Nature Signaling Update News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group. http://www.signaling-gateway.org/update/ weekly 1 2003-06-20T20:00+00:00 Nature Signaling Update http://www.signaling-gateway.org/slices/logo_ucsd_sig.gif http://www.signaling-gateway.org/update/ Featured Article: NF-kappaB in hypoxia: And now for something completely different http://www.signaling-gateway.org/update/featured/ The transcription factor NF-kappaB induces the expression of HIF-1alpha, providing a link between innate immunity and the hypoxic response. Selected Update: Metastasis: Bringing up the rear http://www.signaling-gateway.org/update/updates/200805/nrc2380.html Blocking the function of the tetraspanin CD151 in vivo prevents tumor dissemination by inhibiting migration and access to the vasculature (intravasation) at primary tumor sites. Selected Update: Molecular neuroscience: Stress hormones Trk neurons into survival http://www.signaling-gateway.org/update/updates/200805/nrn2382.html The neuroprotective effects of glucocorticoids are mediated by the activation of the neurotrophin receptor TrkB in rats. Selected Update: Host response: Innate mimicry http://www.signaling-gateway.org/update/updates/200805/nrmicro1903.html A new class of virulence factors have been identified that are used by bacterial pathogens to interfere with Toll-like receptor (TLR) signaling. Research Library: TGF-beta-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORt function http://www.nature.com/doifinder/10.1038/nature06878 Research Library: Transcriptional control of human p53-regulated genes http://www.nature.com/doifinder/10.1038/nrm2395 Research Library: A role for ubiquitin in the spliceosome assembly pathway http://www.nature.com/doifinder/10.1038/nsmb.1401 News: Chemists spin a web of data http://www.nature.com/news/2008/080507/full/453139a.html A chemist running a computer server is solving one of his colleagues' biggest frustrations by providing the community with an open-access source of chemical information on millions of molecules. The ChemSpider service scans open-access sources, including PubChem and Wikipedia, for chemical data. It compiles the publicly available information in a single location, and allows users to follow links to the original source material.