Rose and Michael G. Rosenfeld Nature426, 247–254
(20 November 2003); doi:10.1038/nature02083
| Abstract | Full Text (HTML / PDF) |
letters to nature Eyes absent represents a class of protein tyrosine phosphatases
Jayanagendra P. Rayapureddi, Chandramohan Kattamuri, Brian D. Steinmetz, Benjamin J. Frankfort, Edwin J. Ostrin, Graeme Mardon and Rashmi S. Hegde Nature426, 295–298
(20 November 2003); doi:10.1038/nature02093
| First Paragraph | Full Text (HTML / PDF) |
letters to nature The transcription factor Eyes absent is a protein tyrosine phosphatase
Tina L. Tootle , Serena J. Silver , Erin L. Davies , Victoria Newman, Robert R. Latek, Ishara A. Mills, Jeremy D. Selengut, Beth E. W. Parlikar and Ilaria Rebay Nature426, 299–302
(20 November 2003); doi:10.1038/nature02097
| First Paragraph | Full Text (HTML / PDF) |
news and views Signal transduction: An eye on organ development
Jonathan A. Epstein and Benjamin G. Neel Nature426, 238–239
(20 November 2003); doi:10.1038/426238a
| Full Text (HTML / PDF) |
article Regulation of gene expression and cocaine reward by CREB and ΔFosB
Colleen A. McClung and Eric J. Nestler Nature Neuroscience6, 1208–1215
(November 2003); doi:10.1038/nn1143
| Abstract | Full Text (HTML/PDF) |
letters to nature CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ
Stephan Herzig, Susan Hedrick, Ianessa Morantte, Seung-Hoi Koo, Francesco Galimi and Marc Montminy Nature426, 190–193
(13 November 2003); doi:10.1038/nature02110
| First Paragraph | Full Text (HTML / PDF) |
article Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein
Paul G Corn, E Robert McDonald, III James G Herman and Wafik S El-Deiry Nature Genetics35, 229–237
(November 2003); doi:10.1038/ng1254
| Abstract | Full Text (HTML/PDF) |
article Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation
Bin Y Qin, Cheng Liu, Suvana S Lam, Hema Srinath, Rachel Delston, John J Correia, Rik Derynck and Kai Lin Nature Structural Biology10, 913–921
(November 2003); doi:10.1038/nsb1002
| Abstract | Full Text (HTML/PDF) |
article X-ray crystal structure of IRF-3 and its functional implications
Kiyohiro Takahasi, Nobuo N Suzuki, Masataka Horiuchi, Mitsuaki Mori, Wakako Suhara, Yasutaka Okabe, Yukiko Fukuhara, Hiroaki Terasawa, Shizuo Akira, Takashi Fujita and Fuyuhiko Inagaki Nature Structural Biology10, 922–927
(November 2003); doi:10.1038/nsb1001
| Abstract | Full Text (HTML/PDF) |
news and views The nuts and bolts of IRF structure
Aristidis Moustakas and Carl-Henrik Heldin Nature Structural Biology10, 874–876
(November 2003); doi:10.1038/nsb1103-874
| Full Text (HTML/PDF) |
article Enhancement of CIITA transcriptional function by ubiquitin
Susanna F Greer, Eleni Zika, Brian Conti, Xin-Sheng Zhu and Jenny P-Y Ting Nature Immunology4, 1074–1082
(November 2003); doi:10.1038/ni985
| Abstract | Full Text (HTML/PDF) |
review article Regulation of JAK-STAT signalling in the immune system
Ke Shuai and Bin Liu Nature Reviews Immunology3, 900–911
(November 2003); doi:10.1038/nri1226
| Summary | Full Text (HTML / PDF) |
news and views Setting fat on fire
Robert Walczak and Peter Tontonoz Nature Medicine9, 1348–1349
(November 2003); doi:10.1038/nm1103-1348
| Full Text (HTML/PDF) |
article Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi, Hozumi Motohashi, Shuhei Noda, Satoru Takahashi, Sumihisa Imakado, Tomoe Kotsuji, Fujio Otsuka, Dennis R Roop, Takanori Harada, James Douglas Engel and Masayuki Yamamoto Nature Genetics35, 238–245
(November 2003); doi:10.1038/ng1248
| Abstract | Full Text (HTML/PDF) |
news and views A keaper and a striker maintain epidermal homeostasis
Thomas M Magin Nature Genetics35, 202–204
(November 2003); doi:10.1038/ng1103-202
