Nature Signaling Update News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group. http://www.signaling-gateway.org/update/ weekly 1 2003-06-20T20:00+00:00 Nature Signaling Update http://www.signaling-gateway.org/slices/logo_ucsd_sig.gif http://www.signaling-gateway.org/update/ Featured Article: Tumor cell invasion: p53 and integrin duet http://www.signaling-gateway.org/update/featured/ Mutant p53 promotes cancer cell invasion and random motility by enhancing integrin recycling. Selected Update: Viral infection: Entry through tunnel vision http://www.signaling-gateway.org/update/updates/201002/nrmicro2306.html SV40 induces the formation of tubular invaginations in the host cell membrane in a manner that is dependent on the acyl-chain length of GM1 but independent of active host cell trafficking machinery. Selected Update: DNA damage response: DNA takes a break with SUMO http://www.signaling-gateway.org/update/updates/201002/nrm2835.html PIAS1 and PIAS4 promote BRCA1 sumoylation and DNA repair. Selected Update: Systems biology: Network spreading http://www.signaling-gateway.org/update/updates/201002/nrc2794.html Identification of a small transcription factor network that is responsible for the mesenchymal behavior of glioma cells. Research Library: Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells http://www.nature.com/nature/journal/v463/n7280/abs/nature08636.html Research Library: PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1 http://www.nature.com/ncb/journal/v12/n2/full/ncb2012.html Research Library: Tsc2-Rheb signaling regulates EphA-mediated axon guidance http://www.nature.com/neuro/journal/v13/n2/full/nn.2477.html Molecule Page: G protein alpha transducin, cone http://www.signaling-gateway.org/molecule/query?afcsid=A000980 Cone transducin is a member of the family of heterotrimeric G proteins that couples ligand-activated, heptahelical transmembrane receptors (G-protein-coupled receptors; GPCRs) to downstream effector proteins. Visual pigments expressed by the photoreceptor cells are the GPCRs that are activated by photon absorption. Light initiates a conformational change in the GPCR, which then activates cone transducin by causing the exchange of bound GDP for GTP in the cone transducin component Tcalpha. Tcalpha-GTP then binds the inhibitory gamma-subunit of the effector enzyme phosphodiesterase and stimulates its activity. This G-protein-mediated intracellular signaling cascade in photoreceptor cells is called phototransduction. News: Nature Focus on Synthetic Systems Biology http://www.nature.com/nature/focus/syntheticsytemsbiology/index.html Synthetic biology goes beyond classic genetic engineering as it attempts to engineer living systems to perform new functions not found in nature. Ten years ago this week, Nature published a pair of seminal papers that stimulated 'systems biology' thinking in the field. This web focus gathers these two papers together with papers more recently published by Nature in the same spirit.