letters to nature Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes
Christian Wolfrum, Esra Asilmaz, Edlira Luca, Jeffrey M. Friedman and Markus Stoffel Nature432, 1027–1032
(23 December 2004); doi:10.1038/nature03047
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news and views Diabetes: Outfoxing insulin resistance?
Marc Montminy and Seung-Hoi Koo Nature432, 958–959
(23 December 2004); doi:10.1038/432958a
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letters to nature An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division
Ralf Kittler, Gabriele Putz, Laurence Pelletier, Ina Poser, Anne-Kristin Heninger, David Drechsel, Steffi Fischer, Irena Konstantinova, Bianca Habermann, Hannes Grabner, Marie-Laure Yaspo, Heinz Himmelbauer, Bernd Korn, Karla Neugebauer, Maria Teresa Pisabarro and Frank Buchholz Nature432, 1036–1040
(23 December 2004); doi:10.1038/nature03159
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letters to nature The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes
Joseph T. Wade, Daniel B. Hall and Kevin Struhl Nature432, 1054–1058
(23 December 2004); doi:10.1038/nature03175
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letters to nature Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1
Stephan B. Schawalder, Mehdi Kabani, Isabelle Howald, Urmila Choudhury, Michel Werner and David Shore Nature432, 1058–1061
(23 December 2004); doi:10.1038/nature03200
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review article A BAF-centred view of the immune system
Tian Chi Nature Reviews Immunology4, 965–977
(December 2004); doi:10.1038/nri1501
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article Escherichia coli Hfq has distinct interaction surfaces for DsrA, rpoS and poly(A) RNAs
Peter J Mikulecky, Meenakshi K Kaw, Cristin C Brescia, Jennifer C Takach, Darren D Sledjeski and Andrew L Feig Nature Structural and Molecular Biology11, 1206–1214
(December 2004); doi:10.1038/nsmb858
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article Nuclear actin and myosin I are required for RNA polymerase I transcription
Vlada V. Philimonenko, Jian Zhao, Sebastian Iben, Hana Dingová, Katarína Kyselá, Michal Kahle, Hanswalter Zentgraf, Wilma A. Hofmann, Primal de Lanerolle, Pavel Hozák and Ingrid Grummt Nature Cell Biology6, 1165–1172
(December 2004); doi:10.1038/ncb1190
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article Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
Jose M Polo, Tania Dell'Oso, Stella Maris Ranuncolo, Leandro Cerchietti, David Beck, Gustavo F Da Silva, Gilbert G Prive, Jonathan D Licht and Ari Melnick Nature Medicine10, 1329–1335
(December 2004); doi:10.1038/nm1134
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letter Mutations in PTF1A cause pancreatic and cerebellar agenesis
Gabrielle S Sellick, Karen T Barker, Irene Stolte-Dijkstra, Christina Fleischmann, Richard J Coleman, Christine Garrett, Anna L Gloyn, Emma L Edghill, Andrew T Hattersley, Peter K Wellauer, Graham Goodwin and Richard S Houlston Nature Genetics36, 1301–1305
(December 2004); doi:10.1038/ng1475
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article Math1 regulates development of the sensory epithelium in the mammalian cochlea
Chad Woods, Mireille Montcouquiol and Matthew W Kelley Nature Neuroscience7, 1310–1318
(December 2004); doi:10.1038/nn1349
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review article Biochemical mechanisms for translational regulation in synaptic plasticity
Eric Klann and Thomas E. Dever Nature Reviews Neuroscience5, 931–942
(December 2004); doi:10.1038/nrn1557
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research article Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity
Lei Shen, Kevin Evel-Kabler, Randy Strube and Si-Yi Chen Nature Biotechnology22, 1546–1553
(December 2004); doi:10.1038/nbt1035
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research article Negative feedback inhibition of HIV-1 by TAT-inducible expression of siRNA
Hoshang J Unwalla, Ming-Jie Li, James D Kim, Hai Tang Li, Ali Ehsani, Jessica Alluin and John J Rossi Nature Biotechnology22, 1573–1578
(December 2004); doi:10.1038/nbt1040
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article Cell cycle-dependent regulation of yeast telomerase by Ku
Timothy S Fisher, Andrew K P Taggart and Virginia A Zakian Nature Structural and Molecular Biology11, 1198–1205
(December 2004); doi:10.1038/nsmb854
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letter Non-canonical Wnt signals are modulated by the Kaiso transcriptional repressor and p120-catenin
Si Wan Kim, Jae-Il Park, Christopher M. Spring, Amy K. Sater, Hong Ji, Abena A. Otchere, Juliet M. Daniel and Pierre D. McCrea Nature Cell Biology6, 1212–1220
(December 2004); doi:10.1038/ncb1191
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news and views Tudor domains track down DNA breaks
Manuel Stucki and Stephen P. Jackson Nature Cell Biology6, 1150–1152
(December 2004); doi:10.1038/ncb1204-1150
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article Deletion of a conserved Il4 silencer impairs T helper type 1-mediated immunity
K Mark Ansel, Rebecca J Greenwald, Suneet Agarwal, Craig H Bassing, Silvia Monticelli, Jeneen Interlandi, Ivana M Djuretic, Dong U Lee, Arlene H Sharpe, Frederick W Alt and Anjana Rao Nature Immunology5, 1251–1259
(December 2004); doi:10.1038/ni1135
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news and views Micromanaging insulin secretion
Craig C Mello and Michael P Czech Nature Medicine10, 1297–1298
(December 2004); doi:10.1038/nm1204-1297
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technical report Rapid analysis of the DNA-binding specificities of transcription factors with DNA microarrays
Sonali Mukherjee, Michael F Berger, Ghil Jona, Xun S Wang, Dale Muzzey, Michael Snyder, Richard A Young and Martha L Bulyk Nature Genetics36, 1331–1339
(December 2004); doi:10.1038/ng1473
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news and views Shortcuts to the end
Alberto R Kornblihtt Nature Structural and Molecular Biology11, 1156–1157
(December 2004); doi:10.1038/nsmb1204-1156
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letters to nature The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
Ryan T. Phan and Riccardo Dalla-Favera Nature432, 635–639
(02 December 2004); doi:10.1038/nature03147
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letter The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci
Raymond A. Poot, Ludmila Bozhenok, Debbie L.C. van den Berg, Søren Steffensen, Fernando Ferreira, Margaret Grimaldi, Nick Gilbert, Joao Ferreira and Patrick D. Varga-Weisz Nature Cell Biology6, 1236–1244
(December 2004); doi:10.1038/ncb1196
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review article The double-stranded-RNA-binding motif: interference and much more
Bin Tian, Philip C. Bevilacqua, Amy Diegelman-Parente and Michael B. Mathews Nature Reviews Molecular Cell Biology5, 1013–1023
(December 2004); doi:10.1038/nrm1528
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review article Consequences of regulated pre-mRNA splicing in the immune system
Kristen W. Lynch Nature Reviews Immunology4, 931–940
(December 2004); doi:10.1038/nri1497
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letter Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation
Annabelle Lewis, Kohzoh Mitsuya, David Umlauf, Paul Smith, Wendy Dean, Joern Walter, Michael Higgins, Robert Feil and Wolf Reik Nature Genetics36, 1291–1295
(December 2004); doi:10.1038/ng1468