| Full Text (HTML/PDF) |
new and views Playing tag with the yeast proteome
Brenda J Andrews, Gary D Bader & Charles Boone Nature Biotechnology21,1297–1299
(November 2003); doi:10.1038/nbt1103-1297
| Full Text (HTML/PDF) |
October
article Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor
Richard Dahl, Jonathan C Walsh, David Lancki, Peter Laslo, Sangeeta R Iyer, Harinder Singh and M Celeste Simon Nature Immunology4, 1029–1036
(October 2003); doi:10.1038/ni973
| Abstract | Full Text (HTML/PDF) |
article Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element
Michael J Giffin, James C Stroud, Darren L Bates, Konstanze D von Koenig, John Hardin and Lin Chen Nature Structural Biology10, 800–806
(October 2003); doi:10.1038/nsb981
| Abstract | Full Text (HTML/PDF) |
review article HIF-1 as a target for drug development
Amato Giaccia, Bronwyn G. Siim and Randall S. Johnson Nature Reviews Drug Discovery2, 803–811
(October 2003); doi:10.1038/nrd1199
| Abstract | Full Text (HTML / PDF) |
article An asymmetric NFAT1 dimer on a pseudo-palindromic kB-like DNA site
Lei Jin, Piotr Sliz, Lin Chen, Fernando Macián, Anjana Rao, Patrick G Hogan and Stephen C Harrison Nature Structural Biology10, 807–811
(October 2003); doi:10.1038/nsb975
| Abstract | Full Text (HTML/PDF) |
article Global analysis of protein localization in budding yeast
Won-Ki Huh, James V. Falvo, Luke C. Gerke, Adam S. Carroll, Russell W. Howson, Jonathan S. Weissman and Erin K. O'Shea Nature425, 686–691
(16 October 2003); doi:10.1038/nature02026
| Abstract | Full Text (HTML / PDF) |
letters to nature Global analysis of protein expression in yeast
Sina Ghaemmaghami, Won-Ki Huh, Kiowa Bower, Russell W. Howson, Archana Belle, Noah Dephoure, Erin K. O'Shea and Jonathan S. Weissman Nature425, 737–741
(16 October 2003); doi:10.1038/nature02046
| First Paragraph | Full Text (HTML / PDF) |
news and views Proteomics: Where's Waldo in yeast?
James A. Wohlschlegel and John R. Yates
Research in yeast provides the tools and benchmarks for a wide sweep of biology. The latest results reveal the most complete picture yet of the levels and locations of protein production in the organism. Nature425, 671–672
(16 October 2003); doi:10.1038/425671a
| Full Text (HTML / PDF) |
review article Mechanisms of sarcoma development
Lee J. Helman and Paul Meltzer Nature Reviews Cancer3, 685–694
(September 2003); doi:10.1038/nrc1168
| Abstract | Full Text (HTML / PDF) |
article NF-kB functions in synaptic signaling and behavior
Mollie K Meffert, Jolene M Chang, Brian J Wiltgen, Michael S Fanselow and David Baltimore Nature Neuroscience6, 1072–1078
(October 2003); doi:10.1038/nn1110
| Abstract | Full Text (HTML/PDF) |
article Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors
Kyung-Soon Park, Dong-ki Lee, Horim Lee, Yangsoon Lee, Young-Soon Jang, Yong Ha Kim, Hyo-Young Yang, Sung-I Lee, Wongi Seol & Jin-Soo Kim Nature Biotechnology21, 1208–1214
(October 2003); doi:10.1038/nbt868
| Full Text (HTML/PDF) |
letters to nature The Wnt/β-catenin pathway regulates cardiac valve formation
Adam F. L. Hurlstone, Anna-Pavlina G. Haramis, Erno Wienholds, Harry Begthel, Jeroen Korving, Fredericus van Eeden, Edwin Cuppen, Danica Zivkovic, Ronald H. A. Plasterk and Hans Clevers Nature425, 633–637
(09 October 2003); doi:10.1038/nature02028
| First Paragraph | Full Text (HTML / PDF) |
review article Smad-dependent and Smad-independent pathways in TGF-β family signalling
Rik Derynck and Ying E. Zhang Nature425, 577–584
(09 October 2003); doi:10.1038/nature02006
| Abstract | Full Text (HTML / PDF) |
perspectives Opinion: Can transcription factors function as cell-cell signalling molecules?
