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Updates: January 2002

These short, accessible 'Highlights' summarize and contextualize must-read papers related to cell signaling. These articles add background and context to summaries of primary research. 'In brief' articles emphasize key aspects of selected articles.

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	METASTASIS: Adaptable integrins Only by ß4-integrin and Met working together can they recruit sufficient signalling molecules to yield powerful and sustained growth, survival and motility responses. 25 January 2002
	CARCINOGENS: Fishing for trouble H. pylori strains carrying the cagA gene are known to be particularly virulent but little is known about CagA function, however a protein-fishing expedition has led to the discovery of what might be a transformation inducing CagA target. 25 January 2002
	In brief: January 2002 Mouse Models \| G-Protein-Coupled Receptors
	ANGIOGENESIS: What's going on? Several studies have reported that integrin inhibitors prevent tumour growth and angiogenesis, but a new report in Nature Medicine finds that tumour growth is actually enhanced in mice lacking ß3 and ß5 integrins. 18 January 2002
	THERAPEUTIC TARGETS: From microarray to mechanism Eric Davis and colleagues provide a rational basis for developing new types of therapies for diffuse large B-cell lymphoma (DLBCL) patients not responding well to chemotherapy. 18 January 2002
	G-PROTEIN-COUPLED RECEPTORS: Cheek to cheek Several key GPCR families contain functional interfaces consisent with dimerization, and a putative receptor-binding site on G proteins is consisent with binding to a GPCR dimer. 18 January 2002
	DEVELOPMENTAL BIOLOGY: New tricks for an old dog Ramain et al., through their analysis of new dominant Notch alleles, reveal the existence of a novel Notch pathway in Drosophila and show that it is antagonized by Wingless signalling 11 January 2002
	CELL SIGNALLING: From Wingless to boneless There is an intriguing link between the Wingless (Wnt) signalling pathway and the processes that underlie bone formation. 11 January 2002
	SIGNAL TRANSDUCTION: Chop and change Okamoto and co-workers report the identification of a novel CD44 signalling pathway. 4 January 2002
	DNA REPAIR: Damage limitation Cytokines can protect cells from apoptosis in response to DNA damage from UVB by switching on the DNA repair machinery. 4 January 2002
	SIGNAL TRANSDUCTION: Top-Notch result Lateral inhibition is not the only pathway that Notch can use to prevent neural differentiation. 4 January 2002