article Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure
Mary Tang, Guang Wang, Ping Lu, Richard H Karas, Mark Aronovitz, Scott P Heximer, Kevin M Kaltenbronn, Kendall J Blumer, David P Siderovski, Yan Zhu and Michael E Mendelsohn Nature Medicine9, 1506–1512
(December 2003); doi:10.1038/nm958
| Abstract | Full Text (HTML/PDF) |
November
letter G13 is an essential mediator of platelet activation in hemostasis and thrombosis
Alexandra Moers, Bernhard Nieswandt, Steffen Massberg, Nina Wettschureck, Sabine Grüner, Ildiko Konrad, Valerie Schulte, Barsom Aktas, Marie-Pierre Gratacap, Melvin I Simon, Meinrad Gawaz and Stefan Offermanns Nature Medicine9, 1418–1422
(November 2003); doi:10.1038/nm943
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article Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells
Alexandra Aicher, Christopher Heeschen, Christiane Mildner-Rihm, Carmen Urbich, Christian Ihling, Katja Technau-Ihling, Andreas M. Zeiher and Stefanie Dimmeler Nature Medicine9, 1370–1376
(November 2003); doi:10.1038/nm948
| Abstract | Full Text (HTML/PDF) |
October
letter Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator
Xiaoying Wang, Sun-Ryung Lee, Ken Arai, Seong-Ryong Lee, Kiyoshi Tsuji, G William Rebeck and Eng H Lo Nature Medicine9, 1313–1317
(October 2003); doi:10.1038/nm926
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review article From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family
Kristin A. Waite and Charis Eng Nature Reviews Genetics4, 763–773
(October 2003); doi:10.1038/nrg1178
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article The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
Solveig Gretarsdottir, Gudmar Thorleifsson, Sigridur Th Reynisdottir, Andrei Manolescu, Sif Jonsdottir, Thorbjörg Jonsdottir, Thorunn Gudmundsdottir, Sigrun M. Bjarnadottir, Olafur B. Einarsson, Herdis M. Gudjonsdottir, Malcolm Hawkins, Gudmundur Gudmundsson, Hrefna Gudmundsdottir, Hjalti Andrason, Asta S. Gudmundsdottir, Matthildur Sigurdardottir, Thomas T. Chou, Joseph Nahmias, Shyamali Goss, Sigurlaug Sveinbjörnsdottir, Einar M. Valdimarsson, Finnbogi Jakobsson, Uggi Agnarsson, Vilmundur Gudnason, Gudmundur Thorgeirsson, Jurgen Fingerle, Mark Gurney, Daniel Gudbjartsson, Michael L. Frigge, Augustine Kong, Kari Stefansson and Jeffrey R. Gulcher Nature Genetics35, 131–138
(October 2003); doi:10.1038/ng1245
| Abstract | Full Text (HTML/PDF) |
news and views Genetics of common polygenic stroke
Anna F. Dominiczak and Martin W. McBride Nature Genetics35, 116–117
(October 2003); doi:10.1038/ng1003-116
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September
news and views Cardiovascular biology: Signalling silenced
Edward M. Conway and Peter Carmeliet Nature425, 139–141
(11 September 2003); doi:10.1038/425139a
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article The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages
Bo Feng, Pin Mei Yao, Yankun Li, Cecilia M. Devlin, Dajun Zhang, Heather P. Harding, Michele Sweeney, James X. Rong, George Kuriakose, Edward A. Fisher, Andrew R. Marks, David Ron and Ira Tabas Nature Cell Biology5, 781–792
(September 2003); doi:10.1038/ncb1035
| Abstract | Full Text (HTML/PDF) |
news and views Unfolding the toxicity of cholesterol
Kezhong Zhang and Randal J. Kaufman Nature Cell Biology5, 769–770
(September 2003); doi:10.1038/ncb0903-769
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August
article VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts, Erik Storkebaum, Masafumi Morimoto, Jurgen Del-Favero, Frederik Desmet, Stefan L. Marklund, Sabine Wyns, Vincent Thijs, Jörgen Andersson, Ingrid van Marion, Ammar Al-Chalabi, Stephanie Bornes, Rhiannon Musson, Valerie Hansen, Lars Beckman, Rolf Adolfsson, Hardev Singh Pall, Hervé Prats, Severine Vermeire, Paul Rutgeerts, Shigehiro Katayama, Takuya Awata, Nigel Leigh, Loïc Lang-Lazdunski, Mieke Dewerchin, Christopher Shaw, Lieve Moons, Robert Vlietinck, Karen E. Morrison, Wim Robberecht, Christine Van Broeckhoven, Désiré Collen, Peter M. Andersen and Peter Carmeliet Nature Genetics34, 383–394
(August 2003); doi:10.1038/ng1211
| Abstract | Full Text (HTML/PDF) |
news and views A new piece of the ALS puzzle
John L. Cleveland Nature Genetics34, 357–358
(August 2003); doi:10.1038/ng0803-357
| Full Text (HTML/PDF) |
article Transcription factor Egr-1 supports FGF-dependent angiogenesis during neovascularization and tumor growth
Roger G. Fahmy, Crispin R. Dass, Lun-Quan Sun, Colin N. Chesterman and Levon M. Khachigian Nature Medicine9, 1026–1032
(August 2003); doi:10.1038/nm905
| Abstract | Full Text (HTML/PDF) |
July
article Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
Guido Serini, Donatella Valdembri, Sara Zanivan, Giulia Morterra, Constanze Burkhardt, Francesca Caccavari, Luca Zammataro, Luca Primo, Luca Tamagnone, Malcolm Logan, Marc Tessier-Lavigne, Masahiko Taniguchi, Andreas W. Püschel and Federico Bussolino Nature424, 391–397
(24 July 2003); doi:10.1038/nature01784
| Abstract | Full Text (HTML / PDF) |
letters to nature Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
Hiroyuki Watanabe, Joris Vriens, Jean Prenen, Guy Droogmans, Thomas Voets and Bernd Nilius Nature424, 434–438
(24 July 2003); doi:10.1038/nature01807
| First Paragraph | Full Text (HTML / PDF) |
letters to nature WAVE2 is required for directed cell migration and cardiovascular development
Daisuke Yamazaki, Shiro Suetsugu, Hiroaki Miki, Yuki Kataoka, Shin-Ichi Nishikawa, Takashi Fujiwara, Nobuaki Yoshida and Tadaomi Takenawa Nature424, 452–456
(24 July 2003); doi:10.1038/nature01770
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article Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1
Monica Autiero, Johannes Waltenberger, Didier Communi, Andrea Kranz, Lieve Moons, Diether Lambrechts, Jens Kroll, Stephane Plaisance, Maria De Mol, Françoise Bono, Stefanie Kliche, Guido Fellbrich, Kurt Ballmer-Hofer, Domenico Maglione, Ulrike Mayr-Beyrle, Mieke Dewerchin, Saskia Dombrowski, Danica Stanimirovic, Paul Van Hummelen, Christoph Dehio, Daniel J. Hicklin, Graziella Persico, Jean-Marc Herbert, David Communi, Masabumi Shibuya, Désiré Collen, Edward M. Conway and Peter Carmeliet Nature Medicine9, 936–943
(July 2003); doi:10.1038/nm884
| Abstract | Full Text (HTML/PDF) |
article 14-3-3 is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
Kazuhito Toyo-oka, Aki Shionoya, Michael J. Gambello, Carlos Cardoso, Richard Leventer, Heather L. Ward, Ramses Ayala, Li-Huei Tsai, William Dobyns, David Ledbetter, Shinji Hirotsune and Anthony Wynshaw-Boris Nature Genetics34, 274–285
(July 2003); doi:10.1038/ng1169
| Abstract | Full Text (HTML/PDF) |
article SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier
Sae-Won Lee, Woo Jean Kim, Yoon Kyung Choi, Hyun Seok Song, Myung Jin Son, Irwin H. Gelman, Yung-Jin Kim and Kyu-Won Kim Nature Medicine9, 900–906
(July 2003); doi:10.1038/nm889
| Abstract | Full Text (HTML/PDF) |
news and views Building up the blood-brain barrier
Peter Rieckmann and Britta Engelhardt Nature Medicine9, 828–829
(July 2003); doi:10.1038/nm0703-828
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news and views Angiogenesis inhibitors: motivators of metastasis?