Alain Prochiantz and Alain Joliot Nature Reviews Molecular Cell Biology4, 814–819
(October 2003); doi:10.1038/nrm1227
| Abstract | Full Text (HTML / PDF) |
review article Targeting HIF-1 for cancer therapy
Gregg L. Semenza Nature Reviews Cancer3, 721–732
(October 2003); doi:10.1038/nrc1187
| Abstract | Full Text (HTML / PDF) |
news and views Developmental biology: Twisting the body into shape
Ian C. Scott and Didier Y. R. Stainier Nature425, 461–463
(02 October 2003); doi:10.1038/425461a
| Full Text (HTML / PDF) |
September
letter Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Chiara Zuccato, Marzia Tartari, Andrea Crotti, Donato Goffredo, Marta Valenza, Luciano Conti, Tiziana Cataudella, Blair R. Leavitt, Michael R Hayden, Tõnis Timmusk, Dorotea Rigamonti and Elena Cattaneo Nature Genetics35, 76–83
(September 2003); doi:10.1038/ng1219
| First Paragraph | Full Text (HTML/PDF) |
news and views An expanded role for wild-type huntingtin in neuronal transcription
Leslie Michels Thompson Nature Genetics35, 13–14
(September 2003); doi:10.1038/ng0903-13
| Full Text (HTML/PDF) |
article Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila
Scott Goeke, Elizabeth A. Greene, Paul K. Grant, Michael A. Gates, Daniel Crowner, Toshiro Aigaki and Edward Giniger Nature Neuroscience6, 917–924
(September 2003); doi:10.1038/nn1105
| Abstract | Full Text (HTML/PDF) |
letters to nature Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
Peter Staller, Jitka Sulitkova, Joanna Lisztwan, Holger Moch, Edward J. Oakeley and Wilhelm Krek Nature425, 307–311
(18 September 2003); doi:10.1038/nature01874
| First Paragraph | Full Text (HTML / PDF) |
news and views Cancer: Cues for migration
René Bernards Nature425, 247–248
(18 September 2003); doi:10.1038/425247a
| Full Text (HTML / PDF) |
article CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions
Athena W. Wong, W. June Brickey, Debra J. Taxman, Hendrick W. van Deventer, William Reed, Jian Xin Gao, Pan Zheng, Yang Liu, Ping Li, Janice S. Blum, Karen P. McKinnon and Jenny P-Y Ting Nature Immunology4, 891–898
(September 2003); doi:10.1038/ni960
| Abstract | Full Text (HTML/PDF) |
news and views ComPLEXIN new targets for CIITA
Walter Reith Nature Immunology4, 819–820
(September 2003); doi:10.1038/ni0903-819
| Full Text (HTML/PDF) |
article Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
Gaël Yvert, Rachel B. Brem, Jacqueline Whittle, Joshua M. Akey, Eric Foss, Erin N. Smith, Rachel Mackelprang and Leonid Kruglyak Nature Genetics35, 57–64
(September 2003); doi:10.1038/ng1222
| Abstract | Full Text (HTML/PDF) |
August
article Contribution of BCAP to maintenance of mature B cells through c-Rel
Tetsuo Yamazaki and Tomohiro Kurosaki Nature Immunology4, 780–786
(August 2003); doi:10.1038/ni949
| Abstract | Full Text (HTML/PDF) |
letters to nature CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members
Eirini Trompouki, Eudoxia Hatzivassiliou, Theodore Tsichritzis, Hannah Farmer, Alan Ashworth and George Mosialos Nature424, 793–796
(14 August 2003); doi:10.1038/nature01803
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
Thijn R. Brummelkamp, Sebastian M. B. Nijman, Annette M. G. Dirac and René Bernards Nature424, 797–801
(14 August 2003); doi:10.1038/nature01811
| First Paragraph | Full Text (HTML / PDF) |
letters to nature The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
Andrew Kovalenko Christine Chable-Bessia, Giuseppina Cantarella, Alain Israël, David Wallach & Gilles Courtois Nature424, 801–805
(14 August 2003); doi:10.1038/nature01802
| First Paragraph | Full Text (HTML / PDF) |
news and views Signal transduction: Aspirin, ubiquitin and cancer
Keith D. Wilkinson Nature424, 738–739
(14 August 2003); doi:10.1038/424738a
| Full Text (HTML / PDF) |
review article The SREBP pathway — insights from Insigs and insects
Robert B. Rawson Nature Reviews Molecular Cell Biology4, 631–640
(August 2003); doi:10.1038/nrm1174
| Summary | Full Text (HTML / PDF) |
article Emx2 patterns the neocortex by regulating FGF positional signaling
Tomomi Fukuchi-Shimogori and Elizabeth A Grove Nature Neuroscience6, 825–831
(August 2003); doi:10.1038/nn1093
| Abstract | Full Text (HTML/PDF) |
article Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
Roger G. Fahmy, Crispin R. Dass, Lun-Quan Sun, Colin N. Chesterman and Levon M. Khachigian Nature Medicine9, 1026–1032
(August 2003); doi:10.1038/nm905
| Abstract | Full Text (HTML/PDF) |
article Functional inactivation of a transcriptional corepressor by a signaling kinase
Christopher J Barnes, Ratna K Vadlamudi, Sandip K Mishra, Raymond H Jacobson, Feng Li and Rakesh Kumar Nature Structural Biology10, 622–628
(August 2003); doi:10.1038/nsb957
| Abstract | Full Text (HTML/PDF) |
July
letters to nature GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
Vidu Garg, Irfan S. Kathiriya , Robert Barnes, Marie K. Schluterman, Isabelle N. King, Cheryl A. Butler, Caryn R. Rothrock, Reenu S. Eapen, Kayoko Hirayama-Yamada, Kunitaka Joo, Rumiko Matsuoka, Jonathan C. Cohen and Deepak Srivastava Nature424, 443–447
(24 July 2003); doi:10.1038/nature01827
| First Paragraph | Full Text (HTML / PDF) |
review article Looking back to the embryo: defining transcriptional networks in adult myogenesis
Maura H. Parker , Patrick Seale and Michael A. Rudnicki Nature Reviews Genetics4, 497–507
(July 2003); doi:10.1038/nrg1109
| Abstract | Full Text (HTML / PDF) |
article Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2
Steven J. Freedman, Zhen-Yu J. Sun, Andrew L. Kung, Dennis S. France, Gerhard Wagner and Michael J. Eck Nature Structural Biology10, 504–512
(July 2003); doi:10.1038/nsb936
| Abstract | Full Text (HTML/PDF) |
news and views ExCITED about HIF
Shoumo Bhattacharya and Peter J. Ratcliffe Nature Structural Biology10, 501–503
(July 2003); doi:10.1038/nsb0703-501
| Full Text (HTML/PDF) |
article Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
Coleen T. Murphy, Steven A. McCarroll, Cornelia I. Bargmann, Andrew Fraser, Ravi S. Kamath, Julie Ahringer, Hao Li and Cynthia Kenyon Nature424, 277–283
(17 July 2003); doi:10.1038/nature01789
| Abstract | Full Text (HTML / PDF) |
news and views Ageing: Microarraying mortality
David Gems and Joshua J. McElwee Nature424, 259–261
(17 July 2003); doi:10.1038/424259a
| Full Text (HTML / PDF) |
letter Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice
Norbert M. Wikonkal, Eva Remenyik, Dejan Knezevic, Wengeng Zhang, Ming Liu, Hongyu Zhao, T. R. Berton, David G. Johnson and Douglas E. Brash Nature Cell Biology5, 655–660
(July 2003); doi:10.1038/ncb1001
| First Paragraph | Full Text (HTML/PDF) |
news and views The yin and yang of E2F-1: balancing life and death
Nicholas B. La Thangue Nature Cell Biology5, 587–589
(July 2003); doi:10.1038/ncb0703-587
| Full Text (HTML/PDF) |
review article Regulation of IL4 gene expression by T cells and therapeutic perspectives
Min Li-Weber and Peter H. Krammer Nature Reviews Immunology3, 534–543
(July 2003); doi:10.1038/nri1128
| Summary | Full Text (HTML / PDF) |
letters to nature Xpd/Ercc2 regulates CAK activity and mitotic progression
Jian Chen, Stéphane Larochelle, Xiaoming Li and Beat Suter Nature424, 228–232
(10 July 2003); doi:10.1038/nature01746
| First Paragraph | Full Text (HTML / PDF) |
June
letters to nature Cks1-dependent proteasome recruitment and activation of CDC20 transcription in budding yeast