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letter Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes
David Umlauf, Yuji Goto, Ru Cao, Frédérique Cerqueira, Alexandre Wagschal, Yi Zhang and Robert Feil Nature Genetics36, 1296–1300
(December 2004); doi:10.1038/ng1467
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article Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Ming Lei, Elaine R Podell and Thomas R Cech Nature Structural and Molecular Biology11, 1223–1229
(December 2004); doi:10.1038/nsmb867
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article High-throughput localization of functional elements by quantitative chromatin profiling Michael O Dorschner, Michael Hawrylycz, Richard Humbert, James C Wallace, Anthony Shafer, Janelle Kawamoto, Joshua Mack, Robert Hall, Jeff Goldy, Peter J Sabo, Ajay Kohli, Qiliang Li, Michael McArthur and John A Stamatoyannopoulos Nature Methods1, 219–225
(December 2004); doi:10.1038/nmeth721
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November
letters to nature The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II
Minkyu Kim, Nevan J. Krogan, Lidia Vasiljeva, Oliver J. Rando, Eduard Nedea, Jack F. Greenblatt and Stephen Buratowski Nature432, 517–522
(25 November 2004); doi:10.1038/nature03041
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letters to nature Human 5′ → 3′ exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
Steven West, Natalia Gromak and Nick J. Proudfoot Nature432, 522–525
(25 November 2004); doi:10.1038/nature03035
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letters to nature Autocatalytic RNA cleavage in the human β-globin pre-mRNA promotes transcription termination
Alexandre Teixeira, Abdessamad Tahiri-Alaoui, Steve West, Benjamin Thomas, Aroul Ramadass, Igor Martianov, Mick Dye, William James, Nick J. Proudfoot and Alexandre Akoulitchev Nature432, 526–530
(25 November 2004); doi:10.1038/nature03032
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news and views Molecular biology: Termination by torpedo
David Tollervey Nature432, 456–457
(25 November 2004); doi:10.1038/432456a
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article Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors
Ioannis Tassiulas, Xiaoyu Hu, Hao Ho, Yogita Kashyap, Paul Paik, Yongmei Hu, Clifford A Lowell and Lionel B Ivashkiv Nature Immunology5, 1181–1189
(November 2004); doi:10.1038/ni1126
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review article Forkhead-box transcription factors and their role in the immune system
Paul J. Coffer and Boudewijn M. T. Burgering Nature Reviews Immunology4, 889–899
(November 2004); doi:10.1038/nri1488
| Abstract | Full Text (HTML / PDF) |
article Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice
Nobuyasu Komazawa, Morihiro Matsuda, Gen Kondoh, Wataru Mizunoya, Masanori Iwaki, Toshiyuki Takagi, Yasuyuki Sumikawa, Kazuo Inoue, Akira Suzuki, Tak Wah Mak, Toru Nakano, Tohru Fushiki, Junji Takeda and Iichiro Shimomura Nature Medicine10, 1208–1215
(November 2004); doi:10.1038/nm1117
| Abstract | Full Text (HTML/PDF) |
news and views Turning up the heat in the fat cell
Domenico Accili and Luca Valenti Nature Medicine10, 1168–1169
(November 2004); doi:10.1038/nm1104-1168
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article Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells
Matthew C Lorincz, David R Dickerson, Mike Schmitt and Mark Groudine Nature Structural and Molecular Biology11, 1068–1075
(November 2004); doi:10.1038/nsmb840
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meeting report ZOMES III: the interface between signalling and proteolysis
Eric C. Chang and Claus Schwechheimer EMBO reports5, 1041–1045
(November 2004); doi:10.1038/sj.embor.7400275
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letters to nature A FADD-dependent innate immune mechanism in mammalian cells
Siddharth Balachandran, Emmanuel Thomas and Glen N. Barber Nature432, 401–405
(18 November 2004); doi:10.1038/nature03124
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letters to nature Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
Yentram Huyen, Omar Zgheib, Richard A. DiTullio Jr, Vassilis G. Gorgoulis, Panayotis Zacharatos, Tom J. Petty, Emily A. Sheston, Hestia S. Mellert, Elena S. Stavridi and Thanos D. Halazonetis Nature432, 406–411
(18 November 2004); doi:10.1038/nature03114
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article Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II
Wilma A. Hofmann, Ljuba Stojiljkovic, Beata Fuchsova, Gabriela M. Vargas, Evangelos Mavrommatis, Vlada Philimonenko, Katarina Kysela, James A. Goodrich, James L. Lessard, Thomas J. Hope, Pavel Hozak and Primal de Lanerolle Nature Cell Biology6, 1094–1101
(November 2004); doi:10.1038/ncb1182
| Abstract | Full Text (HTML/PDF) |
news and views Actin's many actions start at the genes
Werner W. Franke Nature Cell Biology6, 1013–1014
(November 2004); doi:10.1038/ncb1104-1013
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article RITS acts in cis to promote RNA interference-mediated transcriptional and post-transcriptional silencing
Ken-ichi Noma, Tomoyasu Sugiyama, Hugh Cam, Andre Verdel, Martin Zofall, Songtao Jia, Danesh Moazed and Shiv I S Grewal Nature Genetics36, 1174–1180
(November 2004); doi:10.1038/ng1452
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news and views RNA interference on chromosomes
R Kelly Dawe Nature Genetics36, 1141–1142
(November 2004); doi:10.1038/ng1104-1141
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article Microarray-based, high-throughput gene expression profiling of microRNAs
Peter T Nelson, Don A Baldwin, L Marie Scearce, J Carl Oberholtzer, John W Tobias and Zissimos Mourelatos Nature Methods1, 155–161
(November 2004); doi:10.1038/nmeth717
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news and views The age of high-throughput microRNA profiling
Aurora Esquela-Kerscher and Frank J Slack Nature Methods1, 106–107
(November 2004); doi:10.1038/nmeth1104-106
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letters to nature A pancreatic islet-specific microRNA regulates insulin secretion
Matthew N. Poy, Lena Eliasson, Jan Krutzfeldt, Satoru Kuwajima, Xiaosong Ma, Patrick E. MacDonald, Sébastien Pfeffer, Thomas Tuschl, Nikolaus Rajewsky, Patrik Rorsman and Markus Stoffel Nature432, 226–230
(11 November 2004); doi:10.1038/nature03076
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letters to nature Processing of primary microRNAs by the Microprocessor complex
Ahmet M. Denli, Bastiaan B. J. Tops, Ronald H. A. Plasterk, René F. Ketting and Gregory J. Hannon Nature432, 231–235
(11 November 2004); doi:10.1038/nature03049
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letters to nature The Microprocessor complex mediates the genesis of microRNAs
Richard I. Gregory, Kai-ping Yan, Govindasamy Amuthan, Thimmaiah Chendrimada, Behzad Doratotaj, Neil Cooch and Ramin Shiekhattar Nature432, 235–240
(11 November 2004); doi:10.1038/nature03120
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news and views MRL proteins: Leading Ena/VASP to Ras GTPases
John A. Legg and Laura M. Machesky Nature Cell Biology6, 1015–1017
(November 2004); doi:10.1038/ncb1104-1015
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article Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity
Philippe Stock, Omid Akbari, Gerald Berry, Gordon J Freeman, Rosemarie H DeKruyff and Dale T Umetsu Nature Immunology5, 1149–1156
(November 2004); doi:10.1038/ni1122
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article Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses
Jinfang Zhu, Booki Min, Jane Hu-Li, Cynthia J Watson, Alex Grinberg, Qi Wang, Nigel Killeen, Joseph F Urban, Jr Liying Guo and William E Paul Nature Immunology5, 1157–1165
(November 2004); doi:10.1038/ni1128
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review article Human brain evolution: insights from microarrays
Todd M. Preuss , Mario Càceres , Michael C. Oldham and Daniel H. Geschwind Nature Reviews Genetics5, 850–860
(November 2004); doi:10.1038/nrg1469
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article Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin
Beth A Sullivan and Gary H Karpen Nature Structural and Molecular Biology11, 1076–1083
(November 2004); doi:10.1038/nsmb845
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news and views Another piece in the transcription initiation puzzle
Francisco J Asturias Nature Structural and Molecular Biology11, 1031–1033
(November 2004); doi:10.1038/nsmb1104-1031
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letters to nature Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
Heiko Lickert, Jun K. Takeuchi , Ingo von Both, Johnathon R. Walls, Fionnuala McAuliffe, S. Lee Adamson , R. Mark Henkelman, Jeffrey L. Wrana, Janet Rossant and Benoit G. Bruneau Nature432, 107–112
(04 November 2004); doi:10.1038/nature03071
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letters to nature A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay
Nadia Amrani, Robin Ganesan, Stephanie Kervestin, David A. Mangus, Shubhendu Ghosh and Allan Jacobson Nature432, 112–118
(04 November 2004); doi:10.1038/nature03060
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letter Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response
Weiming Xu, Lizhi Liu, Ian G. Charles and Salvador Moncada Nature Cell Biology6, 1129–1134
(November 2004); doi:10.1038/ncb1188
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review article RNA and microRNAs in fragile X mental retardation
Peng Jin, Reid S. Alisch and Stephen T. Warren Nature Cell Biology6, 1048–1053
(November 2004); doi:10.1038/ncb1104-1048
| Abstract | Full Text (HTML/PDF) |
review article A-type lamins: Guardians of the soma?
Chris J. Hutchison and Howard J. Worman Nature Cell Biology6, 1062–1067
(November 2004); doi:10.1038/ncb1104-1062
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review article The LIM domain: from the cytoskeleton to the nucleus
Julie L. Kadrmas and Mary C. Beckerle Nature Reviews Molecular Cell Biology5, 920–931
(November 2004); doi:10.1038/nrm1499
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review article Recent developments in the transcriptional regulation of cytolytic effector cells
Laurie H. Glimcher, Michael J. Townsend, Brandon M. Sullivan and Graham M. Lord Nature Reviews Immunology4, 900–911
(November 2004); doi:10.1038/nri1490
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article Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
Jianxin Bao, Hana Lin, Yannan Ouyang, Debin Lei, Abdullah Osman, Tae-Wan Kim, Lin Mei, Penggao Dai, Kevin K Ohlemiller and Richard T Ambron Nature Neuroscience7, 1250–1258
(November 2004); doi:10.1038/nn1342
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article Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
Saumendra N Sarkar, Kristi L Peters, Christopher P Elco, Shuji Sakamoto, Srabani Pal and Ganes C Sen Nature Structural and Molecular Biology11, 1060–1067
(November 2004); doi:10.1038/nsmb847
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news and views Another detour on the Toll road to the interferon antiviral response
John Hiscott Nature Structural and Molecular Biology11, 1028–1030
(November 2004); doi:10.1038/nsmb1104-1028
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October
letter DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei
Stina Simonsson and John Gurdon Nature Cell Biology6, 984–990
(October 2004); doi:10.1038/ncb1176
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news and views Nuclear transfer: Epigenetics pays a visit
Naoyuki Fujita and Paul A. Wade Nature Cell Biology6, 920–922
(October 2004); doi:10.1038/ncb1004-920
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brief communication Regulatory evolution across the protein interaction network
Bernardo Lemos, Colin D Meiklejohn and Daniel L Hartl Nature Genetics36, 1059–1060
(October 2004); doi:10.1038/ng1427
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article A custom microarray platform for analysis of microRNA gene expression
J Michael Thomson, Joel Parker, Charles M Perou and Scott M Hammond Nature Methods1, 47–53
(October 2004); doi:10.1038/nmeth704
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letters to nature Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
Hanno Hock , Melanie J. Hamblen, Heather M. Rooke, Jeffrey W. Schindler, Shireen Saleque, Yuko Fujiwara and Stuart H. Orkin Nature431, 1002–1007
(21 October 2004); doi:10.1038/nature02994
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news and views Cancer: Negative feedback for B cells
Louis M. Staudt
The discovery of a protein that regulates the production of antibody-generating B cells has implications for our understanding of how cancers of the immune system develop — and how they might be treated. Nature431, 919–920
(21 October 2004); doi:10.1038/431919a
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article Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
Binhua P. Zhou, Jiong Deng, Weiya Xia, Jihong Xu, Yan M. Li, Mehmet Gunduz and Mien-Chie Hung Nature Cell Biology6, 931–940
(October 2004); doi:10.1038/ncb1173
| Abstract | Full Text (HTML/PDF) |
news and views GSK-3β sets Snail's pace
Karni Schlessinger and Alan Hall Nature Cell Biology6, 913–915
(October 2004); doi:10.1038/ncb1004-913
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article Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
Charalampos G Spilianakis and Richard A Flavell Nature Immunology5, 1017–1027
(October 2004); doi:10.1038/ni1115
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article Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Taro Kawai, Shintaro Sato, Ken J Ishii, Cevayir Coban, Hiroaki Hemmi, Masahiro Yamamoto, Kenta Terai, Michiyuki Matsuda, Jun-ichiro Inoue, Satoshi Uematsu, Osamu Takeuchi and Shizuo Akira Nature Immunology5, 1061–1068
(October 2004); doi:10.1038/ni1118
| Abstract | Full Text (HTML/PDF) |
letters to nature Hedgehog signalling controls eye degeneration in blind cavefish
Yoshiyuki Yamamoto, David W. Stock and William R. Jeffery Nature431, 844–847
(14 October 2004); doi:10.1038/nature02864
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letters to nature Role of histone H2A ubiquitination in Polycomb silencing
Hengbin Wang, Liangjun Wang, Hediye Erdjument-Bromage, Miguel Vidal, Paul Tempst, Richard S. Jones and Yi Zhang Nature431, 873–878
(14 October 2004); doi:10.1038/nature02985
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article Identification of BRCA1-IRIS, a BRCA1 locus product
Wael M. ElShamy and David M. Livingston Nature Cell Biology6, 954–967
(October 2004); doi:10.1038/ncb1171
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news and views Refocusing on BRCA1
Alan Ashworth Nature Cell Biology6, 916–917
(October 2004); doi:10.1038/ncb1004-916
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review article Molecular mechanisms of translational control
Fátima Gebauer and Matthias W. Hentze Nature Reviews Molecular Cell Biology5, 827–835
(October 2004); doi:10.1038/nrm1488