Patricia S Steeg Nature Medicine9, 822–823
(July 2003); doi:10.1038/nm0703-822
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June
article Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease
Susumu Ishida, Kenji Yamashiro, Tomohiko Usui, Yuichi Kaji, Yuichiro Ogura, Tetsuo Hida, Yoshihito Honda, Yoshihisa Oguchi and Anthony P Adamis Nature Medicine9, 781–788
(June 2003); doi:10.1038/nm877
| Abstract | Full Text (HTML/PDF) |
review article Angiogenesis in health and disease
Peter Carmeliet Nature Medicine9, 653–660
(June 2003); doi:10.1038/nm0603-653
| Abstract | Full Text (HTML/PDF) |
review article Molecular regulation of vessel maturation
Rakesh K Jain Nature Medicine9, 685–693
(June 2003); doi:10.1038/nm0603-685
| Abstract | Full Text (HTML/PDF) |
review article Gene transfer as a tool to induce therapeutic vascular growth
Seppo Ylä-Herttuala and Kari Alitalo Nature Medicine9, 694–701
(June 2003); doi:10.1038/nm0603-694
| Abstract | Full Text (HTML/PDF) |
review article Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma
Mary J. C. Hendrix, Elisabeth A. Seftor, Angela R. Hess and Richard E. B. Seftor Nature Reviews Cancer3, 411–421
(June 2003); doi:10.1038/nrc1092
| Summary | Full Text (HTML / PDF) |
letter Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells
Michele De Palma, Mary Anna Venneri, Cristina Roca and Luigi Naldini Nature Medicine9, 789–795
(June 2003); doi:10.1038/nm871
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review article Endothelial signaling during development
Ondine Cleaver and Douglas A Melton Nature Medicine9, 661–668
(June 2003); doi:10.1038/nm0603-661
| Abstract | Full Text (HTML/PDF) |
review article Regulation of angiogenesis by hypoxia: role of the HIF system
Christopher W Pugh and Peter J Ratcliffe Nature Medicine9, 677–684
(June 2003); doi:10.1038/nm0603-677
| Abstract | Full Text (HTML/PDF) |
review article Angiogenesis: Tumorigenesis and the angiogenic switch
Gabriele Bergers and Laura E. Benjamin Nature Reviews Cancer3, 401–410
(June 2003); doi:10.1038/nrc1093
| Summary | Full Text (HTML / PDF) |
review article The biology of VEGF and its receptors
Napoleone Ferrara, Hans-Peter Gerber and Jennifer LeCouter Nature Medicine9, 669–676
(June 2003); doi:10.1038/nm0603-669
| Abstract | Full Text (HTML/PDF) |
news and views Cancer: Out of air is not out of action
Donald P. Bottaro and Lance A. Liotta Nature423, 593–595
(05 June 2003); doi:10.1038/423593a
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article Pigment epithelium-derived factor regulates the vasculature and mass of the prostate and pancreas
Jennifer A Doll, Veronica M Stellmach, Noël P Bouck, Anders RJ Bergh, Chung Lee, Lisa P Abramson, Mona L Cornwell, Michael R Pins, Jayme Borensztajn and Susan E Crawford Nature Medicine9, 774–780
(June 2003); doi:10.1038/nm870
| Abstract | Full Text (HTML/PDF) |
review article Basement membranes: structure, assembly and role in tumour angiogenesis
Raghu Kalluri Nature Reviews Cancer3, 422–433
(June 2003); doi:10.1038/nrc1094
| Summary | Full Text (HTML / PDF) |
May
article Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
Renhai Cao, Ebba Bråkenhielm, Robert Pawliuk, David Wariaro, Mark J. Post, Eric Wahlberg, Philippe Leboulch and Yihai Cao Nature Medicine9, 604–613
(May 2003); doi:10.1038/nm848
| Abstract | Full Text (HTML/PDF) |
news and views Platelet attraction
Charlotte Schubert Nature Medicine9, 511
(May 2003); doi:10.1038/nm0503-511
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letters to nature Direct observation of catch bonds involving cell-adhesion molecules
Bryan T. Marshall, Mian Long, James W. Piper, Tadayuki Yago, Rodger P. McEver and Cheng Zhu Nature423, 190–193
(08 May 2003); doi:10.1038/nature01605
| First Paragraph | Full Text (HTML / PDF) |
April
article A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2
Jian Hua Qi, Quteba Ebrahem, Nina Moore, Gillian Murphy, Lena Claesson-Welsh, Mark Bond, Andrew Baker and Bela Anand-Apte Nature Medicine9, 407–415
(April 2003); doi:10.1038/nm846
| Abstract | Full Text (HTML/PDF) |
March
article Angiogenins: a new class of microbicidal proteins involved in innate immunity
Lora V. Hooper, Thaddeus S. Stappenbeck, Chieu V. Hong and Jeffrey I. Gordon Nature Immunology4, 269–273
(March 2003); doi:10.1038/ni888
| Abstract | Full Text (HTML/PDF) |
news and views Angiogenin: an antimicrobial ribonuclease
Tomas Ganz Nature Immunology4, 213–214
(March 2003); doi:10.1038/ni0303-213
| Full Text (HTML/PDF) |
February
letters to nature Extra-embryonic function of Rb is essential for embryonic development and viability
Lizhao Wu, Alain de Bruin, Harold I. Saavedra, Maja Starovic, Anthony Trimboli, Ying Yang, Jana Opavska, Pamela Wilson, John C. Thompson, Michael C. Ostrowski, Thomas J. Rosol, Laura A. Woollett, Michael Weinstein, James C. Cross, Michael L. Robinson and Gustavo Leone Nature421, 942–947
(27 February 2003); doi:10.1038/nature01417
| First Paragraph | Full Text (HTML / PDF) |
news and views Developmental biology: A twist in a mouse tale
Nick Dyson Nature421, 903–904
(27 February 2003); doi:10.1038/421903a
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article Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
Leo E. Otterbein, Brian S. Zuckerbraun, Manabu Haga, Fang Liu, Ruiping Song, Anny Usheva, Christina Stachulak, Natalya Bodyak, R. Neal Smith, Eva Csizmadia, Shivraj Tyagi, Yorihiro Akamatsu, Richard J. Flavell, Timothy R. Billiar, Edith Tzeng, Fritz H. Bach, Augustine M.K. Choi and Miguel P. Soares Nature Medicine9, 183–190
(February 2003); doi:10.1038/nm817
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article VEGF: A modifier of the del22q11 (DiGeorge) syndrome?