May C. Morris, Peter Kaiser, Stanislav Rudyak, Chris Baskerville, Mark H. Watson and Steven I. Reed Nature423, 1009–1013
(26 June 2003); doi:10.1038/nature01720
| First Paragraph | Full Text (HTML / PDF) |
letter Differential regulation of E2F1 apoptotic target genes in response to DNA damage
Natalia Pediconi, Alessandra Ianari, Antonio Costanzo, Laura Belloni, Rita Gallo, Letizia Cimino, Antonio Porcellini, Isabella Screpanti, Clara Balsano, Edoardo Alesse, Alberto Gulino and Massimo Levrero Nature Cell Biology5, 552–558
(June 2003); doi:10.1038/ncb998
| First Paragraph | Full Text (HTML/PDF) |
letters to nature Involvement of Notch and Delta genes in spider segmentation
Angelika Stollewerk, Michael Schoppmeier and Wim G. M. Damen Nature423, 863–865
(19 June 2003); doi:10.1038/nature01682
| First Paragraph | Full Text (HTML / PDF) |
article E-proteins directly regulate expression of activation-induced deaminase in mature B cells
Camil Elie Sayegh, Melanie W Quong, Yasutoshi Agata and Cornelis Murre Nature Immunology4, 586–593
(June 2003); doi:10.1038/ni923
| Abstract | Full Text (HTML/PDF) |
article SOCS3 negatively regulates IL-6 signaling in vivo
Ben A Croker, Danielle L Krebs, Jian-Guo Zhang, Sam Wormald, Tracy A Willson, Edouard G Stanley, Lorraine Robb, Christopher J Greenhalgh, Irmgard Förster, Björn E Clausen, Nicos A Nicola, Donald Metcalf, Douglas J Hilton, Andrew W Roberts and Warren S Alexander Nature Immunology4, 540–545
(June 2003); doi:10.1038/ni931
| Abstract | Full Text (HTML/PDF) |
article SOCS3 regulates the plasticity of gp130 signaling
Roland Lang, Anne-Laure Pauleau, Evan Parganas, Yutaka Takahashi, Jörg Mages, James N Ihle, Robert Rutschman and Peter J Murray Nature Immunology4, 546–550
(June 2003); doi:10.1038/ni932
| Abstract | Full Text (HTML/PDF) |
article IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Hideo Yasukawa, Masanobu Ohishi, Hiroyuki Mori, Masaaki Murakami, Takatoshi Chinen, Daisuke Aki, Toshikatsu Hanada, Kiyoshi Takeda, Shizuo Akira, Masahiko Hoshijima, Toshio Hirano, Kenneth R Chien and Akihiko Yoshimura Nature Immunology4, 551–556
(June 2003); doi:10.1038/ni938
| Abstract | Full Text (HTML/PDF) |
news and views Matching SOCS with function
James A Johnston and John J O'Shea Nature Immunology4, 507–509
(June 2003); doi:10.1038/ni0603-507
| Full Text (HTML/PDF) |
article Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data
Eran Segal, Michael Shapira, Aviv Regev, Dana Pe'er, David Botstein, Daphne Koller and Nir Friedman Nature Genetics34, 166–176
(June 2003); doi:10.1038/ng1165
| Abstract | Full Text (HTML/PDF) |
May
letters to nature Modulation of oestrogen receptor signalling by association with the activated dioxin receptor
Fumiaki Ohtake, Ken-ichi Takeyama, Takahiro Matsumoto, Hirochika Kitagawa, Yasuji Yamamoto, Keiko Nohara, Chiharu Tohyama, Andree Krust, Junsei Mimura, Pierre Chambon, Junn Yanagisawa, Yoshiaki Fujii-Kuriyama and Shigeaki Kato Nature423, 545–550
(29 May 2003); doi:10.1038/nature01606
| First Paragraph | Full Text (HTML / PDF) |
news and views Gene expression: Oestrogen receptor hijacked
Jan J. Brosens and Malcolm G. Parker Nature423, 487–488
(29 May 2003); doi:10.1038/423487a
| Full Text (HTML / PDF) |
letters to nature Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1α interaction
Pere Puigserver, James Rhee, Jerry Donovan, Christopher J. Walkey, J. Cliff Yoon, Francesco Oriente, Yukari Kitamura, Jennifer Altomonte, Hengjiang Dong, Domenico Accili and Bruce M. Spiegelman Nature423, 550–555
(29 May 2003); doi:10.1038/nature01667
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors
Zhulun Wang, Gérard Benoit, Jinsong Liu, Srividya Prasad, Piia Aarnisalo, Xiaohong Liu, Haoda Xu, Nigel P. C. Walker and Thomas Perlmann Nature423, 555–560
(29 May 2003); doi:10.1038/nature01645
| First Paragraph | Full Text (HTML / PDF) |
news and views Mastering innate immunity
Robert M. Strieter Nature Medicine9, 512–513
(May 2003); doi:10.1038/nm0503-512
| Full Text (HTML/PDF) |
article Tissue-specific nuclear architecture and gene expession regulated by SATB1
Shutao Cai, Hye-Jung Han and Terumi Kohwi-Shigematsu Nature Genetics34, 42–51
(May 2003); doi:10.1038/ng1146
| Abstract | Full Text (HTML/PDF) |
news and views A nuclear address with influence
M. Frances Shannon Nature Genetics34, 4–6
(May 2003); doi:10.1038/ng0503-4
| Full Text (HTML/PDF) |
review Control of osteoblast function and regulation of bone mass
Shun-ichi Harada and Gideon A. Rodan Nature423, 349–355
(15 May 2003); doi:10.1038/nature01660
| Summary | Full Text (HTML / PDF) |
article Chk2 activates E2F-1 in response to DNA damage
Craig Stevens, Linda Smith and Nicholas B. La Thangue Nature Cell Biology5, 401–409
(May 2003); doi:10.1038/ncb974
| Abstract | Full Text (HTML/PDF) |
article IKK and TBK1 are essential components of the IRF3 signaling pathway
Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia, Daniel C. Rowe, Eicke Latz, Douglas T. Golenbock, Anthony J. Coyle, Sha-Mei Liao and Tom Maniatis Nature Immunology4, 491–496
(May 2003); doi:10.1038/ni921
| Abstract | Full Text (HTML/PDF) |
news and views Linking Toll-like receptors to IFN-a/b expression
Gregory M. Barton and Ruslan Medzhitov Nature Immunology4, 432–433
(May 2003); doi:10.1038/ni0503-432
| Full Text (HTML/PDF) |
article The two faces of IKK and NF-kB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
Lee-Wei Chen, Laurence Egan, Zhi-Wei Li, Florian R. Greten, Martin F. Kagnoff and Michael Karin Nature Medicine9, 575–581
(May 2003); doi:10.1038/nm849
| Abstract | Full Text (HTML/PDF) |
original paper v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1
A Maclaren, W Clark, E J Black, D Gregory, H Fujii and D A F Gillespie Oncogene22, 2383–2395
(May 2003); doi:10.1038/sj.onc.1206329
| Abstract | Full Text (HTML/PDF) |
April
article Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Jason D. Fontenot, Marc A. Gavin and Alexander Y. Rudensky Nature Immunology4, 330–336
(April 2003); doi:10.1038/ni904
| Abstract | Full Text (HTML/PDF) |
article An essential role for Scurfin in CD4+CD25+ T regulatory cells
Roli Khattri, Tom Cox, Sue-Ann Yasayko and Fred Ramsdell Nature Immunology4, 337–342
(April 2003); doi:10.1038/ni909
| Abstract | Full Text (HTML/PDF) |
news and views Twenty-first century Foxp3
Anne O'Garra and Paulo Vieira Nature Immunology4, 304–306
(April 2003); doi:10.1038/ni0403-304
| Full Text (HTML/PDF) |
letters to nature Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2
Aidong Han, Fan Pan, James C. Stroud, Hong-Duk Youn, Jun O. Liu and Lin Chen Nature422, 730–734
(17 April 2003); doi:10.1038/nature01555
| First Paragraph | Full Text (HTML / PDF) |
letters to nature Coordinated histone modifications mediated by a CtBP co-repressor complex
Yujiang Shi, Jun-ichi Sawada, Guangchao Sui, El Bachir Affar, Johnathan R. Whetstine, Fei Lan, Hidesato Ogawa, Margaret Po-Shan Luke, Yoshihiro Nakatani and Yang Shi Nature422, 735–738
(17 April 2003); doi:10.1038/nature01550
| First Paragraph | Full Text (HTML / PDF) |
article Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1
Neal N. Iwakoshi, Ann-Hwee Lee, Prasanth Vallabhajosyula, Kevin L. Otipoby, Klaus Rajewsky and Laurie H. Glimcher Nature Immunology4, 321–329
(April 2003); doi:10.1038/ni907
| Abstract | Full Text (HTML/PDF) |
news and views The stressful road to antibody secretion
Yanjun Ma and Linda M. Hendershot Nature Immunology4, 310–311
(April 2003); doi:10.1038/ni0403-310
| Full Text (HTML/PDF) |
article Transcriptional profiling identifies Id2 function in dendritic cell development
Christine Hacker, Ralf D. Kirsch, Xin-Sheng Ju, Thomas Hieronymus, Tatjana C. Gust, Christiane Kuhl, Thorsten Jorgas, Steffen M. Kurz, Stefan Rose-John, Yoshifumi Yokota and Martin Zenke Nature Immunology4, 380–386
(April 2003); doi:10.1038/ni903
| Abstract | Full Text (HTML/PDF) |
letters to nature PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression
Yuxin Yin, Yu-Xin Liu, Yan J. Jin, Eric J. Hall and J. Carl Barrett Nature422, 527–531
(03 April 2003); doi:10.1038/nature01519
| First Paragraph | Full Text (HTML / PDF) |
March
article Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex
Gianluca Canettieri, Ianessa Morantte, Ernesto Guzmán, Hiroshi Asahara, Stephan Herzig, Scott D. Anderson, John R. Yates and III Marc Montminy Nature Structural Biology10, 175–181
(March 2003); doi:10.1038/nsb895
| Abstract | Full Text (HTML/PDF) |
news and views The decline of induced transcription: a case of enzymatic symbiosis
Paolo Sassone-Corsi Nature Structural Biology10, 151–152
(March 2003); doi:10.1038/nsb0303-151
| Full Text (HTML/PDF) |
letters to nature Links between signal transduction, transcription and adhesion in epithelial bud development
Colin Jamora, Ramanuj DasGupta, Pawel Kocieniewski and Elaine Fuchs Nature422, 317–322
(20 March 2003); doi:10.1038/nature01458
| First Paragraph | Full Text (HTML / PDF) |
news and views Developmental biology: A hairy situation
Yann Barrandon Nature422, 272–273
(20 March 2003); doi:10.1038/422272a
| Full Text (HTML / PDF) |
perspectives Armadillo/β-catenin signals in the nucleus - proof beyond a reasonable doubt?
Mariann Bienz and Hans Clevers Nature Cell Biology5, 179–182
(March 2003); doi:10.1038/ncb0303-179
| Full Text (HTML/PDF) |
review article How the ubiquitin-proteasome system controls transcription
Masafumi Muratani and William P. Tansey Nature Reviews Molecular Cell Biology4, 192–201
(March 2003); doi:10.1038/nrm1049
| Summary | Full Text (HTML / PDF) |
letter Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency
Stéphanie Dupuis, Emmanuelle Jouanguy, Sami Al-Hajjar, Claire Fieschi, Ibrahim Zaid Al-Mohsen, Suliman Al-Jumaah, Kun Yang, Ariane Chapgier, Céline Eidenschenk, Pierre Eid, Abdulaziz Al Ghonaium, Haysam Tufenkeji, Husn Frayha, Suleiman Al-Gazlan, Hassan Al-Rayes, Robert D. Schreiber, Ion Gresser and Jean-Laurent Casanova Nature Genetics33, 388–391
(March 2003); doi:10.1038/ng1097
| First Paragraph | Full Text (HTML/PDF) |
February
article Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
Zusen Fan, Paul J. Beresford, Dong Zhang, Zhan Xu, Carl D. Novina, Akira Yoshida, Yves Pommier and Judy Lieberman Nature Immunology4, 145–153
(February 2003); doi:10.1038/ni885
| Abstract | Full Text (HTML/PDF) |
news and views Granzyme A: the road less traveled
Michael J. Pinkoski and Douglas R. Green Nature Immunology4, 106–108
(February 2003); doi:10.1038/ni0203-106
| Full Text (HTML/PDF) |
letter iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
Daniele Bergamaschi, Yardena Samuels, Nigel J. O'Neil, Giuseppe Trigiante, Tim Crook, Jung-Kuang Hsieh, Daniel J. O'Connor, Shan Zhong, Isabelle Campargue, Matthew L. Tomlinson, Patricia E. Kuwabara and Xin Lu Nature Genetics33, 162–167
(February 2003); doi:10.1038/ng1070
| First Paragraph | Full Text (HTML/PDF) |
letter t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway
Giovanni Tonon, Sanjay Modi, Lizi Wu, Akihito Kubo, Amy B. Coxon, Takefumi Komiya, Kevin O'Neil, Kristen Stover, Adel El-Naggar, James D. Griffin, Ilan R. Kirsch and Frederic J. Kaye Nature Genetics33, 208–213
(February 2003); doi:10.1038/ng1083