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article Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription
Holly Maier, Rachel Ostraat, Hua Gao, Scott Fields, Susan A Shinton, Kay L Medina, Tomokatsu Ikawa, Cornelis Murre, Harinder Singh, Richard R Hardy and James Hagman Nature Immunology5, 1069–1077
(October 2004); doi:10.1038/ni1119
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letter Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia
C. Graux, J. Cools, C. Melotte, H. Quentmeier, A. Ferrando, R. Levine, J.R. Vermeesch, M. Stul, B. Dutta, N. Boeckx, A. Bosly, P. Heimann, A. Uyttebroeck, N. Mentens, R. Somers, R.A.F. MacLeod, H.G. Drexler, A.T. Look, D.G. Gilliland, L. Michaux, P. Vandenberghe, I. Wlodarska, Peter Marynen and Anne Hagemeijer Nature Genetics36, 1084–1089
(October 2004); doi:10.1038/ng1425
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article The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type
Andrea Pichler, Puck Knipscheer, Hisato Saitoh, Titia K Sixma and Frauke Melchior Nature Structural and Molecular Biology11, 984–991
(October 2004); doi:10.1038/nsmb834
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news and views Arginine methylation signals mRNA export
Kiven E Lukong and Stéphane Richard Nature Structural and Molecular Biology11, 914–915
(October 2004); doi:10.1038/nsmb1004-914
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article Direct integration of Hox and segmentation gene inputs during Drosophila development
Brian Gebelein, Daniel J. McKay and Richard S. Mann Nature431, 653–659
(07 October 2004); doi:10.1038/nature02946
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letters to nature p19ARF directly and differentially controls the functions of c-Myc independently of p53
Ying Qi, Mark A. Gregory, Zhaoliang Li, Jeffrey P. Brousal, Kimberly West and Stephen R. Hann Nature431, 712–717
(07 October 2004); doi:10.1038/nature02958
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news and views Molecular biology: No exception to reversibility
Yi Zhang Nature431, 637–639
(07 October 2004); doi:10.1038/431637a
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review article A stepwise epigenetic process controls immunoglobulin allelic exclusion
Yehudit Bergman and Howard Cedar Nature Reviews Immunology4, 753–761
(October 2004); doi:10.1038/nri1458
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September
news and views Stretching cell fate
Donald McDonald Nature Cell Biology6, 803
(September 2004); doi:10.1038/ncb0904-803
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perspectives Opinion: Transcription — guarding the genome by sensing DNA damage
Mats Ljungman and David P. Lane Nature Reviews Cancer4, 727–737
(September 2004); doi:10.1038/nrc1435
| Abstract | Full Text (HTML / PDF) |
letters to nature Genomic analysis of regulatory network dynamics reveals large topological changes
Nicholas M. Luscombe, M. Madan Babu, Haiyuan Yu, Michael Snyder, Sarah A. Teichmann and Mark Gerstein Nature431, 308–312
(16 September 2004); doi:10.1038/nature02782
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article Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
Tatiana V Petrova, Terhi Karpanen, Camilla Norrmén, Russell Mellor, Tomoki Tamakoshi, David Finegold, Robert Ferrell, Dontscho Kerjaschki, Peter Mortimer, Seppo Ylä-Herttuala, Naoyuki Miura and Kari Alitalo Nature Medicine10, 974–981
(September 2004); doi:10.1038/nm1094
| Abstract | Full Text (HTML/PDF) |
article Abnormal TNF activity in Timp3−/− mice leads to chronic hepatic inflammation and failure of liver regeneration
Fazilat F Mohammed, David S Smookler, Suzanne E M Taylor, Barbara Fingleton, Zamaneh Kassiri, Otto H Sanchez, Jane L English, Lynn M Matrisian, Billie Au, Wen-Chen Yeh and Rama Khokha Nature Genetics36, 969–977
(September 2004); doi:10.1038/ng1413
| Abstract | Full Text (HTML/PDF) |
news and views TIMP3 checks inflammation
Roy A Black Nature Genetics36, 934–935
(September 2004); doi:10.1038/ng0904-934
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article CBFβ allosterically regulates the Runx1 Runt domain via a dynamic conformational equilibrium
Jiangli Yan, Yizhou Liu, Stephen M Lukasik, Nancy A Speck and John H Bushweller Nature Structural and Molecular Biology11, 901–906
(September 2004); doi:10.1038/nsmb819
| Abstract | Full Text (HTML/PDF) |
news and views Spindle checkpoint protein links Rb pathway to aneuploidy
Bernd Pulverer Nature Cell Biology6, 806
(September 2004); doi:10.1038/ncb0904-806
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article PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
Bin Liu, Sheldon Mink, Kelly A Wong, Natalie Stein, Crescent Getman, Paul W Dempsey, Hong Wu and Ke Shuai Nature Immunology5, 891–898
(September 2004); doi:10.1038/ni1104
| Abstract | Full Text (HTML/PDF) |
news and views A peek at PIAS
John J O'Shea and Wendy Watford Nature Immunology5, 875–876
(September 2004); doi:10.1038/ni0904-875
| Full Text (HTML/PDF) |
brief communication The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
Héctor G Pálmer, María Jesús Larriba, José Miguel García, Paloma Ordóñez-Morán, Cristina Peña, Sandra Peiró, Isabel Puig, Rufo Rodríguez, Ricardo de la Fuente, Antonio Bernad, Marina Pollán, Félix Bonilla, Carlos Gamallo, Antonio García de Herreros and Alberto Muñoz Nature Medicine10, 917–919
(September 2004); doi:10.1038/nm1095
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letters to nature Transcriptional regulatory code of a eukaryotic genome
Christopher T. Harbison, D. Benjamin Gordon, Tong Ihn Lee, Nicola J. Rinaldi, Kenzie D. Macisaac, Timothy W. Danford, Nancy M. Hannett, Jean–Bosco Tagne, David B. Reynolds, Jane Yoo, Ezra G. Jennings, Julia Zeitlinger, Dmitry K. Pokholok, Manolis Kellis, P. Alex Rolfe, Ken T. Takusagawa, Eric S. Lander, David K. Gifford, Ernest Fraenkel and Richard A. Young Nature431, 99–104
(02 September 2004); doi:10.1038/nature02800
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August
article B cell-specific loss of histone 3 lysine 9 methylation in the VH locus depends on Pax5
Kristen Johnson, David L Pflugh, Duonan Yu, David G T Hesslein, Kuo-I Lin, Alfred L M Bothwell, Andrei Thomas-Tikhonenko, David G Schatz and Kathryn Calame Nature Immunology5, 853–861
(August 2004); doi:10.1038/ni1099
| Abstract | Full Text (HTML/PDF) |
letters to nature Structural basis for redox regulation of Yap1 transcription factor localization
Matthew J. Wood, Gisela Storz and Nico Tjandra Nature430, 917–921
(19 August 2004); doi:10.1038/nature02790
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article Periodic gene expression program of the fission yeast cell cycle
Gabriella Rustici, Juan Mata, Katja Kivinen, Pietro Lió, Christopher J Penkett, Gavin Burns, Jacqueline Hayles, Alvis Brazma, Paul Nurse and Jürg Bähler Nature Genetics36, 809–817
(August 2004); doi:10.1038/ng1377
| Abstract | Full Text (HTML/PDF) |
news and views STARTing to recycle
Gavin Sherlock Nature Genetics36, 795–796
(August 2004); doi:10.1038/ng0804-795
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research article Systematic identification of abundant A-to-I editing sites in the human transcriptome
Erez Y Levanon, Eli Eisenberg, Rodrigo Yelin, Sergey Nemzer, Martina Hallegger, Ronen Shemesh, Zipora Y Fligelman, Avi Shoshan, Sarah R Pollock, Dan Sztybel, Moshe Olshansky, Gideon Rechavi and Michael F Jantsch Nature Biotechnology22, 1001–1005
(August 2004); doi:10.1038/nbt996
| Abstract | Full Text (HTML/PDF) |
news and views Editing the message from A to I
Kazuko Nishikura Nature Biotechnology22, 962–963
(August 2004); doi:10.1038/nbt0804-962
| Full Text (HTML/PDF) |
letters to nature Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
Eva Hernando, Zaher Nahlé , Gloria Juan, Elena Diaz-Rodriguez, Miguel Alaminos, Michael Hemann, Loren Michel, Vivek Mittal, William Gerald, Robert Benezra, Scott W. Lowe and Carlos Cordon-Cardo Nature430, 797–802
(12 August 2004); doi:10.1038/nature02820
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article SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells
Ryuji Hamamoto, Yoichi Furukawa, Masashi Morita, Yuko Iimura, Fabio Pittella Silva, Meihua Li, Ryuichiro Yagyu and Yusuke Nakamura Nature Cell Biology6, 731–740
(August 2004); doi:10.1038/ncb1151
| Abstract | Full Text (HTML/PDF) |
news and views From chromatin to cancer: a new histone lysine methyltransferase enters the mix
Robert J. Sims 3rd and Danny Reinberg Nature Cell Biology6, 685–687
(August 2004); doi:10.1038/ncb0804-685
| Full Text (HTML/PDF) |
letter Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Daniel J Ceradini, Anita R Kulkarni, Matthew J Callaghan, Oren M Tepper, Nicholas Bastidas, Mark E Kleinman, Jennifer M Capla, Robert D Galiano, Jamie P Levine and Geoffrey C Gurtner Nature Medicine10, 858–864
(August 2004); doi:10.1038/nm1075
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letters to nature De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Ingrid E. Wertz, Karen M. O'Rourke, Honglin Zhou, Michael Eby, L. Aravind, Somasekar Seshagiri, Ping Wu, Christian Wiesmann, Rohan Baker, David L. Boone, Averil Ma, Eugene V. Koonin and Vishva M. Dixit
Nature430, 694–699
(05 August 2004); doi:10.1038/nature02794
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article Olfactory receptor neuron axon targeting: intrinsic transcriptional control and hierarchical interactions
Takaki Komiyama, John R Carlson and Liqun Luo Nature Neuroscience7, 819–825
(August 2004); doi:10.1038/nn1284
| Abstract | Full Text (HTML/PDF) |
research article Analysis of the transcriptional complexity of Arabidopsis thaliana by massively parallel signature sequencing
Blake C Meyers, Tam H Vu, Shivakundan Singh Tej, Hassan Ghazal, Marta Matvienko, Vikas Agrawal, Jianchang Ning and Christian D Haudenschild Nature Biotechnology22, 1006–1011
(August 2004); doi:10.1038/nbt992
| Abstract | Full Text (HTML/PDF) |
news and views Tagging all genes
Jeffrey F D Dean Nature Biotechnology22, 961–962
(August 2004); doi:10.1038/nbt0804-961
| Full Text (HTML/PDF) |
July
letters to nature Median bundle neurons coordinate behaviours during Drosophila male courtship
Devanand S. Manoli and Bruce S. Baker Nature430, 564–569
(29 July 2004); doi:10.1038/nature02713
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letter Proteolysis-independent regulation of the transcription factor Met4 by a single Lys 48-linked ubiquitin chain
Karin Flick, Ikram Ouni, James A. Wohlschlegel, Chrissy Capati, W. Hayes McDonald, John R. Yates 3rd and Peter Kaiser Nature Cell Biology6, 634–641
(July 2004); doi:10.1038/ncb1143
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news and views Ubiquitin signalling: what's in a chain?
Mark Hochstrasser Nature Cell Biology6, 571–572
(July 2004); doi:10.1038/ncb0704-571
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letter HIF activation by pH-dependent nucleolar sequestration of VHL
Karim Mekhail, Lakshman Gunaratnam, Marie-Eve Bonicalzi and Stephen Lee Nature Cell Biology6, 642–647
(July 2004); doi:10.1038/ncb1144
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review article A new modality for immunosuppression: targeting the JAK/STAT pathway
John J. O'Shea, Marko Pesu, Dominic C. Borie and Paul S. Changelian Nature Reviews Drug Discovery3, 555–564
(July 2004); doi:10.1038/nrd1441
| Abstract | Full Text (HTML / PDF) |
letter Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma
Hsei-Wei Wang, Matthew W B Trotter, Dimitrios Lagos, Dimitra Bourboulia, Stephen Henderson, Taija Mäkinen, Stephen Elliman, Adrienne M Flanagan, Kari Alitalo and Chris Boshoff Nature Genetics36, 687–693
(July 2004); doi:10.1038/ng1384
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brief communication Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus
Young-Kwon Hong, Kimberly Foreman, Jay W Shin, Satoshi Hirakawa, Christine L Curry, David R Sage, Towia Libermann, Bruce J Dezube, Joyce D Fingeroth and Michael Detmar Nature Genetics36, 683–685
(July 2004); doi:10.1038/ng1383
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article Critical functions for c-Myb at three checkpoints during thymocyte development
Timothy P Bender, Christopher S Kremer, Manfred Kraus, Thorsten Buch and Klaus Rajewsky Nature Immunology5, 721–729
(July 2004); doi:10.1038/ni1085
| Abstract | Full Text (HTML/PDF) |
article TFIIH contains a PH domain involved in DNA nucleotide excision repair
Virginie Gervais, Valérie Lamour, Anass Jawhari, Florent Frindel, Emeric Wasielewski, Sandy Dubaele, Jean-Marc Egly, Jean-Claude Thierry, Bruno Kieffer and Arnaud Poterszman Nature Structural and Molecular Biology11, 616–622
(July 2004); doi:10.1038/nsmb782
| Abstract | Full Text (HTML/PDF) |
news and views Transcription meets DNA repair at a PH domain
Kon Yew Kwek, William O'Gorman and Alexandre Akoulitchev Nature Structural and Molecular Biology11, 588–589
(July 2004); doi:10.1038/nsmb0704-588
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letter Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function
Fiona M. Townsley, Adam Cliffe and Mariann Bienz Nature Cell Biology6, 626–633
(July 2004); doi:10.1038/ncb1141
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news and views A nuclear escort for β-catenin
Nicholas S. Tolwinski and Eric Wieschaus Nature Cell Biology6, 579–580
(July 2004); doi:10.1038/ncb0704-579
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perspectives Opinion: Analysis of genomic targets reveals complex functions of MYC
Jagruti H. Patel, Andrey P. Loboda, Michael K. Showe, Louise C. Showe and Steven B. McMahon Nature Reviews Cancer4, 562–568
(July 2004); doi:10.1038/nrc1393
| Abstract | Full Text (HTML / PDF) |
research article Engineered riboregulators enable post-transcriptional control of gene expression
Farren J Isaacs, Daniel J Dwyer, Chunming Ding, Dmitri D Pervouchine, Charles R Cantor and James J Collins Nature Biotechnology22, 841–847
(July 2004); doi:10.1038/nbt986
| Abstract | Full Text (HTML/PDF) |
news and views Custom design of metabolism
James C Liao Nature Biotechnology22, 823–824
(July 2004); doi:10.1038/nbt0704-823
| Full Text (HTML/PDF) |
letter Identification of TFB5, a new component of general transcription and DNA repair factor IIH
Jeffrey A Ranish, Steven Hahn, Yu Lu, Eugene C Yi, Xiao-jun Li, Jimmy Eng and Ruedi Aebersold Nature Genetics36, 707–713
(July 2004); doi:10.1038/ng1385
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letter A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A
Giuseppina Giglia-Mari, Frederic Coin, Jeffrey A Ranish, Deborah Hoogstraten, Arjan Theil, Nils Wijgers, Nicolaas G J Jaspers, Anja Raams, Manuela Argentini, P J van der Spek, Elena Botta, Miria Stefanini, Jean-Marc Egly, Ruedi Aebersold, Jan H J Hoeijmakers and Wim Vermeulen Nature Genetics36, 714–719
(July 2004); doi:10.1038/ng1387
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news and views From proteomics to disease
Kenneth H Kraemer Nature Genetics36, 677–678
(July 2004); doi:10.1038/ng0704-677
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June
news and views Heart disease: An ongoing genetic battle?
Deepak Srivastava Nature429, 819–822
(24 June 2004); doi:10.1038/429819a
| Full Text (HTML / PDF) |
letter Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling
Sachiko Kamakura, Koji Oishi, Takeshi Yoshimatsu, Masato Nakafuku, Norihisa Masuyama and Yukiko Gotoh Nature Cell Biology6, 547–554
(June 2004); doi:10.1038/ncb1138
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news and views Balancing muscle hypertrophy and atrophy
Eric P Hoffman and Gustavo A Nader Nature Medicine10, 584–585
(June 2004); doi:10.1038/nm0604-584
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review article Dissecting the metastatic cascade
Klaus Pantel and Ruud H. Brakenhoff Nature Reviews Cancer4, 448–456
(June 2004); doi:10.1038/nrc1370
| Abstract | Full Text (HTML / PDF) |
letter Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
Frank Rosenbauer, Katharina Wagner, Jeffery L Kutok, Hiromi Iwasaki, Michelle M Le Beau, Yutaka Okuno, Koichi Akashi, Steven Fiering and Daniel G Tenen Nature Genetics36, 624–630
(June 2004); doi:10.1038/ng1361
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news and views Fine-tuning PU.1
Derek L Stirewalt Nature Genetics36, 550–551
(June 2004); doi:10.1038/ng0604-550
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article Ascl1/Mash1 is required for the development of central serotonergic neurons
Alexandre Pattyn, Nicolas Simplicio, J Hikke van Doorninck, Christo Goridis, François Guillemot and Jean-François Brunet Nature Neuroscience7, 589–595
(June 2004); doi:10.1038/nn1247
| Abstract | Full Text (HTML/PDF) |
article Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster
Jan Rehwinkel, Andrea Herold, Kerstin Gari, Thomas Köcher, Michaela Rode, Francesca L Ciccarelli, Matthias Wilm and Elisa Izaurralde Nature Structural and Molecular Biology11, 558–566
(June 2004); doi:10.1038/nsmb759
| Abstract | Full Text (HTML/PDF) |
letter Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
Xiao Yan Zhou, Nobuyuki Shibusawa, Karuna Naik, Delia Porras, Karla Temple, Hesheng Ou, Kelly Kaihara, Michael W Roe, Matthew J Brady and Fredric E Wondisford Nature Medicine10, 633–637
(June 2004); doi:10.1038/nm1050
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article The prepattern transcription factor Irx2, a target of the FGF8/MAP kinase cascade, is involved in cerebellum formation
Ken Matsumoto, Shigeki Nishihara, Mika Kamimura, Tomoki Shiraishi, Takao Otoguro, Masayuki Uehara, Yukiko Maeda, Keiko Ogura, Andrew Lumsden and Toshihiko Ogura Nature Neuroscience7, 605–612
(June 2004); doi:10.1038/nn1249
| Abstract | Full Text (HTML/PDF) |
review article HIF1 and oxygen sensing in the brain
Frank R. Sharp and Myriam Bernaudin Nature Reviews Neuroscience5, 437–448
(June 2004); doi:10.1038/nrn1408
| Abstract | Full Text (HTML / PDF) |
research article Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation
Ralph Brandenberger, Henry Wei, Sally Zhang, Shirley Lei, Jaji Murage, Gregory J Fisk, Yan Li, Chunhui Xu, Rixun Fang, Karl Guegler, Mahendra S Rao, Ramumkar Mandalam, Jane Lebkowski and Lawrence W Stanton Nature Biotechnology22, 707–716
(June 2004); doi:10.1038/nbt971
| Abstract | Full Text (HTML/PDF) |
letters to nature The transcriptional programme of antibody class switching involves the repressor Bach2
Akihiko Muto, Satoshi Tashiro, Osamu Nakajima, Hideto Hoshino, Satoru Takahashi, Eiichirou Eakoda, Dai Ikebe, Masayuki Yamamoto & Kazuhiko Igarashi Nature429, 566–571
(03 June 2004); doi:10.1038/nature02596
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letters to nature Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene
Joseph A. Martens, Lisa Laprade and Fred Winston Nature429, 571–574
(03 June 2004); doi:10.1038/nature02538
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news and views Gene regulation: A reason for reading nonsense
Sabine Schmitt and Renato Paro Nature429, 510–511
(03 June 2004); doi:10.1038/429510a
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article Selective inhibition of NF-kB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
Eijiro Jimi, Kazuhiro Aoki, Hiroaki Saito, Fulvio D'Acquisto, Michael J May, Ichiro Nakamura, Testuo Sudo, Takefumi Kojima, Fujio Okamoto, Hidefumi Fukushima, Koji Okabe, Keiichi Ohya and Sankar Ghosh Nature Medicine10, 617–624
(June 2004); doi:10.1038/nm1054
| Abstract | Full Text (HTML/PDF) |
May
review article Oxygen sensing by HIF hydroxylases
Christopher J. Schofield and Peter J. Ratcliffe Nature Reviews Molecular Cell Biology5, 343–354
(May 2004); doi:10.1038/nrm1366
| Abstract | Full Text (HTML / PDF) |
review article CARMA1, BCL-10 and MALT1 in lymphocyte development and activation
Margot Thome Nature Reviews Immunology4, 348–359
(May 2004); doi:10.1038/nri1352
| Abstract | Full Text (HTML / PDF) |
brief communication The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
Davide Ruggero, Lorenzo Montanaro, Li Ma, Wei Xu, Paola Londei, Carlos Cordon-Cardo and Pier Paolo Pandolfi Nature Medicine10, 484–486
(May 2004); doi:10.1038/nm1042
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review article C/EBPα mutations in acute myeloid leukaemias
Claus Nerlov Nature Reviews Cancer4, 394–400
(May 2004); doi:10.1038/nrc1363
| Abstract | Full Text (HTML / PDF) |
letter Oligo-astheno-teratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta
Takahisa Nakamura, Ryoji Yao, Takehiko Ogawa, Toru Suzuki, Chizuru Ito, Naoki Tsunekawa, Kimiko Inoue, Rieko Ajima, Takashi Miyasaka, Yutaka Yoshida, Atsuo Ogura, Kiyotaka Toshimori, Toshiaki Noce, Tadashi Yamamoto and Tetsuo Noda Nature Genetics36, 528–533
(May 2004); doi:10.1038/ng1344
| First Paragraph | Full Text (HTML/PDF) |
letters to nature Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
Susumu Yamashita , Chiemi Miyagi, Toshiyuki Fukada, Naofumi Kagara, Yong-Suk Che and Toshio Hirano
Nature429, 298–302
(20 May 2004); doi:10.1038/nature02545
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perspectives Opinion: Regulatory diversity among metazoan co-activator complexes
Dylan J. Taatjes, Michael T. Marr and Robert Tjian Nature Reviews Molecular Cell Biology5, 403–410
(May 2004); doi:10.1038/nrm1369
| Abstract | Full Text (HTML / PDF) |