Ingeborg Stalmans, Diether Lambrechts, Frederik De smet, Sandra Jansen, Jian Wang, Sunit Maity, Paige Kneer, Maren von der Ohe, Ann Swillen, Christa Maes, Marc Gewillig, Daniel G.M. Molin, Peter Hellings, Thurid Boetel, Maartin Haardt, Veerle Compernolle, Mieke Dewerchin, Stephane Plaisance, Robert Vlietinck, Beverly Emanuel, Adriana C. Gittenberger-de Groot, Peter Scambler, Bernice Morrow, Deborah A. Driscol, Lieve Moons, Camila V. Esguerra, Geert Carmeliet, Annett Behn-Krappa, Koen Devriendt, Désiré Collen, Simon J. Conway and Peter Carmeliet Nature Medicine9, 173–182
(February 2003); doi:10.1038/nm819
| Abstract | Full Text (HTML/PDF) |
news and views Splitting vessels: Keeping lymph apart from blood
Shahin Rafii and Mihaela Skobe Nature Medicine9, 166–168
(February 2003); doi:10.1038/nm0203-166
| Full Text (HTML/PDF) |
January
article Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
Yuqing Huo, Andreas Schober, S. Bradley Forlow, David F. Smith, Matthew Craig Hyman, Steffen Jung, Dan R. Littman, Christian Weber and Klaus Ley Nature Medicine9, 61–67
(January 2003); doi:10.1038/nm810
| Abstract | Full Text (HTML/PDF) |
article Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Micaela Zonta, María Cecilia Angulo, Sara Gobbo, Bernhard Rosengarten, Konstantin-A. Hossmann, Tullio Pozzan and Giorgio Carmignoto Nature Neuroscience6, 43–50
(January 2003); doi:10.1038/nn980
| Abstract | Full Text (HTML/PDF) |
news and views An astrocyte bridge from synapse to blood flow
Rheinallt Parri and Vincenzo Crunelli Nature Neuroscience6, 5–6
(January 2003); doi:10.1038/nn0103-5
| Full Text (HTML/PDF) |
review article Scientific and therapeutic advances in antiplatelet therapy
Deepak L. Bhatt and Eric J. Topol Nature Reviews Drug Discovery2, 15–28
(January 2003); doi:10.1038/nrd985
| Summary | Full Text (HTML / PDF) |
original paper Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
Daoyan Wei, Xiangdong Le, Leizhen Zheng, Liwei Wang, Jennifer A Frey, Allen C Gao, Zhihai Peng, Suyun Huang, Henry Q Xiong, James L Abbruzzese and Keping Xie Oncogene22, 319–329
(23 January 2003); doi:10.1038/sj.onc.1206122
| Abstract |
article Angiopoietins have distinct modular domains essential for receptor
binding, dimerization and superclustering
Samuel Davis, Nick Papadopoulos, Thomas H. Aldrich, Peter C. Maisonpierre,
Tammy Huang, Lubomir Kovac, April Xu, Raymond Leidich, Elzbieta Radziejewska,
Ashique Rafique, Judah Goldberg, Vivek Jain, Kevin Bailey, Margaret Karow,
Jim Fandl, Steven J. Samuelsson, Ella Ioffe, John S. Rudge, Thomas J.
Daly, Czeslaw Radziejewski and George D. Yancopoulos Nature Structural Biology10, 38–44
(January 2003); doi:10.1038/nsb880
| Abstract
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is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome