News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group. http://www.signaling-gateway.org/update/ weekly 1 2003-06-20T20:00+00:00 http://www.signaling-gateway.org/slices/logo_ucsd_sig.gif http://www.signaling-gateway.org/update/ http://www.signaling-gateway.org/update/featured/ TGF-beta signaling promotes the nuclear accumulation of CLIC4, which mediates the transcriptional response to TGF-beta by protecting phospho-Smad2 and 3 from dephosphorylation. http://www.signaling-gateway.org/update/updates/200907/nrm2719.html Multiple evolutionarily conserved chaperones generate specific subcomplexes that are assembled into the 19S regulatory particle and the 20S core particle to form the complete 26S proteasome. http://www.signaling-gateway.org/update/updates/200907/nrc2689.html A systems biology approach has enabled the identification of several novel KRAS-dependent signaling pathways and proteins in cancer cell line. http://www.signaling-gateway.org/update/updates/200907/nrn2675.html Chronic cocaine exposure increases deltaFosB-mediated transcription of sirtuins 1 and 2, altering MAPK signaling in the nucleus accumbens. http://www.nature.com/doifinder/10.1038/nature08113 http://www.nature.com/doifinder/10.1038/ncb1897 http://www.nature.com/ng/journal/v41/n7/abs/ng.395.html http://www.signaling-gateway.org/molecule/query?afcsid=A000622 CCR1 was the first human CC chemokine receptor to be identified at the cDNA level. Although CCR1 was initially described as a receptor for the chemokines CCL3 and CCL5, a number of other chemokine ligands have been described, some of which are generated from weak agonists by proteases during inflammatory responses in vivo. Because CCR1 seems to have a role in host defense and inflammation, it represents a potential target for therapeutic intervention in various clinically important diseases. http://www.nature.com/nature/supplements/collections/cancer/ The development of cancer is an evolutionary process that is driven by multiple genetic and epigenetic changes. This free collection contains a selection of recent papers published in Nature that yield insights into the genetic and epigenetic basis of human cancers, the biological processes that drive cancer progression and the efforts to translate such findings into potential clinical applications.