letter Gene regulatory network growth by duplication
Sarah A Teichmann and M Madan Babu Nature Genetics36, 492–496
(May 2004); doi:10.1038/ng1340
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review article Shaping the nuclear action of NF-kB
Lin-Feng Chen and Warner C. Greene Nature Reviews Molecular Cell Biology5, 392–401
(May 2004); doi:10.1038/nrm1368
| Abstract | Full Text (HTML / PDF) |
letters to nature Integrating high-throughput and computational data elucidates bacterial networks
Markus W. Covert, Eric M. Knight, Jennifer L. Reed, Markus J. Herrgard and Bernhard O. Palsson Nature429, 92–96
(06 May 2004); doi:10.1038/nature02456
| First Paragraph | Full Text (HTML / PDF) |
perspectives Innovation: Novel ChIP-based strategies to uncover transcription factor target genes in the immune system
Amy S. Weinmann Nature Reviews Immunology4, 381–386
(May 2004); doi:10.1038/nri1353
| Abstract | Full Text (HTML / PDF) |
brief communication Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis
Fred S Harman, Christopher J Nicol, Holly E Marin, Jerrold M Ward, Frank J Gonzalez and Jeffrey M Peters Nature Medicine10, 481–483
(May 2004); doi:10.1038/nm1026
| First Paragraph | Full Text (HTML/PDF) |
letter Just-in-time transcription program in metabolic pathways
Alon Zaslaver, Avi E Mayo, Revital Rosenberg, Pnina Bashkin, Hila Sberro, Miri Tsalyuk, Michael G Surette and Uri Alon Nature Genetics36, 486–491
(May 2004); doi:10.1038/ng1348
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April
article Rb regulates proliferation and rod photoreceptor development in the mouse retina
Jiakun Zhang, Jonathan Gray, Lizhao Wu, Gustavo Leone, Sheldon Rowan, Constance L Cepko, Xuemei Zhu, Cheryl M Craft and Michael A Dyer Nature Genetics36, 351–360
(April 2004); doi:10.1038/ng1318
| Abstract | Full Text (HTML/PDF) |
news and views A plethora of sites
Ghia Euskirchen and Michael Snyder Nature Genetics36, 325–326
(April 2004); doi:10.1038/ng0404-325
| Full Text (HTML/PDF) |
letter Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
Päivi Pajukanta, Heidi E Lilja, Janet S Sinsheimer, Rita M Cantor, Aldons J Lusis, Massimiliano Gentile, Xiaoqun Joyce Duan, Aino Soro-Paavonen, Jussi Naukkarinen, Janna Saarela, Markku Laakso, Christian Ehnholm, Marja-Riitta Taskinen and Leena Peltonen Nature Genetics36, 371–376
(April 2004); doi:10.1038/ng1320
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news and views USF1 on trial
Carol C Shoulders Nature Genetics36, 322–323
(April 2004); doi:10.1038/ng0404-322
| Full Text (HTML/PDF) |
meeting report Calcineurin: a central controller of signalling in eukaryotes
José Aramburu, Joseph Heitman & Gerald R. Crabtree EMBO reports11, 343–348
(April 2004); doi:10.1038/sj.embor.7400133 Full Text (HTML/PDF) |
article Regulation of the p300 HAT domain via a novel activation loop
Paul R Thompson, Dongxia Wang, Ling Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert G Roeder, Jiemin Wong, Massimo Levrero, Vittorio Sartorelli, Robert J Cotter and Philip A Cole Nature Structural and Molecular Biology11, 308–315
(April 2004); doi:10.1038/nsmb740
| Abstract | Full Text (HTML/PDF) |
news and views Is acetylation the key to opening locked gates?
B Franklin Pugh Nature Structural and Molecular Biology11, 298–300
(April 2004); doi:10.1038/nsmb0404-298
| Full Text (HTML/PDF) |
letter SREBPs suppress IRS-2-mediated insulin signalling in the liver
Tomohiro Ide, Hitoshi Shimano, Naoya Yahagi, Takashi Matsuzaka, Masanori Nakakuki, Takashi Yamamoto, Yoshimi Nakagawa, Akimitsu Takahashi, Hiroaki Suzuki, Hirohito Sone, Hideo Toyoshima, Akiyoshi Fukamizu and Nobuhiro Yamada Nature Cell Biology6, 351–357
(April 2004); doi:10.1038/ncb1111
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article The STAT3 isoforms α and β have unique and specific functions
Diego Maritano, Michelle L Sugrue, Silvia Tininini, Sarah Dewilde, Birgit Strobl, XinPing Fu, Victoria Murray-Tait, Roberto Chiarle and Valeria Poli Nature Immunology5, 401–409
(April 2004); doi:10.1038/ni1052
| Abstract | Full Text (HTML/PDF) |
March
article Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection
Patrick S Costello, Robert H Nicolas, Yasuyuki Watanabe, Ian Rosewell and Richard Treisman Nature Immunology5, 289–298
(March 2004); doi:10.1038/ni1038
| Abstract | Full Text (HTML/PDF) |
article PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing
Ildikó Gyõry, Jian Wu, György Fejér, Edward Seto and Kenneth L Wright Nature Immunology5, 299–308
(March 2004); doi:10.1038/ni1046
| Abstract | Full Text (HTML/PDF) |
news and views Sounds of a silent Blimp-1
Karen W Makar and Christopher B Wilson Nature Immunology5, 241–242
(March 2004); doi:10.1038/ni0304-241
| Full Text (HTML/PDF) |
news and views Laying down the bone
Charlotte Schubert Nature Medicine10, 237
(March 2004); doi:10.1038/nm0304-237
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letter Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation
Gijs R van den Brink, Sylvia A Bleuming, James C H Hardwick, Berber L Schepman, G Johan Offerhaus, Josbert J Keller, Corinne Nielsen, William Gaffield, Sander J H van Deventer, Drucilla J Roberts & Maikel P Peppelenbosch Nature Genetics36, 277–282
(March 2004); doi:10.1038/ng1304
| Abstract | Full Text (HTML/PDF) |
February
article Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
Peng Jin, Daniela C Zarnescu, Stephanie Ceman, Mika Nakamoto, Julie Mowrey, Thomas A Jongens, David L Nelson, Kevin Moses and Stephen T Warren Nature Neuroscience7, 113–117
(February 2004); doi:10.1038/nn1174
| Abstract | Full Text (HTML/PDF) |
letters to nature Direct interaction of geminin and Six3 in eye development
Filippo Del Bene, Kristin Tessmar-Raible and Joachim Wittbrodt Nature427, 745–749
(19 February 2004); doi:10.1038/nature02292
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letters to nature The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions
Lingfei Luo, Xiaoping Yang, Yoshihiro Takihara, Hendrik Knoetgen and Michael Kessel Nature427, 749–753
(19 February 2004); doi:10.1038/nature02305
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news and views Transcription: Origins of licensing control