| First Paragraph | Full Text (HTML/PDF) |
article Activation of the transcription factor NF-κB in Schwann cells is required for peripheral myelin formation
Joshua C. Nickols, William Valentine, Sujata Kanwal and Bruce D. Carter Nature Neuroscience6, 161–167
(February 2003); doi:10.1038/nn995
| Abstract | Full Text (HTML/PDF) |
news and views Insulating axons via NF-κB
Mark P. Mattson Nature Neuroscience6, 105–106
(February 2003); doi:10.1038/nn0203-105
| Full Text (HTML/PDF) |
letters to nature STAT3 signalling is required for leptin regulation of energy balance but not reproduction
Sarah H. Bates, Walter H. Stearns, Trevor A. Dundon, Markus Schubert, Annette W. K. Tso, Yongping Wang, Alexander S. Banks, Hugh J. Lavery, Asma K. Haq, Eleftheria Maratos-Flier, Benjamin G. Neel, Michael W. Schwartz and Martin G. Myers Jr Nature421, 856–859
(20 February 2003); doi:10.1038/nature01388
| First Paragraph | Full Text (HTML / PDF) |
article The orphan nuclear receptor HNF4α determines PXR- and CAR-mediated xenobiotic induction of CYP3A4
Rommel G. Tirona, Wooin Lee, Brenda F. Leake, Lu-Bin Lan, Cynthia Brimer Cline, Vishal Lamba, Fereshteh Parviz, Stephen A. Duncan, Yusuke Inoue, Frank J. Gonzalez, Erin G. Schuetz and Richard B. Kim Nature Medicine9, 220–224
(February 2003); doi:10.1038/nm815
| Abstract | Full Text (HTML/PDF) |
article CTLA-4 regulates the requirement for cytokine-induced signals in TH2 lineage commitment
Hélène Bour-Jordan, Jane L. Grogan, Qizhi Tang, Julie A. Auger, Richard M. Locksley and Jeffrey A. Bluestone Nature Immunology4, 182–188
(February 2003); doi:10.1038/ni884
| Abstract | Full Text (HTML/PDF) |
review article Disruption of differentiation in human cancer: AML shows the way
Daniel G. Tenen Nature Reviews Cancer3, 89–101
(February 2003); doi:10.1038/nrc989
| Summary | Full Text (HTML / PDF) |
January
article Essential role of Id2 in negative regulation of IgE class switching
Manabu Sugai, Hiroyuki Gonda, Takashi Kusunoki, Tomoya Katakai, Yoshifumi Yokota and Akira Shimizu Nature Immunology4, 25–30
(January 2003); doi:10.1038/ni874
| Abstract | Full Text (HTML/PDF) |
news and views Yin outwits Yang at the IgE locus
Nancy Maizels Nature Immunology4, 7–8
(January 2003); doi:10.1038/ni0103-7
| Full Text (HTML/PDF) |
original paper Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
Daoyan Wei, Xiangdong Le, Leizhen Zheng, Liwei Wang, Jennifer A Frey, Allen C Gao, Zhihai Peng, Suyun Huang, Henry Q Xiong, James L Abbruzzese and Keping Xie Oncogene22, 319–329
(23 January 2003); doi:10.1038/sj.onc.1206122
| Abstract |
letters to nature Direct activation of RNA polymerase III transcription by c-Myc
Natividad Gomez-Roman, Carla Grandori, Robert N. Eisenman and Robert J. White Nature421, 290–294
(16 January 2003); doi:10.1038/nature01327
| First Paragraph | Full Text (HTML / PDF) |
article In vivo imaging of transcriptionally active estrogen receptors
Paolo Ciana, Michele Raviscioni, Paola Mussi, Elisabetta Vegeto, Ivo Que, Malcolm G. Parker, Clemens Lowik and Adriana Maggi Nature Medicine9, 82–86
(January 2003); doi:10.1038/nm809
| Abstract | Full Text (HTML/PDF) |
news and views In vivo imaging reveals estrogen receptor's hidden personality
Geoffrey L. Greene Nature Medicine9, 22–23
(January 2003); doi:10.1038/nm0103-22
| Full Text (HTML/PDF) |
article Zinc finger protein too few controls the development of monoaminergic
neurons
Gil Levkowitz, Jörg Zeller, Howard I. Sirotkin, Dorothy French, Sarah
Schilbach, Hisashi Hashimoto, Masahiko Hibi, William S. Talbot and Arnon
Rosenthal Nature Neuroscience6, 28–33
(January 2003); doi:10.1038/nn979
| Abstract
| Full Text (HTML/PDF)
|
and TBK1 are essential components of the IRF3 signaling pathway