Xue Li and Michael G. Rosenfeld Nature427, 687–688
(19 February 2004); doi:10.1038/427687a
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letter Gadd45β mediates the NF-kB suppression of JNK signalling by targeting MKK7/JNKK2
Salvatore Papa, Francesca Zazzeroni, Concetta Bubici, Shanthi Jayawardena, Kellean Alvarez, Shuji Matsuda, Dung U. Nguyen, Can G. Pham, Andreas H. Nelsbach, Tiziana Melis, Enrico De Smaele, Wei-Jen Tang, Luciano D'Adamio and Guido Franzoso Nature Cell Biology6, 146–153
(February 2004); doi:10.1038/ncb1093
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news and views Modifiying NEMO
Ronald T. Hay Nature Cell Biology6, 89–91
(February 2004); doi:10.1038/ncb0204-89
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article Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue, Kiyoshi Teshigawara, Shiyu Jin, Haruhisa Iguchi, Ryuji Hiramatsu, Derek LeRoith, Kiyoshi Takeda, Shizuo Akira and Masato Kasuga Nature Medicine10, 168–174
(February 2004); doi:10.1038/nm980
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review article The STATs of cancer — new molecular targets come of age
Hua Yu and Richard Jove Nature Reviews Cancer4, 97–105
(February 2004); doi:10.1038/nrc1275
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article A physical and functional map of the human TNF-α/NF-kB signal transduction pathway
Tewis Bouwmeester, Angela Bauch, Heinz Ruffner, Pierre-Olivier Angrand, Giovanna Bergamini, Karen Croughton, Cristina Cruciat, Dirk Eberhard, Julien Gagneur, Sonja Ghidelli, Carsten Hopf, Bettina Huhse, Raffaella Mangano, Anne-Marie Michon, Markus Schirle, Judith Schlegl, Markus Schwab, Martin A. Stein, Andreas Bauer, Georg Casari, Gerard Drewes, Anne-Claude Gavin, David B. Jackson, Gerard Joberty, Gitte Neubauer, Jens Rick, Bernhard Kuster and Giulio Superti-Furga Nature Cell Biology6, 97–105
(February 2004); doi:10.1038/ncb1086
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news and views Keeping cartographers busy
Matthew S. Hayden and Sankar Ghosh Nature Cell Biology6, 87–89
(February 2004); doi:10.1038/ncb0204-87
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article TRADD interacts with STAT1-α and influences interferon-γ signaling
Duane R Wesemann, Hongwei Qin, Natalia Kokorina and Etty N Benveniste Nature Immunology5, 199–207
(February 2004); doi:10.1038/ni1025
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article N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation
Naruhisa Ota, Tom J Brett, Theresa L Murphy, Daved H Fremont and Kenneth M Murphy Nature Immunology5, 208–215
(February 2004); doi:10.1038/ni1032
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January
letter Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
Ryo Sumazaki, Nobuyoshi Shiojiri, Shigemi Isoyama, Masayuki Masu, Kazuko Keino-Masu, Mitsujiro Osawa, Hiromitsu Nakauchi, Ryoichiro Kageyama and Akira Matsui Nature Genetics36, 83–87
(January 2004); doi:10.1038/ng1273
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article Principles of transcriptional control in the metabolic network of Saccharomyces cerevisiae
Jan Ihmels, Ronen Levy & Naama Barkai Nature Biotechnology22, 86–92
(January 2004); doi:10.1038/nbt918
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article Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
Noboru Sato, Laurent Meijer, Leandros Skaltsounis, Paul Greengard and Ali H Brivanlou Nature Medicine10, 55–63
(January 2004); doi:10.1038/nm979
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news and views Embryonic stem cells: staying plastic on plastic
Kinichi Nakashima, Sophia Colamarino and Fred H Gage Nature Medicine10, 23–24
(January 2004); doi:10.1038/nm0104-23
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review article Peroxisome-proliferator-activated receptors and cancers: complex stories
Liliane Michalik, Béatrice Desvergne and Walter Wahli Nature Reviews Cancer4, 61–70
(January 2004); doi:10.1038/nrc1254
| Summary | Full Text (HTML / PDF) |
letter Polycomb CBX7 has a unifying role in cellular lifespan
Jesús Gil, David Bernard, Dolores Martínez and David Beach Nature Cell Biology6, 67–72
(January 2004); doi:10.1038/ncb1077
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review article Tubby proteins: the plot thickens
Kilpatrick Carroll, Carlos Gomez and Lawrence Shapiro Nature Reviews Molecular Cell Biology5, 55–64
(January 2004); doi:10.1038/nrm1278
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article Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells
Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya, Kenneth Shain, Shumin Zhang, Raka Bhattacharya, Dmitry Gabrilovich, Richard Heller, Domenico Coppola, William Dalton, Richard Jove, Drew Pardoll and Hua Yu Nature Medicine10, 48–54
(January 2004); doi:10.1038/nm976
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review article The IKK NF-kB system: a treasure trove for drug development
Michael Karin, Yumi Yamamoto and Q. May Wang Nature Reviews Drug Discovery3, 17–26
(January 2004); doi:10.1038/nrd1279
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article Notch activity acts as a sensor for extracellular calcium during vertebrate left-right determination
Ángel Raya, Yasuhiko Kawakami, Concepción Rodríguez-Esteban, Marta Ibañes, Diego Rasskin-Gutman, Joaquín Rodríguez-León, Dirk Büscher, José A. Feijó and Juan Carlos Izpisúa Belmonte Nature427, 121–128
(08 January 2004); doi:10.1038/nature02190
| Abstract | Full Text (HTML / PDF) |
news and views Developmental biology: Asymmetric fixation
Nick Monk Nature427, 111–112
(08 January 2004); doi:10.1038/427111a
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letters to nature Bcl10 activates the NF-kB pathway through ubiquitination of NEMO
Honglin Zhou, Ingrid Wertz, Karen O'Rourke, Mark Ultsch, Somasekar Seshagiri, Michael Eby, Wei Xiao and Vishva M. Dixit Nature427, 167–171
(08 January 2004); doi:10.1038/nature02273
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news and views Notch, the new muscle booster
Charlotte Schubert Nature Medicine10, 24
(January 2004); doi:10.1038/nm0104-24
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